The Ngaye inlier of the Adamawa Yadé Domain is located in the Central African Fold Belt, adjacent to the Nyong Complex at the northern margin of the Congo craton, in central Cameroon. This area consists of metamorphosed granite-greenstone associations comprising amphibole- and pyroxene-rich banded iron formations (BIFs), amphibolites, and migmatitic gneisses. This study reports detailed petrographic, whole-rock geochemical, and LA-ICP-MS U-Pb zircon data for the Ngaye BIFs and associated amphibolites to better constrain their source, tectonic setting, and age. Amphibole-rich BIFs exhibit high REE-Y content and uncommon LREE-enriched patterns. In contrast, pyroxene-rich BIFs display combined low REE-Y content, seawater-like patterns, and positive Eu anomalies, suggesting a mixture of seawater and hydrothermal fluids during their deposition. The geochemical data of associated amphibolites suggest a back-arc setting for the Ngaye metavolcanosedimentary sequence, similar to that of the Nyong Complex. LA-ICP-MS U-Pb zircon dating of amphibole-rich BIFs indicate a maximum depositional age of ca. 2186 Ma and subsequent metamorphism at ca. 2038 Ma, overlapping with that of metavolcanosedimentary sequences from the Nyong Complex. Neoproterozoic age of ca. 598 Ma obtained for these BIFs is interpreted as the Pan-African metamorphic/hydrothermal imprint. This finding suggests that the post-depositional fluid overprint was probably related to the regional Pan-African tectono-thermal event.