P458 Aims: Advanced donor age has been shown to be an independent risk factor for rapid HCV recurrence after liver transplant. We reviewed our data to evaluate the effect of donor age and to identify potential immunosuppressive factors that may obviate recurrence. Methods: Retrospective database review of patients transplanted for HCV. Study population was divided into two chronologic eras: Group I (pts transplanted 1994-1998 pre MMF use) and Group II (1999-2001). Additionally, immunosuppression protocols were either CyA or tacrolimus based with steroid. Statistical analysis these populations was performed and comparisons between the groups were made. Recurrence was based only on biopsy diagnosis. Results: There were no significant differences in donor and recipient ages in both groups. Additionally, the use of tacrolimus and cyclosporine was not different in both groups, nor did they demonstrate a difference in recurrence rates. Univariate analysis of the data was performed and is included in the table below.Figure* p = 0.01, ** p < 0.001 Group I vs. Group II, *** p = 0.0009 Group I vs. Group II Conclusions: Donors over 50 yrs. did not alter the incidence of overall HCV recurrence in either group. This is unlike what is reported by other institutions. Increased use of MMF in Group II was seen. Therefore, its use may suggest a role in negating the increase in HCV recurrence after liver transplantation seen in other centers. Further detailed studies are necessary to correctly identify other factors that may be involved.