BACKGROUND: Although the overall incidence of cervical cancer in the United States is low, African American women carry a disproportionate burden of the disease. The incidence among Black women is nearly 50% higher than in Caucasians, and Black women are more likely than any other group to die from the disease. In order to eliminate such disparities and eradicate a virtually preventable cancer, education is crucial. METHODS: We completed a total of five lectures at four Historically Black Colleges. Each session included a lecture and a hands-on interactive review of HPV and cervical cancer. Participants were given a pre- and postlecture survey that assessed knowledge and beliefs related to cervical cancer, HPV, and HPV vaccination. RESULTS: A total of 57 students completed the surveys. Ninety-six percent of students reported knowledge of the HPV vaccine; however, only 52% reported receiving the vaccine. About 77% of students older than 21 years of age reported having a Pap test. Of the 16 knowledge-based questions, correct response rates significantly increased (74% versus 91%, P=.02) with the intervention. DISCUSSION: Community outreach interventions emphasizing primary prevention and early detection are necessary to reduce racial inequalities in cervical cancer morbidity and mortality. The educational intervention utilized in this study was successful in improving knowledge about HPV and cervical cancer. Further examination of the critical components for educational intervention in this population should be explored.