Advantages Of Dendrimers Research Articles

Facile benchtop reactor design using dendrimer-templating technology for the fabrication of polyethyleneimine-coated CuO nanoparticles on the gram scale

Although there has been a wealth of methods developed to produce nanoparticles (NPs), many still suffer from common limitations, such as the instability of the formed nanoparticles against self-aggregation and the inability to produce significant quantities of nanoparticles (gram level). In this regard, there is a growing need for the development of cost-effective, reliable, and scalable experimental protocols to synthesize stable nanoparticles with desired morphologies and controlled sizes. Hence, in this work, the authors explore the synthesis of copper oxide (CuO) nanoparticles via the construction of a multifunctional flow reactor that uses both polymer-templating and chemical reduction methods to produce nanoparticles at the gram scale. In particular, this flow reactor takes advantage of dendrimers and other polymers, such as polyethyleneimine, to control the size and morphology of the CuO NPs.

Dendrimer Teknolojisi Kullanılarak Aromaterapi Özelliğine Sahip Fonksiyonel Yünlü Kumaş Eldesi / Obtaining Functional Woolen Fabric Having Aromatherapy Feature By Using Dendrimer Technology

Bu araştırmada dendrimerlerin yapılarındaki dallar arasındaki boşluklara çeşitli molekülleri kapsülleyebilme yeteneğinden yararlanılarak aromaterapi özelliğine sahip fonksiyonel yünlü dokuma kumaşların üretimi üzerinde çalışılmıştır. Yünlü kumaşlara dendrimer çözeltisi aplikasyonu yapılmış ve ardından dendrimerle ön işlem görmüş ve görmemiş kumaş numunelerine limon ve lavanta esansı aplikasyonları gerçekleştirilmiştir. Ayrıca dendrimerle işlem görmüş ve işlemsiz numuneler üzerinde kokuların zamana ve yıkama işlemlerine bağlı olarak kalıcılığı da test edilmiştir. Yapılan çalışmalar sonucunda, dendrimerle ön işlem görmüş numunelerde koku yoğunluğunun gerek zamana gerekse de yıkama sayısına bağlı olarak daha kalıcı olduğu saptamıştır. In this research it was studied on the production of functional woolen fabrics that has the aromatherapy feature by taking the advantage of dendrimers' encapsulation ability of various molecules into spaces between their branches. Dendrimer solutions were applied to woolen fabrics, then lemon and lavender essences were applied to dendrimer treated and untreated fabrics. Furthermore, permanence of odors depending on time and washing cycle were also tested for both dendrimer treated and untreated fabrics. Finally it was determined that odor intensity of dendrimer treated samples were more permanent, depending on both time and washing cycle.

Dendrimeric systems and their applications in ocular drug delivery.

Ophthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited by physiological conditions. The use of nonionic or ionic biodegradable polymers in aqueous solutions and colloidal dosage forms such as liposomes, nanoparticles, nanocapsules, microspheres, microcapsules, microemulsions, and dendrimers has been studied to overcome the problems mentioned above. Dendrimers are a new class of polymeric materials. The unique nanostructured architecture of dendrimers has been studied to examine their role in delivery of therapeutics and imaging agents. Dendrimers can enhance drug's water solubility, bioavailability, and biocompatibility and can be applied for different routes of drug administration successfully. Permeability enhancer properties of dendrimers were also reported. The use of dendrimers can also reduce toxicity versus activity and following an appropriate application route they allow the delivery of the drug to the targeted site and provide desired pharmacokinetic parameters. Therefore, dendrimeric drug delivery systems are of interest in ocular drug delivery. In this review, the limitations related to eye's unique structure, the advantages of dendrimers, and the potential applications of dendrimeric systems to ophthalmology including imaging, drug, peptide, and gene delivery will be discussed.

ChemInform Abstract: Dendrimers and Miktoarm Polymers Based Multivalent Nanocarriers for Efficient and Targeted Drug Delivery

AbstractReview: 252 refs.

Dendrimers and miktoarm polymers based multivalent nanocarriers for efficient and targeted drug delivery

The delivery of biologically active agents to the desired site in the body and intracellular organelles is still a big challenge despite efforts made for more than five decades. With the elaboration of synthetic methodologies to branched and hyperbranched macromolecules such as miktoarm stars and dendrimers, the focus has shifted to nanocarriers able to release and direct drug molecules to a desired location in a controlled manner. We present here recent developments in the field of targeted drug delivery with a focus on two specific macromolecular nanocarriers, dendrimers and miktoarm stars, and provide examples of these nanocarriers tested in different biological systems. A particular attraction of miktoarm stars is their versatility in achieving superior drug loading within their self-assembled structures. Advantages of dendrimers over linear polymers are that the former provide a platform for development of multivalent and multifunctional nanoconjugates, in addition to their ability to accommodate a large number of molecules inside, or at their surfaces.

Nanoparticles in dendrimers: From synthesis to application

Methods for synthesizing metal, metal oxide, and metal halide nanoparticles (NPs) in the presence of dendrimers and dendrons are discussed in this review. There are numerous reviews describing dendrimers and their properties and applications in various areas of nanotechnologies, which indicates the growing interest of researchers in this unique class of monodisperse and highly branched macromolecules with highly ordered and controlled structures. The special magnetic, optical, and electronic properties of dendrimer (dendron) nanocomposites with NPs determine their prospects for application in medicine [54–58], in catalysis [32, 58–60], as molecular sensors [61–65], etc. Dendrimers successfully stabilize NPs, playing the role of a template (i.e., NPs are formed inside the dendrimer) or surfactants. In the latter case, dendrimers are stabilizing molecules, so the NPs are formed between the dendrimers. Functional dendrons can be also used as stabilizing molecules (1) directly during NP formation or (2) upon the subsequent functionalization of NPs via the replacement of the initial surfactants with dendrons. The unique advantages of dendrimers are completely fulfilled in those cases when the dendrimer design or reaction conditions allow either (1) the formation of very small NP sizes (for example, functional nanoclusters of gold and silver) or (2) control of the NP sizes, when dendrimer generation or other conditions vary, allowing one to control the properties of nanocomposites. Because the dendrimer (dendron) structure strongly differs from the structure of traditional surfactants, this leads to an opportunity of the targeted variation of solubility, functionality, and morphology of the nanocomposites based on dendrimers (dendrons) even when a dendrimer (dendron) plays the role of a surfactant.