The use of knowledge graph analysis for chronic disease nursing based on visualization technology and literature big data is an unexplored area of research in this field of study. To uncover research hotspots and developmental trends in the field of chronic disease nursing, and to provide a scholarly reference, we employed mathematical and statistical methods along with CiteSpace literature visualization analysis software for quantitative analysis of extensive literature data from the Web of Science Core Collection. We examined aspects such as publication trends, journals, author collaborations, research institutions, national and regional distributions, keyword co-occurrence, clustering, time zones, emergence, literature co-citations, and more. These analyses identified the current hotspots and future directions for research. Notably, scholars' interest in chronic disease nursing exhibited a consistent upward trajectory. In particular, the field of artificial intelligence technology application in nursing yielded $3,610$ published papers in $141$ journals with more than or equal to $10$ published papers on the topic, accounting for $58.41 \%$ of the total number of published papers in this field of study. Furthermore, the top three publishers were the “Journal of Clinical Nursing,” “Journal of Advanced Nursing,” and “BMC Health Services Research.” Among authors, Hu, Frank B., Willett, Walter C., and Rimm, Eric B., ranked as the top three, and 12 authors had more than 10 publications. The most active research institutions included Harvard University, Harvard Medical School, Brigham & Women’s Hospital, University of California System, University of London, US Department of Veterans Affairs, Veterans Health Administration (VHA), Harvard T. H. Chan School of Public Health, University of Sydney, and the University of Toronto. The United States, Australia, England, China, Canada, Netherlands, Spain, Italy, Sweden, and Germany emerged as the leading countries in terms of research output, while emerging hotspots encompassed topics such as incidence, rheumatoid arthritis, qualitative research, burnout, kidney transplantation, critical illness, COVID-19, Sars-COV-2, public health, and the well-being of medical staff. These findings present valuable insights for prospective research endeavors.