Age Range Research Articles

Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in C. elegans

Mutations in highly conserved genes encoding components of the electron transport chain (ETC) provide valuable insights into the mechanisms of oxidative stress and mitochondrial ROS (mtROS) in a wide range of diseases, including cancer, neurodegenerative disorders, and aging. This review explores the structure and function of the ETC in the context of its role in mtROS generation and regulation, emphasizing its dual roles in cellular damage and signaling. Using Caenorhabditis elegans as a model organism, we discuss how ETC mutations manifest as developmental abnormalities, lifespan alterations, and changes in mtROS levels. We highlight the utility of redox sensors in C. elegans for in vivo studies of reactive oxygen species, offering both quantitative and qualitative insights. Finally, we examine the potential of C. elegans as a platform for testing ETC-targeting drug candidates, including OXPHOS inhibitors, which represent promising avenues in cancer therapeutics. This review underscores the translational relevance of ETC research in C. elegans, bridging fundamental biology and therapeutic innovation.

Is The ‘Rule of Tens’ a Necessary Screening Criteria in Cleft Lip Surgeries

Background: The “rule of tens” (ROT) is still widely applied nowadays in many cleft centers worldwide for cleft lip surgery, although many surgeons do not implement it as a standard ru Recent advances in the field of anesthesiology have enhanced the safety of surgery for neonates. In Indonesia, ROT is still applied but is still flexible, due to some pertaining social confiicts. The relevance of ROT to the rate of mortality and morbidity is still unknown. This study aims to assess the need of using ROT in cleft lip surgeries.Methods: A retrospective study was conducted. Data was obtained from the medical records of patients who had undergone cleft lip repair between January 2004 to December 2005 in one day care setting. All data related to ROT parameters was categorized in two groups, either fit or unfit according to ROT criterias. The relationship of ROT to rate of associated morbidity and mortality was evaluated.Results: There were 204 cases of cleft lip repair with age range of 6-week to 12-year old. More than half (52.9%) was unfit for ROT. There were twelve cases of wound dehiscence and one total breakdown of the sutures, and no mortality. There were no statistically significant correlation ce between ROT and the rate of dehiscence. Conclusion: ROT is not a definitive criterion that could predict the success of cleft lip repair surgery.

The Common Site of Impactions and Complications Associated with Foreign Bodies in the UADT: An Observational Study of a Tertiary Care Hospital in Bangladesh

Background: Foreign bodies are frequently encountered in the field of otolaryngology, specifically within the domains of the ear, nose, and throat (ENT). Serious complications, such as tympanic perforations and bronchoaspiration, are infrequently observed. Objective: To see the common site of impactions and complications associated with Foreign Bodies in the UADT. Methods: The Department of Otolaryngorhinology and Head-Neck Surgery at Dhaka Medical College Hospital conducted a cross-sectional study inside a hospital setting. The study was conducted from March 23, 2019, to September 22, 2019. The study included individuals who had a prior medical record of either inhaling or being impacted by a foreign object, as well as individuals who had a history of difficulty swallowing. Results: In this study, the majority of patients (70.0%) were found to be within the age range of 0 to 10 years. The average age of the patients was 6.1±2.8 years. This study found that foreign bodies were frequently observed to be impacted in the nose (42%), oesophagus (20%), and throat (38.0%).There are three main categories of foreign bodies: metallic foreign bodies, which account for 36.0% of cases, non-metallic foreign bodies, which account for 44.0% of cases, and living foreign bodies, which account for 20.0% of cases. The present study has provided evidence that non-invasive treatment methods, specifically direct vision only, accounted for the majority (42.0%) of the treatment approaches utilized. Laryngoscopy was deemed necessary in 38.0% of the patients, whereas esophagoscopy was performed in 14.0% of the cases. The present investigation involved the performance of endoscopic removal of foreign bodies (FB) in 6.0% of cases. Within the scope of this inquiry, it was noted that three subjects experienced postoperative challenges, encompassing sensations of discomfort, instances of bleeding, and issues associated with anesthesia. Conclusion: The majority of instances involving foreign .....

Incidence Rate of Post Coronary Artery Shunt Complications; Age Dependent!

Numerous complications, such as postoperative arrhythmia and stroke, have been observed following coronary artery bypass graft (CABG) surgery. This study sought to examine the impact of aging on the incidence of post-coronary artery shunt complications. Aging is a physiological process experienced by every living cell, beginning early in development. Age plays a crucial role in determining postoperative complications, including those related to CABG. A retrospective analysis was conducted on 290 patients who underwent CABG at the Mordovian Republic Hospital between 2017 and 2021. The sample was divided into two age-based groups: the first group comprised 126 patients (mean age range: 55.21-60.00), and the second group included 163 patients (mean age range: 66.11-80.00). Statistical analyses employed in this study encompassed descriptive statistics, Chi-square test, T-test, one-way ANOVA test, ROC analysis, and Pearson correlation using Statistica 12 software. Elderly patients in the second group demonstrated a higher incidence of post-CABG arrhythmia (p < 0.012528). Moreover, the second group experienced markedly longer ICU and total hospitalization days following CABG, with p-values of less than 0.000000 and 0.000072, respectively. Notably, elderly individuals in the second group faced an increased risk of developing psychosis after CABG surgery (p < 0.007379). Furthermore, psychosis was found to be significantly associated with longer ICU hospitalization (p < 0.000140). Postoperative stroke occurred more frequently among the elderly (second group) with a p-value of less than 0.037736. Consequently, postoperative stroke was associated with extended ICU hospitalization (p < 0.000747). The usage of internal thoracic arteries (ITAs) was lower among the elderly (second group), with a p-value of less than 0.016145. Regarding correlations, a direct association was observed between age and ICU days, total hospitalization days, and the number of complications, with correlation coefficients (r) of 0.189046, 0.141415, and 0.138565, respectively. Elderly individuals in the second group who undergo CABG face a greater risk of developing psychosis, arrhythmia, prolonged total and ICU hospitalization, and stroke. The presence of arrhythmia, which is commonly observed in patients aged 63 years and older, significantly affects total hospitalization days. The number of complications is influenced by age, cardiopulmonary bypass (CPB) time, aortic cross-clamp time, ICU hospitalization, and total hospitalization duration.

BIBSNet: A Deep Learning Baby Image Brain Segmentation Network for MRI Scans.

Brain segmentation of infant magnetic resonance (MR) images is vitally important in studying developmental mental health and disease. The infant brain undergoes many changes throughout the first years of postnatal life, making tissue segmentation difficult for most existing algorithms. Here, we introduce a deep neural network BIBSNet (Baby and Infant Brain Segmentation Neural Network), an open-source, community-driven model that relies on data augmentation and a large sample size of manually annotated images to facilitate the production of robust and generalizable brain segmentations. Included in model training and testing were MR brain images on 84 participants with an age range of 0-8 months (median postmenstrual ages of 13.57 months). Using manually annotated real and synthetic segmentation images, the model was trained using a 10-fold cross-validation procedure. Testing occurred on MRI data processed with the DCAN labs infant-ABCD-BIDS processing pipeline using segmentations produced from gold standard manual annotation, joint-label fusion (JLF), and BIBSNet to assess model performance. Using group analyses, results suggest that cortical metrics produced using BIBSNet segmentations outperforms JLF segmentations. Additionally, when analyzing individual differences, BIBSNet segmentations perform even better. BIBSNet segmentation shows marked improvement over JLF segmentations across all age groups analyzed. The BIBSNet model is 600x faster compared to JLF and can be easily included in other processing pipelines.

Age Matters: Adenoma Detection Rates in Average-risk Screening Patients Aged 45 to 49 Compared With Those Aged 50 to 54.

This study aims to address gaps in medical knowledge by determining whether adenoma detection rate (ADR) in average-risk screening patients aged 45 to 49 is equivalent to screening patients aged 50 to 54. Current guidelines recommend initiating colon cancer screening at age 45, yet our understanding of the effects of ADR in average-risk individuals among 45- to 49-year-olds is still limited. A retrospective analysis was conducted on records of average-risk screening colonoscopies performed on patients aged 45 to 54 from January 2018 to August 2022. Exclusions were prior diagnoses of colorectal cancer or adenomatous polyps, inflammatory bowel disease, personal or family history of genetic cancer syndromes, incomplete colonoscopy, and inadequate bowel preparation. The primary outcome was ADR in the age 45 to 49 group compared with the age 50 to 54 group. Of the 3199 average-risk screening colonoscopies performed, 879 and 2116 patients were included in the age 45 to 49 and 50 to 54 groups, respectively. Both groups were predominantly female, White ethnicity, never smokers, and obese. ADR was found to be 27% in the age 45 to 49 group compared with 34% in the age 50 to 54 group (odds ratio 0.70, 90% CI: 0.60-0.83, P -value for equivalence=0.81 w/ margin 0.77 to 1.30). The study did not demonstrate equivalent ADR between the 2 age groups, with ADR being substantially lower in the age 45 to 49 group (27% vs. 34%). Despite this, the ADR in the 45 to 49 age range surpasses the established benchmark of 25%, supporting the decision to lower the screening age to 45 years. Ongoing national monitoring is essential to comprehensively evaluate the impact of these updated guidelines.

Development of a Superhydrophobic Protection Mechanism and Coating Materials for Cement Concrete Surfaces.

In order to further enhance the erosion resistance of cement concrete pavement materials, this study constructed an apparent rough hydrophobic structure layer by spraying a micro-nano substrate coating on the surface layer of the cement concrete pavement. This was followed by a secondary spray of a hydroxy-silicone oil-modified epoxy resin and a low surface energy-modified substance paste, which combine to form a superhydrophobic coating. The hydrophobic mechanism of the coating was then analysed. Firstly, the effects of different types and ratios of micro-nano substrates on the apparent morphology and hydrophobic performance of the rough structure layer were explored through contact angle testing and scanning electron microscopy (SEM). Subsequently, Fourier transform infrared spectroscopy and permeation gel chromatography were employed to ascertain the optimal modification ratio, temperature, and reaction mechanism of hydroxy-silicone oil with E51 type epoxy resin. Additionally, the mechanical properties of the modified epoxy resin-low surface energy-modified substance paste were evaluated through tensile tests. Finally, the erosion resistance of the superhydrophobic coating was tested under a range of conditions, including acidic, alkaline, de-icer, UV ageing, freeze-thaw cycles and wet wheel wear. The results demonstrate that relying solely on the rough structure of the concrete surface makes it challenging to achieve superhydrophobic performance. A rough structure layer constructed with diamond micropowder and hydrophobic nano-silica is less prone to cracking and can form more "air chamber" structures on the surface, with better wear resistance and hydrophobic performance. The ring-opening reaction products that occur during the preparation of modified epoxy resin will severely affect its mechanical strength after curing. Controlling the reaction temperature and reactant ratio can effectively push the modification reaction of epoxy resin through dehydration condensation, which produces more grafted polymer. It is noteworthy that the grafted polymer content is positively correlated with the hydrophobicity of the modified epoxy resin. The superhydrophobic coating exhibited enhanced erosion resistance (based on hydrochloric acid), UV ageing resistance, abrasion resistance, and freeze-thaw damage resistance to de-icers by 19.41%, 18.36%, 43.17% and 87.47%, respectively, in comparison to the conventional silane-based surface treatment.

Does decreased fetal growth estimation in the appropriate for gestational age range affect delivery outcomes?

To study the effect of decreased estimated fetal weight (EFW) percentiles in appropriate for gestational age fetuses. This retrospective cohort study included women who had second and third trimester ultrasound examinations. Delivery and neonatal outcomes of pregnancies with decreased EFW of ≥ 30 percentiles in EFW between ultrasound examinations (decreased growth group) and those without such a decrease (control group) were compared. Deliveries with EFW or birthweight below the 10th percentile were excluded. Among 1610 deliveries, 57 were in the decreased growth group and 1553 in the control group. Maternal characteristics did not differ between the groups except for higher rate of nulliparity in the decreased growth group. We found similar rates of Category II/III monitoring, cesarean deliveries due to non-reassuring fetal heart rate and adverse neonatal outcomes. Neonatal birthweight was lower in the decreased growth group as compared to controls. This study did not find association between the group of appropriate for gestational age fetuses with decreased growth, with adverse outcomes.

A study on the professional attention and career commitment of health management students.

The education process is based on leading the choice of profession in line with the interests and abilities of the individual and helping them with their career plans in these professions. The aim of this study is to investigate the effect of the occupational interest levels of the Health Management Department students on their career commitment. In the study, descriptive findings were included by using a quantitative research design. In the research, data were collected from 282 students studying Department of Health Management. SPSS 26.0 package program was used for statistical analysis of research data. Parametric tests (t-test, analysis of variance, Pearson correlation analysis, normal linear regression analysis) were utilized since the data fit the normal distribution. 57.1% of the individuals participating in the research are female, 47.8% have the age range of 21 to 22. There is a positive, moderate (r = 0.677 p < 0.01) significant relationship between professional interest and career commitment scales. The level of professional interest and career dedication varies according to gender, age, income status and the class of the student. It is very important that health management students have an interest in their profession. Because this interest will guide them in what kind of a career they should make in their business life after graduation.

Economically optimized forage utilization choices in drylands for adapting to economic, ecological, and climate stress

Improving the economic performance of range forage in drylands internationally faces challenges from economic, ecological, and climate stress. Stakeholders in these drylands wish to protect range forage ecosystems while assuring economic viability of ranching. Despite several recent research achievements, little work to date has integrated relationships among precipitation, grazing pressure, animal performance, and forage production to protect ranching incomes faced with economic, ecological, and climate stress in dryland areas. This work addresses that gap by developing an empirical mathematical programming model for optimizing economic performance of livestock grazing on range forage ecosystems that adapt to several stressors. Its unique contribution is to formulate and apply a ranch income optimization model calibrated using positive mathematical programming. The model replicates observed economic, forage, and climate conditions while accounting for interacting relations among stocking rates, forage conditions, grazing pressure, animal performance, and ranch economic productivity. Results show ranch incomes ranging from about $5 to $88 per acre and marginal values of forage ranging from $0.01 to $0.12 per pound of forage, depending on economic, ecological, and climate conditions. Results reveal how all these stressors affect economically optimized choices of grazing levels, ranch income, and economic values of forage for a range of six biomes seen in the US west. Results help livestock ranchers to adjust stocking and forage choices as well as farm policymakers who seek flexible government programs to adapt to changes in economic, ecological, and climate conditions. The work's importance comes from applicability to forage management problems in dry regions internationally.

New concept of orthosis treatment for knee osteoarthritis: Clinical and radiological outcomes.

Given the increasing numbers of young patients with knee osteoarthritis there is a need for treatments that can postpone a joint prosthesis (total knee replacement). As an alternative to the effective yet invasive knee joint distraction procedure, a knee orthosis was developed aiming to unload the affected knee and improving synovial fluid flow. The aim of this study was to examine the effectiveness of using a load-reducing orthosis for two months on functioning, pain, and disease progression (e.g. amount of damaged cartilage) in patients with symptomatic osteoarthritis of the knee for at least one year. This is an interventional single-center pilot study. Ten patients with symptomatic osteoarthritis of one knee (5males/5 females; median age 57; age range 42-59) used a custom-made orthosis for 60 days during daily life activities that involved knee loading (e.g. standing, walking, but not during stair climbing). Cycling was not allowed. Clinical outcomes were assessed up to 24 months after intervention at 6 timepoints using patient reported-outcome measures Western Ontario and McMaster Universities Osteoarthritis (WOMAC) range 0-100; Visual Analogue Scale (VAS), range 0-100 for pain. Minimum joint space width (mJSW) was assessed using knee images digital analysis (KIDA) and articular cartilage volume with magnetic resonance imaging (MRI) using custom software at baseline and at 12 and 24 months follow-up. Clinically beneficial effects were found for functioning (WOMAC improvement compared to baseline ranged between 18 points at 3 months follow-up and 31 points at 12 months follow-up, with only the 24-months follow-up (improvement of 27 points) not reaching statistical significance (p< 0.05)) and for pain (VAS improvement compared to baseline at follow-up time points ranged between 41-56 points; all p< 0.05). No improvements in mJSW- or MRI-derived parameters were found. This study demonstrates that use of a custom-made knee-unloading orthosis for 60 days can result in improved functional ability and decrease in pain in relatively young patients with knee osteoarthritis. No effect on disease progression could be evidenced.

The Deep-Match Framework: R-Peak Detection in Ear-ECG.

The Ear-ECG provides a continuous Lead I like electrocardiogram (ECG) by measuring the potential difference related to heart activity by electrodes which are embedded within earphones. However, the significant increase in wearability and comfort enabled by Ear-ECG is often accompanied by a degradation in signal quality - an obstacle that is shared by the majority of wearable technologies. We aim to resolve this issue by introducing a Deep Matched Filter (Deep-MF) for the highly accurate detection of R-peaks in wearable ECG, thus enhancing the utility of Ear-ECG in real-world scenarios. The Deep-MF consists of an encoder stage, partially initialised with an ECG template, and an R-peak classifier stage. Through its operation as a Matched Filter, the encoder searches for matches with an ECG template in the input signal, prior to filtering these matches with the subsequent convolutional layers and selecting peaks corresponding to the ground-truth ECG. The latent representation of R-peak information is then fed into a R-peak classifier, of which the output provides precise R-peak locations. The proposed Deep Matched Filter is evaluated using leave-one-subject-out cross-validation over 36 subjects with an age range of 18-75, with the Deep-MF outperforming existing algorithms for R-peak detection in noisy ECG. The Deep-MF achieves a median R-peak recall of 94.9% and a median precision of 91.2% across subjects when evaluated with leave-one-subject-out cross validation. Overall, this Deep-Match framework serves as a valuable step forward for the real-world functionality of Ear-ECG and, through its interpretable operation, the acceptance of deep learning models in e-Health.

A Prerequisite for need of Harmonized Nutrient Reference Values &amp; its Standardized Terminology for Better access of Nutritional Supplements Globally

Abstract: To reduce the risk of insufficient nutrient intake, nutrient reference values for humans are set at the average nutrient need level without a safety margin. The vast majority of nations and areas in the globe set nutritional intake guidelines for their citizens. Currently, no harmonized nutrient reference value has been published, as well as the development of standards cannot be achieved through the use of formalized frameworks or terminology. The study's objective was to create recommendations for appropriate and secure micronutrient intake ranges that could be used to inform dietary advice. As relevant to the study, we examined micronutrient data from food intake surveys from representative nations. The comparison of national standards illustrates that the level of reference values for nutrient for individual countries is dependent on variables such as methodology, data sources, physical activity exemptions, standard body weights, and age range. In the current study, iron, calcium, magnesium, vitamin A, B12, D and folate were identified as the most commonly under-consumed micronutrients. In this article, the level of six countries' standards are compared to the current reference values for nutrients. Further, numerous words for different dietary standards components are discussed, and a final set of harmonized reference nutrient intake for the dietary advice is provided.

Gait ataxia in alcohol use disorder: A systematic review.

A severe and long-term alcohol use can have adverse effects on lower limb function. Over time, some individuals may develop gait ataxia, which refers to the impairment of controlled lower body movements that are important for walking and maintaining proper gait. Gait ataxia is well-documented in patients who have been diagnosed with alcohol-related Wernicke-Korsakoff syndrome (WKS); however, less is known on how common ataxia is among patients with alcohol use disorder (AUD) without WKS. To date, no study has systematically reviewed the evidence focusing on patients suffering only from AUD. Our aim was to perform a qualitative synthesis of the existing literature examining behavioral signs of gait ataxia among abstinent patients with AUD. Two facets were created encompassing keywords for "alcohol use disorder" and "measures of gait ataxia." Databases, including EMBASE, APA PsycInfo, Medline, and Cochrane Library, were searched for studies, and a quality assessment was performed. Ten studies were identified (37 ≥ ns ≤ 247), which were all rated as being of moderate (N = 7) to good quality (N = 3). The age range was 31.4-53.4 years (weighted mean age: 53.6 years), and 78.3% of the participants were male. Eight studies found that patients with AUD and without WKS exhibited behavioral signs of gait ataxia. Although there is evidence of gait ataxia among patients with AUD, heterogeneous results and methodological shortcomings such as lack of screening for neurocognitive deficits deem these findings preliminary and highlight the need for more research in the future. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Social anxiety disorder: prevalence and dominant factor among adolescents in urban and rural school

In the age range of 16-18 years, commonly known as adolescence, individuals undergo a period of self-discovery in their socio-emotional development. Failures during this process can lead to individuals experiencing anxiety in social interactions, which can have a negative impact on their mental health. The Indonesia National Adolescent Mental Health Survey (I-NAMHS), findings also indicate that the most prevalent mental disorder among adolescents is anxiety disorder (a combination of social phobia and generalized anxiety disorder), is equivalent to 15.5 million. The widespread use of the internet and social media, on one hand, has led to a high dependency on smartphones among teenagers, causing them to spend more time interacting in the virtual world. Over an extended period, this condition can lead to social anxiety due to the fear of failure and lack of success. The objective of this research is to explore whether there is a difference in social anxiety among teenagers living in rural or urban areas, related to factors such as the duration of smartphone usage, school activities, and so on. The results of this research are crucial for providing feedback to high schools, especially for early detection of potential anxiety symptoms from the beginning, in order to prevent and provide appropriate treatment for social anxiety, thus not affecting students' academic achievements. It is recommended that schools conduct early detection measures.

Molecular isotopologue measurements toward super star clusters and the relation to their ages in NGC 253 with ALCHEMI

Context. Determining the evolution of the CNO isotopes in the interstellar medium (ISM) of starburst galaxies can yield important constraints on the ages of super star clusters (SSCs), or on other aspects and factors contributing to their evolution, such as the initial mass function (IMF). Due to the time-dependent nature of the abundances of isotopes within the ISM – as they are supplied from processes such as nucleosynthesis or chemical fractionation –, this provides the opportunity to test whether or not isotope ratios trace the ages of highly star-forming regions, such as SSCs. Aims. The goal of this study is to investigate whether the isotopic variations in SSC regions within NGC 253 are correlated with their different ages as derived from stellar population modelling. Methods. We measured abundance ratios of CO, HCN, and HCO+ isotopologues in six regions containing SSCs within NGC 253 using high-spatial-resolution (1.6″, ∼28 pc) data from the ALCHEMI (ALma Comprehensive High-resolution Extragalactic Molecular Inventory) ALMA Large program. We then analysed these ratios using RADEX radiative transfer modelling, with the parameter space sampled using the nested sampling Monte Carlo algorithm MLFriends. These abundance ratios were then compared to ages predicted in each region via the fitting of observed star-formation tracers (such as Brγ) to Starburst99 starburst stellar population evolution models. Results. We determined the isotopic column density ratios across multiple regions of SSC activity in NGC 253 using non-LTE radiative transfer modelling. We do not find any significant trend with age for the CO and HCN isotopologue ratios on timescales of the ages of the SSC* regions observed. However, HCO+ may show a correlation with age over these timescales in 12C/13C. Conclusions. The driving factors of these ratios within SSCs could be the IMF or fractionation effects. To further probe these effects in SSCs over time, a larger sample of SSCs must be observed spanning a larger age range.

Speech services by speech volunteers for children with cleft lip and palate in professional lacking area: Pilot study

Background: Cleft lip and cleft palate are the most common birth defects. Children with cleft lip with or without cleft palate (CP±L) face a vary of challenges, depending on the type and severity of the cleft including speech difficulty, dental problems, feeding difficulty, ear infections and hearing loss. Articulation error is the most common residual defect in children with cleft palate with or without cleft lip. Objective: To compare the numbers of pre- and post- articulation errors after using the Model of Speech Therapy by Volunteers (STV) for children with CP±L. Materials and methods: 9 children, aged range 6; 4-14; 2 years old, were included in this study and completely participated in the study. Pre- and post-articulation tests by Myanmar Articulation, Resonation, Nasal Emission and Nasal Turbulence Test were assessed at Mahamuni Monastery, and Thiriyadana Guha Pone Htoon Shan Monastery, Tachileik, Myanmar. STV is composed of a 3-day speech camp (1st month), 3 times 1-day site visits for complicated cases (2nd, 6th, and 10th months) and 3 times of 1-day follow-up speech camps (4th, 8th, and 12th months), Phonological approaches, traditional strategies, and specific techniques for speech correction in children with CP±L were taught to speech volunteers (SVs) and caregivers. Homework was assigned to SVs and caregivers. SVs provided a session of 45-minute speech correction every week. Caregivers practiced 5 sessions of 30 minutes in speech exercises /weeks at home. Results: STV revealed significant reductions in the numbers of articulation errors including articulation screening test [median difference: MD=6 (95% confident interval: CI=5.2-9.2)], and Myanmar articulation standard test at both word and sentence levels; [MD=8 (95% CI=6.5-10.8) and MD=5 (95% CI=4.2-8.3), respectively]. Conclusion: STV significantly decreased a number of articulation errors in children with CP±L of Myanmar, a professional lacking area, and could be applied in any area that has a similar situation. The result was a primary study, the further research should enroll more participants for generalization.

Personal and illness identity in youth with type 1 diabetes: Developmental trajectories and associations.

Having Type 1 diabetes (T1D) may complicate the normative developmental task of personal identity formation in adolescence and emerging adulthood. Besides exploring and committing to identity choices in different life domains, youth with T1D need to integrate their illness into their identity, a process labeled as illness identity. The present study examined whether youth with T1D belonging to different personal identity trajectory classes developed differently on four illness identity dimensions (acceptance, enrichment, engulfment, rejection). This four-wave longitudinal study over a 3-year period used self-report questionnaires to examine how personal identity trajectory classes were related to illness identity over time in youth with T1D (baseline: n = 558; 54% female; age range = 14-25 years). Personal identity trajectory classes were identified using latent class growth analysis. Differential development of the four illness identity dimensions among these personal identity trajectory classes was examined using multigroup latent growth curve modeling. Five personal identity trajectory classes were identified: achievement, foreclosure, moratorium, carefree diffusion, and troubled diffusion. Individuals in achievement and foreclosure displayed highest levels of diabetes integration (i.e., high levels of acceptance and enrichment; low levels of engulfment and rejection), whereas individuals in troubled diffusion displayed lowest levels of illness integration (i.e., low levels of acceptance and enrichment; high levels of engulfment and rejection). The present study confirms that personal identity development relates to illness identity development over time in youth with T1D. Understanding the intricate link between personal and illness identity may help clinicians to tailor their interventions to patients' individual needs. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Evolution of the relation between the mass accretion rate and the stellar and disk mass from brown dwarfs to stars

The time evolution of the dependence of the mass accretion rate with the stellar mass and the disk mass represents a fundamental way to understand the evolution of protoplanetary disks and the formation of planets. In this work, we present observations with X-shooter of 26 Class II very low-mass stars (&lt; 0.2 M⊙) and brown dwarfs in the Ophiuchus, Chamaeleon-I, and Upper Scorpius star-forming regions. These new observations extend the measurement of the mass accretion rate down to spectral type (SpT) M9 (∼0.02 M⊙) in Ophiuchus and Chamaeleon-I and add 11 very-low-mass stars to the sample of objects previously studied with broadband spectroscopy in Upper Scorpius. We obtained the spectral type and extinction, as well as the physical parameters of the sources. We used the intensity of various emission lines in the spectra of these sources to derive the accretion luminosity and mass accretion rates for the entire sample. Combining these new observations with data from the literature, we compare relations between accretion and stellar and disk properties of four different star-forming regions with different ages: Ophiuchus (∼1 Myr), Lupus (∼2 Myr), Chamaeleon-I (∼3 Myr), and Upper Scorpius (5−12 Myr). We find the slopes of the accretion relationships (L* − Lacc, M∗ − Ṁacc) to steepen in the 1−3 Myr age range (i.e., between Ophiuchus, Lupus, and Chamaeleon-I) and that both relationships may be better described with a single power law. We find that previous claims for a double power-law behavior of the M∗ − Ṁacc relationship may have been triggered by the use of a different SpT–Teff scale. We also find the relationship between the protoplanetary disk mass and the mass accretion rate of the stellar population to steepen with time down to the age of Upper Scorpius. Overall, we observe hints of a faster evolution into low accretion rates of low-mass stars and brown dwarfs. At the same time, we also find that brown dwarfs present higher Mdisk/Ṁacc ratios (i.e., longer accretion depletion timescales) than stars in Ophiuchus, Lupus, and Cha-I. This apparently contradictory result may imply that the evolution of protoplanetary disks around brown dwarfs may be different than what is seen in the stellar regime.

Investigating tedium as a predictor of personality and techno-stress in school teachers during the Covid-19 pandemic

Being a demanding profession, teaching involves the intrinsic components of stress, tiredness along with sensations of inner uneasiness. This directed the current investigation which focused on exploring the predictive nature of tedium in reference to the constructs of personality and techno-stress levels experienced by school teachers during the Covid-19 pandemic. Through a cross-sectional correlation design a non-probability purposive sample of 200 (including n = 92 men and n = 108 women) school teachers from private sector, with an age range of 22-57 years (M = 35.2, SD = 8.54) were recruited. Following the APA-mandated guidelines, the participants provided sociodemographic information and their responses to study variables on the Big-Five Personality Scale, Teacher’s Techno-stress Levels Defining Scale, and Burnout Measure. Findings suggested that tedium had a significant positive correlation with both neuroticism, and techno-stress, while a significant negative association with extraversion, openness, conscientiousness, and agreeableness. Moreover, neuroticism and techno-stress were found to be the positive predictors of tedium, while conscientiousness and agreeableness negatively predicted tedium. Gender differences indicated that women teachers reported more tedium than their male counterparts. The results highlighted the need to seriously address the factors responsible for the decline in teachers’ efficiency and competence.