Adverse Relationships Research Articles

The Impact of Relationships Within Combat Units on Post-Deployment Suicide Risk.

Multiple deployment factors may affect suicidality in combat veterans. The relationships between combat deployments and suicidality are complex and not completely understood. Studies of stress in the military and psychological effects of military actions are mostly focused on stressors relating to combat operations. However, many studies suggest that interactions within combat units affect post-deployment psychiatric conditions, suicidal ideation, and behavior. The goal of this article is to review and discuss how relationships within combat units may influence post-deployment suicide risk. Studies of the relationships within combat units are generally focused on two aspects: unit cohesion and harassment/abuse. Considerable evidence suggests that service members who report strong unit cohesion have a lower risk of post-deployment psychiatric disorders and suicidal behavior. Studies examining deployment sexual and non-sexual harassment and abuse have found that combat veterans who experience harassment and abuse during deployment are at heightened post-deployment suicide risk. Sound post-deployment social support and the efficient treatment of psychiatric disorders may mitigate the suicide risk associated with adverse relationships within combat units. Improvements in units' cohesion and the prevention of harassment/abuse during a military deployment are necessary to reduce post-deployment psychiatric pathology, including suicidal behavior.

A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.

In the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies. As part of the Rush Memory and Aging Project (n=440), we measured accelerometer-based actigraphy, cognitive performance, and after brain autopsy, selected reaction monitoring mass spectrometry. Multilevel network analysis was used to examine the relationships among the molecular machinery of vesicular neurotransmission, Alzheimer's disease (AD) neuropathology, cognition, and late-life physical activity. Synaptic peptides involved in neuronal secretory function were the most influential contributors to the multilayer network, reflecting the complex interdependencies among AD pathology, synaptic processes, and late-life cognition. Older adults with lower physical activity evidenced stronger adverse relationships among phosphorylated tau peptides, markers of synaptic integrity, and tangle pathology. Network-based approaches simultaneously model interdependent biological processes and advance understanding of the role of physical activity in age-associated cognitive impairment. Network-based approaches simultaneously model interdependent biological processes. Secretory synaptic peptides were influential contributors to the multilayer network. Older adults with lower physical activity had adverse relationships among pathology. There was interdependence among phosphorylated tau, synaptic integrity, and tangles. Network methods elucidate the role of physical activity in cognitive impairment.

Study protocol for Sauti ya Vijana (The Voice of Youth): A hybrid-type 1 randomized trial to evaluate effectiveness and implementation of a mental health and life skills intervention to improve health outcomes for Tanzanian youth living with HIV.

Young people living with HIV (YPLWH) experience increased morbidity and mortality compared to all other age groups. Adolescence brings unique challenges related to sexual reproductive health, the elevated importance of peer groups, and often, emerging symptoms of emotional distress. Failure to address this unique life stage for YPLWH can lead to worse HIV and mental health outcomes. Herein lies the protocol for a hybrid-type-1 effectiveness-implementation trial designed to evaluate a mental health and life skills intervention that aims to address these needs for YPLWH in Tanzania. This is an individually randomized group-treatment trial designed to evaluate the effectiveness of Sauti ya Vijana (SYV: The Voice of Youth) toward improving viral suppression (HIV RNA <400 copies/mL) and mental health outcomes and to assess implementation including acceptability, feasibility, fidelity, and cost-effectiveness of the manualized intervention. The trial is being conducted across four geographically distinct regions of Tanzania. Peer group leaders (PGL) with lived HIV experience deliver the 10-session group-based intervention and two individual sessions during which participants describe their disclosure narrative (when they learned they live with HIV) and value-based goal setting. Caregiver or chosen supportive adults are encouraged to attend two specific group sessions with their youth. Participants are 10-24 years of age, prescribed antiretroviral therapy for at least 6 months, fully aware of their HIV status, able to commit to session attendance, and able to understand and meaningfully contribute to group sessions. Participant study visits occur at 5 time points for evaluation: baseline, 4-, 6-, 12-, and 18-months post baseline. A single booster session is conducted before the 12-month visit. Study visits evaluate mental health, adverse childhood events, interpersonal violence, resilience, stigma, HIV knowledge, substance use, sexual relationships, ART adherence, and HIV RNA. Implementation outcomes evaluate feasibility and acceptability through attendance, intervention session notes, focus discussion groups and qualitative interviews. Fidelity to the intervention is measured using fidelity checklists by a PGL observer at each group session. Cost effectiveness is calculated using an incremental cost-effectiveness ratio that utilizes a patient cost questionnaire and financial records of study costs. Few mental health interventions for YPLWH have demonstrated effectiveness. Results from this study will provide information about effectiveness and implementation of a peer-led intervention for delivering a mental health and life skills intervention in low-income settings. This trial is registered at clinicaltrials.gov NCT05374109.

Type 2 diabetes: is obesity for diabetic retinopathy good or bad? A cross-sectional study

BackgroundThe relationship between obesity and diabetic retinopathy (DR) remains controversial, and the relationship between sarcopenic obesity and DR is still unclear. The purpose of this study is to investigate the relationship between obesity, sarcopenic obesity, and DR in patients with type 2 diabetes mellitus (T2DM).MethodsA cross-sectional study was conducted on patients with T2DM. Obesity was assessed by body mass index (BMI), fat mass index (FMI), android fat mass, gynoid fat mass, and visceral adipose tissue (VAT) mass. Sarcopenia was defined according to the criteria of Consensus of the Asian Working Group for Sarcopenia (AWGS 2019). Sarcopenic obesity was defined as the coexistence of sarcopenia and obesity. The association between obesity, sarcopenic obesity, and DR was examined using univariable and multivariable logistic regression models.ResultsA total of 367 patients with T2DM (mean age 58.3 years; 57.6% male) were involved in this study. The prevalence of DR was 28.3%. In total patients, significant adverse relationships between obesity and DR were observed when obesity was assessed by BMI (adjusted odds ratio [aOR] 0.54, 95% confidence interval [CI] 0.31 to 0.96, p = 0.036), FMI (aOR 0.49, 95% CI 0.28 to 0.85, p = 0.012), android fat mass (aOR 0.51, 95% CI 0.29 to 0.89, p = 0.019), gynoid fat mass (aOR 0.52, 95% CI 0.30 to 0.91, p = 0.021) or VAT mass (aOR 0.45, 95% CI 0.25 to 0.78, p = 0.005). In patients with T2DM and obesity, the prevalence of sarcopenic obesity was 14.8% (n = 23) when obesity was assessed by BMI, 30.6% (n = 56) when assessed by FMI, 27.9% (n = 51) when assessed by android fat mass, 28.4% (n = 52) when assessed by gynoid fat mass, and 30.6% (n = 56) when assessed by VAT mass. Sarcopenic obesity was associated with DR when obesity was assessed by BMI (aOR 2.61, 95% CI 1.07 to 6.37, p = 0.035), android fat mass (aOR 3.27, 95% CI 1.37 to 7.80, p = 0.007), or VAT mass (aOR 2.50, 95% CI 1.06 to 5.92, p = 0.037).ConclusionsPatients with T2DM showed a substantial inverse relationship between DR and obesity, and sarcopenic obesity was considerably favorably associated with DR. Detection of sarcopenia in patients with T2DM, especially in obese T2DM, is essential to guide clinical intervention in DR.

Effects of dioxin exposure on reproductive and thyroid hormone levels and male sexual function in airbase military workers in Vietnam.

Dioxins are endocrine disruptors that may disturb male sexual and reproductive function. Studies on human populations are limited, and their results are controversial. This study evaluated the impact of dioxin exposure on reproductive and thyroid hormone levels and sexual function in men. A total of 140 men working in four military airbases (three bases were formerly contaminated with dioxin by the herbicide spraying campaign in the Vietnam War) were recruited to measure the serum dioxin levels. Four reproductive hormones (testosterone, follicle-stimulating hormone, luteinizing hormone (LH), and prolactin) and three thyroid hormones (free triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone) were measured. Male sexual function endpoints including sexual drive, erection, ejaculation, problems, and overall satisfaction were assessed by the Brief Male Sexual Function Inventory. The percentage of subjects with low testosterone and LH levels was 19.6% and 16.7%, respectively. Dioxins, especially 2,3,7,8-tetrachlorodibenzo-P-dioxin and toxic equivalent concentrations of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans, were inversely associated with testosterone and prolactin levels, but positively associated with FT3 and FT4, and showed adverse relationships with sexual function, such as sexual drive, problems, and overall satisfaction. Our results suggested that exposure to dioxin disrupts the homeostasis of reproductive and thyroid hormones leading to adverse effects on male sexual function.

Assessing the land use dynamics and thermal environment using geospatial techniques in the industrial city of Chotanagpur Plateau Region, India.

The phenomenon of urban heat island (UHI) is characterized by industrial, economic development, unplanned and unregulated land use as well as a rapid increase in urban population, resulting a warmer inner core in contrast to the surrounding natural environment, thus requiring immediate attention for a sustainable urban environment. This study examined the land use/land cover (LULC) change, pattern of spectral indices (Normalized Difference Vegetation Index, NDVI; Normalized Difference Water Index, NDWI; Normalized Difference Built-up Index, NDBI and Normalized Difference Bareness Index, NDBaI), retrieval of land surface temperature (LST) and Urban Thermal Field Variance Index (UTFVI) as well as identification of UHI from 2000 to 2022. The relationship among LST and LULC spectral indices was estimated using Pearson's correlation coefficient. The Landsat-5 (TM) and Landsat-8 (OLI/TIRS) satellite data have been used, and all tasks were completed through various geospatial tools like ArcGIS 10.8, Google Earth Engine (GEE), Erdas Imagine 2014 and R-Programming. The result of this study depicts over the period that built-up area and water bodies increased by 119.78 and 35.70%, respectively. On the contrary, fallow and barren decreased by 55.33 and 32.31% respectively over the period. The mean and maximum LST increased by 3.61 °C and 2.62 °C, and the study reveals that a high concentration of UTFVI and UHI in industrial areas, coal mining sites and their surroundings, but the core urban area has observed low LST and intensity of UHI than the peripheral areas due to maintained vegetation cover and water bodies. An inverse relationship has been found among LST, NDVI and NDWI, while adverse relationships were observed among LST, NDBI and NDBaI throughout the period. Sustainable environment planning is needful for the urban area, as well as the periphery region and plantation is one of the controlling measures of LST and UHI increment. This work provides the scientific base for the study of the thermal environment which can be one of the variables for planning of Asansol City and likewise other cities of the country as well as the world.

Adverse Psychosocial Relationships and Substance Use Disorder: a Narrative Review

Adverse Psychosocial Relationships and Substance Use Disorder: a Narrative Review

The stateoftheart in secondary pharmacology and its impact on the safety of new medicines.

Secondary pharmacology screening of investigational small-molecule drugs for potentially adverse off-target activities has become standard practice in pharmaceutical research and development, and regulatory agencies are increasingly requesting data on activity against targets with recognized adverse effect relationships. However, the screening strategies and target panels used by pharmaceutical companies may vary substantially. To help identify commonalities and differences, as well as to highlight opportunities for further optimization of secondary pharmacology assessment, we conducted a broad-ranging survey across 18 companies under the auspices of the DruSafe leadership group of the International Consortium for Innovation and Quality in Pharmaceutical Development. Based on our analysis of this survey and discussions and additional research within the group, we present here an overview of the current state of the art in secondary pharmacology screening. We discuss best practices, including additional safety-associated targets not covered by most current screening panels, and present approaches for interpreting and reporting off-target activities. We also provide an assessment of the safety impact of secondary pharmacology screening, and a perspective on opportunities and challenges in this rapidly developing field.

Use of Exposure Data to Establish Causality in Drug-Adverse Event Relationships: An Example with Desvenlafaxine.

Causality algorithms help establish relationships between drug use and adverse event (AE) occurrence. High drug exposure leads to a higher likelihood of an AE being classified as an adverse drug reaction (ADR). However, there is a knowledge gap regarding what concentrations are predictive of ADRs, as this has not been systematically studied. In this work, the Spanish Pharmacovigilance System (SEFV) algorithm was used to define the relationship between the AE occurrence and drug administration in 178 healthy volunteers participating in five desvenlafaxine single-dose clinical trials, a selective serotonin and norepinephrine reuptake inhibitor that may cause dizziness, headache, nausea, dry mouth, constipation and hyperhidrosis. Eighty-three subjects presented 172 AEs that were classified as possible (101), conditional (31), unrelated (24) and probable (16). AUC∞ and Cmax were significantly higher in volunteers with vs. without ADRs (5981.24 ng·h/mL and 239.06 ng/mL and 4770.84 ng·h/mL and 200.69 ng/mL, respectively). Six of 19 subjects with conditional AEs with an SEFV score of 3 points presented an AUC∞ ≥ 6500 ng·h/mL or a Cmax ≥ 300 ng/mL (i.e., above percentile 75) and were summed one point on their SEFV score and classified as "possible" (4 points), improving the capacity of ADR detection.

Peer acceptance and rejection during secondary school: Doassociations with subsequent educational outcomes vary bysocioeconomic background?

Research shows that peer relationships are associated with students' school adjustment. However, the importance of advantageous and disadvantageous factors for students' educational outcomes may vary by socioeconomic positioning. Drawing on sociometric and register data from a nationally representative sample of Swedish youth (n = 4996, girls 50%; migration background 19%), this study asks if family socioeconomic status moderates associations between youth's peer relationships and their subsequent educational outcomes. Based on preregistered analyses, associations that peer acceptance and rejection at age 14-15 years share with school grades at ~16 years and completion of upper secondary school at ~20 years were tested. The findings showed that positive and adverse peer relationships are most consequential for the educational outcomes of socioeconomically disadvantaged youth.

Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy.

The individual and combined associations of polycyclic aromatic hydrocarbons (PAHs) metabolites on liver function during pregnancy are still lacking. We aimed to explore the connection between urinary PAH metabolites and liver function in early pregnant women in southwest China based on the Zunyi birth cohort. Ten urinary PAH metabolites and five liver function parameters during early pregnancy were measured. The associations of single PAHs with parameters of liver function were assessed using multiple linear regression. A Bayesian kernel machine regression (BKMR) model was used to evaluate the joint associations of the PAH mixture with outcomes. We found that each 1% increment of urinary 2-hydroxyphenanthrene (2-OH-PHE) was associated with 3.36% (95% CI: 0.40%, 6.40%) higher alanine aminotransferase (ALT) and 2.22% (95% CI: 0.80%, 3.67%) higher aspartate aminotransferase (AST). Each 1% increment in 1-hydroxy-phenanthrene (1-OH-PHE) was significantly associated with 7.04% (95% CI: 1.61%, 12.75%) increased total bile acid (TBA). Additionally, there was a significant positive linear trend between 2-OH-PHE and AST and 1-OH-PHE and TBA. BKMR also showed a significant positive association of PAH mixture with AST. Our results indicate that PAH metabolites were associated with increased parameters of liver function among early pregnant women. Early pregnant women should pay more attention to the adverse relationships between PAHs and liver function parameters to prevent environment-related adverse perinatal outcomes.

Geographic Patterns of Dementia in the United States: Variation by Place of Residence, Place of Birth, and Subpopulation.

The prevalence of dementia varies geographically in the United States. However, the extent to which this variation reflects contemporary place-based experiences versus embodied exposures from earlier in the life course remains unclear, and little is known regarding the intersection of place and subpopulation. This study, therefore, evaluates whether and how risk for assessed dementia varies by place of residence and birth, overall and by race/ethnicity and education. We pool data from the 2000 to 2016 waves of the Health and Retirement Study, a nationally representative panel survey of older U.S.adults (n=96,848 observations). We estimate the standardized prevalence of dementia by Census division of residence and birth. We then fit logistic regression models of dementia on region of residence and birth, adjusting for sociodemographic characteristics, and examine interactions between region and subpopulation. The standardized prevalence of dementia ranges from 7.1% to 13.6% by division of residence and from 6.6% to 14.7% by division of birth, with rates highest throughout the South and lowest in the Northeast and Midwest. In models accounting for region of residence, region of birth, and sociodemographic covariates, Southern birth remains significantly associated with dementia. Adverse relationships between Southern residence or birth and dementia are generally largest for Black and less-educated older adults. As a result, sociodemographic disparities in predicted probabilities of dementia are largest for those residing or born in the South. The sociospatial patterning of dementia suggests its development is a lifelong process involving cumulated and heterogeneous lived experiences embedded in place.

Self-Perceived Sources of Stress and Burnout Determinants in Dentistry - A Systematic Review

Introduction. In recent decades, under the influence of various factors, there has been a serious increase in psycho-emotional tension and stress. Furthermore, considering unprecedented times of global pandemic threat, stress levels can rise significantly. Dental profession is physically and mentally stressful as dentists encounter a number of occupational hazards of a biological, chemical, physical, and psycho-emotional nature.&#x0D; Objective. The current review paper aimed to answer the question: what are the most important stressors and burnout determinants in daily dental practice?&#x0D; Materials and Methods. The Web of Science Core Collection database was searched for according to the PRISMA guidelines in September 2022. Empirical studies - observational, experimental, cross-sectional, and longitudinal studies published in English were considered for inclusion.&#x0D; Results. The initial search yielded 355 articles. Eighteen studies met inclusion criteria and were considered for the final analysis. Two articles reported identical data; therefore, they were not included in the current report. Finally, this review presented 16 reports with a total of 8, 824 subjects.&#x0D; Conclusions. Both long-term and short-term stress can cause negative effects on practitioner’s physical, mental, and emotional functioning. As healthcare providers, dentists should be aware of these risk factors, as well as they need to be sufficiently motivated to know the risks and inconveniences of their profession, learning effective strategies how to deal with adverse conditions, factors, and relationships. Providing information on this issue will contribute to increasing dentists’ awareness and improving their personal and professional performance.

Mechanisms of maternal and paternal phubbing on adolescents’ self-control: The attenuating effect of having a sibling

Parental phubbing refers to parents being distracted by their phone during an interaction with their child. The present study investigated how parental phubbing relates to adolescents’ self-control through the mediators of parent–adolescent closeness and loneliness. The current study also compared the effects of maternal and paternal phubbing. Having a sibling may influence adolescent mental health and behaviors. Thus, this study also examined whether siblings attenuate the effects of parental phubbing on self-control. We recruited 670 adolescents to participate in our survey. Path analyses revealed that maternal phubbing had both direct and indirect effects on self-control through mother–adolescent closeness and loneliness. However, paternal phubbing had only a sequential indirect effect through father–adolescent closeness and loneliness. This shows that maternal and paternal phubbing have different effects on adolescents’ self-control. Multi-group comparisons revealed that the direct and indirect effects of maternal phubbing on self-control were non-significant for adolescents with siblings. Thus, siblings attenuated the adverse relationships between maternal phubbing and adolescent self-control.

The role of perseverative cognition in the job strain-health outcome relationship

Objective: Job strain has been implicated in a variety of adverse health outcomes, particularly cardiometabolic and inflammatory diseases. However, the mechanisms underlying these effects remain largely unknown. One possibility is that the maladaptive coping response to stress, (perseverative cognition (PC); the cognitive representation of past stressful events (rumination) or feared future events (worry)), either in work or more generally, mediates the relationship between job strain and physical disease. The aim of this study was thus to test the potential role of both general, and work- related PC as a mediating, or potentially moderating, mechanism between job strain and ill- health outcomes. Design & Measures: Using an online cross- sectional design, 650 full- time employees completed measures of job strain, general and work- related PC (rumination & worry) and health outcomes (burnout, somatization, health behaviours & sleep quality). Results: General and work- related worry and rumination significantly mediated, often independently, the relationship between job strain and burnout, somatization, and sleep quality. No significant mediation effects were observed for health behaviours and no type of PC (general or work- related) moderated job strain- health outcome relations. Conclusion: Both general and work- related worry and rumination are likely to play important, and partly independent, roles in understanding the adverse relationships between job strain and various health outcomes.

Mobile media education as a tool to reduce problematic smartphone use: Results of a randomised impact evaluation

In recent years a public debate has been growing around mobile media and young people, as research has found adverse relationships between the intensive use of smartphones and well-being in this age group. However, there is still a lack of structured interventions targeting teachers and schools on the issue. This paper shows the results of a pre-registered cluster randomised controlled trial evaluating the impact of a media education intervention focusing on screen time management and the conscious use of mobile devices. The impact of a teacher training course is assessed on their 10th grade students (789 treated, 2572 controls), looking at their smartphone use, digital skills, and subjective well-being. Post-intervention differences, controlling for baseline measures at wave 1, show a moderate but significant decrease in smartphone pervasiveness and problematic use among treated students, with girls displaying greater beneficial effects than boys on withdrawal symptoms. Girls also show an increase in subjective well-being. No effect is found on the level of digital skills measured with an ad-hoc test. These results highlight that media education interventions focused on screen time management and content-related digital skills can be effectively incorporated into daily teaching and are relevant for students’ well-being. The paper also offers practical indications to develop effective media education interventions in a constant connectivity environment.

Tradeoffs, Constraints, and Strategies in Transgender and Nonbinary Young Adults' Romantic Relationships: The Identity Needs in Relationships Framework.

Prior research suggests that prejudice and structural disadvantage (e.g., cissexism, racism, sexism) put transgender and nonbinary (TNB) young adults at risk for adverse romantic relationship experiences, yet supportive romantic relationships may help TNB young adults cope with these stressors and promote their psychological wellbeing. Accordingly, there is a need to better understand how TNB young adults navigate romantic relationships in the context of prejudice and structural disadvantage. To address this topic, we analyzed in-depth interviews with TNB young adults (18-30 years; N=30) using template-style thematic analysis, guided by intersectionality as an analytical framework. Our analysis resulted in three themes. Theme 1 describes how prejudice and structural disadvantage constrained the strategies that TNB young adults used to pursue fulfilling romantic relationships (e.g., leaving adverse relationships). Theme 2 addresses the tradeoffs that some participants faced in their romantic relationships, including tradeoffs between psychological needs related to their social identities (e.g., gender identity affirmation) and general psychological needs (e.g., intimacy). Theme 3 highlights individual and contextual factors (e.g., lessons from prior romantic relationships) that helped participants build fulfilling romantic relationship. These themes form the basis for the Identity Needs in Relationships Framework, a new conceptual framework addressing how TNB young adults navigate romantic relationships in the context of prejudice and structural disadvantage. The framework offers an explanation for why some TNB young adults maintain romantic relationships that seem to undermine their wellbeing, and it draws attention to strategies and resources that may help TNB young adults form fulfilling romantic relationships despite the prejudice and structural disadvantage they face.

Linear and non-linear associations of device-measured sedentary time with older adults' skeletal muscle mass.

Time spent sitting is associated adversely with health outcomes in older adults. Nevertheless, it is not clear how sedentary time may be related to appendicular skeletal muscle mass (ASM) - a key attribute of sarcopenia. This cross-sectional study examined associations of total sedentary time with ASM among community-dwelling older Japanese males and females. Participants (n = 281, 74.3 ± 5.2 yr) wore a tri-axial accelerometer for seven days. Body mass index-adjusted ASM (kg/BMI) was derived from bioimpedance measures. Multivariate linear and quadratic regression models examined the associations of ASM with total sedentary time, stratified by sex. Restricted cubic spline models were fitted to estimate non-linear associations. Isotemporal substitution (IS) models were used to estimate the impacts of replacing 30-minute of sedentary time with light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA). After adjustment, total sedentary time had a significant linear and negative association with ASM among females (β = -0.014; p = 0.023). For males, total sedentary time had a significant quadratic association (p = 0.020). Spline models indicated a reverse U-shaped association (p < 0.001) with total sedentary time over 9.3 h/day being associated with lower ASM. The IS models indicated that replacing 30 min/day of sedentary time with LPA would be positively and significantly associated with older females' ASM (β = 0.007, p = 0.022). In older Japanese adults, higher volumes of time spent sedentary were associated with lower ASM. For males, only very high volumes of sedentary time appeared to be detrimental. These adverse relationships may in part be offset by more time spent in either LPA or MVPA.

Understanding Resilience Optimization Architectures: Alignment and Coupling in Multilevel Decomposition Strategies

Abstract Including resilience in an overall systems optimization process is challenging because the space of hazard-mitigating features is complex, involving both inherent and active prevention and recovery measures. Many resilience optimization approaches have thus been put forward to optimize a system’s resilience while systematically managing these complexities. However, there has been little study about when to apply or how to adapt architectures (or their underlying decomposition strategies) to new problems, which may be formulated differently. To resolve this problem, this article first reviews the literature to understand how choice of optimization architecture flows out of problem type and, based on this review, creates a conceptual framework for understanding these architectures in terms of their underlying decomposition strategies. To then better understand the applicability of alternating and bilevel decomposition strategies for resilience optimization, their performance is compared over two demonstration problems. These comparisons show that while both strategies can solve resilience optimization problem effectively, the alternating strategy is prone to adverse coupling relationships between design and resilience models, while the bilevel strategy is prone to increased computational costs from the use of gradient-based methods in the upper level. Thus, when considering how to solve a novel resilience optimization problem, the choice of decomposition strategy should flow out of problem coupling and efficiency characteristics.

COVID-19 distress and interdependence of daily emotional intimacy, physical intimacy, and loneliness in cohabiting couples.

Introduction: COVID-19 has had a profound impact on relationship functioning, though effects have been heterogeneous. Reasons for divergent effects on relationship functioning remain unclear. Theoretical models suggest that it is not just stress exposure that leads to adverse relationships outcomes, but also subjective response to these stressors. Using data from a 14-day intensive longitudinal study of romantic dyads, we hypothesized that COVID-19-related distress would adversely impact one’s own and one’s partner’s report of relationship functioning, on average. Interdependence at the trait level (random effects between couples) and day level (residuals within couples) was also examined. Methods: Participants were 104 female-male romantic couples cohabiting the New York metropolitan area (Mage = 28.86, SDage = 7.69) between August 2020 – April 2021. Couples reported COVID-19 distress during a baseline interview and daily relationship functioning for 14 days. Multilevel models were specified for six outcomes simultaneously: female and male partner daily physical intimacy, emotional intimacy, and loneliness. Interrelationships of the intercepts of the six outcomes were specified, reflecting trait-level associations of each partner’s stable outcome tendencies. Interrelationships of the daily residuals of the six outcomes were also specified, reflecting within-couple associations at the daily level. Results: Female partner COVID-19 distress was inversely associated with her own emotional and physical intimacy and positively associated with her own and her partner’s loneliness. Male COVID-19 distress was associated with his own loneliness only. There was significant interdependence at both levels, such that greater loneliness in either partner was associated with less intimacy in each member of the couple. Discussion: Only one partner effect for COVID-19 distress emerged, such that female partner distress was associated with male partner loneliness; however, trait- and day-level interdependence suggested that distress may adversely impact relational well-being over time. Future studies should examine reciprocal relationships between COVID-19-related distress and relationship functioning.