African Research Research Articles

Towards regional scientific integration in Africa? Evidence from co-publications

Regional scientific integration is a critical pathway for the development of an integrated African research area and knowledge-based society. On the African continent, progress in scientific production and integration has remained limited, mostly led by a global or international agenda, and bound to a few top publishing nations. The high-level policy commitments and the accumulated policies and strategies developed and pursued under the various intertwined sub-regional economic groupings have, to date, only diversely contributed to policy alignment and coordination in the area of science, technology, and innovation (STI) across Africa. In this context, this paper provides a first and hence original assessment of the role of region-specific factors in shaping scientific collaboration on the continent. For this purpose, our study builds upon the proximity approach to analyse the determinants of scientific collaboration between African countries, using co-publications data from Thomson Reuters' Web of Science database as a proxy of such collaboration. Our results suggest that the majority of African regional economic communities (RECs) have not yet had a significant effect on scientific co-publication. Nevertheless, some important region-specific factors do seem to be at play, such as a shared ethnical language, membership in the African and Malagasy Council for Higher Education (CAMES), and the presence of a common European partner as a third partner in co-publication. Existing policies aimed at the development of an Africa-wide research area should aim to leverage existing and emerging regional excellence networks and novel coordination models to accelerate the process of scientific integration in Africa.

Epistemic justice, African values and feedback of findings in African genomics research

ABSTRACT This article draws on key normative principles grounded in important values – solidarity, partiality and friendliness – in African philosophy to think critically and deeply about the ethical challenges around returning individual genetic research findings in African genomics research. Precisely, we propose that the normative implication of solidarity, partiality and friendliness is that returning findings should be considered as a gesture of goodwill to participants to the extent that it constitutes acting for their well-being. Concretely, the value of friendliness may imply that one ought to return actionable results to participants even when their preferences regarding feedback are unknown. Notwithstanding, returning individual genetic results will have a cost implication. The cost of feeding back is relevant in the context of African genomics research projects, which are often funded by international sponsors and should be researched further.

Integrated approaches to nature-based solutions in Africa: Insights from a bibliometric analysis

The recognition of nature-based solutions (NbS) is on a growing trend worldwide in an era of climate change, and intensified demand for improved human health, better preparedness for disasters, food and water security. The solutions seek to restore, protect and sustainably manage natural and modified ecosystems to optimize biodiversity and human wellbeing benefits. In this study, a scientometric analysis of works indexed in Web of Science database until April 2022 was carried out to analyze 123 studies on NbS in Africa. The most active institutions, authors, and countries involved in publication on the topic and their evolution with time was assayed. African countries with exception of South Africa conducted limited research on the topic. About 38.2% of total searched outputs were affiliated to South African institutions. Most research output on the search query was in the environmental sciences and ecology subjects. A sluggish growth in research on the topic was established from the bibliographic coupling of authors and countries as well as keyword analysis. The study recommended for institution and policy overhaul, creation of NbS awareness and better financing of related projects to enhance the documentation and research on the topic in Africa by African researchers to supplement research already conducted by developed countries.

30th Anniversary of Diplomatic Relations Between Russia and South Africa

On March 14, 2022 the Institute for African Studies of the Russian Academy of Sciences held a round table discussion to mark the 30th anniversary of the establishment of diplomatic relations between the Russian Federation and the Republic of South Africa, organized by the Centre for Southern African studies. The history and current state of relations between the two countries and peoples were discussed by African studies researchers, Russian Foreign ministry officials and diplomats in South Africa, South African public figures and civil society activists, veterans of the national liberation movement. Among issues discussed were historic ties between Russia and South Africa dating back to the 18th century, first diplomatic contacts in the 19th century, participation of Russian volunteers in the Anglo-Boer war of 1899–1902, Russian emigration to South Africa, Soviet aid to the national liberation struggle against the apartheid regime, particularly relations with the ANC, first Soviet-South African diplomatic ties, influence on them of perestroika and the dissolution of USSR. Current problems of cooperation and development of relations in different fields within strategic partnership between the two countries, particularly, within the framework of BRICS, were also discussed.

Incidental neuroimaging findings in South African adult research participants with and without neuropsychiatric disorders

There is a lack of comparative data on the occurrence and clinical significance of incidental neuroimaging findings (IFs) in adult research participants with neuropsychiatric disorders and healthy controls. We investigated and compared the frequency, clinical significance and predictors of IFs on structural brain magnetic resonance imaging (MRI) scans of research participants between the ages of 18–78 years living in Cape Town, South Africa. Our sample (N = 295) included individuals with posttraumatic stress disorder (n = 122) or Parkinson's disease (n = 21), and healthy controls (n = 152). T1 ME-MPRAGE weighted structural MRI scans were acquired and subsequently reviewed for IFs by radiologists. A neurologist reviewed radiological reports and categorised IFs according to their estimated clinical significance. IFs were observed on the scans of 95 (32%) participants but most IFs were either judged to be clinically non-significant (49%) or of unknown clinical significance (32%). Eighteen participants (6%) had clinically significant findings that required referral for further clinical management. Age was a significant predictor of having an IF, whereas a diagnosis of Parkinson's disease was a significant predictor of having a clinically significant IF.

“We should be at the table together from the beginning”: perspectives on partnership from stakeholders at four research institutions in sub-Saharan Africa

BackgroundGlobal health research partnerships have been scrutinised for how they operate and criticised for perpetuating inequities. Guidance to inform fair partnership practice has proliferated and the movement to decolonise global health has added momentum for change. In light of this evolving context, we sought in this study to document contemporary experiences of partnership from the perspective of stakeholders in four sub-Saharan African research institutions.MethodsWe conducted qualitative interviews with 20 stakeholders at research institutions in four countries in anglophone eastern and southern Africa. Interview questions were informed by published guidance on equitable research partnerships. Data was analysed through an iterative process of inductive and deductive coding, supported by NVivo software.ResultsEarly-career, mid-career and senior researchers and research administrators from four sub-Saharan African research institutions described wide-ranging experiences of partnership with high-income country collaborators. Existing guidelines for partnership provided good coverage of issues that participants described as being the key determinants of a healthy partnership, including mutual respect, role clarity and early involvement of all partners. However, there was almost no mention of guidelines being used to inform partnership practice. Participants considered the key benefits of partnership to be capacity strengthening and access to research funding. Meanwhile, participants continued to experience a range of well-documented inequities, including exclusion from agenda setting, study design, data analysis and authorship; and relationships that were exploitative and dominated by high-income country partners’ interests. Participants also reported emerging issues where their institution had been the prime recipient of funds. These included high-income country partners being unwilling to accept a subordinate role and failing to comply with reporting requirements.ConclusionsInsights from stakeholders in four sub-Saharan African research institutions suggest that contemporary global health research partnerships generate considerable benefits but continue to exhibit longstanding inequities and reveal emerging tensions. Our findings suggest that long-term support targeted towards institutions and national research systems remains essential to fulfil the potential of research led from sub-Saharan Africa. High-income country stakeholders need to find new roles in partnerships and stakeholders from sub-Saharan Africa must continue to tackle challenges presented by the resource-constrained contexts in which they commonly operate.

Bibliometric Analysis of Municipal Solid Waste Management Research: Global and South African Trends

Municipal solid waste management has become one of the most important environmental management issues around the world. In this study, a bibliometric analysis of the literature related to municipal solid waste management from a global and South African perspective was performed using the software, VOSviewer. Relevant scientific literature was sourced from the Scopus database. Results showed that, globally, articles based on this topic started during the 1968–1969 period, whereas in South Africa such articles only appeared in 1996. The keyword analysis showed that most studies were related to waste-to-energy technologies, waste treatment, and other management aspects. Globally, emerging keywords representing new research areas were COVID 19-related waste streams, life-cycle assessments, and the role of municipal solid waste management in the circular economy. In contrast, South Africa’s prominent keywords were municipal solid waste, developing country, landfills, waste treatment, waste-to-energy technologies, pollution, greenhouse gas emissions, and others. Based on these results, and possible solutions to reduce the amounts of MSW generation rates, recommendations are made to bring South African research on par with international trends.

The COMBAT project: controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa.

Vector-borne diseases affecting livestock have serious impacts in Africa. Trypanosomosis is caused by parasites transmitted by tsetse flies and other blood-sucking Diptera. The animal form of the disease is a scourge for African livestock keepers, is already present in Latin America and Asia, and has the potential to spread further. A human form of the disease also exists, known as human African trypanosomosis or sleeping sickness. Controlling and progressively minimizing the burden of animal trypanosomosis (COMBAT) is a four-year research and innovation project funded by the European Commission, whose ultimate goal is to reduce the burden of animal trypanosomosis (AT) in Africa. The project builds on the progressive control pathway (PCP), a risk-based, step-wise approach to disease reduction or elimination. COMBAT will strengthen AT control and prevention by improving basic knowledge of AT, developing innovative control tools, reinforcing surveillance, rationalizing control strategies, building capacity, and raising awareness. Knowledge gaps on disease epidemiology, vector ecology and competence, and biological aspects of trypanotolerant livestock will be addressed. Environmentally friendly vector control technologies and more effective and adapted diagnostic tools will be developed. Surveillance will be enhanced by developing information systems, strengthening reporting, and mapping and modelling disease risk in Africa and beyond. The socio-economic burden of AT will be assessed at a range of geographical scales. Guidelines for the PCP and harmonized national control strategies and roadmaps will be developed. Gender equality and ethics will be pivotal in all project activities. The COMBAT project benefits from the expertise of African and European research institutions, national veterinary authorities, and international organizations. The project consortium comprises 21 participants, including a geographically balanced representation from 13 African countries, and it will engage a larger number of AT-affected countries through regional initiatives.

Cosmeceuticals: A Newly Expanding Industry in South Africa

Africa is counted amongst the cosmetic market contributors; however, South Africa’s remarkable plant diversity is still largely untapped in terms of its potential for medicinal and cosmetic purposes. Thus, we aim to provide a critical assessment of the advancements made in South African cosmeceuticals with emphasis towards online local companies/brands that are manufactured by small, medium and micro enterprises (SMMEs). For the current study, we limited our search of herbal cosmeceutical products to SMMEs with online websites, or products traded in other online cosmetic directories such as ‘Faithful to Nature’ and ‘African Botanicals’ using a simple Google search. We recorded more than 50 South African SMME companies/brands involved in the trade of cosmeceuticals. Skin and hair care were the major product categories widely traded in these online platforms. Furthermore, few patents were recorded from South African researchers and institutions thereof, which is quite alarming considering the extensive research that has been undertaken to study these commercially valuable plants. Based on the increasing number of new products and the wide pool of economically important plants coupled to their associated rich indigenous knowledge systems, the cosmeceutical sector can contribute to the economy, job creation, entrepreneurship skills, socio-economic development and intellectual property generation.

An updated review of the genus Strigivenifera Hering, 1937 (Lepidoptera: Zygaenoidea: Chrysopolomidae) with the description of a new species.

Following on from a recent revision by Kurshakov Zolotuhin (2013), the genus Strigivenifera Hering, 1937 is reviewed based on recently-collected material held at the African Natural History Research Trust. Investigation of genital morphology and newly-generated barcodes suggested that the diagnoses provided for the species in the previous revision were not entirely reliable for all taxa and as a result, a surplus of names exist in respect to valid species. The following taxonomic changes are implemented: S. livingstonei Kurshakov Zolotuhin, 2013 syn. n. and S. cruisa Kurshakov Zolotuhin, 2013 syn. n. are synonymised with S. albidiscalis (Hampson, 1910), S. ocellaris Kurshakov Zolotuhin, 2013 syn. n. is synonymised with S. eborea Kurshakov Zolotuhin, 2013 and S. tatooifera Kurshakov Zolotuhin, 2013 syn. n. is synonymised with S. bartschi Kurshakov Zolotuhin, 2013. A new species previously confused with S. ocellaris is described from the Western Area Peninsula in Sierra Leone: S. smithi sp. n. The intraspecific variability of the species together with appropriate diagnostic characters for identification are discussed and illustrated and an updated list of the valid species of the genus is provided.

Francine Ntoumi—building research capacity and encouraging female African researchers

Francine Ntoumi's dream had never been to build one of Africa's premier research laboratories, but to do impactful scientific research in Africa. Today, she is director of the Congolese Foundation for Medical Research (FCRM) that she herself created, in Brazzaville, Republic of the Congo. She is also a leading advocate for more women in science in Africa, where positions of all levels are dominated by men. “Around half of our researchers at FCRM are now women”, she tells The Lancet Infectious Diseases.

African researchers do not think differently about Open Data

A key motivation for Open Science is accessibility. For researchers in resource-poor economies, this translates into access to the methods, data and publications that will foster scientific research and discovery in such communities and environments. Attitudes toward Open Science are in flux, and there is a growing awareness of the roles and responsibilities that researchers have to one another in this regard. This paper explores how African researchers approach issues relating to Open Data by reporting on the State of Open Data Report data. Focusing on the attitudes toward Open Data, this paper reports on how African researchers view (i) data sharing, (ii) the use of shared data, and (iii) the Open Data ecosystem. The findings show that, although the attitudes of African researchers have changed over time, they are not very different from those held by their international counterparts. These findings will aid policymakers, as well as academic and research institutions, in highlighting the areas of future growth for Open Data in Africa.

Potential Opportunities and Challenges of Deploying Next Generation Sequencing and CRISPR-Cas Systems to Support Diagnostics and Surveillance Towards Malaria Control and Elimination in Africa.

Recent developments in molecular biology and genomics have revolutionized biology and medicine mainly in the developed world. The application of next generation sequencing (NGS) and CRISPR-Cas tools is now poised to support endemic countries in the detection, monitoring and control of endemic diseases and future epidemics, as well as with emerging and re-emerging pathogens. Most low and middle income countries (LMICs) with the highest burden of infectious diseases still largely lack the capacity to generate and perform bioinformatic analysis of genomic data. These countries have also not deployed tools based on CRISPR-Cas technologies. For LMICs including Tanzania, it is critical to focus not only on the process of generation and analysis of data generated using such tools, but also on the utilization of the findings for policy and decision making. Here we discuss the promise and challenges of NGS and CRISPR-Cas in the context of malaria as Africa moves towards malaria elimination. These innovative tools are urgently needed to strengthen the current diagnostic and surveillance systems. We discuss ongoing efforts to deploy these tools for malaria detection and molecular surveillance highlighting potential opportunities presented by these innovative technologies as well as challenges in adopting them. Their deployment will also offer an opportunity to broadly build in-country capacity in pathogen genomics and bioinformatics, and to effectively engage with multiple stakeholders as well as policy makers, overcoming current workforce and infrastructure challenges. Overall, these ongoing initiatives will build the malaria molecular surveillance capacity of African researchers and their institutions, and allow them to generate genomics data and perform bioinformatics analysis in-country in order to provide critical information that will be used for real-time policy and decision-making to support malaria elimination on the continent.

Building research capacity in an under‐represented group: The STAARS program experience

AbstractFor decades, the lack of high‐quality empirical economic research on the state of Africa's agriculture and rural economies has been an important factor impeding the formulation of evidence‐based policy on the continent. The Structural Transformation of African Agriculture and Rural Spaces program aims to build a critical mass of early career African scholars and policy research through an emphasis on mentorship and professional development to help remedy that deficiency. This paper explains the motivations, origins, and outcomes to date of the program, and offers lessons learned for others wishing to create research capacity development opportunities for under‐represented groups.

Body mass and growth rates in captive chimpanzees (Pan troglodytes) cared for in African wildlife sanctuaries, zoological institutions, and research facilities.

Captive chimpanzees (Pan troglodytes) mature earlier in body mass and have a greater growth rate compared to wild individuals. However, relatively little is known about how growth parameters compare between chimpanzees living in different captive environments. To investigate, body mass was measured in 298 African sanctuary chimpanzeesand was acquired from 1030 zoological and 442 research chimpanzees, using data repositories. An analysis of covariance, adjusting for age, was performed to assess same-sex body mass differences between adult sanctuary, zoological, and research populations. Piecewise linear regression was performed to estimate sex-specific growth rates and the age at maturation, which were compared between sexes and across populations using extra-sum-of-squares F tests. Adult body mass was greater in the zoological and resarch populations compared to the sanctuary chimpanzees, in both sexes. Male and female sanctuary chimpanzees were estimated to have a slower rate of growth compared with their zoological and research counterparts. Additionally, male sanctuary chimpanzees were estimated to have an older age at maturation for body mass compared with zoological and research males, whereas the age at maturation was similar across female populations. For both the zoological and research populations, the estimated growth rate was greater in males compared to females. Together, these data contribute to current understanding of growth and maturation in this species and suggest marked differences between the growth patterns of chimpanzees living in different captive environments.

Commentary on COVID-19 Vaccine Hesitancy in sub-Saharan Africa.

Rates of vaccination against COVID-19 remain lower in sub-Saharan Africa than in other low and middle-income regions. This is, in part, attributed to vaccine hesitancy, mainly due to misinformation about vaccine origin, efficacy and safety. From August to December 2021, we gathered the latest experiences and opinions on four vaccine hesitancy-related areas (policies, perceived risk religious beliefs, and misinformation) from 12 sub-Saharan African researchers, four of whom have published about COVID-19 vaccine hesitancy. The authors included two political and business experts, six public health specialists, five epidemiologists, and four biostatisticians from ten sub-Saharan African countries( Cameroon, Ghana, Kenya, Liberia, Nigeria, Sierra Leone, South Africa, Tanzania, Uganda, and Zimbabwe). The authors’ overarching opinions were that political influences, religious beliefs and low perceived risk exists in sub-Saharan Africa, and they collectively contribute to COVID-19 vaccine hesitancy. Communication strategies should target populations initially thought by policy makers to be at low risk, use multiple communication avenues and address major concerns in the population.

African Centers of Excellence in Bioinformatics and Data Intensive Science: Building Capacity for Enhancing Data Intensive Infectious Diseases Research in Africa.

Africa faces both a disproportionate burden of infectious diseases coupled with unmet needs in bioinformatics and data science capabilities which impacts the ability of African biomedical researchers to vigorously pursue research and partner with institutions in other countries. The African Centers of Excellence in Bioinformatics and Data Intensive Science are collaborating with African academic institutions, industry partners, the Foundation for the National Institutes of Health (FNIH) and the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH) in a public-private partnership to address these challenges through enhancing computational infrastructure, fostering the development of advanced bioinformatics and data science skills among local researchers and students and providing innovative emerging technologies for infectious diseases research.

Predictors of passengers’ satisfaction with long-distance coach liners in South Africa

Background: Long-distance coach liner bus transportation forms an important economic sector in South Africa as it contributes to the gross domestic product (GDP) and employment, and significantly impacts the daily life activities of many people. While this is commendable, there have been reports relating to inefficiency, reliability (late arrivals and departure times) and safety concerns. These concerns have the potential to negatively impact on passengers’ satisfaction.Aim: No South African investigative research study could be found on the predictors of passengers’ satisfaction with long-distance coach liners. This study was conducted to identify predictors of passengers’ satisfaction with long-distance coach liners in South Africa.Setting: The target respondents were passengers who recently travelled on a long-distance coach liner in South Africa. The potential respondent had to be at least 18 years of age.Methods: Primary data were collected using an online survey, and respondents recruited through convenience and snowball sampling. Of the 409 questionnaires received, 399 useful questionnaires were included in the data analysis.Results: The results of the study indicate that peace of mind (β = 0.552, p = 0.000) and efficiency (β = 0.455, p = 0.000) have a predictive power on passengers’ satisfaction.Conclusion: The findings suggest that when there is an improvement in peace of mind and/or efficiency, passengers’ satisfaction will also improve. It is thus recommended that operators/managers of long-distance coach liners prioritise the elements that contribute to peace of mind at all touchpoints (e.g. safety, security, privacy, professionalism of drivers) and efficiency in delivering services to passengers (e.g. reliability and punctuality).

Creating Poetic Expressions for Professional Learning in the HIV and AIDS Context

ABSTRACT As South African researchers facing HIV- and AIDS-related challenges in our professional lives, we continuously turn to self-study methodology to inform our learning and teaching in our teacher education practice. This article explores how we extended our professional knowledge in relation to HIV and AIDS, starting with our own self-study doctoral projects. We each self-selected exemplars from our completed doctoral projects as data sources. We also wrote reflective letters which we emailed to each other to create poems to learn about and improve our practice in the South African context of HIV and AIDS. Using two different sets of poetic representations, we framed possibilities to explore how poetic inquiry enhanced our professional learning. We also considered how poetic inquiry can contribute to professional responsibilities in general. Our collaborative poetic self-study facilitated relooking at our doctoral projects differently. We concluded that our poetic self-study research enabled in-depth considerations of our particular concerns, which in turn assisted us in framing our professional learning as teacher educators researching and teaching in the HIV and AIDS context. Through poetic analysis, we realized that we must extend and continue growing our self-study scholarship that centers on making a difference concerning HIV and AIDS. In our inquiry, we could persist in seeking additional innovative, alternative ways of commencing and continuing conversations around social issues in HIV and AIDS. Collaborative self-study poetic inquiry permits rekindling, revitalizing and rejuvenating one’s research interests for continued professional learning and professional responsibilities.

Innovative Strategies for Developing Biomarker-Informed Cancer Clinical Trials to Accelerate Progress in Precision Oncology in Sub-Saharan Africa.

Well-designed, pragmatic, patient-centered clinical trials in low- and middle-income countries are essential to drive approval of more effective and less toxic cancer medicines to address the rising burden of cancer among populations in low- and middle-income countries. Moreover, through reverse innovation, clinical trials informed by genomic research enable development of precision medicine strategies for underserved populations within all populations. The African continent is home to many low- and middle-income countries; yet, it has seen very few cancer clinical trials. Considering that Africa is the cradle of humanity, with its diverse populations and geography, this represents a missed opportunity to understand the heterogeneity of cancer genomes and their implications for developmental therapeutics. Since 1998, the Nigerian Breast Cancer Study Group has striven to gain a better understanding of the root causes of breast cancer and accelerate progress in clinical research that will benefit the African ancestry diaspora globally through deployment of innovative "leapfrog" technologies. The University of Chicago supports interdisciplinary and interprofessional teams of researchers through the African Cancer Leaders Institute and in partnership with the African Organization for Research and Training in Cancer. By fostering public-private partnerships, the African Organization for Research and Training in Cancer can identify and integrate significant resources needed to build regional networks and establish clinical trial coordinating centers across African countries, enabling resources to be developed and shared equitably. Such resources include a standardized curriculum for specialist training in oncology, including medical oncology and oncology nursing, to increase the numbers of qualified team leaders and principal investigators. Adequate support for study participants-financial and psychosocial-and patient navigation services will be important in growing a clinical trials network. Finally, full participation of African clinical researchers in global oncology trials will ensure workforce retention in Africa and improve financial security and job satisfaction of health professionals on the African continent.