You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy VI1 Apr 2016PD48-04 PROSPECTIVE RANDOMIZED TRIAL COMPARING OPEN TO LAPAROSCOPIC PARTIAL NEPHRECTOMY, INTERIM ANALYSIS. (NCT01809119) Giuliano Guglielmetti, Sanarelly Adonias, Rafael Coelho, Mauricio Cordeiro, Leonardo Borges, José Roberto Colombo, Rodrigo Pessoa, Luiz Neves, José Pontes, Adriano Nesrallah, Miguel Srougi, and William Nahas Giuliano GuglielmettiGiuliano Guglielmetti More articles by this author , Sanarelly AdoniasSanarelly Adonias More articles by this author , Rafael CoelhoRafael Coelho More articles by this author , Mauricio CordeiroMauricio Cordeiro More articles by this author , Leonardo BorgesLeonardo Borges More articles by this author , José Roberto ColomboJosé Roberto Colombo More articles by this author , Rodrigo PessoaRodrigo Pessoa More articles by this author , Luiz NevesLuiz Neves More articles by this author , José PontesJosé Pontes More articles by this author , Adriano NesrallahAdriano Nesrallah More articles by this author , Miguel SrougiMiguel Srougi More articles by this author , and William NahasWilliam Nahas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2726AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Partial nephrectomy (PN) is the treatment of choice for T1a renal tumors (RT) and has progressively gained acceptance for the treatment of T1b and even bigger tumors. Despite no good quality evidence proving that minimally invasive surgery offers as good results as open surgery, it has been widely used for PN and is growing in usage especially after advent of robotic surgery. The objective of this study is to determine if laparoscopic partial nephrectomy can provide good functional and oncological outcomes with acceptable morbidity for the treatment of T1 RT. METHODS Since 2013, patients with RT smaller than 7 cm are being recruited for the study. Inclusion criteria included: T1 RT, candidates for partial nephrectomy. Exclusion criteria are: anatomical or functional solitary kidney, multiple RTs and glomerular filtration rate (GFR) less than 30ml/min. Patients are randomized in 1:1 proportion into 2 groups: Group 1 – laparoscopic partial nephrectomy, Group 2 – open partial nephrectomy. GFR is measured with 51Cr-EDTA realized before, at 3 and 12 months after surgery. Unexpected events up to 3 months after surgery are considered surgical complications and classified following Clavien-Dindo Grading System. RESULTS This is an interim analysis performed in may/2015. 110 patients had been randomized. 35 patients were excluded from analysis because didn’t have sufficient follow-up after surgery. Data from 34 patients in group 1 and 41 patients in group 2 were analyzed. Intra-operative and pathological data are presented in table 1. Group 2 patients had significantly less warm ischemia time. There was no difference in terms of surgical complications or GFR decrease 3 or 12 months after surgery (table 2). CONCLUSIONS Laparoscopic partial nephrectomy offers same functional and oncological outcomes when compared to open surgery, with equivalent morbidity. In specialized centers, laparoscopic approach should be preferred due to its advantages related to surgical access. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1176 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Giuliano Guglielmetti More articles by this author Sanarelly Adonias More articles by this author Rafael Coelho More articles by this author Mauricio Cordeiro More articles by this author Leonardo Borges More articles by this author José Roberto Colombo More articles by this author Rodrigo Pessoa More articles by this author Luiz Neves More articles by this author José Pontes More articles by this author Adriano Nesrallah More articles by this author Miguel Srougi More articles by this author William Nahas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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