Aging Population Research Articles

Contemporary Educational Approaches to the Literacy and Development of the Dong Grand Songs

The Dong Grand Songs, renowned for their polyphonic choral arrangements, are a vital cultural heritage of the Dong ethnic group. This study investigates the contemporary educational approaches to the literacy and development of the Dong Grand Songs in Guangxi, China. Employing a qualitative design, the research includes fieldwork, in-depth interviews, participant observation, and document analysis. Key informants comprise school administrators, teachers, song teachers, cultural inheritors, students, and community members. The findings reveal that integrating Dong Grand Song courses into primary and secondary school curricula, with support from song teachers and cultural inheritors, effectively enhances musical literacy and preserves this tradition. However, challenges such as youth migration, modern entertainment influences, and the aging population of song masters threaten the continuity of this cultural heritage. The study suggests comprehensive approaches, including economic support for rural areas, increased public awareness, and sustainable cultural programs, are necessary to address these challenges. This research provides valuable insights for policymakers, educators, and cultural practitioners on preserving intangible cultural heritage and promoting musical literacy through education.

Older persons, political participation, and the Decade of Healthy Ageing: an international legal analysis

The increase in global population ageing, coupled with advancements in the study of active ageing, underscores the need for deeper discussions centred on older adults. Among various fundamental subjects regarding this population, participation in social and political life stands out, with the act of voting in elections serving as a significant expression of such engagement. This article seeks to explore some key sources of International Law that focus on older people, emphasizing the element of political participation. This study was developed from a qualitative, exploratory research, through a bibliographic and documental review, by gathering pertinent legislation. Initially, it examines international legal frameworks related to the subject, progressing to an analysis of the Decade of Healthy Ageing, and the 2030 Agenda for Sustainable Development. The conclusion drawn from this study is that the lack of a global treaty addressing the rights of older adults reflects the ongoing invisibility experienced by this population. Therefore, it is essential to foster discussions about older people´s political participation and to implement measures that ensure they are not only beneficiaries of services but also agents of change.

Ozone Mortality Burden Changes Driven by Population Aging and Regional Inequity in China in 2013-2050.

Air pollution exposure is closely linked to population age and socioeconomic status. Population aging and imbalance in regional economy are thus anticipated to have important implications on ozone (O3)-related health impacts. Here we provide a driver analysis for O3 mortality burden due to respiratory disease in China over 2013-2050 driven by population aging and regional inequity. Unexpectedly, we find that population aging is estimated to result in dramatic rises in annual O3 mortality burden in China; by 56, 101-137, and 298-485 thousand over the periods 2013-2020, 2020-2030, and 2030-2050, respectively. This reflects the exponential rise in baseline mortality rates with increasing age. The aging-induced mortality burden rise in 2030-2050 is surprisingly large, as it is comparable to the net national mortality burden due to O3 exposure in 2030 (359-399 thousand yr-1). The health impacts of O3 pollution, shown as mortality burden per capita, are inequitably distributed, with more severe effects in less developed provinces than their developed counterparts by 23.1% and 21.5% in 2019 and 2030, respectively. However, the regional inequity in O3 mortality burden is expected to be mitigated in 2050. This temporal variation reflects evolving demographic dividend characterized by a larger proportion of younger individuals in developed regions. These findings are critical for targeted improvement of healthcare services to ensure the sustainability of social development.

Downscaling occupational employment data from the state to the Census tract level

The lack of detailed occupational employment data at more granular geographic levels presents significant challenges in forecasting and analyzing local and regional employment changes in the era of the new technological revolution. This study aims to develop detailed occupational employment data by downscaling state-level employment information to the Census tract level. We introduce two downscaling algorithms that leverage employment, population, and sociodemographic composition data sourced from the American Community Survey, the Current Population Survey, and the Occupational Employment and Wage Statistics. This approach allows us to create a tract-level employment dataset covering 808 occupations. Such data are crucial for examining the effects of expected technological and demographic shifts on employment at this scale, which is critical for understanding tax base implications and job mobility opportunities. We demonstrate the value of these datasets by examining employment projections for two occupations anticipated to decline due to technological advancements in the near future.

Genetic and epidemiological factors in the pathogenesis of neurodegenerative disorders

The aim of this study was to present the current knowledge on the aetiopathogenesis of neurodegenerative disorders, devoting attention not only to neurophysiological and clinical aspects, but above all to the genetic and extra-genomic conditions underlying these diseases. The dynamic development of knowledge and technological progress in medical and related sciences is resulting in changes in the demographic structure of the human population (ageing populations). One of the consequences of these changes is an increase in the incidence of neurodegenerative disorders. Neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. They belong to a group of disorders whose common feature is a pathological process leading to the loss of nerve cells through apoptosis or necrosis. The aetiology of neurodegenerative diseases is multifactorial and, in addition to the involvement of genomic factors, extra-genomic mechanisms have been postulated to be involved in their aetiopathogenesis. The aetiology of numerous neurodegenerative diseases is still not fully understood. Therefore, intensive research has been ongoing for years, focusing, among other aspects, on the causes and course of such conditions. An important direction of research into the pathogenesis of neurodegenerative diseases is assessment of their potential genetic aspect. Many studies also focus on non-genomic factors, highlighting that many of them can have a significant impact on the course of these diseases.

Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes.

In an era when population aging is increasing the burden of neurodegenerative conditions, deciphering the mechanisms underlying brain senescence is more important than ever. Here, we present a spatial metabolomics analysis of age-induced neurochemical alterations in the mouse brain using negative ionization mode mass spectrometry imaging. The age-dependent effects of the acetylcholinesterase inhibitor tacrine were simultaneously examined. For ultrahigh mass resolution analysis, we utilized a Fourier-transform ion cyclotron resonance spectrometer. To complement this, a trapped ion mobility spectrometry time-of-flight analyzer provided high speed and lateral resolution. The chosen approach facilitated the detection and identification of a wide range of metabolites, from amino acids to sphingolipids. We reported significant, age-dependent alterations in brain lipids which were most evident for sulfatides and lysophosphatidic acids. Sulfatide species, which are mainly localized to white matter, either increased or decreased with age, depending on the carbon chain length and hydroxylation stage. Lysophosphatidic acids were found to decrease with age in the detailed cortical and hippocampal subregions. An age-dependent increase in the glutamine/glutamate ratio, an indicator of glia-neuron interconnection and neurotoxicity, was detected after tacrine administration. The presented metabolic mapping approach was able to provide visualizations of the lipid signaling and neurotransmission alterations induced by early aging and can thus be beneficial to further elucidating age-related neurochemical pathways.

Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor

Unilateral magnetic resonance-guided focused ultrasound ablation of ventralis intermedius nucleus of the thalamus for essential tremor reduces tremor on 1 side, but untreated contralateral or midline symptoms remain limiting for some patients. Historically, bilateral lesioning produced unacceptable risks and was supplanted by deep brain stimulation; increasing acceptance of unilateral focused ultrasound lesioning has led to interest in a bilateral option. To evaluate the safety and efficacy of staged, bilateral focused ultrasound thalamotomy. This prospective, open-label, multicenter trial treated patients with essential tremor from July 2020 to October 2021, with a 12-month follow-up, at 7 US academic medical centers. Of 62 enrolled patients who had undergone unilateral focused ultrasound thalamotomy at least 9 months prior to enrollment, 11 were excluded and 51 were treated. Eligibility criteria included patient age (22 years and older), medication refractory, tremor severity (Clinical Rating Scale for Tremor [CRST] part A score ≥2 for postural or kinetic tremor), and functional disability (CRST part C score ≥2 in any category). A focused ultrasound system interfaced with magnetic resonance imaging allowed real-time alignment of thermography maps with anatomy. Subthreshold sonications allowed target interrogation for efficacy and off-target effects before creating an ablation. Tremor/motor score (CRST parts A and B) at 3 months for the treated side after treatment was the primary outcome measure, and secondary assessments for efficacy and safety continued to 12 months. The mean (SD) population age was 73 (13.9) years, and 44 participants (86.3%) were male. The mean (SD) tremor/motor score improved from 17.4 (5.4; 95% CI, 15.9-18.9) to 6.4 (5.3; 95% CI, 4.9 to 7.9) at 3 months (66% improvement in CRST parts A and B scores; 95% CI, 59.8-72.2; P < .001). There was significant improvement in mean (SD) postural tremor (from 2.5 [0.8]; 95% CI, 2.3 to 2.7 to 0.6 [0.9]; 95% CI, 0.3 to 0.8; P < .001) and mean (SD) disability score (from 10.3 [4.7]; 95% CI, 9.0-11.6 to 2.2 [2.8]; 95% CI, 1.4-2.9; P < .001). Twelve participants developed mild (study-defined) ataxia, which persisted in 6 participants at 12 months. Adverse events (159 of 188 [85%] mild, 25 of 188 [13%] moderate, and 1 severe urinary tract infection) reported most commonly included numbness/tingling (n = 17 total; n = 8 at 12 months), dysarthria (n = 15 total; n = 7 at 12 months), ataxia (n = 12 total; n = 6 at 12 months), unsteadiness/imbalance (n = 10 total; n = 0 at 12 months), and taste disturbance (n = 7 total; n = 3 at 12 months). Speech difficulty, including phonation, articulation, and dysphagia, were generally mild (rated as not clinically significant, no participants with worsening in all 3 measures) and transient. Staged, bilateral focused ultrasound thalamotomy significantly reduced tremor severity and functional disability scores. Adverse events for speech, swallowing, and ataxia were mostly mild and transient. ClinicalTrials.gov Identifier NCT04112381.

Monitoring Wearable Devices for Elderly People with Dementia: A Review

The growth in the prevalence of dementias is associated with a phenomenon that challenges the 21st century, population aging. Dementias require physical and mental effort on the part of caregivers, making it difficult to promote controlled and active care. This review aims to explore the usability and integration of wearable devices designed to measure the daily activities of elderly people with dementia. A survey was carried out in the following databases: LILACS, Science Direct and PubMed, between 2018 and 2024 and the methodologies as well as the selection criteria are briefly described. A total of 27 articles were included in the review that met the inclusion criteria and answered the research question. As the main conclusions, the various monitoring measurements and interaction aspects are critically important, demonstrating their significant contributions to controlled, adequate and active monitoring, despite the incomplete compliance with the key aspects which could guarantee solutions economically accessible to institutions or other organizations through the application of the design requirements. Future research should not only focus on the development wearable devices that follow the essential requirements but also on further studying the needs and adversities that elderly people with dementia face as a pillar for the development of a feasible device.

A Structured Narrative Literature Review of the Broader Value of Adult Immunisation Programmes

Vaccine-preventable diseases continue to generate a substantial burden on health, healthcare systems, and societies, which is projected to increase with population ageing. There is a need to better understand the full value of adult immunisation programmes corresponding to the broader value of vaccine frameworks that are recommended for evidence-based decision-making. This review aims to summarise and map evidence for the value of selected adult immunisation programmes (seasonal influenza, pneumococcal disease, RSV, and HZ) in ten diverse countries. We conducted a structured literature review of evidence published from 2017 to 2023. An existing framework was used to structure the assessment, developing matrices demonstrating the elements of value evidenced for each vaccine and country of focus. Our analysis showed substantial evidence base on the value of adult immunisation programmes, but the availability of evidence varied by value element and by vaccine. The impact on the quality of life of the vaccinated individual was the most evidenced value element. Mortality benefits for vaccinated individuals and cost-offsets to healthcare systems were also well-evidenced. The availability of evidence for ‘broader’ societal value elements (such as transmission value, carer productivity and impact on social equity, and antimicrobial resistance prevention) varied. No evidence was identified relating to the broader value elements of macroeconomic effects, value to other interventions, or effects on the quality of life of caregivers. Robust evidence exists to show that adult immunisation programmes generate substantial value for population health and health systems, yet some elements of broader value remain underrepresented in the academic literature. Without such evidence, the full value of immunisation programmes is underestimated, risking suboptimal policy decisions.

Can religion be rescued in the 21st century? On Erich Fromm’s religious humanism in an age of authoritarian populism

Can religion be rescued in the 21st century? On Erich Fromm’s religious humanism in an age of authoritarian populism

Comparison of classical and anchorage methods in sacrospinous ligament fixation

Aims: Pelvic organ prolapse (POP) is a common condition that affects the quality of life in women. As a natural consequence of the aging population, it is believed that POP will increase in the next 40 years. With the increase in life expectancy, there is an expected rise in reconstructive surgical procedures to correct pelvic floor disorders. POP can occur in three vaginal compartments: anterior, apical, and posterior. The apical compartment includes uterine prolapse, cervix, or vaginal cuff prolapse. Our primary objective was to compare the surgical outcomes of the method using the classic technique with pelvic floor anchorage (anchoring). Methods: This retrospective cohort study consisted of women with POP-Q (Pelvic Organ Prolapse Quarejment) grade 2 and above in the apical compartment. In the sample size calculation, G power analysis was performed with α: 0.05 and 80% accuracy. Forty-eight women were included in the study, with 24 of them undergoing the classic method and the other 24 receiving sacrospinous ligament fixation (SSLF) using a pelvic floor anchoring device. The results of both surgical methods were compared in terms of anatomical recurrence. Results: There was no statistically significant difference observed between the postoperative measurements of the C points. However, the difference in the C level between preoperative and postoperative measurements for patients who underwent the classic SSLF operation was statistically significantly higher compared to those who underwent the Anchorage SSLF procedure. Conclusion: When comparing the classic and anchoring systems for the SSLF procedure, no difference was observed in terms of recurrence. However, the classic method was found to be more successful in restoring apical prolapse.

Research on the Interaction Mechanism between Land System Reform and Rural Population Flow: Europe (Taking Spain as an Example) and China

This paper examines the interaction between land policies and rural labor migration in China and Europe, highlighting how land reforms guide labor mobility and their impacts on land and social structures. In China, the Household Contract Responsibility System and land transfer policies have facilitated agricultural scale expansion and the urbanization of the rural labor force. Homestead reforms have further enhanced farmers’ asset liquidity. In Europe, using Spain as a case study, EU agricultural policies have spurred agricultural modernization, economic diversification, and intensive land use. These advancements benefitted from a mature land transfer market and increased non-agricultural employment opportunities. Both China and Europe face challenges of population aging and rural depopulation, necessitating improvements in land use efficiency, the balance of the scale, and the protection of farmers’ rights and interests. Europe addresses labor shortages through technology, mechanization, and cooperatives, while China employs land trusteeship, transfer platforms, and the “three rights separation” system to combat land abandonment and labor shortages. Future research should strengthen comparative studies between China and Europe, quantify interactive relationships, consider the impact of transnational labor mobility under globalization, explore policy innovations, and foster international cooperation to address demographic changes and agricultural labor shortages. Additionally, promoting sustainable land use and farmers’ rights, equalizing urban–rural public services, enhancing education and training, and improving the social security system are crucial for integrated urban–rural development.

Representations of a physically active lifestyle in an aging population: an exploratory study

Institutional ageism remains a significant barrier for older adults seeking to adopt or maintain physical activity. This study explored how organizations promoting active living on a large scale, represent and communicate it to the aging population. Through semi-structured interviews with 11 Quebec non-governmental organizations, findings from an inductive thematic analysis revealed conflicting perceptions about age, aging and active living. Participants lacked sufficient knowledge and resources to adress the needs of this heterogenous population. While they acknowledge the diverse realities and requirements within the aging population, their discourse predominantly centered on fragility and declining capacities. Additionnally, these organizations offered a limited range of activities and promoted an idealized image to conteract sedentary behavior. The findings highlight persistent institutional ageism in physical activity promotion and underscore the necessity for organizations to reflect on their capacity and the services they offer to better support a physically active lifestyle for older adults.

Skin Aging and the Upcoming Role of Ferroptosis in Geroscience

The skin is considered the most important organ system in mammals, and as the population ages, it is important to consider skin aging and anti-aging therapeutic strategies. Exposure of the skin to various insults induces significant changes throughout our lives, differentiating the skin of a young adult from that of an older adult. These changes are caused by a combination of intrinsic and extrinsic aging. We report the interactions between skin aging and its metabolism, showing that the network is due to several factors. For example, iron is an important nutrient for humans, but its level increases with aging, inducing deleterious effects on cellular functions. Recently, it was discovered that ferroptosis, or iron-dependent cell death, is linked to aging and skin diseases. The pursuit of new molecular targets for ferroptosis has recently attracted attention. Prevention of ferroptosis is an effective therapeutic strategy for the treatment of diseases, especially in old age. However, the pathological and biological mechanisms underlying ferroptosis are still not fully understood, especially in skin diseases such as melanoma and autoimmune diseases. Only a few basic studies on regulated cell death exist, and the challenge is to turn the studies into clinical applications.

Anti-aging effects of Lacticaseibacillus paracasei PS117 on cognitive and intestinal health in naturally-aged mice: A focus on senescence-related proteins and microbiota composition

The rising global aging population underscores the urgency of maintaining the health and well-being of the elderly while reducing the healthcare burden. Anti-aging probiotics have emerged as a promising strategy. This study identified a novel anti-senescence probiotic, Lacticaseibacillus paracasei PS117 (PS117). The effects of PS117 and heat-treated PS117 (HT-PS117) supplementation on cognitive function of naturally-aged male mice were investigated. It was found that PS117 supplementation improved the cognitive performance of aged mice in the Y-maze test. Furthermore, the level of senescence-related protein p16INK4a (p16) were reduced, while anti-senescence protein sirtuin 1 (Sirt1) were increased in the hippocampus. In addition, there was an overall improvement in the intestinal function. Distinct changes in the gut microbiota were also identified, suggesting a potential contribution to the beneficial effects of PS117 supplementation. In conclusion, these results suggest that PS117 supplements could improve cognitive and intestinal functions in naturally-aged mice, while HT-117 improves only intestinal function, possibly by improving the gut microbiota composition.

We are not an army of orcs: rethinking youth activism through a critical pedagogy of place

ABSTRACT The authors examine youth activism in Poland, focusing on the University of Gdańsk occupation, the Youth Climate Strike, and Stop Bzdurom’s direct actions. Using critical pedagogy of place, they analyse how youth activists drive social change and reclaim public spaces. The study highlights reinhabitation and decolonisation of public spaces as arenas for the common good and marginalised communities’ rights. It also explores the influence of radicalism and activism on society, particularly amid an ageing population and political polarisation. Detailed case analyses contribute to understanding youth roles in social movements and change, emphasising youth activism’s significance in shaping society’s future.

New Interpretation of Human–Land Relations: Evidence from the Impact of Population Aging on Resource Utilization Efficiency in the Yellow River Basin

New Interpretation of Human–Land Relations: Evidence from the Impact of Population Aging on Resource Utilization Efficiency in the Yellow River Basin

Trend, disparities, and projection analysis of public data on foot fractures in Sweden: a retrospective analysis of 179 129 fractures

IntroductionOrthopedic injuries to the foot constitute a significant portion of lower extremity injuries, necessitating an understanding of trends for effective preventive strategies and resource allocation. Demographic shifts, improved traffic safety, and lifelong physical activity may alter incidence rates, trauma mechanisms, and fracture distribution. This study explores the prevalence of foot fractures in Sweden using publicly available data.MethodsUtilizing data from the Swedish National Board of Health and Welfare (SNBHW) spanning 2008–2022, retrospective study focuses on foot fractures in Sweden. Analysis includes calculating annual incidence rates per 100,000 person-years, assessing temporal trends, and exploring seasonal variations. Poisson regression analysis was used for projections into 2035.ResultsBetween 2008–2022, the average annual foot fracture incidence was 11,942, with notable fluctuations influenced by the COVID-19 pandemic. Age and sex disparities impact rates, and seasonal variance highlights increased incidence in summer. By 2035, foot fractures will decreasae amongst several demographic groups.ConclusionThis study provides insights into temporal trends, sex differences, and seasonal variations foot fracture patterns in Sweden. The identified trends suggest the utilization of targeted preventive strategies, efficient resource allocation, and informed healthcare planning. Despite limitations, this research offers valuable insights into foot fractures within the Swedish population, utilizing publicly aggregated data.

Effects of Singing on Vascular Health in Older Adults with Coronary Artery Disease: A Randomized Trial.

The impact of singing on cardiovascular health has not been extensively studied. The aim of this study is to investigate the effect of singing on cardiovascular biomarkers in an aging population with coronary artery disease. Participants had three study visits separated by 2-7 days, according to a randomized, single-blind, cross-over, controlled design: (1) a 30-minute period of coached singing from an in-person music therapist, (2) a 30-minute period of singing along to an instructional video and (3) a 30-minute rest (control). Primary outcomes included macrovascular endothelial function assessed by brachial artery flow-mediated dilation and microvascular function assessed by peripheral arterial tonometry (Framingham reactive hyperemia index; fRHI). Heart rate variability was a secondary outcome. Sixty-five subjects (mean age 67.7± 0.8, 40% women) completed the study. Compared to control, there was an increase in fRHI for the singing video intervention (estimate 0.54, SE 0.25, p=0.005) but not for the coaching intervention (estimate 0.11, SE 0.18, p=0.570). There was no change in macrovascular function with either intervention. The low frequency/high frequency (LF/HF) ratio increased by 2.80 (SE 1.03, p=0.008), and the LnHF power decreased by -0.90 ms 2 (SE 0.29, p=0.003) with the video (during to pre-change). When assessing post- to pre- change, the coaching intervention showed a significant change of -0.62 ms 2 (SE 0.29, p=0.036) in LnHF power. Singing along to an instructional video for 30 minutes improved microvascular, but not macrovascular, endothelial function, in older patients with CAD. HRV changes with singing are similar to that of exercise.

Cognitive, Neuropsychological and Biological Effects of Oxygen–Ozone Therapy on Frailty: A Study Protocol for a 5-Week, Randomized, Placebo-Controlled Trial

Cognitive frailty (CF) is a heterogeneous syndrome that is becoming one of the most serious health problems as the world’s population age is increasing. Elucidating its biological mechanisms as well as prevention and treatments is becoming increasingly significant, particularly in view of the associated health costs. We presented the study protocol of a research project funded by the Italian Ministry of Health (grant number RF-2016-02363298) aiming to investigate the cognitive and neuropsychological effects of a 5-week treatment with therapy based on the regenerative properties of ozone (O3) in a cohort of subjects stratified according to CF scores. We also studied the potential effects of O3 on blood-based biomarkers indicative of specific biological systems that may be altered in CF. Seventy-five older persons were recruited and randomly assigned to receive the active treatment (150 cc of oxygen-O2-O3 mixture at the concentration of 30 µg of O3 per cc of O2), O2, or the placebo (air) for 5 weeks. The main endpoints were the change in the scores of clinical scales from baseline (T0) to weeks 3 (T3), 9 (T9), and 15 (T15) after treatment and the change in biomarker levels resulting from transcriptomics, proteomics, and metabolomic patterns at the same times. The positive results from this study could have important clinical implications.