Elderly Persons Research Articles

Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report

BackgroundProgressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised due to untreated HIV/AIDS, haematological malignancies, primary immunodeficiencies, solid organ transplantation, or immunomodulatory treatment of autoimmune diseases. There is no effective antiviral treatment, and recovery depends on immune reconstitution. Paradoxically, initiation of antiretroviral therapy for HIV/AIDS or interruption of immunomodulating treatment can worsen the clinical manifestations due to immune reconstitution inflammatory syndrome (IRIS). Here, we report an unusual case of spontaneous IRIS in a 76-year-old immunocompetent woman, unmasking PML and leading to unexpected recovery.Case presentationThe patient was admitted to the hospital due to psychosis, speech impairment, and behavioral changes over the last three months. She had previously been healthy, except for a cerebellar stroke secondary to paroxysmal atrial fibrillation. Magnetic resonance imaging (MRI) revealed multiple contrast-enhancing white matter lesions suspicious of cancer metastases. Due to suspicion of edema, dexamethasone was administered, and the patient was released while waiting for a stereotactic brain biopsy. Eight days later, she suffered tonic seizures and was readmitted. Intravenous levetiracetam gave rapid effect, but the patient was paranoid and non-cooperative, and dexamethasone was unintentionally discontinued. Ten days later, the brain biopsy revealed demyelination, abundant perivascular T cells, macrophages, and scattered JCPyV-infected oligodendrocytes, rendering the diagnosis of PML-IRIS. The cerebrospinal fluid contained low amounts of JCPyV-DNA, and plasma contained high levels of anti-JCPyV immunoglobulin G. Despite extensive immunological testing, no evidence of immunodeficiency was found. The patient gradually recovered clinically and radiologically. More than 19 months after diagnosis, the patient has only a slight impairment in language and behavior.ConclusionsAn apparently immunocompetent elderly person developed clinically symptomatic PML, which spontaneously resolved with symptoms and signs of IRIS. The atypical MRI lesions with contrast enhancement and the lack of known immunological risk factors for PML delayed the diagnosis, eventually proved by biopsy. PML and PML-IRIS should be considered in the differential diagnosis of patients presenting CNS symptoms and focal lesions with contrast enhancement on MRI.

A STUDY TO COMPARE THE EFFECTIVENESS OF SPINAL MOBILIZATION WITH ARM MOVEMENT VERSUS NEURAL TISSUE MOBILIZATION ALONG WITH MUSLE ENERGY TECHNIQUE AMONG CERVICAL RADICULOPATHY PATIENTS

Background: Cervical Radiculopathy is a disease of the cervical spine and a space occupying lesion that occurs because of pathological problems with cervical nerve roots. It usually causes the pain in the neck ,radiating to one arm with reduced motor function and reflex changes in the affected nerve root and commonly affect the middle aged to elderly person. Objective: A study to compare the effectiveness of spinal mobilization with arm movement versus neural tissue mobilization along with muscle energy technique among cervical radiculopathy patients. Method: Comparative study, 30 patients were selected from Sri Venkateshwara group of institution. They were allocated into two groups, group A(n=15) spinal mobilization with arm movement along with MET, group B (n= 15) neural tissue mobilization with MET given for 3 days per week for 6 weeks, the outcome measures NPRS and goniometric measurement were used. Result: Data analysis was done by paired ‘t’ test for within the group and unpaired ‘t’ test for between the group analysis respectively. The statistical analysis shows that the group A had significant improvement than group B. It has been concluded that group A showed reduction in the pain and improvement in ROM than group B. Conclusion: This study concludes that spinal mobilization with arm movement along with MET for group A shows more significant in reducing the pain and improve ROM among cervical radiculopathy patients than neural tissue mobilization with MET in group B.

Wisdom of age is the main psychological geroprotector in older people (analytical review)

The article presents an analytical review of the problem of aging from the standpoint of social and spiritual forms of human life. The intensive growth in the number of elderly people has sharply reduced the quality of public attitude towards them. The foundations of social relations between elderly people and the state, intergenerational, family, and other relations have acquired a new colouring, in connection with which the importance of wisdom in solving these problems increases. The wisdom in an elderly person is potent of keeping his inner world in a state of balance. A wise person perceives his presence in life as a paradigm of integration, which determines the coexistence of all age phases during his life. It helps to cast aside regret about past failures, unfulfilled hopes, to find a lot of good even in a far from easy life. Wisdom is the universe to which a person should come in old age. Wisdom will always find something that will please and strengthen the spiritual strength of a person, make his life positions stable, lead away from despondency and a sense of helplessness. The wisdom of age creates self-confidence in an elderly person, pride in the years lived with dignity, in the benefits created, which are used by the young. The concept of “conscious aging” is based on inner strength and spiritual stability over old age. Of course, old age is full of sorrows, but life experience gives it prudence to endure them with dignity. Wisdom serves as a support for an aging person for the normal perception of all life changes, it constantly reminds him that life does not close its doors to him.

THE THEME OF OLD AGE IN THE STORIES BY VAGIF SULTANLI (CASE STUDY THE STORIES “KUFI XETTI”, “XIFFET” AND “SEHER DUMANI”)

Old age is one of the most discussed topics in literature, like death, love and separation. In the literature of almost all peoples, to say old, orator means an experienced person. In fiction, respect for old people, white hair, and white beard is preached, trust in their experience, and criticism of disrespect for them is inculcated. The best example of this in Azerbaijani literature is the monument “Kitabi-Dede Gorgud”. In the literature of the peoples of the world, in the works of Ernest Hemingway, Victor Hugo, Leo Tolstoy, Necip Fazil Kisakurek and others, we are faced with descriptions of the sometimes bitter and sometimes proud aspects of this topic. However, in the era of modernization, decelerating family ties, the spread of the desire for individualization among both young and old people weakened social policy, limited the possibilities of the weaker sections of the population. ` In the stories of Vagif Sultanlı, we will explore the theme of illness and loneliness, which tests not only themselves, but also their children, of this “powerless” class. The object of our research is the stories “Xiffet”, “Seher dumani” and “Kufi Xetti” from Vagif Sultanli's collection “Ters akin”. The subject of the research is the theme of death, loneliness and old age in the writer's stories, and the presentation of these themes. The feelings and pains caused by the Covid 19 pandemic, which makes loneliness felt not only by the elderly, but by all people from children to adults, are presented in the writer's story “Kufi Xetti” through the experience of an elderly person. The story, which shows the resistance of a person who lived to the marrow of loneliness to nature, does not just describe an epidemic, which once again proves that development and science will not work if time comes. Here the struggle of an elderly and especially lonely person with life, with people, with a way of thinking is reflected. When describing elderly people, the writer who chooses an elderly orphan or a parent on a sick bed as an image has increased the emotional load, and has created key points by emphasizing tradition and mentalism in almost every episode.

Are older adults perceived as morally better than middle-aged persons? Focus on the stereotype content model

Identifying and improving existing morality perceptions regarding older adults is crucial for fostering intergenerational cooperation and constructing an inclusive society. In this study, we conducted two online experiments with Japanese participants to investigate the degrees to which older adults are perceived as moral. We predicted that older adults are more likely to be perceived as morally good compared to middle-aged individuals (Hypothesis 1), and that regardless of the target person's age, individuals perceived as warm (Hypothesis 2) and competent (Hypothesis 3) are more likely to be regarded as morally good. In Study 1, participants were instructed to freely describe a typical older (aged 80 years) or middle-aged (aged 50 years) target individual. Contrary to expectations, the middle-aged target individual was perceived as morally better than the older counterpart. Meanwhile, regardless of the target individual's age, the target individuals perceived as warm and competent were more likely to be viewed as morally good. In Study 2, participants were presented with a simple vignette describing an older (aged 80 years) or middle-aged (aged 50 years) target individual, manipulating their warmth (warm/cold) and competence (competent/incompetent). The results indicated no effect of target age on moral perceptions, but warmer and/or more competent target individuals elicited higher moral perceptions. Thus, Hypothesis 1 was not supported in either study, whereas Hypotheses 2 and 3 were supported across both studies. These findings underscore the importance of enhancing moral perceptions, warmth, and competence regarding older adults to facilitate appropriate assistance from other generations.

Time Since Injury Is Key to Modeling Trends in Aging and Overall Functioning of Persons With Spinal Cord Injury: A Longitudinal Analysis of a Swiss Community Survey.

The aim of the study is to model the health indicator of functioning for persons with spinal cord injury or disorder living in Switzerland in the long-term context, considering chronological age, time since injury, and age at injury. This is a longitudinal analysis of three waves of a community survey. An interval-scaled functioning metric was constructed using modern test theory. Random effects within-between mixed models were used to investigate trends in functioning over time. Persons with complete injuries have lower levels of functioning than persons with incomplete injuries, and persons with complete tetraplegia have the lowest levels of functioning. The person's age when injured, the level and completeness of the injury, the presence of secondary health conditions, and various combinations of these factors significantly influenced how functioning changed over time. Our study shows that chronological age is not necessarily the best time variable for understanding the aging process of people with spinal cord injury in terms of changes in functioning over time and that modeling functioning over time since injury provides important insights into how functioning of people with complete or incomplete injuries declines with increasing time living with the injury.

Depressive syndrome, cognitive impairment, and associated factors among community-dwelling aged persons in Cameroon.

Background: Depressive syndrome (DS) and cognitive impairment (CI) are associated with unsuccessful aging. However, little is known about Cameroon. This study aimed to assess the factors associated with DS and CI among older adults in Cameroon. Methods: A representative sample of 599 individuals aged ≥ 60 years was selected for this cross-sectional study. Sociodemographic and health data were also collected. DS and CI were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D) and Mini-Mental State Examination (MMSE), respectively. The Rosow Mobility Scale, Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scales were used to evaluate functional abilities. Chi-2, ANOVA, and multiple regression analyses were performed to assess the factors associated with DS and CI. The threshold of statistical significance was 5%. Results: The average age was 68.9±7.2 years, sex ratio M/F=0.93, and weight 68.5±14.7 kg. DS affected 14.5% of the population and the CI was 21.4%. In the multivariate analysis, DS was positively associated with male gender (Odds Ratio (OR)=1.7 [95% Confidence Interval (CI):1.1-2.7], p=0.031) and inactivity (OR=1.7 [95% CI:1.0-3.0], p=0.043). CI was positively associated with lack of education (OR=6.5 [95% CI:3.5-12.2], p<0.001), inactivity (OR=5.3 [95% CI:1.6-17.9], p=0.008), single (OR=3.7 [95% CI:1.2-11.3], p=0.023), and widowhood (OR=3.3 [95% CI:1.6-6.5], p=0.001), and negatively associated with no IADL (OR=0.3 [95% CI:0.2-0.6], p=0.001) and ADL disability (OR=0.5 [95% CI:0.2-0.9], p=0.032) limitations. Conclusions: The associated factors suggest that it might be of interest to fight inactivity and encourage early and long-term education to prevent DS and/or CI among older adults.

The Characteristics of Everyday Life Safety Incidents among Vulnerable Groups

As society diversifies, everyday life safety incidents have emerged as a major social concern. Consequently, support measures for vulnerable groups who are less capable of responding to such accidents are increasingly necessary. This study is intended to diagnose the causes of everyday life safety incidents among vulnerable groups and establish preventive measures by analyzing the spatial, temporal, and variable characteristics of these accidents. The study’s findings reveal distinct spatial patterns and monthly and hourly trends in the occurrence of everyday life safety incidents, with a significant relationship between the age of the vulnerable persons and the accident type. The results of this study are expected to 1) contribute to the development of preventive measures tailored to different vulnerable groups and 2) inform regional safety policies.

An interrogation of family-based care for the elderly in Kaloleni sub-location, Kisumu, Kenya

The aim of this study was to interrogate family based care services for the elderly within Kaloleni Sub-Location, Kisumu, Kenya. The population of the elderly (age 60 and above) is projected to outnumber children (0-9 years) by the year 2030, and by 2050, to exceed the population of adolescents and youth aged between 10 to 14 years. The Kenya government is exploring the development of a community care strategy and the roll-out of an Integrated Care of Older Persons (ICOPE) package. While family-based care has been the policy and cultural preference for offering long term elderly care, the state recognized growing demand for responsive changes to current realities. This research set the following three objectives: First, to establish the state of family based care in Kaloleni sub-location; second, to examine alternatives to family based care that exist in the sub-location, and, lastly, to interrogate policy options as suggested by respondents in the study. Using Krejcie and Morgan sample size determination table, a total of 120 elderly persons aged 70 and above were traced and 92 of them randomly sampled. The methodology deployed was mixed methods involving narrative interviewing and cross sectional survey. Descriptive data analysis and thematic analysis were deployed for quantitative and qualitative results respectively. Narrative interviewing/In depth interviews method was used in collecting data from Kaloleni sub-location. While findings from this research may not be generalizable due to study limitations and scope, the study strongly demonstrated the desperate state of gerontological care in informal settlements in urban centers in Kisumu, where over 90% of respondents sought improvement on care service provision for the elderly. The elderly persons mostly rely on care givers from the family but these care givers also tend to be dependent on the elderly respondents for general upkeep. Results support the literature that contends that older people are vulnerable to poverty. It was recommended that policy must shift to address factors that promote healthy aging and diminish suffering in old age as population aging continues. Further studies of a longitudinal nature are required to lend greater insight and inform policy.

Prevalence of osteoarthritis knee among elderly in rural field practice area of Rajarajeswari Medical College, Bengaluru, India

Background: The most prevalent kind of arthritis and a highly common disease of the elderly is osteoarthritis (OA). It is a major contributor to disability among elders. The cervical and lumbosacral spine, the hip, the knee, and the first metatarsal phalangeal joint are the joints most frequently afflicted by it. Objective was to estimate the prevalence of osteoarthritis knee and to assess the risk factors associated with osteoarthritis knee among elderly persons in rural field practice area of Rajarajeswari Medical College, Bangalore. Methods: A cross-sectional study was conducted by visiting house to house among 150 elderly people selected by purposive sampling technique at Chunchunnakuppe village which is located on South Bangalore from June 2023 to July 2023. A detailed clinical examination of knee using American College of Rheumatology (ACR) criteria and Socio demographic information were also elicited. Results: A total of 150 elder respondents were interviewed out of which 63 (42%) had OA knee. Female gender, history of a knee injury, family history of knee pain, other chronic illness, current physical activity, BMI, and smoking status were found to be significantly associated with knee OA (p&lt;0.05). Conclusions: In the study area, osteoarthritis of the knee was quite prevalent. Some of the modifiable factors like physical activity, smoking, BMI are significantly associated with OA knee.

Disability trends among elderly Ukrainians in war conditions: a 10-year retrospective study

AimNon-communicable diseases (NCDs) in elderly are a significant problem in Ukraine. It is expected that the ongoing war will augment this problem. The study aimed to analyze the trends of disability due to NCDs s in newly-diagnosed elderly patients between 2013 and 2023.MethodsThis retrospective study included data obtained from the official document “Report on the Causes of Disability and Indications for Medical, Professional, and Social Rehabilitation” commissioned by the Ministry of Health of Ukraine. The data on disability due to NCDs s were obtained from for 2013–2023.ResultsDuring the 2013–2021 the average number of disabled elderly patients due to NCDs per 10,000 elderly persons was significantly lower in compare with working-age. During the first year of full-scaled war the average number of disabled elderly patients due to NCDS s per 10,000 elderly persons dramatically increased by 2-fold, and in 2023 – by 2.8-fold against 2013 value (p < 0.05), while in working-age the disability rate increased significantly only in 2023 by 1.4-fold compared to the pre-war level. In 2013–2021 the main causes of disability among those related to NCDs in elderly were cardiovascular diseases, followed by cancer. In 2022 compared to the pre-war level, the indicators of disability of the elderly due to CVD increased by 1.5 times, due to cerebrovascular diseases - by 2.2 times, due to cancer - by 1.7 times, due to musculoskeletal diseases - by 2 times (p < 0.05). The most significant increase in the number of elderly people with disabilities during the full-scale war occurred due to coronary artery disease - by 55.1%, and osteoarthritis - by 83.4% from baseline in 2013. It estemated the differences in indicators of disability of elderly between regions of Ukraine, significantly higher indicators of disability of the elderly due to cardiovascular diseases, cancer, cerebrovascular diseases, musculoskeletal diseases were noted in the frontline regions.ConclusionsData on primary disability among elderly Ukrainians indicates a significant increase in NCDs-related disability during the war in compare with working population, especially in frontline regions and regions with a high concentration of displaced persons. In this structure of NCDs-related increasing disability, CVD, oncology and musculoskeletal diseases system prevailed.

A review of artificial intelligence-based brain age estimation and its applications for related diseases.

The study of brain age has emerged over the past decade, aiming to estimate a person's age based on brain imaging scans. Ideally, predicted brain age should match chronological age in healthy individuals. However, brain structure and function change in the presence of brain-related diseases. Consequently, brain age also changes in affected individuals, making the brain age gap (BAG)-the difference between brain age and chronological age-a potential biomarker for brain health, early screening, and identifying age-related cognitive decline and disorders. With the recent successes of artificial intelligence in healthcare, it is essential to track the latest advancements and highlight promising directions. This review paper presents recent machine learning techniques used in brain age estimation (BAE) studies. Typically, BAE models involve developing a machine learning regression model to capture age-related variations in brain structure from imaging scans of healthy individuals and automatically predict brain age for new subjects. The process also involves estimating BAG as a measure of brain health. While we discuss recent clinical applications of BAE methods, we also review studies of biological age that can be integrated into BAE research. Finally, we point out the current limitations of BAE's studies.

The Role of Social Media for the Elderly in Lembean Village, Kauditan District, North Minahasa Regency

This study aims to determine the role of social media for the elderly in Lembean Village, Kauditan District. Based on the definition of WHO (World Health Organization), the elderly are people who are in the age range of over 60 years. The use of social media can provide the elderly with social activities and communication to live a happy and joyful old age, the theory of social activity Successful aging depends on how an elderly person feels satisfaction in doing activities and maintaining those activities. Spradley's qualitative research method; study of individuals/groups with the aim of describing cultural characteristics more deeply systematically in their own space and time. the number of informants is 4 people, namely 2 elderly women and 2 elderly men using purposive sampling techniques, in-depth interview data collection techniques, analyzed and described. The results of the study obtained the role of social media for the elderly in Lembean Village, namely; a means of social activity through whats app groups with family, elderly community groups, religious groups; a means of entertainment activities by exposing daily activities both at home and outside the home; a means of information sources of joy or sorrow and events in the outside world through Facebook, a means of economic activity exposing sales for elderly people who are still productive. Social media becomes a means of digital activity for the elderly to fill their time at home, a source of information and a means of immortalizing activities with photos.

Analysis of migraine characteristics in postmenopausal women

Objective: to identify characteristics of migraine in women in postmenopause (PM) by analyzing the frequency, duration and intensity of migraine attacks, assessment of quality of life, anxiety, depression and sleep disturbances in patients in the reproductive phase (RP) and in the PM.Material and methods. The study comprised 60 migraine patients (30 patients in the RP, 30 patients in the PM). During the personal interview, age, migraine type, frequency and duration of attacks and headache (HA) intensity on the visual analogue scale (VAS) were recorded. The patients then completed the questionnaires: HIT-6, MIBS-4, HURT, Migraine- ACT, MIDAS, SF-36, HADS, ISQ. The statistical analysis was performed in Microsoft Office Excel 2021.Results. The risk of high intensity HA (≥8 points on the VAS) was significantly higher in patients in the PM than in patients in the RP [p&lt;0.05; relative risk (RR) 1.77]. The risk of necessity of a revision of therapy of attacks was higher in the PM than in the RP (p=0.004; RR=2.2). The risk of insomnia was higher in the PM than in the RP (p=0.004; RR=4.67). The risk of severe headache impact (HIT-6) and high migraine burden (MIBS-4) was higher in patients in the PM than in the RP (ORHIT6=1.7; ORMIBS4=1.78). All indicators of SF-36 quality of life questionnaire were significantly lower in patients in the PM group than in the RP group (p&lt;0.05). The risk of subclinical and clinical anxiety (p&lt;0.05; RR=4.33) and depression (p&lt;0.05; RR=2.75) was significantly higher in the PM than in the RP.Conclusion. Migraine attacks in women in the PM are more intense than in women in the RP, quality of life is lower, and revision of therapy for attacks is required more frequently. Patients with migraine in the PM are more likely to suffer from anxiety, depression and insomnia. Further research is needed to determine the causes of the observed phenomena and to develop migraine therapy in patients in the PM.

Yoga fitness with middle-aged women: benefits for physical and mental health

Physical education of adults is important for maintaining their health. The choice of directions for the use of means of physical education should be based on the prevailing needs for motor activity of persons of mature age. The goal is to develop and experimentally substantiate the methodology of yoga classes for women aged 21-35. Participants Women 21-35 years old. Methods. Psychodiagnostics, movement testing, pedagogical experiment. Intervention. The method of yoga classes with middle-aged women has been developed and tested. The peculiarity of the proposed method is connected with the systematic use of original sets of yoga gymnastics exercises. The developed complexes were applied taking into account the successive increase in exposure and were used in accordance with the solution of specific training tasks. The results. The effectiveness of the proposed format of using yogic gymnastics exercises to improve indicators of the physical and psychological state of middle-aged women has been established. The improvement of performance characteristics, the cardiorespiratory system and the normalization of the psychological state of the participants under the influence of the applied sets of exercises were recorded. Discussion. Systematic yoga classes in the format of using developed sets of exercises were to determine their effectiveness in improving physical conditions and improving the psychological state of middle- aged women. The selected physical exercises belonged to the field of mental fitness and were stato-dynamic in nature. Accordingly, the mild effect of the classes on women who do not regularly engage in fitness should be related to the improvement of physical conditions, and meditative practices were associated with expectations regarding the normalization of the psychological state of the participants. The obtained results confirmed the stated expectations and do not contradict the results of similar studies. Conclusions. The established features of building effective yoga classes with middle-aged women allow us to recommend this type of fitness as an affordable means of improving the health of this contingent of people. The obtained results contribute to the further search for possibilities of detailing the program of yoga classes with middle-aged women in order to expand the range of tasks of physical education of this continent of people.

The Role of Social Media for the Elderly in Lembean Village, Kauditan District, North Minahasa Regency

This study aims to determine the role of social media for the elderly in Lembean Village, Kauditan District. Based on the definition of WHO (World Health Organization), the elderly are people who are in the age range of over 60 years. The use of social media can provide the elderly with social activities and communication to live a happy and joyful old age, the theory of social activity Successful aging depends on how an elderly person feels satisfaction in doing activities and maintaining those activities. Spradley's qualitative research method; study of individuals/groups with the aim of describing cultural characteristics more deeply systematically in their own space and time. the number of informants is 4 people, namely 2 elderly women and 2 elderly men using purposive sampling techniques, in-depth interview data collection techniques, analyzed and described. The results of the study obtained the role of social media for the elderly in Lembean Village, namely; a means of social activity through whats app groups with family, elderly community groups, religious groups; a means of entertainment activities by exposing daily activities both at home and outside the home; a means of information sources of joy or sorrow and events in the outside world through Facebook, a means of economic activity exposing sales for elderly people who are still productive. Social media becomes a means of digital activity for the elderly to fill their time at home, a source of information and a means of immortalizing activities with photos.

Hidradenitis Suppurativa and Maternal and Offspring Outcomes

Hidradenitis suppurativa (HS) is associated with morbidity in persons of reproductive age, but the effect on maternal and offspring outcomes is understudied. To determine the association of HS with pregnancy outcomes and maternal and child morbidity in the long term. This population-based longitudinal cohort study with up to 16 years of follow-up took place between 2006 and 2022 in Quebec, Canada. . Maternal HS. Outcomes included hypertensive disorders of pregnancy, gestational diabetes, and other birth outcomes as well as the long-term risk of hospitalization up to 16 years after delivery. The study used adjusted log-binomial and Cox proportional hazards regression models to estimate the association between maternal HS and pregnancy outcomes or hospitalization following pregnancy. Outcomes in both mothers and offspring were assessed. There were 1 324 488 deliveries during the study, including 1332 (0.1%) among mothers with HS. Compared with patients without HS, patients with HS had a greater risk of hypertensive disorders of pregnancy (risk ratio [RR], 1.55 [95% CI, 1.29-1.87]), gestational diabetes (RR, 1.61 [95% CI, 1.40-1.85]), and severe maternal morbidity (RR, 1.38 [95% CI, 1.03-1.84]). In neonates, maternal HS was associated with risk of preterm birth (RR, 1.28 [95% CI, 1.07-1.53]) and birth defects (RR, 1.29 [95% CI, 1.07-1.56]). In the long term, HS was associated with 2.29 times the risk of maternal hospitalization (95% CI, 2.07-2.55) and 1.31 times the risk of childhood hospitalization (95% CI, 1.18-1.45), including hospitalization for respiratory, metabolic, psychiatric, and immune-related morbidity over time. This cohort study found that HS is associated with adverse maternal and offspring outcomes in the peripartum period and in the long term. Early detection and management of HS may help mitigate these outcomes.

Computer-assisted morphometric analysis of the relationship between the coronoid and condylar processes of the mandible

: The mandible is the most durable and only movable bone that constitutes the lower one-third of the face.The mandibular condyle and coronoid processes are two anatomical structures located in the superior portion of the ramus of the mandible. Morphometric understanding of these structures is key to the diagnosis of various disorders associated with the temporomandibular region. It also aids in devising a plan for the management of such disorders.: The purpose of this study is to evaluate the anatomical corelation between the condyle and coronoid of the mandible.: This retrospective study was conducted by obtaining 100 high-resolution computed tomography images from departmental archived records between 2018 and 2024. After acquisition, these images were incorporated into MIMICS Materialize software to create stereolithography models, and morphometric analysis was carried out. Out of 100 HRCT data obtained, 87 were male and 13 were female. There is a statistically significant difference in length and angulation of the coronoid and condyle on both sides. The condyle length for males was (4 ± 5.5 mm) higher than the condyle length of females on both sides. However, the coronoid length of males and females varies in a range of 0.5-2mm on both sides of the mandible. Understanding the morphological variation of mandibular condylar and coronoid processes aids in various fields of medicine like forensics, anthropology, and reconstructive maxillofacial surgery. Our study inference will aid surgeons in planning coronoid grafts for condylar reconstruction as well as other maxillofacial reconstructions. Additionally, it helps in forensic odontology to determine a person's age and gender.

Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) analysis of human nails: Implications for age determination in forensics.

A person's age estimation from biological evidence is a crucial aspect of forensic investigations, aiding in victim identification and criminal profiling. In this study, we present a novel approach of utilizing Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy to predict the age of donors based on nail samples. A diverse dataset comprising nails from donors spanning different age groups was analyzed using ATR FT-IR, with subsequent multivariate analysis techniques used for age prediction. The developed partial least squares regression (PLS-R) model demonstrated promising accuracy in age estimation, with a root mean square error of prediction (RMSEP) equal to 11.1 during external validation. Additionally, a partial least squares discriminant analysis (PLS-DA) classification model achieved high accuracy of 88% in classifying donors into younger and older age groups during external validation. This proof-of-concept study highlights the potential of ATR FT-IR spectroscopy as a non-destructive and efficient tool for age estimation in forensic investigations, offering a new approach to forensic analysis with practical implications.

Self-creation of Older People in the Perspective of Developing Wisdom and Adaptation to Changing Roles in the Family and Society

Old age is a stage of life during which a person must confront the changes that occur both in the reality around them and in themself. Those are changes at the biological, psychological and social levels. Adapting to old age and the roles it brings becomes a difficult and demanding task. One of the most important developmental tasks of an elderly person is developing wisdom that can support and facilitate the process of adaptation to old age. Entering the period of late adulthood is therefore a special opportunity for further development and self-creative action of the individual leading to the creation of a mature identity of an old person. The aim of this text is to provide insight into the meaning and manifestations of this self-creative involvement, with particular emphasis on its importance in the process of adaptation to changing roles in old age and building wisdom.