Aerosol Physics Research Articles

Dry Powder Inhalers: An Overview.

Dry powder inhaler products have played an important role in the treatment and prevention of asthma and more recently chronic obstructive pulmonary disease. The considerations that go into formulation development to support these products cover a unique range of disciplines including analytical and physical chemistry, aerosol physics, device technology, process engineering and industrial design. An enormous research effort has been expended in the last half century to provide understanding of this complex dosage form. The guiding principles in considering the development of dry powder inhaler products encompass requirements for disease therapy, advantages and limitations of adopting certain technological approaches, and desirable features to facilitate patient use, which are all embodied in the target product profile.

Thirty-Five Years of Aerosol–PBAP in situ Research in Brazil: The Need to Think outside the Amazonian Box

Aerosols and primary biological aerosol particles (PBAPs) play an important role in regulating the global climate, but information summarizing the available knowledge is limited. Here, we present a systematic review of in situ studies performed in the last 35 years on aerosols–PBAPs in Brazil, with 212 studies encompassing 474 cases. The Amazon rainforest was the most studied biome, represented by 72% of cases, followed by the Atlantic Forest with 18%. Studies focusing the Amazon mostly investigated climate-related issues and aerosol physics, with less than 5% examining the biological identity of aerosols, whereas outside the Amazon, this number reached 16%. Whilst more than half of the cases within Amazon (55%) were held at seven sampling sites only, conclusions were mainly extrapolated to the entire biome. Contrarily, research beyond the Amazon has mostly addressed the temporal and biological characterisation of PBAPs, and not only is it scattered, but also scarce. Regarding sampling efforts, most cases (72%) had fewer than 100 days of sampling, and 60% of them spanned less than half a year of study. We argue that scientists should produce more detailed/complete assessments of aerosols–PBAPs in Brazil as a whole, particularly considering their biological identity, given their importance to global climate regulation.

Validation Matrix for Pool Scrubbing Models

The removal of aerosol particles and vapors in gas bubbles moving through a water pool is known to be an efficient means to reduce source term to the environment during severe accidents, as happened in Fukushima Daiichi. This trapping, called pool scrubbing, entails a complex phenomenology in which hydrodynamics, thermal hydraulics, and aerosol physics strongly affect each other and determine the net transfer of radioactivity coming out from the aqueous pond. More than 20 experimental programs have addressed this issue since the early 1980s, but few of them did it in a systematic and representative way. This paper thoroughly reviews the entire pool scrubbing database until 2016 and assesses the adequacy of the experimental setup, representativeness of boundary conditions, weaknesses in decontamination factor derivation, data uncertainties, and some other aspects to finally synthesize a reduced number of experiments that could be used as an experimental matrix for the validation of pool scrubbing models. More than 500 tests were reviewed and classified as Qualified for Validation, Useful for Understanding, or Not Useful; less than 15% of these experiments are considered in the proposed validation matrix due to different reasons. Major insights and remaining needs are also highlighted. This work was conducted under the framework of the Integration of Pool Scrubbing Research to Enhance Source-Term Calculations, or the IPRESCA project, led by Becker Technologies, in the framework of the Sustainable Nuclear Energy Technology Platform/Nuclear Generation II & III Alliance/Technical Area 2.

Insights into recent aerosol trends over Asia from observations and CMIP6 simulations

Aerosols continue to contribute the largest uncertainty in climate change. Over Asia, a global aerosol hotspot, spatial patterns of aerosol emissions are changing mainly because of changes in anthropogenic emissions, producing a dipole in atmospheric aerosol loading between East (decrease in emissions) and South Asia (increase in emissions). The resultant aerosol radiative effects are expected to be different as compared to the last decades of the 20th century because of this emerging Asian aerosol dipole. The projection and assessments of radiative and climate impacts of aerosols rely on simulating accurately the aerosol properties, thus, making it imperative that current climate models involved in climate assessments including the Intergovernmental Panel on Climate Change Assessment Reports, simulate well the magnitude and trends in changing aerosol properties. For the first time, in this study we analyze trends in aerosol properties over Asia from satellite and ground-based observations, and simulations from climate models in Coupled Model Intercomparison Project Phase 6 (CMIP6) experiment with state-of-the-art treatment of aerosol chemistry, physics and meteorology. The results reveal large inter-model differences in model estimates, and discrepancies between model simulations and observations as most models are not able to capture the recent observed magnitudes and trends in aerosol optical depth (AOD) and single scattering albedo (SSA) over Asia. The absolute and the relative (percent) trends (positive and/or negative) in AOD are significantly higher than the trends in SSA. The aerosol-induced effective radiative forcing within the atmosphere simulated with three CMIP6 models show a positive (increasing) trend over Asia. A positive trend in atmospheric heating due to aerosols in model simulations is consistent with model simulated trends in AOD (positive) and SSA (negative). These results on model-observations comparison need to be taken into account while examining the projected/expected future climate impacts due to aerosols, and potential value of various mitigation measures, in particular on regional and decadal climate change in Asia which is largely uncertain. Main findingOur analysis of satellite and ground-based observations, and simulations from climate models in CMIP6 experiment with state-of-the-art treatment of aerosol chemistry, physics and meteorology reveal large difference in model calculations, and most models are not able to capture the recent observed trends in aerosol optical depth and single scattering albedo over Asia during 2000-2018.

Minimising exposure to respiratory droplets, ‘jet riders’ and aerosols in air-conditioned hospital rooms by a ‘Shield-and-Sink’ strategy

ObjectivesIn COVID-19, transfer of respiratory materials transmits disease and drives the pandemic but the interplay of droplet and aerosol physics, physiology and environment is not fully understood. To advance understanding...

Significant contrasts in aerosol acidity between China and the United States.

Aerosol acidity governs several key processes in aerosol physics and chemistry, thus affecting aerosol mass and composition and ultimately climate and human health. Previous studies have reported aerosol pH values separately in China and the United States (USA), implying different aerosol acidity between these two countries. However, there is debate about whether mass concentration or chemical composition is the more important driver of differences in aerosol acidity. A full picture of the pH difference and the underlying mechanisms responsible is hindered by the scarcity of simultaneous measurements of particle composition and gaseous species, especially in China. Here we conduct a comprehensive assessment of aerosol acidity in China and the USA using extended ground-level measurements and regional chemical transport model simulations. We show that aerosols in China are significantly less acidic than in the USA, with pH values 1-2 units higher. Based on a proposed multivariable Taylor series method and a series of sensitivity tests, we identify major factors leading to the pH difference. Compared to the USA, China has much higher aerosol mass concentrations (gas + particle, by a factor of 8.4 on average) and a higher fraction of total ammonia (gas + particle) in the aerosol composition. Our assessment shows that the differences in mass concentrations and chemical composition play equally important roles in driving the aerosol pH difference between China and the USA - increasing the aerosol mass concentrations (by a factor of 8.4) but keeping the relative component contributions the same in the USA as the level in China increases the aerosol pH by ~1.0 units and further shifting the chemical composition from US conditions to China's that are richer in ammonia increases the aerosol pH by ~0.9 units. Therefore, China being both more polluted than the USA and richer in ammonia explains the aerosol pH difference. The difference in aerosol acidity highlighted in the present study implies potential differences in formation mechanisms, physicochemical properties, and toxicity of aerosol particles in these two countries.

Minimizing Exposure to Respiratory Droplets, 'Jet Riders' and Aerosols in Air-Conditioned Hospital Rooms by a 'Shield-And-Sink' Strategy

Objectives: In COVID-19, transfer of respiratory materials transmits disease but the interplay of droplet and aerosol physics, physiology and environment is not fully understood. To advance understanding of disease transmission mechanisms and to find novel exposure minimization strategies, we studied cough-driven material transport modes and the efficacy of control strategies.Design and methods: Computer simulations and real-world experiments were used for integrating an intensive care setting, multi-physics, and physiology. Patient-focused airflow management and air purification strategies were examined computationally and validated by submicron particle exhalation imaging in volunteers.Results Respiratory materials ejected by cough exhibited four transport modes: long-distance ballistic, short-distance ballistic, “jet rider”, and aerosol modes. Interaction with air conditioning driven flow contaminated a hospital room rapidly. Different than large droplets or aerosols, “jet rider” droplets travelled with the turbulent air jet initially, but fell out at a distance, were not well eliminated by air conditioning and exposed bystanders at larger distance and longer time; their size predisposes them to preferential capture in the nasal mucosa, the primordial COVID-19 infection site. “Cough shields” captured large droplets but induced lateral dispersion of aerosols and jet riders. An air purification device alone had limited efficacy. A “Shield and Sink” approach combining “cough shields” with “virus sinks” miminized exposure to all secretions in modeling and real-life experiments.Conclusions “Jet riders” have characteristics of highly efficient respiratory infection vectors and may play a role in COVID-19 transmission. Exposure to all droplet types can be minimized through an easily implemented “Shield and Sink” strategy.

Overview of the Norwegian Earth System Model (NorESM2) and key climate response of CMIP6 DECK, historical, and scenario simulations

Abstract. The second version of the coupled Norwegian Earth System Model (NorESM2) is presented and evaluated. NorESM2 is based on the second version of the Community Earth System Model (CESM2) and shares with CESM2 the computer code infrastructure and many Earth system model components. However, NorESM2 employs entirely different ocean and ocean biogeochemistry models. The atmosphere component of NorESM2 (CAM-Nor) includes a different module for aerosol physics and chemistry, including interactions with cloud and radiation; additionally, CAM-Nor includes improvements in the formulation of local dry and moist energy conservation, in local and global angular momentum conservation, and in the computations for deep convection and air–sea fluxes. The surface components of NorESM2 have minor changes in the albedo calculations and to land and sea-ice models. We present results from simulations with NorESM2 that were carried out for the sixth phase of the Coupled Model Intercomparison Project (CMIP6). Two versions of the model are used: one with lower (∼ 2∘) atmosphere–land resolution and one with medium (∼ 1∘) atmosphere–land resolution. The stability of the pre-industrial climate and the sensitivity of the model to abrupt and gradual quadrupling of CO2 are assessed, along with the ability of the model to simulate the historical climate under the CMIP6 forcings. Compared to observations and reanalyses, NorESM2 represents an improvement over previous versions of NorESM in most aspects. NorESM2 appears less sensitive to greenhouse gas forcing than its predecessors, with an estimated equilibrium climate sensitivity of 2.5 K in both resolutions on a 150-year time frame; however, this estimate increases with the time window and the climate sensitivity at equilibration is much higher. We also consider the model response to future scenarios as defined by selected Shared Socioeconomic Pathways (SSPs) from the Scenario Model Intercomparison Project defined under CMIP6. Under the four scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5), the warming in the period 2090–2099 compared to 1850–1879 reaches 1.3, 2.2, 3.0, and 3.9 K in NorESM2-LM, and 1.3, 2.1, 3.1, and 3.9 K in NorESM-MM, robustly similar in both resolutions. NorESM2-LM shows a rather satisfactory evolution of recent sea-ice area. In NorESM2-LM, an ice-free Arctic Ocean is only avoided in the SSP1-2.6 scenario.

UNATTACHED 212PB FRACTION IN THE WORKER'S BREATHING ZONE AT HIGH THORON CONCENTRATIONS.

Classical aerosol physics predicts that it is impossible to observe noticeable values of the unattached fraction of decay products of thoron at typical concentrations of aerosol particles. The experimental data have shown that the unattached fraction of the thoron decay products in a monazite storage facility is in the range 0.3-0.6. This effect is caused by local increase in air exchange near the inlet of the sampling device at high 220Rn concentrations. It was found that a dynamic shift between the unattached and attached thoron decay products is also observed in the worker's breathing zone at a high concentration of thoron. The 212Pb unattached fraction in worker's breathing zone was ~0.4. It demonstrates that when evaluating inhalation exposure to the products of the decay of thoron, it is necessary to take into account the increase of the 212Pb unattached fraction in the worker's breathing zone.

Interactive Worksheets for Teaching Atmospheric Aerosols and Cloud Physics

AbstractStudent-centered active learning pedagogies improve learning outcomes and increase the engagement of underrepresented groups. Implementing such pedagogies requires interactive tools for students to manipulate inputs and use the outputs to construct knowledge. This work introduces interactive worksheets for teaching about atmospheric aerosol and cloud physics and describes the toolchain to create and deliver the content. The material is appropriate for upper-level undergraduate and graduate instruction with pedagogy based on process-oriented guided inquiry learning. Students playfully interact with physical relationships and atmospheric models. Two examples are the interaction with an aerosol–cloud parcel model for simulating the early stage of cloud formation and the interaction with the Bowen model for simulating the formation of rain by coalescence. Photos, text, figures, and software associated with the project are free to be shared and free to be adapted. In addition to focusing on discipline-based learning objectives, the worksheets emphasize interacting with real-world data and practicing graph comprehension. Hosting the content in the cloud ensures reliable and scalable delivery to any device with a browser and Internet access. The worksheets are designed to be used in a student-centered active learning classroom but can also be used in an online setting.

Puzzling Haze Events in China During the Coronavirus (COVID-19) Shutdown.

It is a puzzle as to why more severe haze formed during the New Year Holiday in 2020 (NYH‐20), when China was in an unprecedented state of shutdown to contain the coronavirus (COVID‐19) outbreak, than in 2019 (NYH‐19). We performed a comprehensive measurement and modeling analysis of the aerosol chemistry and physics at multiple sites in China (mainly in Shanghai) before, during, and after NYH‐19 and NYH‐20. Much higher secondary aerosol fraction in PM2.5 were observed during NYH‐20 (73%) than during NYH‐19 (59%). During NYH‐20, PM2.5 levels correlated significantly with the oxidation ratio of nitrogen (r 2 = 0.77, p < 0.01), and aged particles from northern China were found to impede atmospheric new particle formation and growth in Shanghai. A markedly enhanced efficiency of nitrate aerosol formation was observed along the transport pathways during NYH‐20, despite the overall low atmospheric NO2 levels.

Liquid-Liquid Phase Separation in Supermicrometer and Submicrometer Aerosol Particles.

ConspectusThe interactions of aerosol particles with light and clouds are among the most uncertain aspects of anthropogenic climate forcings. The effects of aerosol particles on climate depend on their optical properties, heterogeneous chemistry, water uptake behavior, and ice nucleation activity. These properties in turn depend on aerosol physics and chemistry including composition, size, shape, internal structure (morphology), and phase state. The greatest numbers of particles are found at small, submicrometer sizes, and the properties of aerosol particles can differ on the nanoscale compared with measurements of bulk materials. As a result, our focus has been on characterizing the phase transitions of aerosol particles in both supermicrometer and submicrometer particles. The phase transition of particular interest for us has been liquid-liquid phase separation (LLPS), which occurs when components of a solution phase separate due to a difference in solubilities. For example, organic compounds can have limited solubility in salt solutions especially as the water content decreases, increasing the concentration of the salt solution, and causing phase separation between organic-rich and inorganic-rich phases. To characterize the systems of interest, we primarily use optical microscopy for supermicrometer particles and cryogenic-transmission microscopy for submicrometer particles.This Account details our main results to date for the phase transitions of supermicrometer particles and the morphology of submicrometer aerosol. We have found that the relative humidity (RH) at which LLPS occurs (separation RH; SRH) is highly sensitive to the composition of the particles. For supermicrometer particles, SRH decreases as the pH is lowered to atmospherically relevant values. SRH also decreases when non-phase-separating organic compounds are added to the particles. For submicrometer particles, a size dependence of morphology is observed in systems that undergo LLPS in supermicrometer particles. In the limit of slow drying rates, particles <30 nm are homogeneous and larger particles are phase-separated. This size dependence of aerosol morphology arises because small particles cannot overcome the activation barrier needed to form a new phase when phase separation occurs by a nucleation and growth mechanism. The inhibition of LLPS in small particles is observed for mixtures of ammonium sulfate with single organic compounds as well as complex organics like α-pinene secondary organic matter. The morphology of particles affects activation diameters for the formation of cloud condensation nuclei. These results more generally have implications for aerosol properties that affect the climate system. In addition, LLPS is also widely studied in materials and biological chemistry, and our results could potentially translate to implications for these fields.

A missing component of Arctic warming: black carbon from gas flaring

Gas flaring during oil extraction over the Arctic region is the primary source of warming-inducing aerosols (e.g. black carbon (BC)) with a strong potential to affect regional climate change. Despite continual BC emissions near the Arctic Ocean via gas flaring, the climatic impact of BC related to gas flaring remains uncertain. Here, we present simulations of potential gas flaring using an earth system model with comprehensive aerosol physics to show that increases in BC from gas flaring can potentially explain a significant fraction of Arctic warming. BC emissions from gas flaring over high latitudes contribute to locally confined warming over the source region, especially during the Arctic spring through BC-induced local albedo reduction. This local warming invokes remote and temporally lagging sea-ice melting feedback processes over the Arctic Ocean during winter. Our findings imply that a regional change in anthropogenic aerosol forcing is capable of changing Arctic temperatures in regions far from the aerosol source via time-lagged, sea-ice-related Arctic physical processes. We suggest that both energy consumption and production processes can increase Arctic warming.

Convergence analysis of finite volume scheme for nonlinear aggregation population balance equation

In this work, we introduce the convergence analysis of the recently developed finite volume scheme to solve a pure aggregation population balance equation that is of substantial interest in many areas such as chemical engineering, aerosol physics, astrophysics, polymer science, pharmaceutical sciences, and mathematical biology. The notion of the finite volume scheme is to conserve total mass of the particles in the system by introducing weight in the formulation. The consistency of the finite volume scheme is also analyzed thoroughly as it is an influential factor. The convergence study of the numerical scheme shows second order convergence on uniform, nonuniform smooth (geometric) as well as on locally uniform meshes independent of the aggregation kernel. Moreover, the first‐order convergence is shown when the finite volume scheme is implemented on oscillatory and random meshes. In order to check the accuracy, the numerical experimental order of convergence is also computed for the physically relevant as well as analytically tractable kernels and validated against its analytical results.

FeinPhone: Low-cost Smartphone Camera-based 2D Particulate Matter Sensor.

Precise, location-specific fine dust measurement is central for the assessment of urban air quality. Classic measurement approaches require dedicated hardware, of which professional equipment is still prohibitively expensive (>10k$) for dense measurements, and inexpensive sensors do not meet accuracy demands. As a step towards filling this gap, we propose FeinPhone, a phone-based fine dust measurement system that uses camera and flashlight functions that are readily available on today’s off-the-shelf smart phones. We introduce a cost-effective passive hardware add-on together with a novel counting approach based on light-scattering particle sensors. Since our approach features a 2D sensor (the camera) instead of a single photodiode, we can employ it to capture the scatter traces from individual particles rather than just retaining a light intensity sum signal as in simple photometers. This is a more direct way of assessing the particle count, it is robust against side effects, e.g., from camera image compression, and enables gaining information on the size spectrum of the particles. Our proof-of-concept evaluation comparing several FeinPhone sensors with data from a high-quality APS/SMPS (Aerodynamic Particle Sizer/Scanning Mobility Particle Sizer) reference device at the World Calibration Center for Aerosol Physics shows that the collected data shows excellent correlation with the inhalable coarse fraction of fine dust particles (r > 0.9) and can successfully capture its levels under realistic conditions.

Assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology.

The airborne transmission of infection relies on the ability of pathogens to survive aerosol transport as they transit between hosts. Understanding the parameters that determine the survival of airborne microorganisms is critical to mitigating the impact of disease outbreaks. Conventional techniques for investigating bioaerosol longevity in vitro have systemic limitations that prevent the accurate representation of conditions that these particles would experience in the natural environment. Here, we report a new approach that enables the robust study of bioaerosol survival as a function of relevant environmental conditions. The methodology uses droplet-on-demand technology for the generation of bioaerosol droplets (1 to greater than 100 per trial) with tailored chemical and biological composition. These arrays of droplets are captured in an electrodynamic trap and levitated within a controlled environmental chamber. Droplets are then deposited on a substrate after a desired levitation period (less than 5 s to greater than 24 h). The response of bacteria to aerosolization can subsequently be determined by counting colony forming units, 24 h after deposition. In a first study, droplets formed from a suspension of Escherichia coli MRE162 cells (108 ml-1) with initial radii of 27.8 ± 0.08 µm were created and levitated for extended periods of time at 30% relative humidity. The time-dependence of the survival rate was measured over a time period extending to 1 h. We demonstrate that this approach can enable direct studies at the interface between aerobiology, atmospheric chemistry and aerosol physics to identify the factors that may affect the survival of airborne pathogens with the aim of developing infection control strategies for public health and biodefence applications.

Principles of aerosol jet printing

Aerosol jet printing (AJP) has emerged as a promising method for microscale digital additive manufacturing using functional nanomaterial inks. While compelling capabilities have been demonstrated in the research community in recent years, the development and refinement of inks and process parameters largely follows empirical observations, with an extensive phase space over which to optimize. While this has led to general qualitative guidelines and ink- and machine-specific correlations, a more fundamental understanding based on principles of aerosol physics and fluid mechanics is lacking. This contrasts with more mature printing technologies, for which foundational physical principles have been rigorously examined. Presented here is a broad framework for describing the AJP process. Simple analytical models are employed to ensure generality and accessibility of the results, while experimental validation using a silver nanoparticle ink supports the physical relevance of the approach. This basic understanding enables a description of process limitations grounded in fundamental principles, as well as guidelines for improved printer design, ink formulation, and print parameter optimization.

Perspective: Aerosol microphysics: From molecules to the chemical physics of aerosols.

Aerosols are found in a wide diversity of contexts and applications, including the atmosphere, pharmaceutics, and industry. Aerosols are dispersions of particles in a gas, and the coupling of the two phases results in highly dynamic systems where chemical and physical properties like size, composition, phase, and refractive index change rapidly in response to environmental perturbations. Aerosol particles span a wide range of sizes from 1 nm to tens of micrometres or from small molecular clusters that may more closely resemble gas phase molecules to large particles that can have similar qualities to bulk materials. However, even large particles with finite volumes exhibit distinct properties from the bulk condensed phase, due in part to their higher surface-to-volume ratio and their ability to easily access supersaturated solute states inaccessible in the bulk. Aerosols represent a major challenge for study because of the facile coupling between the particle and gas, the small amounts of sample available for analysis, and the sheer breadth of operative processes. Time scales of aerosol processes can be as short as nanoseconds or as long as years. Despite their very different impacts and applications, fundamental chemical physics processes serve as a common theme that underpins our understanding of aerosols. This perspective article discusses challenges in the study of aerosols and highlights recent chemical physics advancements that have enabled improved understanding of these complex systems.

Co-suspension delivery technology in pressurized metered-dose inhalers for multi-drug dosing in the treatment of respiratory diseases.

Technologies for long-term delivery of aerosol medications in asthma and chronic obstructive pulmonary disease have improved over the past 2 decades with advancements in our understanding of the physical chemistry of aerosol formulations, device engineering, aerosol physics, and pulmonary biology. However, substantial challenges remain when a patient is required to use multiple inhaler types, multiple medications, and/or combinations of medications. Combining multiple drugs into a single inhaler while retaining appropriate dosing of the individual agents in the combination may enhance patient adherence to therapy and reduce device errors that occur when patients are using multiple inhalers. Pressurized metered-dose inhaler (pMDI) devices are widely used by patients for acute symptom relief as well as maintenance treatment, so the pMDI may be a suitable option with which to explore medication combinations. However, optimizing drug formulation remains a key challenge for pMDI delivery systems. This article introduces a new pMDI formulation approach: co-suspension delivery technology, which uses drug crystals with porous, low-density phospholipid particles engineered to deliver combinations of drugs to the airways with accurate and consistent dosing via pMDIs, independent of medication types and combinations. We describe the key characteristics of pMDIs, and discuss the rationale for the co-suspension delivery technology platform based on the limitations associated with traditional formulations. Finally, we discuss the clinical implications of co-suspension delivery technology for developing combination drug therapies administered by pMDIs.

Aerobiology: Experimental Considerations, Observations, and Future Tools.

ABSTRACTUnderstanding airborne survival and decay of microorganisms is important for a range of public health and biodefense applications, including epidemiological and risk analysis modeling. Techniques for experimental aerosol generation, retention in the aerosol phase, and sampling require careful consideration and understanding so that they are representative of the conditions the bioaerosol would experience in the environment. This review explores the current understanding of atmospheric transport in relation to advances and limitations of aerosol generation, maintenance in the aerosol phase, and sampling techniques. Potential tools for the future are examined at the interface between atmospheric chemistry, aerosol physics, and molecular microbiology where the heterogeneity and variability of aerosols can be explored at the single-droplet and single-microorganism levels within a bioaerosol. The review highlights the importance of method comparison and validation in bioaerosol research and the benefits that the application of novel techniques could bring to increasing the understanding of aerobiological phenomena in diverse research fields, particularly during the progression of atmospheric transport, where complex interdependent physicochemical and biological processes occur within bioaerosol particles.