Aerobic Exercise Regimen Research Articles

Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women

Regular aerobic exercise has a significant impact on glucose metabolism and lipid profiles, contributing to overall health improvement. However, evidence for optimal exercise duration to achieve these effects is limited. This study aims to explore the effects of 4 and 8 weeks of moderate-intensity aerobic exercise on glucose metabolism, lipid profiles, and associated metabolic changes in young female students with insulin resistance and varying body mass, seeking to determine the optimal duration for physiological adaptations. Twenty-eight physically semi-active female students were randomly assigned to 4-week (G4, n = 13, age = 23.31 ± 5.19, BMI = 24.78 ± 5.87) and 8-week (G8, n = 15, age = 21.8 ± 2.56, BMI = 24.95 ± 4.81) training groups. The aerobic intervention maintained an intensity of 40–70% of maximum heart rate (HRmax). 6-min-walk test (6MWT), handgrip strength tests, insulin, HOMA-IR, lipid profiles, and metabolic profiles were assessed pre- and post-intervention. Following the intervention, G8, but not G4, exhibited a significant decrease in HOMA-IR (-14.59%, p = 0.047). The improvement in HOMA-IR was accompanied by notable improvements in 6-MWT (+ 38.18%, p < 0.001) and handgrip strength (+ 11.62, p = 0.027 and + 17.59%, p = 0.013), and increased levels of bilirubin degradation products, ribose, and glutarate. The elevated levels of bilirubin degradation products, known for their antioxidant properties, suggested a potential antioxidative response triggered by prolonged aerobic exercise. Additionally, an increase in ribose and glutarate indicated improved metabolic flexibility and enhanced utilization of alternative energy substrates. The 8-week aerobic exercise regimen demonstrated enhanced insulin sensitivity, upper body strength, and cardiovascular performance in young females compared to a 4-week regimen by triggering specific metabolic adaptations. These findings emphasize the complex relationship between exercise duration, metabolic adaptations, and overall well-being in young women, providing valuable insights for optimizing exercise prescriptions in promoting metabolic health.

Aerobic exercise attenuates insulin resistance via restoring branched chain amino acids homeostasis in obese mice.

Emerging evidences suggests that the disrupted branched-chain amino acids (BCAAs) homeostasis and elevated BCAAs promote obesity-related insulin resistance (IR). Exercise improves insulin sensitivity. However, whether BCAAs plays a role in the exercise-attenuated IR remains to be fully investigated. In this study, male C57BL/6J mice were induced to become diet-induced obese (DIO) and served as subjects. The initial investigation focused on the impact of exercise on IR and BCAAs. The DIO mice were randomly assigned to either a sedentary group (CON, n = 16) or an exercise group (EX, n = 16). The EX group underwent a 12-week aerobic exercise regimen on a treadmill. After 12-week, plasma BCAAs and branched-chain keto acids (BCKAs) were measured by liquid chromatography-mass spectrometry, glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed, and the expression and phosphorylation of BCAAs catabolic proteins, as well as AKT T308 in gastrocnemius muscle and liver tissues, were evaluated using western blotting. Subsequently, the study explored the role of BCAAs in enhancing IR through exercise. Mice were randomly allocated into 4 groups: sedentary group (CON, n = 8), sedentary with BCAAs supplementation group (CON+BCAA, n = 8), exercise group (EX, n = 16), and exercise with BCAAs supplementation group (EX+BCAA, n = 16). The exercise protocol was as above. Mice in the BCAAs supplemented groups received drinking water containing 2% BCAAs. After 12-week, plasma BCAAs and BCKAs were measured, GTT and ITT tests were performed, and the phosphorylation of AKT T308, as well as p70S6K T389 in gastrocnemius muscle and liver, were compared between the EX group and the EX+BCAA group. Additionally, the phosphorylation of AMPKα T172 in both tissues was measured across all four groups. 12-week aerobic exercise improved insulin sensitivity in DIO mice while inducing BCAAs catabolic protein expression in skeletal muscle and liver, and reducing the plasma BCAAs level. Importantly, BCAAs supplementation elevated the plasma level of BCAAs and counteracted the exercise-attenuated IR. In skeletal muscle and liver tissues, BCAAs supplementation impaired the exercise-improved insulin signaling without enhancing mammalian target of rapamycin activity. AMPK activity was enhanced by aerobic exercise, which was abolished by BCAAs supplementation. Aerobic exercise attenuated insulin resistance via restoring BCAAs homeostasis and AMPK activity. The impacts of BCAAs intake on the metabolic effects of exercise sheds light on the combined exercise and nutrition intervention strategy for diabetes management.

Effect of Lifestyle Modification on Plasma Lipids of Adults in a Part of North Central Nigeria

Background: Plasma lipids are precursors of adrenal and gonadal steroid hormones, bile acids as well as important component of animal cell wall. However, abnormal plasma lipids are major risk factor for cardiovascular diseases globally. Researchers are currently considering lifestyle modification such as exercise, as an approach to maintaining normal plasma lipids level as well as addressing abnormal ones. Methodology: This study investigated the effect of lifestyle modification (vigorous intensity aerobic exercise regimen) on plasma triglycerides and low density lipoprotein-cholesterol of adults in Benue State University, Makurdi. The design of the study was guided by two research questions. Two hypotheses were formulated and tested at 0.05 level of significance. The study adopted two group pretest posttest quasi experimental design. The study population comprises twenty-one (21) Benue State University staff in the experimental group, and another twenty-one (21) for the control group. The proforma used for the data collection was validated by three experts, one from measurement and evaluation, one from the Department of Human Kinetics and Health Education and one from College of Health Sciences; all in Benue State University, Makurdi. Data generated were analyzed using Statistical Package for Social Sciences (SPSS Version 25). A descriptive statistics, mean and standard deviation were used to answer the research questions, and inferential statistics, Analysis of Covariance (ANCOVA) and Paired Samples Test were used to test the hypotheses at 0.05 level of significance. Results: The findings revealed that out of the 21 participants in the two groups, 12(57.14%) were males, while 9(42.86%) were females. The age range in the control group was between 28 to 65years, while that of the experimental group was between 36-68years. Vigorous intensity aerobic exercise regimen was found to have statistically significant effect on plasma low density lipoprotein-cholesterol (P = 0.000&lt;0.05). Even though plasma triglyceride was found to be reduced by vigorous intensity aerobic exercise regimen, the level of the reduction was found not to be statistically significant (P = 0.293 &gt; 0.05). Conclusion: The study concluded that healthcare workers should henceforth incorporate vigorous intensity aerobic exercise regimen prescription in public health awareness on the maintenance of plasma level of triglycerides and low density lipoprotein-cholesterol, as well as clinical management of patients with abnormal plasma low density lipoprotein-cholesterol.

Outcomes of the effect of exercise on cognitive function in patients with depression: A meta-analysis.

Major depressive disorder is a common mental disorder, characterized by a high rate of suicide and recurrence, which is frequently accompanied by cognitive impairments, particularly in executive function, memory, attention, and information processing speed. As such, improving the cognitive function in patients with depression and enhancing their quality of life are urgent issues. To perform a systematic review and meta-analysis of the effects of exercise on cognitive function in patients with depression. The PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang Medical, VIP, and Biomedical Databases for randomized controlled trials (RCTs) databases were searched (from inception to October 19, 2023) for studies investigating improvements in cognitive function in patients with depression through exercise. Tools recommended by the Cochrane Handbook for RCT evaluation, and GRADEpro and Stata17 software, were employed for risk of bias assessment, evidence grading, forest plot construction, subgroup and sensitivity analyses, and assessment of publication bias. Seventeen RCTs (1173 patients with depression) were included. Exercise had a small but significant positive effect on attention, with an effect size of 0.21, 95%CI: 0.07-0.34, P < 0.01. Specifically, aerobic exercise regimens of 30-60 minute/session, thrice a week, at moderate intensity, and sustained over 3-12 weeks, were associated with the most pronounced benefits (P < 0.05), with effect sizes for executive function, memory, and information processing speed of 0.11, 95%CI: -0.11-0.32, P = 0.34; 0.08, 95%CI: 0.00-0.16, P = 0.05; and 0.14, 95%CI: 0.04-0.25, P = 0.01, respectively. The evidence levels for attention, information processing speed, and memory were rated as 'low,' whereas that for executive function was rated as 'very low'. Exercise could improve attention and information-processing speed in patients with depression, although improvements in executive function and memory are not significant.

Investigating the Causal Effects of Exercise-Induced Genes on Sarcopenia

Exercise is increasingly recognized as an effective strategy to counteract skeletal muscle aging and conditions such as sarcopenia. However, the specific exercise-induced genes responsible for these protective effects remain unclear. To address this, we conducted an eight-week aerobic exercise regimen on late-middle-aged mice and developed an integrated approach that combines mouse exercise-induced genes with human GWAS datasets to identify causal genes for sarcopenia. This approach led to significant improvements in the skeletal muscle phenotype of the mice and the identification of exercise-induced genes and miRNAs. By constructing a miRNA regulatory network enriched with transcription factors and GWAS signals related to muscle function and traits, we focused on 896 exercise-induced genes. Using human skeletal muscle cis-eQTLs as instrumental variables, 250 of these exercise-induced genes underwent two-sample Mendelian randomization analysis, identifying 40, 68, and 62 causal genes associated with sarcopenia and its clinical indicators—appendicular lean mass (ALM) and hand grip strength (HGS), respectively. Sensitivity analyses and cross-phenotype validation confirmed the robustness of our findings. Consistently across the three outcomes, RXRA, MDM1, RBL2, KCNJ2, and ADHFE1 were identified as risk factors, while NMB, TECPR2, MGAT3, ECHDC2, and GINM1 were identified as protective factors, all with potential as biomarkers for sarcopenia progression. Biological activity and disease association analyses suggested that exercise exerts its anti-sarcopenia effects primarily through the regulation of fatty acid oxidation. Based on available drug–gene interaction data, 21 of the causal genes are druggable, offering potential therapeutic targets. Our findings highlight key genes and molecular pathways potentially responsible for the anti-sarcopenia benefits of exercise, offering insights into future therapeutic strategies that could mimic the safe and mild protective effects of exercise on age-related skeletal muscle degeneration.

EFFECT OF VIGOROUS INTENSITY AEROBIC EXERCISE REGIMEN ON PLASMA CHOLESTEROLS OF ADULTS IN BENUE STATE UNIVERSITY, MAKURDI-NIGERIA

Background: Abnormal plasma cholesterols are major risk factors for stroke, coronary heart disease and peripheral vascular diseases globally. Efforts are currently ongoing to come up with the best approach for health promotion and disease prevention, as well as clinical management of abnormal plasma cholesterol. Vigorous intensity aerobic exercise regimen is presently being investigated in this direction.. Methodology: This study investigated the effect of vigorous intensity aerobic exercise regimen on plasma total cholesterol and high density lipoprotein-cholesterol of adults in Benue State University, Makurdi. The design of the study was guided by two research questions. Two hypotheses were formulated and tested at 0.05 level of significance. The study adopted two group pretest posttest quasi experimental design. The study population comprises twenty-one (21) Benue State University staff in the experimental group, and another twenty-one (21) for the control group. The proforma used for the data collection was validated by three experts, one from Measurement and Evaluation, one from the Department of Human Kinetics and Health Education and one from College of Health Sciences all in Benue State University, Makurdi. Data generated were analyzed using Statistical Package for Social Sciences (SPSS Version 25). A descriptive statistics, mean and standard deviation were used to answer the research questions, and an inferential statistics, Analysis of Covariance (ANCOVA) and Paired Samples Test were used to test the hypotheses at 0.05 level of significance. Results: The findings revealed that out of the 21 participants in the two groups, 12(57.14%) were males, while 9(42.86%) were females. The age range in the control group was between 28 to 65years, while that of the experimental group was between 36-68years. Vigorous intensity aerobic exercise regimen was found to have statistically significant effect on plasma total cholesterol (P = 0.000&lt;0.05). Even though high density lipoprotein-cholesterol was found to be elevated by vigorous intensity aerobic exercise regimen, the level of the elevation was discovered not to be statistically significant (P = 0.110 &gt; 0.05). Conclusion: The study concluded that public health education experts as well as other healthcare workers should henceforth incorporate vigorous intensity aerobic exercise regimen prescription in public health awareness on health promotion and disease prevention, as well as clinical management of patients with abnormal plasma total cholesterol.

Effects of postprandial exercise timing on blood glucose and fluctuations in patients with type 2 diabetes mellitus.

The aim of this study was to assess how moderate-intensity aerobic exercise performed 45 minutes and 90 minutes after a meal affects blood glucose levels and fluctuations in individuals diagnosed with type 2 diabetes mellitus (T2DM). Twenty-two patients with T2DM, who were solely receiving oral hypoglycemic medication, were enrolled and divided randomly into two categories: those exercising 45 minutes after a meal (45-minute postprandial exercise group) and those exercising 90 minutes post-meal (90-minute postprandial exercise group). Both groups engaged in a 30-minute session of moderate-intensity aerobic stationary bike exercise following breakfast. This aerobic exercise regimen consisted of two stages, with the groups switching exercise timings after the initial phase. Continuous glucose monitoring (CGM) was utilized to evaluate the blood glucose levels and fluctuations in the participants. After breakfast, both overall daily blood glucose levels and the area under the curve for blood glucose following breakfast were reduced in the 45-minute postprandial exercise group compared to the 90-minute postprandial exercise group. The 45-minute postprandial exercise group demonstrated greater time spent within the target glucose range and less time above the target range than the 90-minute postprandial exercise group. Additionally, measures such as standard deviation, mean amplitude of glycemic excursions, largest amplitude of glycemic excursions, and postprandial glucose excursion for breakfast, peak postprandial glucose levels, and duration of elevated glucose levels were all lower in the 45-minute postprandial exercise group compared to the 90-minute postprandial exercise group. Moderate-intensity aerobic exercise lasting 45 minutes after meals was found to be more efficient in decreasing blood glucose levels and minimizing fluctuations compared to exercising 90 minutes after meals in patients with T2DM. Additionally, it notably reduced the peak in blood glucose levels after meals.

The role of exercise therapy in reducing the risk of cardiovascular disease in an elderly population: a prospective cohort study

This study examined how exercise therapy reduces the risk of cardiovascular disease (CVD) in older adults, using a prospective cohort study methodology to evaluate the effects of exercise therapy on cardiovascular events. We carefully review relevant research publications and clinical studies, as well as partner with specialists on these topics. Several studies have examined how exercise therapy affects cardiovascular health in older adults. These studies have consistently shown that regular exercise lowers the risk of cardiovascular disease and improves outcomes in this population. A review of randomised controlled studies found that aerobic exercise regimens, resistance, and combinations increased cardiovascular risk factors. To assess long-term health changes and trends, we measured key cardiovascular parameters before and after the intervention using longitudinal data from subjects engaged in different types of physical activity. We selected the research subjects using strict inclusion and exclusion criteria to ensure the reliability of the data. These changes involve reduced circulatory tension, an improved lipid profile, and glucose digestion. A prospective cohort study showed a dose-response relationship between exercise and CVD risk reduction. Higher physical activity reduces cardiovascular incidence and mortality among the elderly. Exercise treatments improve the elderly's physical fitness and functional capacity, as well as cardiovascular risk factors. Physical fitness improves heart health and quality of life. Sports medicine has also demonstrated improvements in obesity, diabetes, and musculoskeletal disease among the elderly. This review of studies emphasises the role of exercise therapy in preventing and treating cardiovascular disease in the elderly. Regular exercise in this population is essential for heart health, functional independence, and well-being. Keywords: sports therapy; cardiovascular diseases; prospective cohort studies; physical fitness; heart health.

Comparing the efficacy of traditional Chinese exercises and general aerobic exercises in university students with sleep disorders: A systematic review and meta-analysis.

The objective of this study was to compare the impact of traditional Chinese exercise (TCEs) and general aerobic exercise (GAEs) on the sleep quality of university students and to determine which exercise is more effective in improving sleep quality in this specific population. We utilized Review Manager 5.3 to analyze data from 21 randomized controlled trials (RCTs), which included a total of 1252 participants. Effect sizes of TCEs and GAEs were compared using a random-effects model. Subgroup analyses were conducted on 3 modulating variables: times per session, frequency per week, and period. A Meta-analysis of 14 RCTs showed that both TCEs (standard mean difference [SMD] = -0.89, 95% CI: -1.18 to -0.61; P < .00001) and GAEs (SMD = -1.53, 95% CI: -2.10 to -0.97; P < .00001) can significantly improve the sleep of university students, with a significant difference between TCEs and GAEs (P = .05). Both GAEs and TCEs had positive effects on various aspects of sleep quality, including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleep medication, and daytime dysfunction. A subgroup analysis of aerobic exercise showed that the effect size was larger in the 40 to 60 minutes group compared to the 60 to 90 minutes group (SMD = -1.89; 95% CI: -2.19 to -1.59; P < .00001). Furthermore, the effect size was larger in the 3 to 5 times per week group compared to the 2 times per week group (SMD = -1.56; 95% CI: -2.33 to -0.80; P < .0001). The effect size was also found to be larger in a period of 2 to 4 weeks compared to 6 to 18 weeks (SMD = -1.85; 95% CI: -2.17 to -1.54; P < .00001). GAEs is more effective than TCEs in improving the sleep quality of university students. An optimal aerobic exercise regimen for enhancing sleep quality among university students involves engaging in sessions lasting 40~60 minutes, 3~5 times per week, over a duration of 4 weeks.

Chemerin regulates glucose and lipid metabolism by changing mitochondrial structure and function associated with androgen/androgen receptor.

The adipokine chemerin contributes to exercise-induced improvements in glucose and lipid metabolism; however, the underlying mechanism remains unclear. We aimed to confirm the impact of reduced chemerin expression on exercise-induced improvement in glycolipid metabolism in male diabetic (DM) mice through exogenous chemerin administration. Furthermore, the underlying mechanism of chemerin involved in changes in muscle mitochondria function mediated by androgen/androgen receptor (AR) was explored by generating adipose-specific and global chemerin knockout (adipo-chemerin-/- and chemerin-/-) mice. DM mice were categorized into the DM, exercised DM (EDM), and EDM + chemerin supplementation groups. Adipo-chemerin-/- and chemerin-/- mice were classified in the sedentary or exercised groups and fed either a normal or high-fat diet. Exercise mice underwent a 6-wk aerobic exercise regimen. The serum testosterone and chemerin levels, glycolipid metabolism indices, mitochondrial function, and protein levels involved in mitochondrial biogenesis and dynamics were measured. Notably, exogenous chemerin reversed exercise-induced improvements in glycolipid metabolism, AR protein levels, mitochondrial biogenesis, and mitochondrial fusion in DM mice. Moreover, adipose-specific chemerin knockout improved glycolipid metabolism, enhanced exercise-induced increases in testosterone and AR levels in exercised mice, and alleviated the detrimental effects of a high-fat diet on mitochondrial morphology, biogenesis, and dynamics. Finally, similar improvements in glucose metabolism (but not lipid metabolism), mitochondrial function, and mitochondrial dynamics were observed in chemerin-/- mice. In conclusion, decreased chemerin levels affect exercise-induced improvements in glycolipid metabolism in male mice by increasing mitochondrial number and function, likely through changes in androgen/AR signaling.NEW & NOTEWORTHY Decreased chemerin levels affect exercise-induced improvements in glycolipid metabolism in male mice by increasing mitochondrial number and function, which is likely mediated by androgen/androgen receptor expression. This study is the first to report the regulatory mechanism of chemerin in muscle mitochondria.

Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway.

Obesity has been identified as an independent risk factor for cardiovascular disease. Recent reports have highlighted the significance of stimulator of interferon genes (STING)-NOD-like receptor protein 3 (NLRP3) signaling pathway mediated pyroptosis, and inflammation in cardiovascular disease. Previous studies have demonstrated that exercise training effectively prevents cardiac pyroptosis and inflammation in high-fat diet (HFD)-fed mice. However, it is currently unknown whether exercise reduces pyroptosis and inflammation in obese hearts by targeting the STING-NLRP3 signaling pathway. We investigated the impact of an 8-week aerobic exercise regimen on cardiac function, pyroptosis, inflammation, and the STING-NLRP3 signaling pathway in HFD-induced obese mice. Additionally, to explore the underlying mechanism of STING in exercise-mediated cardioprotection, we administered intraperitoneal injections of the STING agonist diABZI to the mice. Furthermore, to investigate the role of the STING-NLRP3 signaling pathway in HFD-induced cardiac dysfunction, we administered adeno-associated virus 9 (AAV9) encoding shRNA targeting STING (shRNA-STING) via tail vein injection to knockdown STING expression specifically in mouse hearts. After one week of AAV9 injection, we intraperitoneally injected nigericin as an NLRP3 agonist. We first found that aerobic exercise effectively suppressed HFD-mediated upregulation of STING and NLRP3 in the hearts. Moreover, we demonstrated that the protective effect of aerobic exercise in HFD-induced cardiac dysfunction, pyroptosis, and inflammation was impaired by stimulating the STING pathway using diABZI. Additionally, activation of the NLRP3 with nigericin abolished the ameliorative effect of STING deficiency in HFD-induced cardiac dysfunction, pyroptosis, and inflammation. Based on these findings, we concluded that 8-week aerobic exercise alleviates HFD-induced cardiac dysfunction, pyroptosis, and inflammation by targeting STING-NLRP3 signaling pathway. Inhibition of STING-NLRP3 signaling pathway may serve as a promising therapeutic strategy against obesity-induced cardiomyopathy.

The role of long-term combination training in reducing and maintaining of body fat in obese young adult women

Reducing body weight and body fat is the primary goal for overcoming obesity. Lifestyle modifications with a non-pharmacological approach based on programmed physical exercise are recommended for increasing energy expenditure and reducing body weight and body fat. This study aims to analyze different types of exercise in reducing and maintaining body fat in obese young adult women. This study was a randomized controlled trial (RCT) with a true experimental design. A group of 28 sedentary overweight women were enlisted and provided with aerobic, strength, and mixed exercise regimens. Aerobic, resistance, and combined training programs were conducted with an intensity of 60-70% HRmax for aerobic, and 60-70% 1-RM for resistance. These sessions were performed 3x/week for 4 weeks. Measurement of body fat before-intervention and 24 hours after-intervention for 4 weeks using Seca mBCA 554. The one-way ANOVA test was utilized for statistical analysis, with a significance level of 5%. The findings demonstrated a significant reduction in body fat through all three forms of exercise, evident in the decrease in changes in body mass index, body weight, fat mass, and free fat mass (p ≤ 0.05). Additionally, all three exercise modalities led to a significant increase in changes in skeletal muscle mass in comparison to the control group (p ≤ 0.05). Our study results concluded that the combination type of exercise performed 3x/week for 4 weeks was more beneficial in lowering body fat and increasing muscle mass compared to aerobic exercise and resistance type exercise in obese young adult women. Keyword: Body fat, combined training, obesity, sedentary, healthy lifestyle

Effectiveness of a dose-graded aerobic exercise regimen on cardiopulmonary fitness and physical performance in pediatric survivors of acute lymphoblastic leukemia: a randomized clinical trial.

To determine whether a 12-week supervised dose-graded aerobic exercise (D-GAE) training, when implemented in conjunction with traditional rehabilitation, could help pediatric survivors of acute lymphoblastic leukemia (ALL) enhance their cardiopulmonary capacity and improve their physical performance. Fifty-eight pediatric survivors of ALL (age 13.78 ± 2.47years; boys 60.34%) were assigned at random to either undergo the D-GAE in addition to the traditional physical rehabilitation (D-GAE group; n = 29) or the traditional physical rehabilitation solely (control group; n = 29). The cardiopulmonary fitness (peak oxygen uptake (VO2peak), ventilatory equivalent (VEq/VO2), minute ventilation (VE, L/min), oxygen pulse (O2P), maximum heart rate (HRmax), 1-min heart rate recovery (HRR1), and respiratory exchange ratio (RER)) and physical performance (6-min walk test (6-MWT), timed up and down stairs (TUDS), and 4 × 10-m shuttle run test (4 × 10mSRT)) were assessed on the pre- and post-intervention occasions. The mixed-model ANOVA revealed a meaningful increase of VO2peak (P = .002), VE (P = .026), O2P (P = .0009), HRmax (P = .004), and HRR1 (P = .011), and reduction of VEq/VO2 (P = .003) and RER (P = .003) in the D-GAE group compared with the control group. Besides, the analysis detected a favorable increase in the physical performance for the D-GAE group (6-MWT (P = .007), TUDS (P < .001), 4 × 10mSRT (P = .009)). A 12-week D-GAE program in conjunction with traditional rehabilitation holds promise in enhancing cardiopulmonary fitness and improving the physical performance of pediatric survivors of ALL. Clinicians and physical rehabilitation professionals can, therefore, integrate the D-GAE into the traditional rehabilitation protocols for such a patient population to optimize their cardiopulmonary fitness and physical function, while also facilitating a gradual transition to practice and adaption. The favorable outcomes of this study bolster the inclusion of D-GAE as a crucial element in the care and rehabilitation of pediatric survivors of ALL. By embracing these findings, healthcare professionals and oncologists can contribute to mitigating the long-term cardiopulmonary and physical complications associated with cancer treatments and fostering a state of enhanced well-being and increased physical activity among survivors.

Comparing The Effects of Metformin and Exercise-Based Lifestyle Interventions for Symptom Management of Polycystic Ovary Syndrome (PCOS): A Literature Review

Introduction: Polycystic ovary syndrome (PCOS) is a common hormone problem characterized by androgen excess and typically leads to the development of small cysts in the ovaries, insulin resistance, hirsutism, irregular menstrual cycles, and hyperandrogenism. While there is no cure for PCOS, treatments like metformin and lifestyle modifications work to manage individual symptoms. While studies in the past have compared individual effects of metformin and lifestyle modifications on symptoms of PCOS, a limited number of studies have compared the effects of metformin with lifestyle modifications, specifically aerobic exercise. This review compared the effects of metformin treatment and exercise interventions on metabolic symptoms, such as high blood glucose and insulin levels in PCOS. Methods: A literature search using Pubmed and Google Scholar was conducted. A total of five articles focusing on metformin were included in the review; some focusing inclusively on the drug itself, others comparing lifestyle modifications alone and modifications combined with metformin. In this review, the lifestyle modification was aerobic exercises, taking the form of exercise regimes (walks, marching in place, or supervised fitness sessions). Results: Results show that metformin improves metabolic symptoms, including blood glucose and insulin levels, significantly more than lifestyle interventions alone; however, if both treatments were combined, these effects were more profound. Discussion: Metformin serves as an effective treatment for metabolic and hormonal symptoms, consequently improving PCOS symptomology. Although exercise is shown to be less effective than metformin, the addition of exercise to metformin treatment further ameliorates symptomology. Conclusion: Combining metformin and aerobic exercise demonstrates the greatest impact on managing PCOS symptoms. Future studies should examine the standardization of an aerobic exercise regimen and pharmaceutical treatments for the management of PCOS.

Efficacy and feasibility of aerobic exercise interventions as an adjunctive treatment for patients with schizophrenia: a meta-Analysis

Schizophrenia is a chronic mental disorder primarily treated with antipsychotics, which have limited efficacy for negative symptoms. This study aims to evaluate the effectiveness and feasibility of exercise interventions as adjuncts to pharmacotherapy through a meta-analysis, providing valuable insights for rational intervention design. Four databases were searched, and randomized controlled trials with no language restrictions published up to March 27, 2023, were included. The primary outcome indicator was the Positive and Negative Symptom Scale (PANSS) total score along with its three sub-scales. Secondary outcomes included the Scale for Assessment of Negative Symptoms (SANS) and Body Mass Index (BMI), which were used to assess the efficacy of aerobic exercise interventions in patients with schizophrenia. Subgroup analyses were conducted to explore the impact of intervention duration and total weekly exercise time, while treatment feasibility was assessed through adherence rates. A total of 17 publications involving 973 patients with schizophrenia were deemed eligible and included in the analysis. Compared to other forms of adjunctive interventions, the network meta-analysis of 12 PANSS-based studies revealed that adjunctive aerobic exercise interventions were the most effective in reducing overall PANSS scores in patients with schizophrenia, with statistically significant pooled results (MD = −4.84, 95% CI: −5.72, −3.96). Both the PANSS negative symptom subscale (MD = −2.11, 95% CI: −3.26, −0.95) and SANS (MD = −9.11, 95% CI: −11.94, −6.27) indicated that adjunctive aerobic exercise interventions effectively alleviate negative symptoms. Subgroup meta-analysis indicated that 2-3 month interventions involving 100–220 min of exercise per week were the most effective. Additionally, adherence to the adjunctive aerobic exercise regimen was found to be comparable to that of conventional treatment alone. Aerobic exercise interventions, as adjunctive therapy, are an effective measure for reducing PANSS scores in patients with schizophrenia, contributing to the alleviation of both the positive and negative symptoms, and patients demonstrated strong adherence to aerobic exercise.

The aerobic exercise system for increasing Body Mass Index, waist circumference of overweight and obese students ages 20-22

Aerobic exercise has been widely recognized as an efficacious intervention for enhancing students’ body mass index and waist circumference, particularly among individuals classified as overweight and obese. However, a comprehensive search for studies conducted within the context of higher education in the Indonesia yielded no existing research. This study investigates the impact of aerobic activities on male students aged 20 – 22 [(N21 YEARS OLD = 9(45.00%), N20 YEARS OLD = 7(35.00%), N22 YEARS OLD = 4(20.00%); age mean of mean = 20.85 ± 0.75] from a selected higher education institution in the country. The present study employed an experimental research methodology, utilizing a sample of male college students who were overweight or obese. The sample size was divided equally, with a total of 20 participants (N = 20). The participants engaged in a 12-week aerobic fitness regimen consisting of one-hour session, three times per week. Independent samples t-test was used to examine the difference in the performance of both groups in relation to their BMI and WC post-test scores, while paired t-test was employed to compare the difference in the pre-test and post-test scores on participants’ BMI and WC. Based on the results, a notable disparity in performance was detected between the two groups, with obese students demonstrating a considerable enhancement in their BMI [t(15.887) = −9.797, p &lt; 0.05]. On the other hand, no significant difference was observed in the performance of the groups in terms of WC [t(16.665) = −0.505, p = 0.620]. A notable disparity was noted in the pre- and post-test scores of the participants’ BMI and WC subsequent to engaging in a 12-week regimen of aerobic exercise, both in a general sense (BMI [t(19) = 14.439, p &lt; 0.05 and WC t(19) = 14.333, p &lt; 0.05) and within each group [Overweight: BMI t(9) = 14.488, p &lt; 0.05] and WC t(9) = 15.057, p &lt; 0.05; Obese: BMI t(9) = 7.922, p &lt; 0.05] and WC t(9) = 7.746, p &lt; 0.05]. Based on the findings, it can be inferred that involving male students who are overweight or obese in a meticulously planned aerobic exercise regimen has the potential to yield substantial improvements in their BMI and WC. This, in turn, may lead to increased performance in physical activity. Limitations and future research endeavors are hereby presented.

Effect of laser and exercises in venous ulcer: A case report

Abstract This case report outlines the effect of a low-level laser therapy (LLLT) and exercise regimen on a 59-year-old patient with a venous ulcer. The current case examines the impact of a combination of LLLT and exercise on blood flow and healing in a patient with venous leg ulcer (VLU) brought on by ambulatory venous hypertension due to venous incompetence. Above the left lateral malleolus, the patient had a circular, well-defined raw area covered in pale granulation tissue that was not healing. Wound assessment was done using a two-dimensional method using graph paper. The patient received LLLT therapy and an aerobic exercise regimen, reducing wound size and improving healing. It demonstrates the potential advantages of using LLLT and aerobic exercise to treat venous ulcers.

Association of exercise, brain-derived neurotrophic factor, and cognition among older women: A systematic review and meta-analysis

This systematic review and meta-analysis explored the effects of structured exercise regimens on brain-derived neurotrophic factor (BDNF) levels, a proxy for cognitive function, in older women. In this study, we collated evidence from the available clinical trials that reported BDNF levels and other outcomes following structured exercise regimens. Adhering to PRISMA Statement 2020 guidelines. PubMed/MEDLINE, Scopus, CINAHL Plus, and Cochrane were systematically searched using a combination of the following keywords: brain-derived neurotrophic factor, women, exercise, older, cognition, and/or cognitive. A random-effects model was applied; the statistical analysis was conducted in RevMan 5.4 (Cochrane). The risk of bias in the included trials was assessed using the Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool. Across 12 trials, 994 older women were included that were enrolled in different exercise regimens globally. Exercise regimens were categorized as aerobic, resistance/power training, aquatic, taekwondo, and multimodal and ranging from 30 to 60 min, 1–5 times per week across 5–24 weeks. Moderate improvement (Cohen's d: 0.44, 95% CI: 0.04–0.84, p = 0.03) was found in BDNF levels across all trials. There was a small yet insignificant improvement in mini-mental state examination (MMSE) scores (Cohen's d: 0.17, 95% CI: -0.79–1.13, p = 0.73). Aerobic exercise, aquatic exercise, and multimodal regimens showed significant association with improved BDNF levels but the sample size for individual exercise regimens was small A main limitation was the inclusion of 114 (10.3%) males in the data, introducing gender bias. This study provides novel insight into the association between various exercise regimens and BDNF levels among older women.

Successful lifestyle modifications may underlie umbilical cord-mesenchymal stromal cell effects in type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is a lifelong condition and a grave threat to human health. Innovative efforts to relieve its detrimental effects are acutely needed. The sine qua non in T2DM management is consistent adherence to a prudent lifestyle and nutrition, combined with aerobic and resistance exercise regimens, together repeatedly shown to lead to complete reversal and even long-term remission. Non-adherence to the above lifestyle adjustments condemns any treatment effort and ultimately the patient to a grim fate. It is thus imperative that every study evaluating the effects of innovative interventions in T2DM objectively compares the novel treatment modality to lifestyle modifications, preferably through double-blind controlled randomization, before claiming efficacy.

An 8-week exercise study to improve cancer treatment related fatigue and QOL among African American breast cancer patients undergoing radiation treatment: A pilot randomized clinical trial

Cancer treatment related fatigue (CTRF) is one of the most debilitating side effects of adjuvant radiation therapy (RT). Several studies have found that physical activity (PA) may be an effective intervention to decrease fatigue and enhance QOL in cancer survivors. The primary objective of the PEDLAR study is to test the feasibility of an easily administered 8-week structured moderate-intensity PA intervention, delivered concurrently with RT, in reducing CTRF and improving health-related QOL among African-American breast cancer patients. This study is also designed to provide pilot data on the acceptability and adherence of PA interventions in African-American women with breast cancer. It is a prospective, 2-arm, 8-week feasibility trial. Participants are randomized to either a structured, moderate-intensity aerobic training exercise regimen concurrent with radiotherapy or a control group. Participants in intervention group reported high satisfaction with exercise and adherence was >75% for exercise sessions. African-American breast cancer patients in a moderate-intensity 75 min/wk aerobic exercise intervention had marginally lower fatigue at 8-wk follow-up compared to baseline. The control group participants had marginally higher fatigue at 8-wk follow-up compared to baseline. Participants in the intervention group reported slightly better quality of life at 8-wk follow-up compared to baseline (P = 0.06).