The aero-engine casing is subjected to high-temperature and high-pressure aerodynamic loads during operation. It is essential to perform the ground strength tests for the casing. To optimize the ground strength test and to improve the accuracy of temperature and pressure loading during the test, a mathematical model of high-temperature and high-pressure aerodynamic loading system for simulating the ground strength test of typical aero-engine casing is established to study the actual temperature and pressure loads on casing during ground test. The temperature and pressure results calculated by the mathematical model under typical loads matched well with the experimental measurements. The verification results show that under the test conditions, the thermal inertia of the heater, the radiation heating of the gas in the test chamber by the heater, and the heat transfer of gas mixing in the pressure process can be ignored. The sensitivity analysis of the parameters affecting the accuracy of pressure and temperature loading is carried out. We show that the pressure can be controlled quantitatively by adjusting the inlet and exhaust pipe parameters, and accurate temperature control can be achieved by designing reasonable heater power and selecting appropriate heating control parameters.