Adverse Social Factors Research Articles

The impacts of area-level social deprivation on overall survival in patients receiving immune-checkpoint inhibitors (ICI) treatments: A retrospective cohort study.

1613 Background: Despite recent advancements in ICI therapy, disparities in treatment outcomes persist, potentially influenced by social factors. We investigated the association between Area-level social deprivation (ALSD) and overall survival in patients treated with ICIs, aiming to uncover the potential socioeconomic barriers to effective cancer care. Methods: The study included newly diagnosed solid or liquid tumor patients treated with ICIs between 2012 and 2020 at the Ohio State University Comprehensive Cancer Center. Socioeconomic deprivation was defined using the Social Deprivation Index (SDI), a validated measure of disadvantage across small areas using seven components related to demographic and household characteristics. A high ALSD was defined as an SDI score above the sample’s third quartile. Crude and Adjusted Cox proportional models with robust variance to account for group clustering were used to examine the association between overall survival and ALSD. We also examined the relationship between all-cause mortality and each of the seven components of ALSD. Results: A total of 3,317 patients were included in the study with a median age of 62 years, 59.1% males and 89% White non-Hispanics. An estimated 30.7% of patients had lung cancer, 16.3% melanoma, and 10.8% head and neck cancer. Type of cancer was significantly associated with deprivation states (P <0.001). The median (interquartile range) survival time for all participants was 10.3 (3.7–22.3) months. The high ALSD group had 440/800 (55.0%) deaths over 10,999.0 person-years reported, while the low ALSD group had 1275/2517 (50.7%) deaths over 40,994.8 person-years reported – risk ratio of 1.29 (95% CI: 1.15–1.43). High ALSD was significantly associated with a higher risk of all-cause: the crude risk of all-cause mortality was 21% higher for patients in the high vs. low ALSD groups [HR: 1.21; 95% CI: 1.08–1.36]. In the fully adjusted models, high ALSD was associated with an 18% higher risk of all-cause mortality [adjusted HR: 1.18; 95% CI: 1.06–1.33] compared to low ALSD. In a sub-analysis, we limited our cohort to patients undergoing immunotherapy as first-line treatment, and low ALSD remained a significant predictor of increased risk of all-cause mortality. Area-level poverty and residing in areas with higher percentages of rented housing were the main drivers of the increased risk of all-cause mortality in patients residing in high ALSD areas. Conclusions: Patients from areas with higher levels of social deprivation had a significantly higher risk of all-cause mortality compared with their counterparts in less deprived areas. Addressing adverse social factors could expand the benefits of ICIs for everyone and help reduce disparities in cancer care. Future strategies should consider social interventions to advance equitable healthcare outcomes for all cancer patients.

Development and content validation of a questionnaire to assess the social determinants of mental health in clinical practice.

There is growing consensus that consideration of the Social Determinants of Mental Health should be at the centre of mental health care provision. To facilitate this, a validated means to assess mental health service users' social contextual information is arguably needed. We therefore developed a questionnaire to assess the Social Determinants of Mental Health in clinical practice. Our guideline-informed development consisted of three steps; i) construct and purpose definition, ii) initial item generation based on the literature, similar questionnaires, and a selection of the ICD-10, iii) evaluation, revision, and content validation of the questionnaire. Initially we developed 249 items that were reduced, revised, and validated in several stages to 73 items. Content validation of the questionnaire was achieved through surveys and focus groups including mental health care service users and professionals. The surveys and focus groups indicated the need for a standardised assessment of adverse social factors and highlighted that the benefits of such an assessment would be a more holistic approach to identifying and addressing fundamental factors involved in the development of mental health difficulties. Importantly, this study also revealed how any assessment of the Social Determinants of Mental Health must prioritise the assessed person having a central role in the process and control over their own data. The focus groups identified contradicting recommendations regarding the most suitable context to administer the questionnaire. The resulting questionnaire can be considered to be theoretically robust and partially validated. Future research is discussed.

Associations Between Early-Life Adversity, Ambient Air Pollution, and Telomere Length in Children.

Examine the independent associations and interaction between early-life adversity and residential ambient air pollution exposure on relative buccal telomere length (rBTL). Experiences of abuse, neglect, household challenges, and related life events were identified in a cross-sectional sample of children aged 1 to 11 years ( n = 197) using the 17-item Pediatric ACEs and Related Life Event Screener (PEARLS) tool. The PEARLS tool was analyzed both as a total score and across established domains (Maltreatment, Household Challenges, and Social Context). Ground-level fine particulate matter (PM 2.5 ) concentrations were matched to residential locations for the 1 and 12 months before biospecimen collection. We used multivariable linear regression models to examine for independent associations between continuous PM 2.5 exposure and PEARLS score/domains with rBTL. In addition, effect modification by PEARLS scores and domains on associations between PM 2.5 exposure and rBTL was examined. Study participants were 47% girls, with mean (standard deviation) age of 5.9 (3.4) years, median reported PEARLS score of 2 (interquartile range [IQR], 4), median 12-month prior PM 2.5 concentrations of 11.8 μg/m 3 (IQR, 2.7 μg/m 3 ), median 1-month prior PM 2.5 concentrations of 10.9 μg/m 3 (IQR, 5.8 μg/m 3 ), and rBTL of 0.1 (IQR, 0.03). Mean 12-month prior PM 2.5 exposure was inversely associated with rBTL ( β = -0.02, 95% confidence interval = -0.04 to -0.01). Although reported PEARLS scores and domains were not independently associated with rBTL, we observed a greater decrement in rBTL with increment of average annual PM 2.5 as reported Social Context domain items increased ( p -interaction < .05). Our results suggest that adverse Social Context factors may accelerate the association between chronic PM 2.5 exposure on telomere shortening during childhood.

Mental health and psychosocial interventions integrating sexual and reproductive rights and health, and HIV care and prevention for adolescents and young people (10-24 years) in sub-Saharan Africa: a systematic scoping review.

Interventions targeting combined sexual and reproductive health, Human Immunodeficiency Virus (HIV) management and mental health care in sub-Saharan Africa (SSA) are few. There is a need to address common determinants of poor mental, psychosocial and sexual and reproductive health and rights (SRHR) through multimodal and multipronged interventions for adolescents. The main objective of this study was to identify whether and how interventions targeting adolescent SRHR and HIV with a focus on pregnant and parenting adolescents in SSA include mental health components and how these components and their outcomes have been reported in the literature. We carried out a two process scoping review approach between 01.04.2021 and 23.08.2022. In the first stage, we searched the PubMed database to identify studies focusing on adolescents and young people aged 10 to 24 from 2001 to 2021. We identified studies focusing on HIV and SRHR that had mental health and psychosocial aspects to the interventions. Our search yielded 7025 studies. Of these 38 were eligible based on our screening criteria that covered interventions, and on further scrutiny, using PracticeWise, an established coding system, we identified select problems and practices to provide a more granular assessment of how interventions developed for this context mapped on to specific problems. At this second stage process, we selected 27 studies for inclusion as actual interventional designs for further systematic scoping of their findings and we used the Joanna Briggs Quality Appraisal checklist to rate these studies. This review was registered within the International Prospective Register of Systematic Reviews (PROSPERO), number CRD42021234627. Our first set of findings is that when coding problems and solutions, mental health concerns were the least common category of problems targeted in these SRHR/HIV interventions; nevertheless, psychoeducation and cognitive behavioral strategies such as improved communication, assertiveness training, and informational support were offered widely. Of the 27 interventional studies included in the final review, 17 RCTs, 7 open trials, and 3 mixed designs, represented nine countries of the 46 countries in SSA. Intervention types included peer, community, family, digital, and mixed modality interventions. Eight interventions focused on caregivers and youth. Social or community ecology associated problems (being an orphan, sexual abuse, homelessness, negative cultural norms) were the most common risk factors and were more frequent than medical issues associated with HIV exposure. Our findings highlight the relevance and centrality of social issues related to adolescent mental and physical health along with the need to strengthen multimodal interventions along the lines of problems we have identified in our review. Combined interventions jointly addressing adolescent SRHR, HIV, and mental health have been relatively understudied, despite evidence that adverse social and community factors are rampant in this population. MK was funded by Fogarty International CenterK43 TW010716-05 and lead the initiative.

Hurricane Michael and Adverse Social and Mental Health Risk Factors.

To assess changes in mental health and social risk factors in pregnant women in counties affected by Hurricane Michael (October 2018). Data from the Universal Perinatal Risk Screen (UPRS) and vital statistics for the state of Florida were obtained. Prenatal risk factors (unplanned pregnancy, mental health services, high stress, use of tobacco or alcohol, young children at home or with special needs, trouble paying bills) were compared in the year before and year after Hurricane Michael in affected counties (n = 18,887). Log-Poisson regression with robust variance was used for binary outcomes, adjusting for maternal age, race, BMI, and education. A smaller proportion of pregnant women were screened in the months after the hurricane. No changes were seen in overall scores. The proportion referred was lower in the 1 month after Michael compared to that in 1 month before Michael (RR 0.78, 95% CI = 0.71, 0.86), but greater in the year after (RR = 1.07, 95% CI: 1.04, 1.10). Most individual risk factors on the screener did not change significantly, except having an illness that required ongoing medical care was less common in the short term (3 months after vs. 3 months before: aRR = 0.76, 95% CI: 0.66, 0.87), and more common in the longer term (1 year after vs. 1 year before, aRR = 1.09, 95% CI: 1.02, 1.18). Birth certificate data suggested smoking during pregnancy was higher among women who experienced Michael during their pregnancies (aRR = 1.15, 95% CI: 1.01, 1.32). Perinatal screening and referral declined in the short-term aftermath of Hurricane Michael.

Clinical and Psychological Features of Patients With Poisoning By Antihypertensive and Antiarrhythmic Drugs as a Result of Suicidal Actions

The effective care for patients with self-poisoning with antihypertensive and antiarrhythmic drugs is associated with taking into account both clinical and adverse social, psychological and environmental stress factors. To identify their specifics, a retrospective analysis of 120 medical records and a clinical and psychological examination of 20 patients with antihypertensive and antiarrhythmic drugs self-poisoning and a comparison group of 34 patients with selfpoisoning with psychotropic drugs were carried out. It has been shown that the risk group for re-suicide in self-poisoning with antihypertensive and antiarrhythmic drugs is about 30% of patients. Risk factors are depressive symptoms that persist before discharge from the hospital, as well as dysfunctional personality traits (perfectionism in the form of increased preoccupation with the assessments of other people and frequent unfavorable comparisons with them, experiencing loneliness and isolation, increased impulsivity and a feeling of hostility from others) and unproductive ways of coping with stress (ruminative thinking or repetitive unpleasant and unproductive thoughts about anergy, lack of strength and loneliness). The results of the study and the developed psychodiagnostic complex can be used to identify targets for urgent psychological assistance and screening for the risk of re-suicide.

AAGP Session to Highlight Research on Resilience, Emotional Well-Being in Aging

AAGP Session to Highlight Research on Resilience, Emotional Well-Being in Aging

Discussing the unspoken: A qualitative analysis of online forum discussions on mental health problems in young Moroccan-Dutch migrants.

Migrants and their offspring are at increased risk of developing mental disorders. Previous research has shown associations between adverse social factors (e.g., discrimination, lack of social support) and mental health problems in migrants, but it is unknown how these associations are understood by migrants themselves. In this study, we aimed to gain explorative insight into the way young Moroccan-Dutch people experience their social environment, and how they relate this social environment to the development of mental health problems. At www.marokko.nl, the largest online discussion platform for young Moroccan-Dutch people, contributors discuss a broad variety of subjects, including societal, cultural, religious, and mental health issues. Combining deductive and inductive approaches to qualitative data analysis, we analysed 22 forum discussions at marokko.nl about mental health problems, after which data saturation was reached. Contributors described feeling isolated and experiencing discrimination in their social environment. Contributor comments identified social challenges arising from Dutch society, Dutch culture (e.g., being too individualistic), Moroccan culture (e.g., strict parenting style), and living between these two cultures. These social challenges are perceived to be associated with mental health problems. Furthermore, we created a model describing the different types of explanations contributors used for mental health problems, being: religious (e.g., possession); medical (i.e., a bio-psycho-social cause); or a combination of both. This model can help clinicians in delivering culturally sensitive mental health care. Lastly, this study shows the taboo on mental health problems in the Moroccan-Dutch population and the opportunity to open up in the online environment.

Diabetic ketoacidosis: a canary in the mine for mental health disorders?

Recurrent diabetic ketoacidosis (DKA) has been linked to mental health disorders, but less is known about single DKA episodes. Most studies are retrospective, lacking control groups. To prospectively examine psychosocial factors in patients presenting with recurrent or single episode DKA and compare with people who have not had DKA. Case-controlled study (consecutive adult DKA admissions April 2015 to December 2016) at Western Health, Melbourne. Data were prospectively collected regarding diagnosed mental health disorders, likely depression (Patient Health Questionnaire (PHQ-9)), diabetes distress (Problem Areas in Diabetes (PAID) questionnaire) and presence of adverse social factors. A control group without a history of DKA was also recruited. Of 123 patients admitted with DKA (164 consecutive episodes), 70 consented to participate and 73 age-matched Type 1 diabetes controls were recruited. Eleven (61%) of 18 with recurrent DKA had a diagnosed mental health disorder versus 8 (19%) of 42 in the single episode group (P = 0.016). The prevalence of likely depression using PHQ-9 was: recurrent 50%; single 40%; and controls 22% (recurrent vs controls, P = 0.036; single vs controls, P = 0.053). Severe diabetes distress (PAID) was present in 47% of recurrent and 34% of single episode DKA (P = 0.387). As a group, DKA patients had significantly more unemployment, illicit drug use and tobacco smoking, a lower level of formal education and less regular medical contact compared with controls. Mental health disorders and adverse socioeconomic factors appear to be common in patients with DKA. The diagnosis of DKA presents an excellent opportunity to screen for depression and offer appropriate intervention.

Poverty, Homelessness, Hunger in Children, and Adolescents

Abstract Poverty, hunger, and homelessness have been shown to be perhaps the greatest adverse biological and social risk factors for mental health problems and disorders worldwide. They also have significant adverse impact on cognitive, psychological, psychosocial, and physical development in children and youth. This article reviews the psychosocial effects of poverty, hunger, and homelessness on children and youth, including their impact on psychopathology and mental health. It also includes recommendations for governmental entities, advocates, and care providers on mitigating their adverse effects.

Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.

Black individuals have high incident diabetes risk, despite having paradoxically lower triglyceride and higher HDL (high-density lipoprotein) cholesterol levels. The basis of this is poorly understood. We evaluated the participants of SPRINT (Systolic Blood Pressure Intervention Trial) to assess the association of estimated European genetic ancestry with the risk of incident diabetes in self-identified Black individuals. Self-identified non-Hispanic Black SPRINT participants free of diabetes at baseline were included. Black participants were stratified into tertiles (T1-T3) of European ancestry proportions estimated using 106 biallelic ancestry informative genetic markers. The multivariable-adjusted association of European ancestry proportion with indices of baseline metabolic syndrome (ie, fasting plasma glucose, triglycerides, HDL cholesterol, body mass index, and blood pressure) was assessed. Multivariable-adjusted Cox regression determined the risk of incident diabetes (fasting plasma glucose ≥126 mg/dL or self-reported diabetes treatment) across tertiles of European ancestry proportion. Among 2466 Black SPRINT participants, a higher European ancestry proportion was independently associated with higher baseline triglyceride and lower HDL cholesterol levels (P<0.001 for both). European ancestry proportion was not associated with baseline fasting plasma glucose, body mass index, and blood pressure (P>0.05). Compared with the first tertile, those in the second (hazard ratio, 0.64 [95% CI, 0.45-0.90]) and third tertiles (hazard ratio, 0.61 [95% CI, 0.44-0.89]) of the European ancestry proportion had a lower risk of incident diabetes. A 5% point higher European ancestry was associated with a 29% lower risk of incident diabetes (hazard ratio, 0.71 [95% CI, 0.55-0.93]). There was no evidence of a differential association between the European ancestry proportion tertiles and incident diabetes between those randomized to intensive versus standard blood pressure treatment. The higher risk of incident diabetes in Black individuals may have genetic determinants in addition to adverse social factors. Further research may help understand the interplay between biological and social determinants of cardiometabolic health in Black individuals. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01206062.

Одежда как "вторая кожа": вестиментарные практики приватности

The article examines bodily privacy as the ability to independently regulate access to private space. Such a need exists in all cultures, and its violation means deprivation and humiliation of human dignity. Body boundaries are marked with the help of clothing, which acts as a “second skin” and performs the function of protection from adverse natural and social factors, as well as providing an opportunity for public self-presentation. Bodily privacy is a conventional social practice because its boundaries are fluid and change with social norms.

A DIAGNOSTIC STUDY OF PSYCHOLOGICAL WELL-BEING OF AN INDIVIDUAL

The article highlights the need for developing new standardized psychodiagnostic tools for studying the psychological well-being of a personality, which would be safe for clients and convenient for use by practicing psychologists during individual and group diagnosis. It is especially relevant nowadays, when various population groups are intensively affected by adverse social, economic, political, and biological factors, causing prolonged stress and various manifestations of psychological distress. Diagnosing children, youth, and adults using standardized, reliable methods will enable practicing psychologists to identify manifestations of psychological distress that, in their situation, are the basis for further psycho-prophylactic and psycho-correction work. Works of N. Bradburn, M.Y. Varii, A.V. Voronina, K. Riff, P.P. Fesenko on understanding the concept of "psychological well-being" were analyzed. In general, the use of the term "psychological well-being of a personality" means the inner, subjective attitude of a man to his life and the general level of his assessment. The notion of psychological well-being is differentiated from other related psychological categories: "mental health", "quality of life" as well as from similar notions such as "happiness", "feeling of satisfaction with one's own life". It is determined that the components of psychological well-being include, in particular, the following components: a positive attitude to yourself and your life, the presence of meaningful goals, competence, a sense of continuous development and self-realization, positive relationships with others, autonomy. The purpose of the article is to analyze and present the results of standardization and validation of the author's psychodiagnostic methodology to determine the psychological well-being of an individual (S.M. Zabarovska). The author presents a diagnostic technique for determining psychological well-being of an individual, based on self-esteem. The full text of the technique is given below. The diagnostic scales of the technique are "Life satisfaction", "Positive emotions", "Attitude to yourself", "Attitude to others", "Representation of the future", "Availability of social support", "Life goals", "Ability to self-regulation ". The summation of data on scales gives an integrated indicator - the level of psychological well-being of a personality. Levels on scales and integrated indicators are low, average, and high. The interpretation of these 8 scales in their high values is given. The results of validation of the methodology were presented on a sample of students of vocational education institution. In particular, the test of criterion validity showed significantly positive correlation coefficients between the integrated indicator of psychological well-being and overall scores according to the methods of "Scale of psychological well-being" by K. Riff, "Scale of satisfaction with the life by E. Diner"; significantly negative correlation coefficient with indicators on the Beck Depression Scale. Verification of the reliability of parts of the methodology was carried out by the method of splitting - division into equal parts. The correlation coefficient between the results of the study tasks of the two parts of the questionnaire figured out statistically significant, which indicates the high reliability of parts of the methodology and characterizes the degree of homogeneity of its tasks. The internal consistency of the scales of the methodology was calculated using the Cronbach's Alpha coefficient, which showed a high rate of internal consistency. It is concluded that the results of approbation and validation of the author's methodology allow its use in empirical studies of psychological well-being of an individual and in the study of other related problems of psychological science and practice.

Association between allostatic load, symptom burden and mortality in E1A11 trial for myeloma.

12102 Background: Allostatic load (AL) conceptualizes the effects of chronic psychosocial adversity on physiologic dysregulation. To date, studies have shown an association between elevated AL and higher disease-specific and overall mortality among cancer patients; however, none have focused on multiple myeloma (MM) patients. We aim to understand the relationship between baseline AL, symptom burden, and mortality among patients enrolled in the E1A11 therapeutic trial in MM. Methods: ECOG-ACRIN E1A11 was a phase III RCT comparing induction with Bortezomib (Arm A) versus Carfilzomib (Arm B) in conjunction with Lenalidomide +Dexamethasone. AL included 7 biomarkers: BMI, alkaline phosphatase, creatinine, C-reactive protein, white blood cell count, albumin and creatinine clearance. AL7 was a composite summary score with a point was assigned for each biomarker value in the highest quartile, except for albumin and creatinine clearance, where a point was assigned for values in the lowest quartile. Endpoints included symptom burden at baseline and ̃1 month, non-completion of induction therapy, and overall survival (OS). Functional Assessment of Cancer Therapy Multiple Myeloma (FACT-MM) items assessed patient-reported symptom burden, including fatigue (item HI7), pain (GP4), and bother by side effects of treatment (GP5) on a 5-point Likert scale. Multivariable logistic regressions assessed the effect of AL7 (ranging 0-7) on high-pain, -fatigue, and -bother (QOL score &gt; = 3 vs &lt; 3), and non-completion of induction therapy. The effect of AL7 on OS was assessed using multivariable Cox regression. Regression covariates included study arm, age, sex, race, ECOG performance status, and the target symptom burden score at baseline. Results: The study cohort included 1087 patients. Mean baseline AL7 was 1.8 (±1.4). In adjusted analysis, a unit increase in AL7 was associated with a greater odds of high pain (OR 1.15, 95%CI [1.04-1.27]) and high fatigue (OR 1.19, 95%CI [1.07-1.32]) at baseline, which did not persist at ̃1 month (pain OR 0.96, 95%CI [0.84-1.10]; fatigue OR 1.03, 95%CI [0.91-1.16]). There was no association between AL7 and high side effect bother at baseline (OR 1.06, 95% CI [0.83-1.35]) or at ̃1 month (OR 1.06, 95%CI [0.90-1.24]). There was no association between AL7 and induction non-completion (OR 1.07, 95%CI [0.96-1.18]). Notably, each unit increase in AL7 was associated with higher mortality (HR 1.26, 95%CI [1.14-1.39]). Conclusions: Despite its association with fatigue and pain at baseline, AL7 was not associated with these symptoms at ̃1 month nor induction non-completion. However, elevated baseline AL7 was associated with poorer OS. AL composite score at baseline, which we interpret as a measure of physiological dysregulation associated with adverse social factors, may have implications on clinical outcomes within clinical trials despite presumed equal treatment access.

Social epigenomics: are we at an impasse?

Social scientists have placed particularly high expectations on the study of epigenomics to explain how exposure to adverse social factors like poverty, child maltreatment and racism - particularly early in childhood - might contribute to complex diseases. However, progress has stalled, reflecting many of the same challenges faced in genomics, including overhype, lack of diversity in samples, limited replication and difficulty interpreting significance of findings. This review focuses on the future of social epigenomics by discussing progress made, ongoing methodological and analytical challenges and suggestions for improvement. Recommendations include more diverse sample types, cross-cultural, longitudinal and multi-generational studies. True integration of social and epigenomic data will require increased access to both data types in publicly available databases, enhanced data integration frameworks, and more collaborative efforts between social scientists and geneticists.

Do females have worse surgical outcomes after radical cystectomy? Impact of gender on 30-day complications in a national cohort.

402 Background:: Men have higher rates of bladder cancer and are more likely to undergo cystectomy than women, yet women seem to have worse oncologic outcomes. This is attributed to biologic factors including adverse histologic variants and social factors including delay in diagnosis. There is early evidence that women also have worse surgical outcomes. We further examined the role of gender in 30-day perioperative outcomes following radical cystectomies in a national cohort. Methods: We examined the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) from 2012 to 2016. The database was searched for CPT codes reflecting radical cystectomy and a diagnosis of “cancer of the bladder.” Frailty was estimated by the modified frailty index (functional status, diabetes, chronic obstructive pulmonary disorder, history of chronic heart failure, and hypertension requiring medication.) To compare demographic and perioperative characteristics between genders, Chi-Square analyses were performed for categorical variables, student’s t test to compare averages, and the Wilcoxon rank sum test for operative time and length of stay (LOS). Results: 4,681 radical cystectomies were identified including 842 (18.0%) females. Of the female cohort, average age was 68.6 (+/-11.2 years), 77.3% was Caucasian and 278 (33%) had a BMI of at least 30. There were no differences appreciated between genders with regards to age, average ASA score, frailty, or minimally-invasive approach (all p=NS). Compared to males, female gender was associated with longer operative time (350 vs. 336 min, p&lt;0.009), length of stay (LOS) (8 vs 7, p&lt;0.001) and lower rates of discharge to home (79.9% vs 87.0%, p&lt;0.0001). Reoperation (4.8% vs. 6.0%), readmission (22.2% vs 20.6%), and death within 30 days (1.9% vs. 2.0%) were similar. Clavien 3 or greater was also similar among gender (Table). Conclusions: Female patients comprise a minority of radical cystectomies with slightly longer LOS and less home discharge than men, yet 30-day major complications, reoperation and mortality appear similar. [Table: see text]

Impact of lifestyle on the physical development and health of elderly and old age people (review)

Taking into account the peculiarities of age-related changes in the body, which determine the relevance of medical and social activities, the main tasks of geriatrics are the preservation of the physical and mental health and social well-being of the elderly and old people. The basis for maintaining the health of older age groups is not only qualified treatment, but also competent prevention, which implies a solid foundation of knowledge and capabilities of medicine. A sedentary lifestyle, which prevails in old age, leads to premature deterioration in health, illness and weakness. The physiological rationale for physical activity, risks of adverse events, social and psychological factors are discussed to inform public health initiatives for relatively healthy older people as well as those with disabilities. The most common sign of premature aging is an energy imbalance, accompanied by obesity, decreased mobility, a decrease in the rate of neurohumoral regulation of metabolism and a number of other physiological functions of the body. Meanwhile, in connection with the increase in the average life expectancy of the population, knowledge in the field of geriatrics should be constantly replenished and improved.

Risk management strategy for preventing the reduced treatment effectiveness from the position of drug interactions and polypharmacy in patients with coronary heart disease

Introduction: In modern clinical practice, various drug combinations are widely used, especially in cardiological pa­tients. The existing clinical recommendations necessitate using organ protective agents, especially with a patient having a comorbid pathology and with an ineffective monotherapy. In some cases, drug interaction decreases the effectiveness of pharmacotherapy and increases the risk of developing adverse events (AE).&#x0D; The purpose of the study was to analyze the modern pharmacotherapy of patients with coronary heart disease (CHD), identify polypharmacy of treatment, evaluate its significance for the treatment process, and determine ways to solve the problem of using a multi-component system of pharmacotherapy risk management.&#x0D; Materials and methods: The study involved 156 patients with CHD, among whom 39 received more than 8 drugs at a time.&#x0D; Results and discussion: In these patients, the evaluation of drug interactions revealed 580 variants (48 were danger­ous, 428 – significant, 104 – insignificant). The administration of a therapy to comorbid patients, taking into account possible changes in the activity of cytochrome P450 isoenzymes, is one of the promising ways to improve the safety of a combined pharmacotherapy.&#x0D; Conclusion: It was revealed that with a mutated cytochrome P450 most of processes of drug biotransformation occurs. And there is a greater risk of developing AE against the background of polypragmasia in polymorbid patients, which makes it possible to individually adjust the dose of beta-blockers, thus affecting the frequency of their development. The choice of management measures should be determined considering all the areas of personalized medicine, includ­ing pharmacogenetic predictors, pharmacoepidemiological data, pharmacoeconomic effectiveness, the development of adverse reactions, polypragmasia, and medical and social risk factors.

Adverse social factors and all-cause mortality among male and female patients receiving care in the Veterans Health Administration

Social factors account more for health outcomes than medical care, yet health services research in this area is limited due to the lack of social factors data contained within electronic health records (EHR) systems. Few investigations have examined how cumulative burdens of co-occurring adverse social factors impact health outcomes. From 293,872 patients in one region of the Veterans Health Administration (VHA), we examined how increasing numbers of adverse social factors extracted from the EHR were associated with mortality across a one-year period for male and female patients. Adverse social factors were identified using four sources in the EHR: responses to universal VHA screens, International Classification of Disease (ICD) diagnostic codes that indicate social factors, receipt of VHA services related to social factors, and templated social work referrals. Seven types of adverse social factors were coded: violence, housing instability, employment or financial problems, legal issues, social or familial problems, lack of access to care or transportation, and nonspecific psychosocial needs. Overall, each increase in an adverse social factor was associated with 27% increased odds of mortality, after accounting for demographics, medical comorbidity, and military service-related disability. Non-specific psychosocial factors were most strongly associated with mortality, followed by social or familial problems. Although women were more likely than men to have multiple adverse social factors, social factors were not associated with mortality among women as they were among men. By incorporating social factors data, health care systems can better understand patient all-cause mortality and identify potential prevention efforts built around social determinants.

Policy in pediatric nephrology: successes, failures, and the impact on disparities.

Pediatric nephrology has a history rooted in pediatric advocacy and has made numerous contributions to child health policy affecting pediatric kidney diseases. Despite this progress, profound social disparities remain for marginalized and socially vulnerable children with kidney disease. Different risk factors, such as genetic predisposition, environmental factors, social risk factors, or health care access influence the emergence and progression of pediatric kidney disease, as well as access to life-saving interventions, leading to disparate outcomes. This review will summarize the breadth of literature on social determinants of health in children with kidney disease worldwide and highlight policy-based initiatives that mitigate the adverse social factors to generate greater equity in pediatric kidney disease.