Age Limit Research Articles

Allocation Rules and Age-Dependent Waiting Times for Kidney Transplantation.

Rigid age limits in the current allocation system for post-mortem donor kidneys in Germany may have problematic effects. The new German national transplantion registry enables data analysis with respect to this question. Using anonymized data from the German national transplantion registry, we extracted and evaluated information on the recipients and postmortem donors of kidneys that were allocated in Germany through Eurotransplant over the period 2006-2020. Data on 19 664 kidney transplantations in Germany from 2006 to 2020 were analyzed. The median waiting time for kidney transplantation was 5.8 years. Persons under age 18 waited a median of 1.7 years; persons aged 18 to 64, 7.0 years; and persons aged 65 and older, 3.8 years. Over the period of observation, postmortem kidneys were transplanted into 401 people of age 64 (2.0% of all organ recipients) and 1,393 people of age 65 (7.1% of all organ recipients). The difference in waiting times between allocation programs for persons under age 65 (ETKAS, "Eurotransplant Kidney Allocation System") and those aged 65 and older (ESP, "Eurotransplant Senior Program") increased over the period of observation, from 2.6 years in 2006-2010 to 4.1 years in 2017-2020. The rigid age limits in the current allocation rules for post-mortem kidney donations in Germany are prolonging the waiting times for transplants among patients aged 18 to 64. We think these rules need to be fundamentally reassessed.

Cognitive abilities as one of the criteria for the selection and orientation of athletes of various ages in game team sports (for example, football)

Selection in the system of long-term training of athletes is one of the most complex problems in the theory and practice of sports training and involves the development and implementation of scientific and methodological developments in several directions at once: forecasting, modeling and control. As a result, in game team sports and in particular in football, ensuring the effectiveness of the selection and orientation process is determined by a comprehensive assessment of the athlete's abilities, covering all aspects of his preparation. Nowadays, psychodiagnostics and the practical application of the obtained data in the process of selection, competitive activity and in the educational and training process of young football players of various ages are still a reserve that can significantly increase the effectiveness of the training of the sports reserve in football. Not an exception is the study of the cognitive sphere of players, the lack of attention to which leads to a decrease in the prognostic value of conclusions about the potential capabilities of football players, as well as a negative impact on the effectiveness of training in certain areas and, first of all, tactical and technical. In order to determine the level of formation of a number of cognitive abilities of young football players of various ages, appropriate diagnostic measures were carried out, which made it possible to establish the dynamic characteristics of changes in individual cognitive indicators at different stages of training. The two tests used during the diagnosis showed consistent results in determining the age limits, where there is a stabilization of the rate of growth of the studied indicators. The obtained data can be used as criteria for assessing the degree of suitability of a young football player for effective functioning within sports activities at a specific stage of multi-year training.

The influence of number of comorbidities on the quality of life of diabetic patients

Introduction: With the continuous aging of the population of Western societies, an increase is expected not only in the number of patients with diabetes but also in the number of patients with comorbidities. Population studies suggest that most patients with diabetes have at least one comorbidity. Comorbidities can profoundly impact a person’s ability to care for himself/herself and can present barriers to adherence to lifestyle changes and compliance with therapy. Methods: The research was conducted in the Public Institution Health Centre of Sarajevo Canton - Health Center Hadžići and Health Center Novi Grad. It included 161 patients diagnosed with diabetes; 96 women and 65 men.The respondents were between 18 and 65 years old (the upper age limit for the working population for both genders). The instruments for conducting the research were a questionnaire on the socio-demographic characteristics of the respondents and Ferrans and Powers index of quality of life, a version for diabetes. Results: The research included 43.48% of respondents with diabetes mellitus (DM) Type II, 31.06% with DM Type I, while even 25.46% of respondents did not know which type of diabetes they suffered from. There were no statistically significant differences in the Total Quality of Life Index (TQLI) (p=0.328) between respondents with different types of diabetes. The average TQLI value in the group with diabetes duration from 1 to 5 years was 22.07 +/- 5.10; in the group from 6 to10 years was 21.23 +/- 6.0; in the group from 11 to 20 years was 21.86 +/- 4.82; in the group from 21 to 30 years was 19.20 +/- 6.81; and in the group with diabetes duration >30 years, was 23.36 +/- 5.46. High blood pressure was present in 60.24% of respondents, followed by elevated blood fats in 51.55% of respondents, and heart/brain blood vessel diseases, in 43.48% of respondents. Neuropathies were present in 38.5%, visual impairment in 26.08%, and malignant diseases were present in a total of 14.28% of respondents. Conclusion: The average value of the quality of life of respondents with 1 comorbidity was 21.30; with 2 comorbidities 20.91; and with 3 comorbidities was 21.94. There was no statistically significant difference in the quality of life of diabetes patients about the presence of one, two, or more comorbidities (p=0.537). The presence of a greater number of comorbidities in patients with diabetes does not contribute to poor quality of life.

Relevansi Batas Usia Perkawinan di Indonesia: Perspektif Madzhab Syafi’i dan Kompilasi Hukum Islam

This research is motivated by the existence of age limits for marriage in Indonesia. The aim is for the common good in building a household built through a marriage bond, although in reality, early marriage can still be carried out by submitting a marriage dispensation through the courts for specific reasons. The focus of this research is: (1) How is the argument of the Syafi'i school of thought about the age limit for marriage; (2) How is the age limit for marriage in the Compilation of Islamic Law (KHI); and (3) The relevance of the age limit for marriage in Indonesia from the perspective of the Syafi'i School of Thought and the Compilation of Islamic Law. The type of research used in this research is library research, namely by using data from books or books that are in accordance with the title of the research as a source of study, along with reviewing and reading writings and books that are related to the object of discussion. The approach used by researchers in this writing is normative, in the sense of trying to examine the law that has been conceptualized as rules and norms that have been applied in society and become a legal reference for everyone. The results of this study, in the view of the Syafi'i School, the age limit for marriage is seen from maturity, namely when he has reached puberty. Among the signs for someone who has reached puberty is the release of semen for men, usually at the age of 12 years, and menstruation for women, usually at the age of 9 years, because for someone who has reached the nature of puberty and aqil, it means that they have become ahliyah al-ada' who can be burdened with the responsibilities of sharia such as muamalah and other transactions. On the other hand, the Compilation of Islamic Law has provided an age limit for marriage, namely 19 years for men and 16 years for women, because Indonesian scholars see several factors that limit the age of marriage, such as avoiding early marriage, which has a terrible impact on married couples. Regarding its relevance in its implementation in Indonesia, the age limit for marriage in the Compilation of Islamic Law has been determined. However, if you still want to marry under the age that has been determined, you must go through a trial process to request a marriage dispensation from the panel of judges. The opinion of the Syafi'i School can be a choice that can be considered by the panel of judges to approve a marriage dispensation, namely the adequacy of the age of puberty as one indicator of maturity.

Historical Development of Diagnostic Criteria for NF2-related Schwannomatosis.

NF2-related schwannomatosis (NF2; previously termed neurofibromatosis type 2) is a tumor-prone disorder characterized by development of multiple schwannomas and meningiomas. The diagnostic criteria of NF2 have been regularly revised. Clinical criteria for NF2 were first formulated at the National Institutes of Health Consensus Conference in 1987 and revised in 1990. Revised criteria were also proposed by the Manchester group in 1992 and by the National Neurofibromatosis Foundation (NNFF) in 1997. The 2011 Baser criteria improved the sensitivity of diagnostic criteria, particularly for patients without bilateral vestibular schwannomas. Revisions to the Manchester criteria were published in 2019, with replacement of "glioma" by "ependymoma," removal of "neurofibroma," addition of an age limit of 70 years for development of vestibular schwannomas, and introduction of molecular criteria, which led to the most widely used criteria. In 2022, the criteria were reviewed and updated by the international committee of NF experts. In addition to changes in diagnostic criteria, the committee recommended the use of "schwannomatosis" as an umbrella term for conditions that predispose to schwannomas. Each type of schwannomatosis was classified by the gene containing the disease-causing pathogenic variant. Molecular data from NF2 patients led to further clarification of the diagnostic criteria for NF2 mosaic phenotypes. Given all these changes, the diagnostic criteria of NF2 may be confusing. Herein, to help healthcare professionals who diagnose NF2 conditions in the clinical setting, we review the historical development of diagnostic criteria.

Limiting access to assisted reproductive technologies for males of advanced age-Pros and cons from a Nordic perspective.

It is not controversial to state that parental age is increasing in several countries. But how to deal with this increase might be. Some Nordic countries have set an upper age limit for females seeking assisted reproduction in their national legislation, but none have done so for males. There are also recommendations in place that restrict access to publicly funded assisted reproduction for both females and males of advanced age in some Nordic countries. As recent data now show somatic and psychiatric health risks related to advanced paternal age, we ask if the time has come for countries to set an upper age limit for males seeking assisted reproduction like there already is for females, and summarize some of the risks and rewards involved in treating couples with advanced age in fertility clinics.

Upaya DP3APPKB Kabupaten Karanganyar dalam Memberikan Edukasi Kepada Masyarakat Akan Resiko Pernikahan Dini

Marriage is defined as an inner innate bond between a man and a woman to form a family that is sakinah, mawaddah, warahmah. Ideally, marriage is carried out by those who are mentally ready and old, but it is not uncommon to find many marriages under the age set by law. The marriage age limit is regulated in Law Number 16 of 2019 concerning Marriage, namely both men and women must be at least 19 years old. Data from UNICEF states that Indonesia alone has 1.2 million cases of underage marriage. The purpose of this study itself is to see the efforts made by the government in terms of overcoming the problem of early marriage in the Karanganyar area. The research method carried out is qualitative with a case study approach, or data is taken according to the stipulation of criteria that have been set previously. The results of the research obtained from the Karanganyar Regency DP3APPKB are efforts made by the government, namely by educating the public about the risks of early marriage and what negative impacts will be felt. The data is then processed using the structural perspective of Talcott Parsons' functionalism, in the concept of AGIL (Adaptation, Goal Attainment, Integration, Latency).

Reconciling moral discourses on choice, risk and pronatalism: the politics of elective egg freezing in Singapore

This article examines the framing of choice, risk and pronatalism in Singapore’s debate on elective egg freezing, beginning from the government’s review of the ban in 2012 and ending in 2023 when the procedure was legalised. It demonstrates the possibility of reconciling liberal discourses on reproductive choice with technocritical discourses on egg freezing as a risky and oppressive pronatalist technology. While medical complications, false hope and commercial abuse were longstanding concerns in Singapore, these risks were perceived as reconcilable with choice through an age limit, mandatory counselling and comparative frames from the national and international regulatory context. Additionally, low fertility rates and efforts to advance gender equality enabled the reconciliation of choice and pronatalism as policy justifications, while the construction of female candidates’ heteronormative reproductive desire framed pronatalism in women-centric ways. Such reconciliation was facilitated by Singapore’s strong interventionist culture which normalises paternalism and pronatalism. Within this context and through actors’ articulation of policy ideas, elective egg freezing was reinterpreted as a technology with manageable risks, and a hope technology for women and nation. A moral Singapore State which permits elective egg freezing while supporting the interests of women and society was thus co-produced by politicians, journalists and doctors.

Aircraft Age Limitation versus Three Indonesian Fatal Air Accidents in HFCAS Perspective

An aircraft deemed to be airworthy, not limited by aircraft age but by well maintenance and by the operation of the aircraft. The investigation by KNKT between 2014 -2021 found no statement related of aircraft aging like material fatique or other phrases. The latent errors started with repetitive failures which were not solved as early as possible. Three fatal accidents involved aircrafts with age of 27, 6 and 1 year old, all below the Minister Regulation No. 160 (2015) which stated maximum age was 30 years. The cancelation of Minister Regulation No. 027 (2020) is the correct decision from Indonesian Government as per other countries policy in term of aircraft airworthy not affected by aircraft aging. The cancelation empowers the technology innovation for old aircraft to be remanufactured which is common practise in other countries, latest technology innovation, safe operation, sustainability by reserving raw material of natural resources from scarcity. Incosistency regulations about aircraft age limit which operated since beginning in Indonesian airspace, showed that the regulations were made not based on academic or research approach.

Age and Functional Outcomes in Patients With Large Ischemic Stroke Receiving Endovascular Thrombectomy

Randomized clinical trials have demonstrated the efficacy and safety of endovascular thrombectomy for acute ischemic stroke with large infarct. Patients older than 80 years with large infarct are commonly encountered in clinical practice but underrepresented in randomized clinical trials. To provide an age-based analysis of functional outcomes in endovascular thrombectomy for acute ischemic strokes with large infarct. This retrospective multicenter cohort study included patients from the German Stroke Registry who received endovascular thrombectomy for acute ischemic stroke with large infarct at 1 of 25 German stroke centers between May 2015 and December 2021. Patients with acute ischemic stroke due to anterior circulation large vessel occlusion and large infarct were included. Large infarct was defined as an Alberta Stroke Program Early Computed Tomography Score of 0 to 5. Patients were subdivided by age to evaluate its association with functional outcomes. Age. Primary outcomes were independent ambulation (90-day modified Rankin Scale score of 0-3) and mortality (90-day modified Rankin Scale score of 6). A total of 408 patients with large infarct were included (217 women [53.2%]; median [IQR] age, 75 [64-83] years). The rate of independent ambulation decreased from 56.4% in patients aged 60 years and younger (44 of 78 patients) to 15.1% in patients older than 80 years (19 of 126 patients) (P < .001), while mortality increased from 15.4% (12 patients) to 64.3% (81 patients) (P < .001). Being older than 80 years was associated with lower rates of independent ambulation (adjusted odds ratio [aOR], 0.44; 95% CI, 0.23-0.82; P = .01) and higher mortality (aOR, 2.75; 95% CI, 1.61-4.72; P < .001). A final modified Thrombolysis in Cerebral Infarction grade of 2b or 3 was associated with higher rates of independent ambulation (aOR, 4.95; 95% CI, 2.14-11.43; P < .001), independent of age and without significant interaction (aOR, 0.69; 95% CI, 0.35-1.34; P = .27). In this cohort study of patients with acute ischemic stroke and large infarct, age was associated with functional outcomes. Patients older than 80 years had poor prognosis with high mortality but with sizeable differences depending on additional baseline and treatment characteristics. While it does not seem justified to apply a fixed upper age limit for endovascular thrombectomy, these results could assist clinicians in making informed treatment decisions in older patients with large ischemic stroke.

Transformasi Sosial: Pengabdian Masyarakat dalam Sosialisasi UU Batas Usia Perkawinan di Kecamatan Cilengkrang Kabupaten Bandung

Early marriage is a significant social problem in Indonesia, including in Cilengkrang District, Bandung Regency. In an effort to address this problem, the Indonesian government issued Law Number 16 of 2019 which sets the minimum age of marriage to 19 years for both men and women. Community service in socializing this law in Cilengkrang Sub-district aims to increase community understanding and compliance with the regulation. The program involves various educational activities, such as counseling, group discussions, and training for community leaders and educators. The methods used include direct approaches through village meetings and indirect methods through social and print media. The results showed that the involvement of community leaders and religious leaders was very effective in conveying messages and reducing resistance to legal change. The main challenges faced were changing entrenched mindsets and problems accessing information in remote areas. Recommendations to improve the effectiveness of this program include increasing the involvement of community leaders, optimizing the use of media, continuous training, inter-agency cooperation, periodic evaluation, and a culturally sensitive approach. With the implementation of these recommendations, it is expected that the socialization of the marriage age limit law in Cilengkrang Sub-district can be more effective, reduce the number of early marriages, and create an environment that supports the optimal development of children and improves the overall welfare of the community.

The Association Between Trajectories of Self-reported Psychotic Experiences and Continuity of Mental Health Care in a Longitudinal Cohort of Adolescents and Young Adults.

Young people (YP) with psychotic experiences (PE) have an increased risk of developing a psychiatric disorder. Therefore, knowledge on continuity of care from child and adolescent (CAMHS) to adult mental health services (AMHS) in relation to PE is important. Here, we investigated whether the self-reported trajectories of persistent PE were associated with likelihood of transition to AMHS and mental health outcomes. In this prospective cohort study, interviews and questionnaires were used to assess PE, mental health, and service use in 763 child and adolescent mental health service users reaching their service's upper age limit in 8 European countries. Trajectories of self-reported PE (3 items) from baseline to 24-month follow-up were determined using growth mixture modeling (GMM). Associations were assessed with auxiliary variables and using mixed models. Study results. At baseline, 56.7% of YP reported PE. GMM identified 5 trajectories over 24 months: medium increasing (5.2%), medium stable (11.7%), medium decreasing (6.5%), high decreasing (4.2%), and low stable (72.4%). PE trajectories were not associated with continuity of specialist care or transition to AMHS. Overall, YP with PE reported more mental health problems at baseline. Persistence of PE or an increase was associated with poorer outcomes at follow-up. PE are common among CAMHS users when reaching the upper age limit of CAMHS. Persistence or an increase of PE was associated with poorer mental health outcomes, poorer prognosis, and impaired functioning, but were less discriminative for continuity of care.

Suitability and Early Clinical Outcomes of Corneal Donor Tissue in the 76–80-Year-Old Age Group

Purpose: There is a significant global shortage of corneal donor tissue suitable for keratoplasty. One simple strategy for addressing this shortage is to increase the upper age limit for acceptable tissue over the current customary upper limit of age 75. We describe a pilot study completed at one eye bank procuring, processing, and distributing keratoplasty tissue from donors aged 76 to 80 years. Methods: This is a retrospective case series of donor tissues aged 76 to 80 years in comparison with donor tissues aged 71 to 75 years. Standard tissue parameters were evaluated for all tissues, including tissue suitability, mean endothelial cell density (ECD), death-to-procurement time, and cause of death. For the older tissues, clinical outcomes through 3 months were obtained from each surgeon, including intraoperative and postoperative complications. Results: Corneal tissues from donors aged 76 to 80 years had a similar suitability rate (57%) when compared with donors aged 71 to 75 years (59%) (P = 0.635). Both groups had comparable ECDs (P = 0.097). Early clinical outcomes of corneal grafts from donors older than 76 years were favorable, with no early graft failure or significant concerns for clinical safety or efficacy. Conclusions: Our findings suggest that corneal tissues aged 76 to 80 years can be safely and efficiently transplanted in the United States. While additional study is needed, our results strengthen the case that expanding the upper age limit for donor age has the potential to help meet the global shortage for suitable keratoplasty tissue.

A Review of Feminist Legal Theory on Abortion Regulations for Rape Victims in Indonesia

The purpose of this study is to review and evaluate abortion regulations for rape victims, especially the requirements outlined in the Health Law and Government Regulation No. 61 of 2014 concerning Reproductive Health, using feminist legal theory as an analysis framework. This study uses an extra-doctrinal methodology outside the laws and regulations, emphasizing feminist legal theory as the basis of thought. The findings suggest that abortion regulations for rape victims still largely ignore women's life experiences and put them in difficult situations. The marginalization of women victims of rape in accessing safe abortion is a consequence of the gestational age limit for abortion, which fails to acknowledge the different experiences of women and treat them as a homogeneous group. To effectively address this issue, it is critical to involve the participation of women who have experienced rape, including victims of sexual violence, in the development of policies related to abortion for rape victims.

Virtual Clinic Telehealth Abortion Services in the United States One Year After Dobbs: Landscape Review.

Telehealth abortion has taken on a vital role in maintaining abortion access since the Dobbs v. Jackson Women's Health Organization Supreme Court decision. However, little remains known about the landscape of new telehealth-only virtual clinic abortion providers that have expanded since telehealth abortion first became widely available in the United States in 2021. This study aimed to (1) document the landscape of telehealth-only virtual clinic abortion care in the United States, (2) describe changes in the presence of virtual clinic abortion services between September 2022, following the Dobbs decision, and June 2023, and (3) identify structural factors that may perpetuate inequities in access to virtual clinic abortion care. We conducted a repeated cross-sectional study by reviewing web search results and abortion directories to identify virtual abortion clinics in September 2022 and June 2023 and described changes in the presence of virtual clinics between these 2 periods. In June 2023, we also described each virtual clinic's policies, including states served, costs, patient age limits, insurance acceptance, financial assistance available, and gestational limits. We documented 11 virtual clinics providing telehealth abortion care in 26 states and Washington DC in September 2022. By June 2023, 20 virtual clinics were providing services in 27 states and Washington DC. Most (n=16) offered care to minors, 8 provided care until 10 weeks of pregnancy, and median costs were US $259. In addition, 2 accepted private insurance and 1 accepted Medicaid, within a limited number of states. Most (n=16) had some form of financial assistance available. Virtual clinic abortion providers have proliferated since the Dobbs decision. We documented inequities in the availability of telehealth abortion care from virtual clinics, including age restrictions that exclude minors, gestational limits for care, and limited insurance and Medicaid acceptance. Notably, virtual clinic abortion care was not permitted in 11 states where in-person abortion is available.

The Influence of Epilepsy on Oral Health Outcomes: A Retrospective Study in South Indian Adults.

Introduction Epilepsy, a chronic neurological disorder marked by recurrent seizures, affects approximately 50 million people worldwidewith a higher prevalence in developing countries. This condition challenges motor skills and coordination, leading to poor oral health maintenance. The study aimed to evaluate the effect of epilepsy on oral health outcomes in adults by contrasting South Indian epileptics with healthy controls. The primary objective was to assess the prevalence of oral health issues in patients with epilepsy compared to healthy individuals and to analyze the types andfrequency of dental procedures required inepileptic patients compared to healthy controls in the South Indian population. Materials and methods A retrospective study was conducted in the Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Chennai, India. Approved by the Institutional Human Ethical Committee (Registration ID: IHEC/SDC/OMED-2202/23/106), the study involved105 epileptic patients and 105 healthy controls from records between January 2021 and December 2023. Both male and female patients within the age limit of 18-55 years were included. Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 29.0 (Released 2022; IBM Corp., Armonk, New York, United States). Results The study involved 210 participants with an equal gender distribution. Valproate was the most common medication used by 39% of epileptic patients. Gingival hyperplasia was significantly more prevalent in the epileptic group (24%). The epileptic group also required more dental procedures, with 32% of teeth needing restoration, 20% root canal treatment, and 20% extraction, compared to 12%, 11%, and 5%, respectively, in the control group. Conclusion Epileptic patients exhibit poorer oral health outcomes, including higher rates of gingival hyperplasia and a greater need for dental procedures compared to healthy controls. These findings highlight the necessity for targeted dental care and regular monitoring for individuals with epilepsy to improve their oral health and overall quality of life.

Investigating the Variables Associated with Physical Exercise Status among United States Adults with Arthritis.

Background/Objectives: Arthritis is a chronic, debilitating condition affecting millions of United States (US) adults. Regular physical exercise is particularly important for adults with arthritis. This study aimed to investigate the characteristics associated with regular physical exercise in US adults with arthritis. Methods: This cross-sectional database study used 2021 Medical Expenditure Panel Survey data and included US adults (age ≥ 18) alive with arthritis. A multivariable logistic regression model was developed to test the association of the following variables with regular physical exercise (defined as moderate-vigorous intensity exercise for ≥30 min ≥5 times weekly; yes, no): age, sex, Hispanic, race, census region, marriage status, schooling, employment, health insurance, household income, mental health, general health, smoking status, chronic conditions, pain, and functional limitations. Results: Overall, 5091 people (regular physical exercise n = 2331, no regular physical exercise n = 2760) were involved in this analysis. Most were female, non-Hispanic, white, married, had schooling beyond high school, were unemployed, had private health insurance, had mid-high household income, had good mental health, had good general health, were non-smokers, had two or more chronic conditions, had little/moderate pain, and did not have a functional limitation. In multivariable logistic regression analysis, male vs. female sex (odds ratio [OR] = 1.440, 95% confidence interval [CI] = 1.185-1.749), employed vs. unemployed (OR = 1.277, 95% CI = 1.005-1.624), good vs. poor general health (OR = 2.174, 95% CI = 1.673-2.824), little/moderate vs. quite a bit/extreme pain (OR = 1.418, 95% CI = 1.109-1.818), and no functional limitation (OR = 1.592, 95% CI = 1.282-1.980) were associated with higher odds of reporting regular physical exercise, while Midwest vs. West census region (OR = 0.698, 95% CI = 0.521-0.935) was associated with lower odds of reporting regular physical exercise. Conclusions: This study identified variables associated with regular physical exercise among US adults with arthritis. Further work is needed to develop interventions for characteristics that may help increase exercise and, subsequently, health outcomes in this population.

Single‐Stage Synchronous India‐Asia Collision Model Revealed by Himalayan High‐Pressure Metamorphic Rocks

AbstractDespite a half‐century of intense research, the timing and diachroneity of initial collision between India and Asia remain highly debated, largely due to different definitions of “initial collision” and correspondingly different methods adopted. This study focuses on high‐pressure pelitic granulites of the Eastern Himalayan Syntaxis (EHS) to elucidate their metamorphic evolution and provide new constraints on the timing of initial India‐Asia collision. Petrological examination and phase equilibria modeling show that high‐pressure pelitic granulites have undergone four metamorphic stages, with the peak assemblage of garnet + K‐feldspar + kyanite + biotite ± plagioclase ± rutile + ilmenite + quartz at P‐T conditions of 13.1–15.7 kbar and 790–850°C. Clockwise P‐T paths suggest that the Indian continent underwent tectonometamorphic processes of initial collision and subsequent continent subduction. Zircon and monazite dating results indicate that the metamorphic ages of pelitic granulites range from 60 to 15 Ma, with the oldest ones clustered at 60–58 Ma. The oldest metamorphic ages of high‐ to ultrahigh‐pressure Himalayan metamorphic rocks can provide an upper age limit of the initial collision. Therefore, the initial India‐Asia collision must have occurred before 60–58 Ma in the EHS, roughly consistent with ca. 57 Ma in the western Himalaya and 63–60 Ma in the central Himalaya. Collectively, we conclude that the northern margin of India most likely underwent a single‐stage synchronous collision with the southern margin of Asia initially at around 60 Ma along the entire Yarlung‐Tsangpo suture zone.

Evaluation of the Regional Head Age Limit Policy in Indonesia After the Supreme Court Decision Number 23 P / HUM / 2024

This study evaluates the regional head age limit policy in Indonesia following the Supreme Court Decision Number 23 P/HUM/2024 through a normative juridical analysis. The age limit policy, governed by Law No. 10 of 2016, aims to ensure capable leadership by imposing a minimum age requirement for candidates. However, the Supreme Court's decision raises questions about the policy's alignment with constitutional principles of equality, non-discrimination, and democratic participation. The analysis examines statutory regulations, legal principles, and comparative insights from other democratic countries to understand the policy's rationale and implications. Findings highlight the need for a balanced approach that ensures legal consistency and promotes inclusive, effective regional governance. Recommendations include lowering the minimum age requirement, implementing a flexible age range, and incorporating empirical evidence to refine the policy, ensuring it serves the principles of justice, democratic participation, and effective governance.

Invasive group A Streptococcus infection (Streptococcus pyogenes): Current situation in Spain.

Group A ß-hemolytic Streptococcus (S. pyogenes), also known as GAS, is a Gram-positive bacterium. It can be easily identified in the microbiology laboratory by its ability to hemolyse blood in culture media. This bacterium is highly virulent due to its production of enzymes and toxins, and its ability to cause immunologically mediated diseases such as rheumatic fever and post-streptococcal glomerulonephritis. GAS is the primary cause of bacterial pharyngotonsillitis, although it is typically a benign and non-invasive disease. However, it also has the potential to cause severe skin and soft tissue infections, necrotising fasciitis, bacteraemia and endocarditis, pneumonia and empyema, and streptococcal toxic shock syndrome, without any age or predisposition limits. The term invasive GAS disease (iGAS) is used to refer to this group of conditions. In more developed countries, iGAS disease has declined thanks to improved hygiene and the availability of antibiotics. For example, rheumatic fever has practically disappeared in countries such as Spain. However, recent data suggests a potential increase in some iGAS diseases, although the accuracy of this data is not consistent. Because of this, the COVID and Emerging Pathogens Committee of the Illustrious Official College of Physicians of Madrid (ICOMEM) has posed several questions about invasive GAS infection, especially its current situation in Spain. The committee has enlisted the help of several experts in the field to answer these questions. The following lines contain the answers that we have collaboratively produced, aiming to assist not only the members of ICOMEM but also anyone interested in this topic.