Females In Age Group Research Articles

Medical, dental, and optical care utilization among community-living people with spinal cord injury in the United States

Context/Objective Information about patterns of healthcare utilization for people living with spinal cord injury (SCI) is currently limited, and this is needed to understand independent community living after SCI. This study investigates self-reported healthcare utilization among community-living people with SCI and assesses disparities across demographic, socioeconomic, and injury-related subgroups. Design Secondary analysis of cross-sectional survey data administered via telephone interview. Setting 6 SCI Model Systems centers in the United States (California, Colorado, New Jersey, New York, Ohio, and Pennsylvania). Participants Adults with chronic, traumatic SCI who were community-living for at least one year after the completion of an inpatient rehabilitation program (N = 617). Interventions Not applicable. Outcome Measures Utilization of a usual source of 4 types of health care in the past 12 months: primary, SCI, dental, and optical. Results 84% of participants reported utilizing primary care in the past year. More than half reported utilizing SCI (54%) and dental (57%) care, and 36% reported utilizing optical care. There were no significant differences across key subgroups in the utilization of primary care. Participants who had been injured for 5 years or less and participants with greater educational attainment were more likely to report utilizing SCI care. Participants with higher household income levels were more likely to report using dental care. Female participants and older age groups were more likely to report using optical care. Conclusion Rates of healthcare utilization among people with SCI are below recommended rates and vary across demographic, socioeconomic, and injury-related subgroups. This information can inform future research to target barriers to using healthcare services among community-living people with SCI.

Global survey to assess preferences for attending virtual orthodontic learning sessions

Nowadays, there is a tremendous increase in the conducting of virtual orthodontic learning sessions (VOLSs). This study aimed to investigate the fundamental technical and settings aspects of VOLSs. Three thousand orthodontic residents and specialists worldwide were invited via e-mail to complete an anonymous survey, including 23 prevalidated questions. Reminders were sent at 2-week intervals. When the sample size was reached, the survey was locked. Descriptive and inferential statistics were performed. Two hundred ninety-four males and 299 females of various age groups completed the survey; 61.9% of the participants opted to view the speaker's live video and the presentation's screen concurrently. Participants favored a speaker/screen ratio of 1:6 (57.5%), e-housekeeping before VOLSs (58%), appointed moderators for each VOLS (8.31 out of 10; 95% CI: 8.13, 8.48), and a nondistractive virtual background for the speakers/moderators (21.9%). Participants supported broadcasting before the start of the lecture of the VOLS (6.7 out of 10; 95% CI: 6.50, 6.95), with this being significantly influenced by the gender of participants and their continent of residence (P<0.001). Only 17.4% opted against live streaming of the VOLSs. Muting the attendees' microphones (90.5%) and having their videos switched off (62.39%) was preferable; 49.4% used their personal computers to view the lecture, whereas 27.5% used mobile phones. A webinar of 60-90 minutes duration was preferred by 76.6% of the VOLSs participants; 53.1% of the participants opted for a questions and answers session at the end of VOLSs. Organizers should take into consideration the impact of the digital body language of the speaker, the role of the moderator, cultural background, and privacy concerns of the attendees while organizing VOLSs. Orthodontic clinicians prefer to spend 60-90 minutes attending an interactive online session in which they can raise their questions during and at the end of the VOLSs.

Sex differences in suicide mortality in Newfoundland and Labrador: An observational study with medical examiner data from 1997 to 2016.

Globally, the suicide rate is two times higher for males than for females. Previous studies in Newfoundland and Labrador did not examine age-specific rates by sex. The objectives of this study were to determine suicide rates by sex and age group and to compare the demographic and clinical characteristics of males and females who died by suicide. This observational study analyzed a routinely collected dataset based on all medical examiner-determined suicide deaths among people aged 10 years and older in Newfoundland and Labrador, Canada, between 1997 and 2016. Age-standardized and age-specific suicide rates and rate ratios were calculated based on the number of deaths during the period, and descriptive statistics were used to compare demographic and clinical characteristics between males and females. The age-standardized suicide rate was 4.6 times higher among males than females and was higher for males in most age groups. Rates were highest in the young adult age groups for males (20 to 24 years) and females (35 to 39 years). Males who died by suicide were more likely to be from a rural community and to have died by firearm; females were more likely to die by self-poisoning and to have had a mental illness or substance use history. The results are broadly consistent with previous research, though this is the first study to report age-specific suicide rates among females across the life course in Newfoundland and Labrador. The results underscore the need to design public health and clinical interventions that account for sex differences in suicide risks.

Predictors of enablers and barriers to community pharmacists’ management of minor ailments in a developing setting: A theory-driven assessment

BackgroundThe clinical and financial burdens associated with minor ailments are well documented, but published evidence suggests that minor ailment services led by community pharmacists have a remarkable positive impact, mainly in developed settings. There is a paucity of evidence on community pharmacists’ self-perceived enablers and barriers to the effective management of minor ailments. ObjectivesThe objective of the study was to identify community pharmacists’ self-perceived enablers and barriers to the effective management of minor ailments as well as their significant predictors. MethodsA Kurt Lewin’s theory-driven cross-sectional survey of 305 community pharmacists was conducted in Qatar using a pretested 25-item structured questionnaire developed with an adapted conceptual framework focused on 4 key areas: education, regulation, practice, and research. Bivariate logistic regression was used to identify significant predictors of community pharmacists’ self-perceived enablers and barriers. ResultsThe response rate was 92.5% (282/305). Most of the respondents (68.1%) were males, who were 31-40 years of age (55.3%) and worked for pharmacy chains (77.3%). Community pharmacists identified a higher proportion of enablers (positive force) (82.4%) relative to only 3 barriers (negative force) (17.6%). The barriers identified included insufficient private or semiprivate space for patient counseling, the paucity of invitations to participate in practice-based research, and lack of feedback regarding the results and recommendations of previous research in which they were participants. The significant predictors of self-perceived enablers and barriers were female gender (odds ratio [OR], 2.21; 95% CI, 1.25-3.91; P = 0.007) and age group of ≤40 years (OR, 4.74; 95% CI, 3.50-7.16; P = 0.006). ConclusionCommunity pharmacists’ perceptions of the factors that enhance their effective management of minor ailments were overwhelmingly positive, as 14 enablers were identified relative to only 3 barriers. Female and young community pharmacists were significantly more likely to perceive enablers than barriers. The insights provided are potentially useful in developing pharmacy-based schemes to improve the effective management of minor ailments.

Trends in incidence and mortality of esophageal cancer in China 1990-2019: A joinpoint and age-period-cohort analysis.

BackgroundThe incidence and mortality trends of esophageal cancer (EC) remain unknown in China. This study aimed to describe the trend in incidence and mortality of EC in China.MethodsWe extracted age-standardized rates and numbers of EC in China for 1990−2019 from the Global Burden of Disease study 2019. The age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) were calculated to describe the trends, while the annual percentage of change and the average annual percent change (AAPC) were analyzed by the joinpoint regression analysis. The incidence and mortality data were analyzed via age-period-cohort model analysis.ResultsThe ASIR and ASMR decreased slightly before 1999, then increased from 1999 to 2004, and decreased again thereafter, with overall AAPC values of −2.5 (−2.8, −2.1) for females and -0.9 (−1.1, −0.8) for males regarding incidence, with overall AAPC values of −3.1 (−3.3, −2.9) for females and −1.2 (−1.3, −1.1) for males regarding mortality. As a whole, the relative risk (RR) of EC increased with age in both females and males regarding incidence and mortality, except for the 80–84-year-old age group in females and the 85–89-year-old age group in males regarding incidence, where they began to decrease. The RR of EC increased with age in females and males regarding mortality, except for the 85–89-year-old age group in males. The time period showed a trend of first rising and then decreasing, and the RR of time period effect was lower in 2015 than that in 1990 in females regarding both incidence and mortality, whereas males showed a significant upward trend in both incidence and mortality. The birth cohort effect showed an overall downward trend.ConclusionsThe overall incidence and mortality of EC in China shows an increased and then decreased trend from 1990 to 2019. The AAPC decreased in incidence and mortality from 1990 to 2019. The RR of incidence and mortality of EC in China is greatly affected by age in both sexes, by time period in male, we should be paid more attention to.

Bacterial profile and antibiotic susceptibility pattern of uropathogens causing urinary tract infection in the eastern part of Northern India.

Urinary tract infection (UTI) is a common infectious disease that affects men and women. It is a significant health concern due to multidrug-resistant (MDR) organisms. Therefore, it is necessary to have a current understanding of the antibiotic susceptibility (AS) pattern of uropathogens to manage UTI effectively. Since the bacterial pathogen causing UTI and its AS vary with time and place, the prevailing AS pattern of the causative agents are essential for empirical antibiotic therapy. This study aims to determine the prevalence and AS of uropathogens isolated from UTI patients in the eastern part of Northern India. The study was carried out between November 2018 and December 2019. Clean catch midstream urine samples were collected and processed using standard guidelines for microbiological procedures. Positive microbiological cultures were found in 333 of the 427 patients, where 287 were gram-negative bacteria (GNB), and 46 were gram-positive bacteria (GPB). Females had a higher prevalence of UTI (60.7%) than males (39.3%) (p = 0.00024). The most susceptible age group in females was 18–50 years as compared to males, whereas at the age of 51–80 years and >80 years males were more susceptible than females (p = 0.053). The most prevalent pathogen identified were Escherichia coli (55.0%), followed by Proteus sp. (6.9%), Klebsiella pneumoniae (6.6%), Pseudomonas aeruginosa (6.3%), of which 96.0% were MDR bacteria. The susceptibility pattern of our study also revealed that amikacin, gentamycin and imipenem were the most effective drugs against GNB. In contrast, nitrofurantoin, vancomycin, and chloramphenicol were the most effective drugs against GPB. According tothe findings, MDR pathogens are very much prevalent. Since UTI is one of the most frequent bacterial diseases, proper management necessitates extensive investigation and implementation of antibiotic policy based on AS patterns for a particular region.

Prevalence of Patients Seeking Treatment for Tooth Wear Related Problems

Introduction: Tooth wear is defined as the loss of tooth structure that occurs in the absence of carious mechanism which can cause deleterious effects in the dental health. The aim of this study was to assess the prevalence of awareness among patients and if they seek the treatment for tooth wear. Methods: This study was done in the Department of Conservative Dentistry and Endodontics KIST Medical College and Teaching Hospital Imadol during October 2019 to March 2020. A cross-sectional study was done including data collection from a questionnaire and clinical examination. Total 370 participants, both male and females of age group 18-70 years were included in the study. Results: A total of 370 patients were examined out of which 148 male and 222 females were examined. 351 (95%) of them showed the sign of tooth wear. Prevalence of tooth wear was 95% for both males and females. More than half of the patients with tooth wear reported of having GI symptoms (54%). Patients who brushed twice daily (54.9%) and using soft (46.2%) and medium (43.5%) showed the sign of tooth wear. Patients lacking awareness of tooth wear was 64.9%. however, those seeking treatment was 68.9%. Chi Square test was applied for statistical analysis Conclusion: Tooth wear is a common finding having higher prevalence in this population. Severity increased with progressing age group. Even though there was lack of awareness of the condition, most of them sought treatment for tooth wear.

Gender disparities in incidence and projections of lung cancer in China and the United States from 1978 to 2032: an age-period-cohort analysis.

Lung cancer incidences tend to be higher among males than females in both China and the United States, yet secular incidence patterns are different due to distinct population and environmental exposures. We examined long-term and future trends of lung cancer incidence, as well as the associations of age, period, and cohort effects with gender disparities. Using data from the Cancer Incidence in Five Continents from 1978 to 2012, we calculated age-standardized, age-specific incidence, and male-to-female incidence rate ratios (IRR), and conducted an age-period-cohort analysis. The average annual percentage change (AAPC) of the trends was obtained by Joinpoint Regression. Bayesian age-period-cohort analysis was also conducted to project incidences to 2032. In China, age-standardized incidence revealed a decreasing trend among males, but showed increasing trends among the younger age groups (30-54years) in females. Age-standardized incidence rates of males decreased but remained stable among females from 1972 to 2012 in the United States. Male-to-female incidence rate ratios narrowed in both countries and reversed among younger birth cohorts in the United States. Gender disparities are expected to continue to diminish in both countries, and incidence among females appears to exceed that of males in the United States by around 2023-2027. Gender disparities in lung cancer incidence persist and will continue into the future in both countries, but our findings suggested that smoking may play different roles in gender disparities in lung cancer incidence between the two countries. Further population-based epidemiological studies among females in China are imperative.

No Postoperative Change in Body Mass Index Was Observed Among Adolescent Female Patients After Sports or Trauma Surgery

Purpose: The purpose of this study was to identify whether adolescent females are more prone to postoperative BMI decreases when compared to other female age groups and all male age groups. We hypothesized postoperative BMI would decrease in adolescent females when compared to males and younger females. Methods: A list of patients aged 5 to 19 who underwent surgery from 2016-2020 was generated with the 50 most frequently used diagnosis codes of two orthopedic surgeons at an orthopaedic hospital. Patients were excluded if they had undergone multiple surgeries. BMI data was collected at baseline and 2-8 months post-surgery. Patients were divided in cohorts by age: school-age, pre-adolescent, and adolescent. Results: A total of 156 patients were analyzed with a mean BMI of 20.9. There were 24 school-aged, 72 pre-adolescent, and 60 adolescent patients. No statistically significant difference in BMI change was noted between groups as determined by one-way ANOVA (p=0.86). Conclusion: There were no significant postoperative changes in BMI between males and females over the time intervals measured, however, surgeons should still be attentive to this risk. Further research focused on subtle changes in eating habits is necessary to determine if eating disorders develop without BMI changes following surgical intervention.

CLINICAL AND RADIOLOGICAL PROFILE OF PATIENTS OF IDIOPATHIC INTRACRANIAL HYPERTENSION PATIENTS ATTENDING TERTIARY CARE HOSPITAL IN SOUTH INDIA

Background: idiopathic intracranial hypertension (IIH) is one of the causes of headache presenting in tertiary hospital. However, there are only limited studies on IIH. : To study the clinical and radiological prole of IIH patients. hospital based observationalAim Setting and Design: descriptive study. Headache patients were admitted and evaluated in the department of Neurology (from April 2021 toMaterial and Methods: April 2022) detailed history, clinical examination, and neuroimaging, Cerebral spinal uid (CSF)routine analysis and manometry were done. After evaluation, diagnosed 32 cases of IIH by modied Dandy criteria and the secondary causes of raised intracranial pressure and primary ocular pathology were excluded. Entire study population were females. The mean age was 30 years. 16 (50%) cases were obese, 9 overweightResults: and normal BMI were seven. All case has Headache, bifrontal headache was very common rather than occipital as presentation. Bilateral papilledema seen in all except one case of secondary optic atrophy with equivalent nding in Optical Coherent tomography. CSF analysis was normal and CSF pressure was elevated(≥250mmg) in all cases. Empty Sella was the most common radiological nding (26/32; 81.25%). Conclusion: IIH typically affects females of childbearing age group, mostly obese. However, it is not uncommon in the nonobese female as seen in the present study. In Indian subcontinent overweight and obesity may not be a dominant risk factor for the development of IIH. Cases with normal BMI with clinical features of raised intracranial pressure, refractory headache, visual symptoms and normal neuroimaging or empty Sella on MRI should be evaluated for IIH

A study to evaluate the effectiveness of Jacobson progressive muscle relaxation technique (JPMRT) on relief of premenstrual syndrome (PMS) among girls at selected colleges in Bengaluru

Adolescence is a time when people develop, and females in that reproductive age group have a variety of changes and growing obstacles. As a result of these changes menstruation occurs which is normal and usual process in every adolescent girls. And majority of the girls will suffer with the premenstrual syndrome. The prevalence of PMS is increasing and knowledge about management techniques are lacking among the adolescent girls. A total of 350 adolescence girls were selected for the study and convenient sampling technique is used to allocate the study subjects in experimental one group pretest and posttest group. The knowledge and PMS symptoms was assessed through structured questionnaire and modified PSST tool. The intervention for the study selected was Jacobson’s progressive muscle relaxation technique. The results of the study revealed that the pretest mean score 79.44±15.616 after intervention in post-test mean score is 53.73±13.204. Analysis of paired t test was done showed significant difference between pretest and posttest mean score of subjects as the P value is <0.001. findings of paired t test were interpretated that significant difference was found between before and after test scores with paired t value, t (31.319), p = <0.001. Hence, it proved by this study that JPMRT is effective technique in relieving the symptoms of PMS among adolescence girls.

A STUDY OF SOCIODEMOGRAPHIC CHARACTERSTICS, ANXIETY &amp; DEPRESSION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Background: Polycystic ovarian syndrome (PCOS) is the most common and distressing disorder of reproductive age group female which include symptoms like amenorrhea, hirsutism, obesity, acne, infertility etc. Because of these distressing symptoms PCOS has been associated with signicant psychiatric morbidity. Aims &amp; objectives: 1.To study the sociodemographic characterstics of females with PCOS. 2.To nd out the frequency of different symptoms in females suffering from PCOS. 3.To study the prevalence of anxiety and depression among females suffering from PCOS. Materials &amp; methods: 30 consecutive female patients attending gynae OPD from 1/3/2022 to 1/4/2022 suffering from PCOS as per Rotterdam criteria diagnosed by a consulatant gynaecologist were taken for the study. They were thoroughly evaluated on a specially designed semistructred proforma,GHQ-12,Hamilton anxiety rating scale, Beck's depression inventory and PCOS questionnaire. Results were analysed using suitable statistics. Result and conclusion: Majority (60%) of the patients were from the age group 25-30 years. Most common symptom of PCOS in the patient was menstrual irregularity(90%) followed by obesity(80%), hirsutism(50%), acne(40%), alopecia(20%) and acanthosis nigricans(10%), 33%of the patients showed clinically signicant anxiety symptoms, 10% shown clinically signicant depression and 10% showed mixed anxiety depression disorders.

Awareness about menstruation and menstrual hygiene management among females in the reproductive age group working as class 4 workers in Sumandeep Vidyapeeth campus

Background: Too often especially in the developing world mindsets, customs and institutional biases prevent women from achieving menstrual health. Thus objective of the study is to assess the practices of menstrual hygiene among women in the reproductive age group working as class 4 workers in sumandeep vidyapeeth campus. Methods: It was a cross sectional study in which total 80 class 4 female workers from Sumandeep Vidyapeeth campus were taken as study population. Data was collected through pre-structured questionnaires. Descriptive and analytical statistical methods were used for the preparation of results. Results: Among 80 reproductive age group women, 71.25% women had a regular cycle. 62.5% women had abdominal pain during menstruation. 52.5% women were using sanitary napkins for menstruation. 42.5% women were not using sanitary napkins due to its high cost. Conclusion: This study was conducted to a certain menstrual hygiene among women in reproductive age group and to improve the knowledge and practices among them. The study revealed the menstrual hygiene was far from satisfactory among many women in study population. It becomes necessary to educate girls and young adults about the physiology of menstruation and hygiene management well before menarche.

Consumer perception of insect-based foods in the community of Zhejiang University

Insect foods are nutritious and acceptable for human consumption. The research was to determine the factors of motivation choices, satisfaction and food safety knowledge on insect foods consumption among Zhejiang University community. This study takes the form of a structured online questionnaire designed by the investigators for this convenience sample survey. Data were collected from Zhejiang University, China. A total of 873 respondents, (students, teachers and staff) ranging in age from 18 to 85 years (503 men and 370 women) completed the survey. Factor analysis was employed to identify related variables. An analysis revealed three factors; what motivates insect foods consumption by the respondents showed that taste (40.4%) is the major reason to consume insect foods followed by nutritional value (27.3%) and affordability (13.9%). Majority of the respondents were satisfied with the price of insect foods (51.7%). The survey also showed that majority of respondents did not have food safety concerns on the potential toxicity of insect (47.2%), 33% were concerned, while 19.8% did not think about the safety concerns. The study revealed that males between 18-28 years consume insect foods more than females in the same age group. Although some insect foods may be toxic, consumption is enjoyed by many of the respondents and they are not discouraged from consuming them. This study shows the current trend on insect foods consumption, bring awareness on the safety of insect foods consumption and promote insect foods consumption as some edible insects are reported to have health benefits.

Glycemic status among newly diagnosed tuberculosis patients and their treatment outcomes- A prospective cohort study

Introduction and Aim: Tuberculosis is a serious systemic infection, which is a serious threat for developing countries including India. To address the disease burden, India has rolled out National Tuberculosis Elimination Program (NTEP) incorporating daily drug regimen with appropriate weight bands for treatment. Monitoring treatment outcomes for daily drug regimen with one-year post-treatment follow-up was the objective of the study. Materials and Methods: A prospective community-based cohort study was conducted between January 2020 and September 2021, in Udupi district. Patients were recruited from 62 different Primary health centres. Their baseline data was collected, glycaemic status was assessed using glycated hemoglobin. The patients were followed up till their treatment completion and one-year post-treatment follow-up was also done. Results: One hundred and two patients were diagnosed with tuberculosis during the 1st quarter of 2020 (Jan-Mar 2020) and started on daily drug regimen treatment. Favourable outcomes were noted among 107(95.1%), while unfavourable outcomes were noted among 5(4.9%). Females in younger age group and free from comorbidities had favourable outcomes. Older age groups, prediabetics, patients with lower BMI, and pulmonary tuberculosis had unfavourable outcomes. Conclusion: The daily drug regimen for tuberculosis was found to be effective in terms of reducing the treatment failure rates. Evaluation of glycaemic status using Glycosylated hemoglobin at the time of diagnosis of tuberculosis is desirable. So that, life style modification could be suggested to avoid progression of prediabetes to diabetes. Screening for diabetes using Glycosylated hemoglobin at treatment initiation is advocated to avoid unfavourable outcomes during TB treatment.

Assessment of Stress Incontinence in Indian Female CrossFit Trainers Aged 20-40 Years: A Cross-Sectional Study

Background: Stress incontinence is involuntary and uncontrollable loss of urine which is caused by activities that elevate intra-abdominal pressure. Cross fit training involves exercises which are performed above the normal level of intensity of other form of exercises. Although these set of exercises strengthen abdominal muscles, they eventually cause weakening of pelvic floor muscles making them susceptible to develop stress incontinence. Objective: To study and assess stress incontinence in Indian Female cross Fit trainers aged 20-40 years. Method: n = 100 subjects were included in the study who then performed pad test. Based on the results of pad test, they were classified as continent or incontinent. Further they filled Questionnaire for urinary incontinence (QUID) which confirmed whether they were suffering from stress incontinence or urgency incontinence Results: Female cross fit trainers in the age group of 20-40 years with an average of 23.67 (±5.92 years), were segregated into 4 age groups, that is 20- 25 years, 26-30 years, 31-35 years and 36-40 years. Majority of females in age group of 36-40 were positive for pad test. Out of the total females positive, in nulligravid females, only 1 female was positive for pad test, in females who were primigravid 7 females were positive for pad test and in multigravida females that is females with 2 children15 were positive for pad test. Conclusion: The study concludes that there is a positive correlation between age of women and parity on incontinence. Keywords: Stress urinary incontinence (SUI), Parity, Pelvic floor muscles (PFM).

Engelli Bireylerin enerji ve besin ögesi alımlarının referans değerler ile kıyaslanması: Kesitsel bir çalışma

Aim: It was aimed to evaluate the daily intake of energy and nutrients to determine the nutritional status of individuals with disabilities.&#x0D; Subjects and Method: The study was carried out under the Disability Support Program in 8 special education, practice and rehabilitation centres in the city centre of [removed for blind peer review] as a cross-sectional study. The demographic characteristics and daily energy and nutrient intake levels of individuals with disabilities were questioned. Daily energy and nutrient intake levels were compared with recommendations.&#x0D; Results: It has been determined that disabled individuals in all age groups diverged negatively from the reference energy value and the rate of energy of carbohydrates was low, the rate of fat was high. Vitamin A was low in males in the 14-18 age group and high in females in the 19-30 age group. Vitamin B1 in 10-30 years old, folic acid was in ≥10 years of age were low in both genders. Calcium and magnesium were low in both genders in all age groups.&#x0D; Conclusion: It has been determined that disabled people were inadequate and unbalanced, and it was thought that periodic evaluation of nutritional status will play an important role in improving their health.

Socio-economic Correlates of Body Mass Index, Blood Pressure and Contraceptive Use by Reproductive age-group Females

Background: Oral Contraceptive use, BP and BMI are strongly associated variables in terms of socio economic conditions. Oral Contraceptives are an important and widely accepted contraceptive modality used throughout the world. Aim &amp; Objective: This study aims to examine the effects of socio-economic factors on Body Mass Index (BMI), Blood pressure (BP) and contraceptive use by reproductive age-group females of Uttarakhand. Settings and Design: This study utilizes nationwide data from the Fourth National Family Health Survey (NFHS-IV). Methods and Material: Information was collected from Indian Institute of Population Sciences (IIPS) Mumbai and 17,300 women of Uttarakhand were considered for this study. Statistical analysis used: For inter age-group comparisons of blood pressure, BMI and socio-demographic indicators, analysis of variance (ANOVA) technique has been used. Results: The variation in mean age at menarche was found to be significant (p&lt; 0.01, ANOVA). The numbers of live births over the women's total lifetime were lower in the younger age groups (p&lt;0.01, ANOVA). Conclusions: The important findings of present study were that the use of contraceptive tended to have increased BMI and elevated blood pressure, even though the magnitude of these was little (equal to 4% and 40% respectively).

P-066 The impact of male factor infertility on the chromosomal status of the pre-implantation embryo

Abstract Study question Do poor sperm parameters and/or advance male age increase the rate of aneuploid blastocysts in PGT-A cycles? Summary answer In our study neither impaired semen quality nor advanced male age increased the rate of aneuploid blastocysts after PGT-A. What is known already The vast majority of aneuploidies in pre-implantation embryos arise from failures during the meiotic division of the oocyte. The extend of the paternal contribution to aneuploidies in the embryo is still discussed. It is known that that the rates of aneuploid spermatozoa increase from around 4.5% in normozoospermia by 2-6-fold in severe male factor infertility. Despite this fact, several studies reported no effect of sperm quality or male age on aneuploidy rates in IVF-embryos, however reports are controversial. Actually, severe male factor is still rated as an indication for PGT-A in several countries. Study design, size, duration In this retrospective multi-center study (2016-2018) we analyzed 298 PGT-A cycles from 179 patients. Calculations was performed for two groups according to female age (group 1 women ≤ 35 years; group 2 women ≥ 36 years). Sperm parameter were classified according to the WHO 2010 criteria and the motile sperm organelle morphology examination (MSOME) classification. Participants/materials, setting, methods Blastocyst culture was performed in a single step culture medium in a time-lapse incubator. Biopsy of 5-10 TE-cells was performed on culture day 5-6 on 1012 blastocysts. For whole genome amplification (WGA) PicoPlex (Rubicon Genomics) or SurPlex (BlueGenome/ Illumina) platforms were used. Next generation sequencing (NGS) was processed using the VeriSeq platform and data analysis by BlueFuse Multi (Illumina). Main results and the role of chance Comparing men with normozoospermia to men showing reduced sperm sperm parameters, we found in the group of women ≤ 35 years (group 1) a rate of 40.3% vs. 45.2% euploid blastocysts after TE biopsy. In the group of women ≥ 36 years (group 2) the rate of euploid blastocysts was 19.3% vs. 23.1% in normozoospermia vs. non-normozoospermia men. No difference in the number of blastocysts with uniform or mosaic chromosomal abnormalities were found between both groups. In a further analysis, no impact of sperm parameters on the number embryos with of sex chromosome aberrations was observed. With application of the MSOME-classification we found a similar picture. There was no difference in the rate of aneuploid blastocysts with o%, 1-3% or min. 4% normal forms in both groups. When focusing on male age by comparing men ≤ 49 years and ≥ 50 years, we found no difference in the rate of euploid blastocysts. In group the rate of euploid blastocysts was 42.1% vs. 47.5% and in group 2 the rates for euploid blastocysts were 21.8% vs. 19.8% in men ≤ 49 years and ≥ 50 years, respectively. Limitations, reasons for caution Chromosomal screening of all chromosomes using PGT-A will not detect small chromosomal aberrations such as small deletions, insertions or mutations. These small aberration could play an important role in male factor infertility. Focus if the present study was to test the efficiency of PGT-A in reduced sperm parameters. Wider implications of the findings In line with previous studies we found neither an impact of poor sperm quality, nor of advanced male age on the rate of euploid blastocysts after PGT-A. However, results published are controversial and male factor as indication for PGT-A has to be further evaluated. Trial registration number EK-2-8/2020

P-709 Fine-tuning IVF laboratory key performance indicators of the Vienna consensus according to female age

Abstract Study question Is the Vienna consensus appropriate to monitor IVF laboratory outcomes of treatments involving women of different age ranges? Summary answer Most IVF laboratory key performance indicators(KPIs) are reliably applicable irrespective of female age, while total good blastocyst rate should be adjusted according to female age What is known already The IVF laboratory is central to ART treatments. This demands methodical and precise monitoring of the performance. To assess laboratory efficiency, the Vienna consensus identified a set of relevant performance indicators(PIs) and KPIs applicable to a “reference population” defined by female age &amp;lt;40years, exclusion of PGT cases and use of own fresh oocytes and ejaculated sperm. It is known that women older than 39years – whose treatment outcome is affected by reduced oocyte quality–represent an increasingly large proportion of IVF patients. Thus, in this subgroup of patients the relevance of the Vienna indicators to treatments of remains to be demonstrated. Study design, size, duration Reported data concern a retrospective, single-center cohort analysis of 862 ART cycles carried out between January 2014 and May 2021. Inclusion criteria were indication for IVF/ICSI, blastocyst culture of all embryos formed in each cohort, use of own ejaculated spermatozoa (fresh or frozen), and complete cycles, i.e. those whose all embryos were transferred, cryopreserved or disposed of. Cancelled and PGT cycles were not included Participants/materials, setting, methods The overall population was divided into two groups according to female age: Vienna consensus (≤39 years) and older female age(≥40 years). We measured a selection of the Vienna performance indicators and KPIs, with a focus on measures relevant to embryo cleavage and blastocyst formation. Assessment of fertilization, cleavage and blastocyst rates was carried out. To assess more comprehensively blastocyst quality and quantity, we estimated the total usable blastocyst rate(TBUR). Finally, blastocyst cryosurvival rate was assessed. Main results and the role of chance No differences were observed in fertilization and embryo cleavage KPIs between the Vienna consensus and the older female age groups (standard IVF fertilization, 67.2 vs. 67.3; ICSI fertilization, 72.3 vs. 75.3; Day 2 development, 57.6% vs 58.7%; Day 3 development, 52.4% vs. 50.7 %, respectively). TBUR was lower in the older female age group (45.5% vs. 33.4% p &amp;lt; 0.001). This outcome decreased steadily with increasing female age. Clinical outcome significantly decreased with increasing female age. Implantation rate decreased from 34.3% in the Vienna consensus group to 16.9% in the older female age group (p&amp;lt;.001). Cumulative CPR showed a similar trend decreasing from 52.4% to 23.9% (p&amp;lt;.001). In the two populations, TBUR was further assessed after normalization of the number of retrieved oocytes. Rates were comparable in cycles with only few (1- 5 oocytes) collected oocytes (51.9% and 45.5%, p=ns). In cycles with 6-10, 11-15 and&amp;gt;15 collected oocytes TBUR was lower in older patient groups(p &amp;lt; 0.01). Univariate and multivariate logistic regression analysis showed female age as a factors independently associated with TBUR. Higher female age was associated with a reduced probability to achieve a TBUR greater than 40%. Limitations, reasons for caution The study design is retrospective and requires further refinement to control for factors that may impact clinical outcome Wider implications of the findings The study confirms the general validity of the Vienna Consensus but also indicate a need for fine-tuning in relation to factors intrinsic to gamete quality that can impact laboratory outcomes. Trial registration number Not applicable