Adult Rhabdomyoma Research Articles

Case Report: Unveiling the unexpected: a rare case of adult-type rhabdomyoma in a 9-year-old boy

Rhabdomyoma is an exceedingly rare benign soft tissue tumor of skeletal muscle origin, classified into cardiac and extracardiac types based on location. Extracardiac rhabdomyoma further includes adult, genital, and fetal types depending on the degree of differentiation. Most patients are between 40 and 70 years old, with a mean age of 60 years and a male predominance. This case report presents a 9-year-old boy diagnosed with an oropharyngeal tumor, initially presenting with a 6-month history of a foreign body sensation in the throat, presenting as night-time snoring. Postoperative histological examination revealed adult rhabdomyoma, characterized by specific immunohistochemical and histologic traits including cytoplasmic positivity for muscle-specific Actin (MSA), Desmin, Myogenin, and MYOD1, large polygonal skeletal muscle cells and frequent extensive vacuolization. This report highlights the unusual age of presentation for this variant and underscores the need for heightened clinical awareness to ensure accurate diagnosis and effective management of such rare occurrences.

An unusual case of adult rhabdomyoma in thyroid

An unusual case of adult rhabdomyoma in thyroid

Clear cell adult rhabdomyoma-a rare variant of an unusual tumour.

Adult rhabdomyoma is an uncommon benign mesenchymal neoplasm that most often occurs in the head and neck. We present a 70 year-old male with a swelling on the floor of the mouth. Subsequent excision of the tumor revealed a hitherto undescribed morphological variant of this tumor that features a predominance of clear cells, which on light microscopy may mimic other other clear cell tumours of the head and neck region. We perform an in-depth analysis of the morphological and immunohistochemical features of this tumor, as well as discuss pitfalls in the diagnosis of this tumor and its differential diagnosis in the head and neck region.

Adult rhabdomyoma – a case report

Adult rhabdomyoma – a case report

Rhabdomyoma of the Oral Cavity Mimicking Reactive Lesions: A Case Report and Review of the Literature.

Extracardiac rhabdomyoma is a tumor that rarely occurs in head and neck region. Adult and fetal types of extracardiac rhabdomyoma are diagnosed only by histopathological examination. In the oral cavity, this lesion usually affects the mouth floor and tongue. Despite the low incidence, adult rhabdomyoma should be considered in the differential diagnosis of oral cavity lesions, and histopathological evaluation might be helpful for the final diagnosis. This study aims to report a rare case of rhabdomyoma mimicking reactive lesions and review the literature. A 34-year-old male was referred to the pathology department with a yellowish sessile lesion in the labial maxillary vestibule. During an excisional biopsy, a mass of unencapsulated soft tissue beneath the vestibular mucosa was observed. The yellowish color in clinical features has led to lipoma as the initial clinical diagnosis. The histological examination exhibited an encapsulated, well-circumscribed benign neoplasm composed of multiple lobules of large polygonal cells with prominent abundant granular eosinophilic cytoplasm. No cellular atypia was observed. Diagnosis of the adult type of rhabdomyoma was made by collective agreement. Rhabdomyoma can be mistaken for other reactive lesions and may resemble their appearance.

Role of magnetic resonance imaging and dual-energy computed tomography in diagnosis of adult heart rhabdomyoma: A clinical case

This article describes a clinical case of the heart rhabdomyoma in an adult patient diagnosed in early childhood. The result of the continued tumor growth was cardiac arrhythmia in the form of ventricular extrasystole with runs of ventricular tachycardia. Authors also present a literature review on the frequency of occurrence, morphology, clinical manifestations, and diagnosis of this type of heart tumors, including using dual-energy computed tomography and cardiac magnetic resonance imaging with intravenous contrast enhancement.

ADULT RHABDOMYOMA OF THE ORAL CAVITY

This report describes a case of adult rhabdomyoma (AR) in the oral cavity. A 47-year-old male was referred for diagnosis of a painless lesion located in floor of the mouth, with 2 years of duration. Intra-orally, the lesion appeared as a large, well-delimited swelling mass measuring about 5.0 cm, projecting the tongue superiorly and posteriorly. On computerized tomography examination, there was a well-delimited, solid, hypodense mass. The main hypothesis of diagnosis was a salivary gland tumor. The patient was submitted to surgical excision. Microscopically, the nodule was composed by large polygonal cells with well-defined borders, which exhibited abundant, eosinophilic, and granular cytoplasm. Cross-striation in the cytoplasm was also observed, and there were no atypia or mitoses. The cells were positive for muscle-specific actin, desmin, and α-sarcomeric actin. Calponin, h-caldesmon, and myogenin were negative. Based on these features, the diagnosis of AR was established. No recurrence was observed after 24 months.

Multiple synchronous rhabdomyomas in the tongue and floor of the mouth: case report

Observation: A 61-year-old male patient presented with tongue and base floor of the mouth firm swelling with intact overlying mucosa with ballottement by bimanual palpation. Histopathological examination and immunodiagnosis revealed this mass as adult rhabdomyoma. Comments: Any tongue base or floor of the mouth mass with intact overlying mucosa should be approached by magnetic resonance imaging with great concern of rhabdomyoma.

An Unusual Cause of Dysphagia: Hypopharyngeal Rhabdomyoma

Extra-cardiac rhabdomyomas are rare benign soft tissue tumors accounting for 2% of sk eletal muscle neoplasms. Oral cavity and pharynx are the most common sites for rhabdomyomas origina ting from the head and neck region. The presenting symptom for head and neck rhabdomyomas may change according to tumor size and location. The main treatment modality is total surgical excision.In this study, we aimed to report an adult hypopharyngeal rhabdomyoma case presenting with dysphagia and globus sensation and to discuss head and neck extra-cardiac rhabdomyomas reported in the literature.

Adult Rhabdomyoma of the Tongue in a Child: Report of a Case and a Literature Appraisal.

Rhabdomyoma, by definition is a benign muscle tumour.. Rhabdomyomas constitute 2% of all myogenous neoplasms. This tumour is in incongruence with other benign soft tissue tumours, in that it is rarer than its malignant counterpart. They are broadly categorised as cardiac and extra-cardiac. Three different subtypes exists as 1) the adult type, 2) the fetal type and 3) the genital type, the adult type being the most common.[1] AR (Adult Rhabdomyoma) generally occurs in the 4th and 5th decade with a male predilection.[2] There have been very few presentations of this lesion in the paediatric age group. Here we present a case of lingual adult rhabdomyoma in an 11 year old girl.

Multinodular adult rhabdomyoma in the base of the tongue excised conservatively using submental midline approach with hyoid bone split: A case report

Background: Adult rhabdomyoma (ARh) is a rare benign tumor of skeletal muscle origin. ARh occurs mainly in the head and neck region. This report details the surgical excision of a large multinodular ARh in the base of the tongue that was causing severe sleep apnea. Findings: Magnetic resonance imaging revealed that the base of the tongue was almost completely replaced by a 6 cm × 8 cm tumor. Methods: Conservative surgical excision was done by submental midline approach with hyoid bone split. Results: Surgery improved the patient’s sleep apnea without damaging the swallowing function. The patient was able to secede from nasal continuous positive airway pressure and has remained symptom-free for 12 months postoperatively. Conclusions: This newly designed approach is suitable for excision of benign tumors in the base of the tongue to obtain a patent airway without damaging the function of the tongue base.

Fetal Rhabdomyoma of the Right Tonsil with Polyp-Like Appearance.

Skeletal muscle neoplasms, in contrast to other groups of tumors, are almost malignant. The benign variant, rhabdomyoma, is distinctly rare. Rhabdomyomas can be classified generally into two types: cardiac and extracardiac. Extracardiac rhabdomyoma can be further divided into three subtypes: adult, fetal, and genital type. Adult rhabdomyoma is the most common subtype of rhabdomyoma even though it remains relatively rare. Fetal rhabdomyomas are less common than the adult type. In this paper we report a rare case of a fetal rhabdomyoma with polyp-like appearance originating from right tonsil. Punch biopsy and then right tonsillectomy were performed for complete excision. There was no obvious recurrence.

Crystal storing histiocytosis associated with marginal zone B-cell lymphoma: A rare initial clinical presentation diagnosed by fine-needle aspiration.

Crystal storing histiocytosis associated with marginal zone B-cell lymphoma: A rare initial clinical presentation diagnosed by fine-needle aspiration.

A rare soft tissue tumor masquerading as a parathyroid adenoma in a patient with birt-hogg-dubé syndrome and multiple cervical endocrinopathies.

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder that presents with renal tumors, pulmonary cysts with spontaneous pneumothoraces, and skin hamartomas. We present a case of a 67-year-old female with multiple endocrinopathies and a history of BHD syndrome. In 2011, a thyroidectomy with a four-gland parathyroidectomy was performed for toxic multinodular goiter (TMNG) and parathyroid hyperplasia. On frozen section, a tumor was identified next to a hypercellular parathyroid. After being worked up, this tumor was determined to be an adult rhabdomyoma. This represents the first time that both TMNG and parathyroid hyperplasia have been present in a BHD patient. Additionally, this is the first adult rhabdomyoma reported in a patient with BHD syndrome. Adult rhabdomyomas have no reported associations; however, potential colocation of the mutation in BHD syndrome and translocation in adult rhabdomyomas on chromosome 17p suggests a possible connection. Further work is needed to better understand this connection.

Adult Laryngeal Rhabdomyoma with Extralaryngeal Extension: Surgical Excision and Reconstruction with Aortic Homograft

Objectives:1) Review the presentation, pathology, and treatment of rhabdomyomas. 2) Recognize the potential need for open resection with reconstruction as a treatment of benign laryngeal lesions in rare cases.Methods:A 67-year-old female presented with dyspnea and hoarseness. On examination she had a soft, mobile, centrally-located neck mass. Fiberoptic laryngoscopy revealed a large, submucosal supraglottic mass. Computed tomography (CT) showed a 3-cm supraglottic tumor with extralaryngeal extension. Needle aspiration suggested rhabdomyoma, confirmed by direct laryngoscopy with biopsy. She subsequently underwent awake tracheostomy, hemilaryngectomy, and reconstruction with aortic homograft. Pathology showed adult rhabdomyoma with representative large, polygonal cells with abundant cytoplasm, focal cross-striations, and occasional “strap” cells. Three weeks postoperatively she was decannulated and found to have a functional voice and swallow. After six months of follow-up she is without evidence of recurre...

Adult Rhabdomyoma of the Extremity

Adult rhabdomyoma is a rare benign tumor. It mainly occurs in the head and neck region and rarely occurs outside the head and neck region. We present an extremely rare case of the adult rhabdomyoma arising in the left foot in a 46-year-old male. Microscopically, large polygonal cells and large strap-shaped cells were observed. This is the third case of adult rhabdomyoma arising in an extremity.

Adult Supraglottic Rhabdomyoma with Extralaryngeal Extension: Surgical Excision and Reconstruction with Aortic Homograft

Objectives: 1) Review the presentation, pathology, and treatment of rhabdomyomas. 2) Recognize the potential need for open resection with reconstruction as a treatment of benign laryngeal lesions in rare cases. Methods: A 67-year-old female presented with dyspnea and hoarseness. On examination she had a soft, mobile, centrally-located neck mass. Fiberoptic laryngoscopy revealed a large, submucosal supraglottic mass. Computed tomography (CT) showed a 3-cm supraglottic tumor with extralaryngeal extension. Needle aspiration suggested rhabdomyoma, confirmed by direct laryngoscopy with biopsy. She subsequently underwent awake tracheostomy, hemilaryngectomy, and reconstruction with aortic homograft. Pathology showed adult rhabdomyoma with representative large, polygonal cells with abundant cytoplasm, focal cross-striations, and occasional “strap” cells. Three weeks postoperatively she was decannulated and found to have a functional voice and swallow. After six months of follow-up she is without evidence of recurrence. Conclusions: Laryngeal rhabdomyoma is a rare benign clinical entity, which may present with airway distress and extralaryngeal extent. Treatment is complete surgical excision, possibly requiring open surgery with reconstruction. Aortic homograft reconstruction is safe, is technically straight-forward, and has good postoperative results.

Multifocal Adult Rhabdomyoma of the Head and Neck Manifestation in 7 Locations and Review of the Literature

Background. Adult rhabdomyoma is a rare benign tumour with the differentiation of striated muscle tissue, which mainly occurs in the head and neck region. Twenty-six cases of multifocal adult rhabdomyoma are documented in the literature. Method. We report a 55-year-old male with simultaneous diagnosis of 7 adult rhabdomyomas and review the literature of multifocal adult rhabdomyoma. Result. Review of the literature revealed 26 cases of multifocal adult rhabdomyoma, of which only 7 presented with more than 2 lesions. Mean age at diagnosis was 65 years with a male to female ratio of 5.5 : 1. Common localizations were the parapharyngeal space (36%), larynx (15%), submandibular (14%), paratracheal region (12%), tongue (11%), and floor of mouth (9%). Besides the known radiological features of adult rhabdomyoma, our case showed FDG-uptake in (18) F-FDG PET/CT. Conclusion. This is the first case of multifocal adult rhabdomyoma published, with as many as 7 simultaneous adult rhabdomyomas of the head and neck.

Intraoral Adult Rhabdomyoma: A Case Report

A case of adult rhabdomyoma is reported. The lesion is a rare benign tumor of skeletal muscle origin which occurs predominantly in the head and neck region. In the present case, the clinical diagnosis favored a benign salivary gland tumor. Histologically, the tumor was composed of large round, oval, and polygonal cells of varying size with abundant pale, eosinophilic, fine, granular cytoplasm with peripherally located nuclei. Immunohistochemically, the lesion was positive for muscle-specific actin, smooth muscle actin, desmin, S100 protein, and Masson's trichrome. Electron microscopic examination confirmed the presence of numerous myofibrils. The lesion was treated by surgical resection. The clinical, histological, immunohistochemical, and ultrastructural features are discussed in this study.

A case of multifocal adult rhabdomyoma in the larynx and neck

A case of multifocal adult rhabdomyoma in the larynx and neck