The rapid digitalization of healthcare has brought about new opportunities and challenges for patient empowerment. This comprehensive literature review explores the importance of transparent access to personal health information (PHI) in enabling patients to take control of their health in the digital age. The findings reveal that patients with access to their PHI report greater engagement in their care and improved health outcomes. The development of patient-centered health information exchanges (HIEs) and clinically integrated networks (CINs) can help bridge the gap between patients and their health data. To achieve patient empowerment in the digital age, healthcare organizations must prioritize the development of patient-centric tools and platforms that facilitate transparent access to PHI, while policymakers should consider regulations that mandate patient access to their health data and incentivize the adoption of interoperable electronic health record (EHR) systems.