5163 Background: African American (AA) men continue to bear a disproportionate burden of prostate cancer relative to White (W) men, making it important to monitor their response to disease and subsequent treatment. This study compared AA and W ratings of the extent to which prostate cancer and its treatment interfered with several domains of daily living for 190 patients who participated in a group therapy intervention and reported their racial background. Methods: One-way ANOVAs were used to determine whether there were significant differences in mean scores for each group on the Impact of Illness scale at baseline and at 3- and 6-month follow-up. Results: There were significant differences (all ps < 0.05) in total scale scores at baseline (AA mean = 32.08 vs. W mean = 19.04; F = 12.83), 3 mo. (AA mean = 29.91 vs. W mean = 18.89; F = 9.77) and 6 mo. (AA mean = 28.00 vs. W mean = 18.28; F = 5.42), with AA men reporting more disruption. A similar pattern was observed for the Relationship and Personal Development and the Instrumental subscale scores, but there were no significant differences on the Intimacy subscale. At baseline 10 of 13 domains covered by the Impact of Illness scale (e.g., work, relationships, financial situation, recreation, diet) were significantly more disrupted for AA men compared to W men, and 5 of 13 domains were still worse for AA men at 6 mo. follow-up. Conclusions: Results suggest that, compared to W men, AA men are experiencing more disruption in their daily lives across multiple domains and that this disruption persists over time. Targeted efforts are required to address the particular needs of AA prostate cancer patients who face serious negative consequences of disease and treatment in addition to established disparities in incidence and mortality. No significant financial relationships to disclose.