Mojave Air & Space Port is located in Mojave, California, United States. It is at an elevation of 2,801 feet (854 m), is nearly 3000 acres in size and has three runways. It is licensed by the FAA for horizontal launches of reusable spacecraft and is already a major hub for aerospace research and space enterprises, which includes potential space flights and very high altitude subsonic, supersonic, and hypersonic flights.During potential very high-altitude ‘near space’ space flights, the effects of cosmic radiation exposure, especially during sudden changes in space weather, such as ground level enhancement (GLE) or solar particle events (SPEs), could have significant health implications for crew and passengers. This case study examines the intricate landscape of radiation risks, regulatory challenges, licensing complexities, and approaches to risk management for very high-altitude ‘near space’ space flights from Mojave Air and Space Port carrying one or more paying "space flight participant" (being an individual, who is not crew, carried aboard a launch vehicle or re-entry vehicle).The study explores the specific challenges of risk assessment of very high-altitude flights, looking in detail at the risk posed by the space weather radiation environment in flight planning and execution, for both Space Port and flight operator. The study covers the ‘end to end’ licensing process and the regulatory considerations of space weather required for both Space Port and flight operator. Further, we look at the integration of Safety Management Systems (SMS), namely, we explore how SMS frameworks proactively identify, assess, and mitigate risks throughout the ‘near space’ space flight process. Further, the study presents a template for addressing the regulatory framework for flights, risk assessment, pre-flight briefings, and the flight licensing procedure.This case study offers valuable insights for Space Port and flight operators, regulators, and policymakers, contributing to the development of comprehensive safety strategies, which are crucial for safe very high-altitude ‘near space’ space exploration.Plain Language Summary: A case study of how the potential space weather risks can be successfully managed for very high altitude ‘near space’ subsonic, supersonic, and hypersonic flights from Mojave Air and Space Port, California, USA carrying one or more space flight participant(s).