International inequality is not just inequality between countries but as well inequality between individuals and groups within and outside countries. It is also inequality between regions of the world or globe vis a vis economic, social and political inequalities. International inequality is cross-country that cuts across countries of the world at individual, group, state and regional levels. The modern world is thus defined by extreme inequality. In all indices, economically, socially, and politically, there is widening international inequality between developed and underdeveloped countries of which Africa belongs to the latter. Whilst international politics is characterized by extreme inequalities, international inequality has been deeply politicized. Thus, the politicization of international inequality has fostered inequality of international politics. The research question investigated by this paper is: Has extreme inequality of international politics deepened crisis of African integration? By adopting qualitative methods and relying on secondary sources of data, the paper concludes that extreme inequality of international politics as embedded in international political economy deepens crisis of African integration. The paper recommends post-neo-functionalism or post-neo-nationalism as a panacea for resolving crisis of African integration.