Adult Population Of Russia Research Articles

Comparative Results of Standard Coronary Artery Bypass Grafting, Staged Hybrid Myocardial Revascularization and Purely Endovascular Correction in Patients with Coronary Artery Disease in Long-Term Period after Surgery

INTRODUCTION: Coronary artery disease (CAD) currently remains the leading cause of morbidity and mortality in Russia and in the world. In 2022, the overall morbidity with CAD among the adult population of Russia was 6517.9 per 100 thousand populations. The main surgical methods of treatment for CAD are coronary artery bypass grafting (CABG) and stenting of the coronary arteries. In some cases, a single-step complete revascularization is not possible, and one of solutions is a hybrid approach. AIM: To compare 5-year results of CABG, staged hybrid myocardial revascularization and isolated endovascular intervention in patients with CAD and multi-vessel lesion of the coronary arteries. MATERIALS AND METHODS: The prospective study included 330 patients with CAD and multi-vessel atherosclerotic lesion of the coronary arteries, who underwent planned myocardial revascularization in 2010–2018. Group 1 included 110 patients who underwent CABG, group 2 — 110 patients who underwent staged hybrid myocardial revascularization, group 3 included 110 patients after percutaneous coronary intervention. In 5-year follow-up period, clinical and instrumental data were evaluated, complications, lethal outcomes and re-interventions were considered. RESULTS: In the immediate period after the surgical intervention, frequency of cardiovascular complications and residual myocardial ischemia was expectedly low in all the groups (р 0.05). At 1 year of follow-up, cardiovascular complications were less common in group 2 (17.3%) compared to group 1 (29.1%, p = 0.038), while in group 3, adverse events were also noted in 27.3% of cases, however, the differences were not significant (p = 0.075). At 5 years, the frequency of cardiovascular complications prevailed in patients of group 1 (80.0%) compared to group 2 (57.3%) and group 3 (67.3%, p = 0.001–0.032). At the end of follow-up, the frequency of repeat revascularization was significantly higher in group 1 (41.8%) compared to group 2 (29.1%, p = 0.049). The number of such cases in group 3 (33.6%) was less than in group 1, however, the differences were not statistically significant (p = 0.125). CONCLUSION: Isolated CABG demonstrates a higher frequency of repeat endovascular interventions at 5 years after surgery compared to hybrid revascularization that also provides better results in terms of preventing cardiovascular complications.

Prevalence of gastroesophageal reflux disease in Russia: a meta-analysis of population-based studies

To systematize data on the prevalence of gastroesophageal reflux disease (GERD) in the adult population of Russia. The search for studies was conducted in the electronic databases MEDLINE/PubMed, EMBASE, and RSCI (Russian Science Citation Index) from January 2000 to December 2022. The review included relevant publications in peer-reviewed periodicals in English or Russian, publications with data from cross-sectional epidemiological studies assessing the prevalence of GERD in the Russian population, studies on adult patients with GERD, and publications with detailed descriptive statistics that allow using the data in the meta-analysis. The final analysis included 6 studies involving 34,192 subjects. The overall prevalence of GERD (prevalence of heartburn ± regurgitation once a week or more frequently) in the analyzed studies was 25.605% (95% confidence interval [CI] 17.913-34.147). The analysis used a random effect model, as there was significant heterogeneity between the results in both groups (I2=99.63%; p<0.0001). The overall mean age of GERD patients in the study population was 48.14 (95% CI 32.25-4.03) years. The prevalence of GERD in the male population was 23.653% (95% CI 13.351-35.832) and 25.457% (95% CI 17.094-34.849) in females. This meta-analysis demonstrated that GERD is a common esophageal disease in the Russian population, affecting approximately one in four country residents.

Response to an expert opinion on the article "Association between cardiovascular mortality and deprivation in the adult population of Russia"

Response to an expert opinion on the article "Association between cardiovascular mortality and deprivation in the adult population of Russia", published in the Cardiovascular Therapy and Prevention 2024;23(3):3903, contains comments and explanations for a better understanding of issues raised in expert opinion.

Regional Differences in the Spread of Pneumonia in Russia: A Comparative Spatiotemporal Analysis of the Situation in 2017–2021

Introduction: Pneumonia remains a respiratory disease of concern that keeps influencing morbidity and mortality throughout the world in the 21st century. Increased incidence rates of pneumonia have been registered in Russia for a long time. In this regard, regional surveillance seems relevant across the country for a better understanding of recent spatial differences in the disease spread and their fluctuations. Objective: To carry out a spatiotemporal analysis of regional differences in pneumonia prevalence in the adult population of Russia in 2017–2021 with a focus on pre- and COVID-19 pandemic periods, given the Russian long-term dynamics for 2010–2022. Materials and methods: The study covers the years 2017–2021 with sufficient data on pneumonia prevalence collected. Static and dynamic parameters were calculated for the compared pre- and pandemic periods. A series of cartograms developed using GIS tools made it possible to visualize the information obtained and assess the spatiotemporal situation of the process under study. Results: The long-term dynamics of pneumonia prevalence rates in the adult population in Russia was examined with the regional trends in 2017–2021 assessed. In 2017–2019, they rose in most regions of Russia but the growth rate did not exceed 30 %. In 2019–2021, in the context of the COVID-19 pandemic, the pneumonia situation changed dramatically and the disease rates increased in most regions. A significant deterioration of the situation was observed in most of the European part of Russia with the growth rates ranging from 70 % to 90 %. The number of regions with a null increase in the pneumonia prevalence dropped from 25 to five. Conclusions: Changes in the regional differences in the disease prevalence in the adult population of Russia for 2017–2021 were assessed. The uneven interregional spread of pneumonia complicated during the pandemic compared with the pre-pandemic period. Increased growth rates of the disease prevalence of varying intensity were observed in 80 Russian regions.

Expert opinion on the article "Association between cardiovascular mortality and deprivation in the adult population of Russia"

Экспертная оценка статьи "Ассоциация между смертностью от болезней системы кровообращения и депривацией у взрослого населения России" была выполнена на предмет её соответствия общим критериям качества научных исследований, таких как актуальность для здравоохранения, правильность выбора и использования статистических методов, достоверность и научно-практическая ценность результатов исследования, и отражает исключительно личную позицию рецензента.

Association between cardiovascular mortality and deprivation in the adult population of Russia

According to the Federal State Statistics Service of Russia, from 1970 to 2019, cardiovascular diseases remain one of the main causes of death in Russia. To date, the relationship between cardiovascular mortality and deprivation in Russia remains insufficiently studied.Aim. To identify the relationship between regional deprivation and cardiovascular mortality among the adult population of Russia.Material and methods. The Russian deprivation index was used to measure the deprivation level. The index indicators were obtained from official Rosstat statistics and the All-Russian Population Census for 2010. Cardiovascular mortality by age (five-year groups) and sex in the constituent entities of Russia from 2006 to 2012 was obtained from the Russian database on fertility and mortality of the Center for Demographic Research of the Russian Economic School.Results. The fully adjusted model showed a reduction in mortality (Mortality Rate Ratio (MRR), 0,93; 95% confidence interval: 0,91-0,94) in regions with the greatest overall deprivation compared to the least deprived regions. There is a decrease in mortality in the most socially deprived regions compared to the least deprived ones. The fully adjusted model showed a trend toward increased mortality across levels of economic deprivation (from less deprived (Q2) to more deprived (Q3 and Q4) compared to least deprived regions (Q1)). Our study showed an increase in mortality in the most environmentally deprived regions — MRR, 1,02; 95% confidence interval: 1,00-1,04.Conclusion. The study established a link between general, social, economic and environmental deprivation and cardiovascular mortality.

The investigation of the dynamics of changes in neutralizing antibody titers against type 5 adenovirus in the context of vaccination against a new coronavirus infection

This research focuses on analyzing the dynamics of neutralizing antibody (nAbs) titers against type 5 adenovirus (Ad5) in the adult population of Russia following vaccination against the novel coronavirus infection with recombinant adenovirus type-5 COVID-19 vaccine (CanSino Biologics, China). The impact of the Ad5 vector on nAb titers was investigated using 302 blood serum samples from individuals who received a single dose of the Ad5-nCoV vector vaccine. The research revealed that 33.8% of adults in Russia had pre-existing anti-Ad5 nAbs before the pandemic. Notably, 40% of vaccinated individuals did not exhibit an increase in nAbs titers upon receiving the Ad5-based vaccine. However, in the group with no or low titers of anti-Ad5 nAbs (1:10–1:40), a significant 8-16-fold increase in nAb titers to Ad5 was observed.

Anterior chamber depth and angle and associations in a pediatric and adult population in Russia

PurposeTo investigate the normative data of anterior chamber depth (ACD) and angle (ACA) and their associations in multiethnic cohorts spanning three generations in Russia. MethodsThe study cohort included the participants of three population-based studies performed in urban and rural Bashkortostan/Russia: The Ural Eye and Medical Study (UEMS; age:40+ years), Ural Children Eye Study (UCES; age:6–18 years), and Ural Very Old Study (UVOS; age:85+ years). Using Scheimflug camera-based anterior chamber imaging, we measured ACD and ACA as part of a comprehensive ophthalmological and systemic examination. Exclusion criterion was previous cataract surgery. ResultsThe study included 4869 (98.7 %) children out of 4933 children of the UCES, 5426 (92.0 %) out of 5899 UEMS participants, and 268 (16.3 %) out of 1526 UVOS participants. In the UEMS, shallower ACD (mean:3.14 ± 0.37 mm) correlated (multivariable analysis; r[2] = 0.57) with older age (beta: 0.08;P < 0.001), shorter body height (beta:0.03;P = 0.003), shorter axial length (beta:0.34;P < 0.001), lower corneal volume (beta:0.06;P < 0.001) and corneal refractive power (beta:0.12;P < 0.001), thicker lens (beta: 0.09;P < 0.001), higher IOP (beta: 0.03;P = 0.02), higher prevalence of angle-closure glaucoma (beta: 0.03;P = 0.003) and lower prevalence of open-angle glaucoma (beta:0.03;P = 0.007). Similar associations were found in the UCES (ACD mean:3.70 ± 0.27 mm) and UVOS (ACD mean:2.96 ± 0.56 mm). ConclusionsIn this population-based cohort of three generations from rural and urban Bashkortostan, ACD decreased from the children cohort (mean:3.70 ± 0.27 mm) to the adult cohort (mean:3.14 ± 0.37 mm) and to the very old cohort (2.96 ± 0.56 mm). Determinants of shallow ACD were older age and lower body height, in addition to the ocular biometric parameters of shorter axial length, lower corneal volume, corneal refractive power, and thinner lens thickness.

Associations of the spatial QRS-T angle with clinical, laboratory and echocardiographic parameters in patients with arterial hypertension

Introduction. The prevalence of arterial hypertension (AH) among the adult population of Russia is high; up to 48% of deaths are due to its complications. Recently, prognostic indicators of the electrocardiogram (ECG) have attracted the attention of researchers. One of them is the QRS-T spatial angle (sQRS-Ta).The aim of the work is to study what clinical, laboratory and echocardiographic parameters are associated with increased sQRS-Ta in patients with AH.Material and methods. The study included 240 AH patients (48% men), mean age 62 ± 11 years. The study did not include patients with valvular disease, bundle branch block, preexcitation and ventricular pacing. Orthogonal leads were synthesized from digital ECGs in 12 leads and sQRS-Ta was calculated as a spatial angle between the integral QRS and T vectors. sQRS-Ta ≥ 90° was considered enlarged. We assessed the associations sQRS-Ta ≥ 90° with the following indicators by the method of logistic regression: sex; the presence of cardiovascular diseases; 5 age groups; overweight, obesity; smoking; heart rate (HR); systolic blood pressure (SBP), diastolic blood pressure; pulse blood pressure; blood glucose; total cholesterol; end-diastolic dimension (EDD) of the left ventricle (LV), LV wall thickness, relative LV wall thickness, left ventricular myocardial mass (LVMM), LVMM/body surface area (BSA); LVMM/height in the degree of 2,7, the presence of LV diastolic dysfunction.Results. According to univariate logistic regression, sQRS-Ta ≥ 90° associations were found with age, SBP, obesity, heart rate, LV EDD, LVMM, LVMM/BSA, and LVMM/ height2,7. In multivariate logistic regression models, the contribution of SBP ≥ 140 mmHg (odds ratio (OR) 2,22, 95% CI 1,20–4,10; p=0.01), age 55–64 years (OR 1,87; 1,01–3,44; p=0 .04), increased LV EDD (OR 2,70; 95% CI 1,27–5,72; p=0.01) and HR (OR 2,27; 95% CI 1,10–6,05; p =0.01) was independent.Conclusions. According to multivariate analysis, independent predictors of an increase in sQRS-Ta in patients with AH were SBP ≥ 140 mm Hg, an increase in LV EDD, HR &gt; 80 beats/min, and age 55–64 years.

Acute Cerebrovascular Accident during the pandemic of a new coronavirus infection in the Ural Federal District

Introduction. Acute cerebrovascular accidents are among the leading causes of death and disability in the population. The study of regional features of the incidence of acute disorders of cerebral circulation in the context of a pandemic of a new coronavirus infection COVID-19 is an urgent task. Purpose - to conduct a comparative analysis of the primary incidence of acute disorders of cerebral circulation, including transient ischemic attacks, in the adult population of Russia, the Urals Federal District and the constituent entities of the Russian Federation as part of the Urals Federal District. Materials and methods. A comparative analysis of the primary incidence of acute cerebrovascular accidents in the adult population in the Urals Federal District and in individual subjects of the district during the 2020 pandemic was carried out relative to the average long-term indicators for 2015-2019. Transient transient cerebral ischemic attacks, intracerebral and other intracranial hemorrhages, cerebral infarctions and strokes not specified as hemorrhage or infarction were taken into account. Average long-term levels of primary morbidity, standard deviation, coefficient of variation were calculated. Statistical data analysis was carried out using Microsoft Excel software products. Results. During the COVID-19 pandemic, the levels of primary incidence of certain acute cerebrovascular accidents in the Russian Federation and the Urals Federal District as a whole decreased compared to the long-term averages of 2015-2019. Conclusions. Indicators of primary morbidity of the adult population of the Ural Federal District with certain acute cerebrovascular accidents, including transient ischemic attacks, in different subjects of the district have pronounced regional features. Regional peculiarities of morbidity should be taken into account when planning the volume and financial parameters of territorial programs for the provision of free medical care to citizens. Significant differences in morbidity rates should be in the focus of attention of the chief neurologists of the Ministry of Health of the Russian Federation and the constituent entities of the Russian Federation.

The incidence of tuberculosis and HIV-infection among adult population in Russia

Introduction. Assessment of dynamics of the overall incidence of both tuberculosis and HIV-infection, without a detailed analysis of its distribution by age, is insufficient to understand the current trends and their forecast from the standpoint of achieving WHO and UNAIDS targets in relation to the elimination of tuberculosis (2035) and HIV-infection (2030). The purpose of the study: to study the age characteristics of the incidence of tuberculosis and HIV-infection in the adult population of Russia in dynamics for 2010-2019. Material and methods: retrospective analysis of the incidence of tuberculosis and HIV-infection, and its age structure for 2010-2019. Results: In Russia, in 2010-2019, the incidence of tuberculosis in the adult population (≥ 18 years) has been steadily decreasing. However, analysis of its distribution by age showed that among young groups (25-44 years) its level was higher and reached the maximum value of 84.6 per 100000 of population in the group of 35-44 years. In recent years, an increase in the incidence of HIV-infection was observed in Russia, and its highest values were recorded among patients from young age groups (25-44 years). Limitations of the study. The analysis of the incidence of tuberculosis and HIV infection in the adult population of Russia was carried out both in general for the entire population and in individual age groups for the period from 2010 to 2019, which seemed sufficient to effectively achieve this goal. Discussion: Retention of high incidence of tuberculosis and an increase in the incidence of HIV-infection among patients aged 25-44 is largely due to widespread prevalence of tuberculosis among patients with HIV-infection. Today in Russia every fourth patient with tuberculosis, both newly diagnosed and among the contingents with TB, is a patient with HIV-infection with manifestations of tuberculosis. Conclusion: In Russia over the past 10 years, an increase in the number of newly diagnosed HIV-infected patients with TB manifestations, which are included in the structure of both the incidence of HIV infection and TB, has led to an increase in the incidence of HIV infection and a slowdown in the rate of decline in the incidence of TB among young age groups.

The prevalence of obesity in the adult population in Russia and over the world (literature review)

Introduction. The prevalence of obesity shows a significant gain in rate, which is a serious threat to the entire world community In this regard, special attention should be paid to the problem of rational nutrition and increasing the preventive activity of the population The purpose of study is to analyze the features and dynamics of the spread of the problem of obesity in Russia and over the world, to determine the main directions of prevention of obesity in the adult population. Material and methods. In the course of this study, a retrospective analysis of official statistics of the Ministry of Health and WHO databases was executed. In order to provide a more complete representation of rank distributions and dynamics of indicators, histograms were used, calculated growth coefficients, as well as chain and basic growth rates were used as statistical indicators. Statistical data processing was carried out using SPSS, Excel-2007 packages. Separate methods of literature search were used including the databases Scopus, Web of Science, MedLine, CyberLeninka, RSCI, eLibrary, and analytical, statistical methods, study and generalization of experience, comparative analysis. Results. The analysis showed the lowest level of obesity to be typical for countries with low or lower middle income: (Vietnam (2.1%), India (3.8%), Indonesia (6.9%), Bangladesh (3.4%), Nepal (3.8%), Ethiopia (3.6%), Afghanistan (4.5%)). The maximum level of obesity in 2016 in Europe was recorded in the UK. The maximum value of obesity among adults in Russia is typical for the Siberian Federal District, which is by 1.7 times higher than the average in Russia. The Central Federal District, the North Caucasian Federal District and the Far Eastern Federal District have low values of the obesity index (71.1%, 75.3% and 77.1%, respectively). Conclusion. With the aim of reducing the growth of the morbidity rate of obesity it is necessary to conduct the state adequate preventive measures, strengthening the role health-saving activities and health technologies, and the formation of the motivational attitude to their own health - from the side of man as the subject of health.

Association of COVID-19 lockdown measures with changes in physical activity of the adult population of Russia

Aim. To assess the impact of lockdown measures during coronavirus disease 2019 (COVID-19) pandemic on physical activity (PA) of the adult population in Russia.Material and methods. The online survey was conducted during the period of strict restrictions in Russia from April 26, 2020 to June 6, 2020. The survey involved respondents aged ≥18 years. Participants reported the frequency and duration of moderate to high-intensity PA, as well as walking and other types of exercise, before the pandemic and during the last seven days during the survey period.Results. In the country as a whole, there was a decrease in all types of PA during the pandemic. The proportion of participants who met the World Health Organization recommendations for any type of PA decreased from 68 to 49% (p&lt;0,001). Proportion of those who followed the World Health Organization recommendations for strength training for ≥2 days per week decreased from 53 to 45% (p&lt;0,001).Conclusion. The results of the study are the evidence base to substantiate the feasibility of measures aimed at correcting the lifestyle of the population in the context of the COVID-19 pandemic.

Contribution of cardio-ankle vascular index to prediction of cardiovascular events in the adult urban population: data from the ESSE-RF study (Tomsk)

Aim. To determine the role of cardio-ankle vascular index (CAVI) in predicting cardiovascular events (CVEs) in adult Russian population using model of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study (Tomsk).Material and methods. We analyzed the data of 1342 people aged 25-64 (4,3±11,6) years, in whom arterial stiffness was assessed as part of the ESSE-RF study using the vascular screening system VaSeraVS-1500, followed by phone contacts, on average, 4,7 years later. We studied the prognostic role of CAVI in relation to primary composite (cardiovascular death, nonfatal myocardial infarction (MI) or stroke) and secondary composite (all CVEs) endpoints.Results. We revealed that prior myocardial infarction or stroke (n=52) is associated with an increase in CVE incidence from 2,3 to 11,5% (p=0,0003) and from 5% to 23% (p&lt;0,001) for primary and secondary composite endpoints, respectively. In a group of 1290 people (without prior MI or stroke), CAVI was significantly higher in men than in women: 7,4±1,4 vs 7,1±1,3 (p=0,002), despite more young age: 45,4±11,8 vs 48,0±11,3 years (p&lt;0,001). The risk criterion for CVE was CAVI &gt;7,8 (relative risk (RR): 5,06; 95% confidence interval (CI): 2,32-11,06) (p&lt;0,001) and (RR: 3,95; 95% CI: 2,37-6,58) (p&lt;0,001), which retains its predictive value when adjusted for conventional risk factors (RR: 3,13; 95% CI: 1,26-7,75) (p=0,014) and (RR: 2,16; 95% CI: 1,18-3,98) (p=0,013) — primary and secondary composite endpoints, respectively.Conclusion. CAVI has a significant independent value in predicting CVEs in Tomsk adult urban population aged 25-64 years. To clarify the cardiovascular risk, vascular screening with identifying CAVI should be carried out during preventive and screening examinations for men over 35 and women over 45.

Abdominal obesity and adipocyte metabolic activity: criteria for "health" and "neutrality"

The last decades of the late 20th and early 21st centuries have seen a rapid growth of non-infectious diseases such as abdominal obesity, prehypertension, hypertension, diabetes mellitus type 2. According to official data, preobesity is diagnosed in 40.1% of the adult population of Russia; 21.6% of Russians are obese; and only 36.3% of our fellow citizens have normal body weight. The combination of obesity, hypertension, diabetes mellitus type 2 and atherogenic dyslipidemia are the criteria for metabolic syndrome a proven risk factor for progression and complicated course of cardiovascular disease. The scientific community is actively discussing about the appropriateness of singling out a group of patients with metabolically healthy obesity and criteria for its diagnosis, but the hormonal activity of adipose tissue is not evaluated. Leptin is involved in the metabolism of glucose and fatty acids, and leptinresistance is an important prognostic marker of the complicated obesity. On the based of our own scientific data results, the concept of metabolically neutral obesity - obesity with normal adipokines activity (leptin concentration 3.5 ng/ml) without signs of insulinresistance was formulated and proposed. It was shown that in this metabolic type of obesity the prevalence of dyslipidemia was 1.7 times, prediabetes 2 times, atherosclerosis of common carotid arteries 1.5 times lower than in metabolically healthy obesity. Determining the level of leptin in uncomplicated obesity allows stratifying patients into groups with normal and increased adipokines activity. The highlighting of the metabolically neutral type of obesity is considered by us to be practically justified, as it allows to determine the stage of the disease at which the frequency of metabolic and cardiovascular disorders is still minimal and non-drug prevention is necessary. Exceeding the threshold of leptin level 3.5 ng/ml in obesity may require a more aggressive lifestyle correction, and possibly an early start to drug therapy.

Change in the quality of life of the Russian population as a factor of the value structure transformation

Based on the empirical data from the sociological study conducted in 2012 and 2019, the article analyzes the nature of transformations in the value structure by the adult population of Russia and how they were impacted by the changes in the quality of life over 7 years.Factor analysis is used in the article to reveal the changes in the typological values structure of the adult Russian population in 2012 and 2019. It is shown that in 2012 it was predominantly “materialistic” (according to R. Inglehart). The value of Active patriotism was the most significant. The value of hedonistic prosperity was of high importance, perceived as a desire for material prosperity for the sake of comfortable life. The family was of great importance. The significance of “postmaterialistic” values, i.e. creativity and freedom, was low. Bellicose patriotism was presented in the structure of values, but with low significance.The change in the value structure of the Russian population that occurred in 2019 is revealed. Although it remained predominantly “materialistic”, it underwent significant changes in comparison with 2012. The value of active patriotism remained the most significant for people, and the value of Bellicose patriotism rose to the second place from the fifth one, which was due to the changes that had taken place in the economic and political situation in relation to Russia in the world over seven years, and sanctions pressure on it. High importance of the Family and Hedonistic prosperity was preserved. “Post-materialistic” values of freedom and creativity remained insignificant. Transformation of the value structure of the Russian population from “materialistic” to “post-materialistic” did not occur. The transformation nature of the value structure by Russian population under the influence of changes in the state of the perceived quality of life is revealed. In 2012, physical and social activity of the Russian population had the highest level in comparison with other components. The role of physical and emotional problems in limiting the life of people and their subjective pain were at the mid-level. A relatively low level was characteristic for the mental and general health of people and their vitality. In 2019, the state of many parameters characterizing the quality of life of the population changed. Physical and social activity of people increased, and the role of physical and emotional problems in limiting their daily life and subjectivepain sensations decreased. However, it was conjoined by the same relatively low level of indicators for mental and general health of people, their vitality.In2012,the state of people’s quality of life influenced the formation of only a few values; Active patriotism, the state of which was determined by all components of people’s quality of life and was a powerful factor in the formation of this value; the significance of Bellicose patriotism was influenced only by the state of people’s physical activity; the significance of hedonistic prosperity and creativity, fundamental values — family and self-preservation — also did not depend on the state of people’s quality of life.In2019,the nature of the quality of life impact on the formation of the value structure of the Russian population changed; its impact on the importance of active patriotism, hedonistic prosperity and self-preservation increased. The quality of life ceased to influence the formation of the significance of bellicose patriotism, its level did not depend on the state of people’s quality of life.Thus,in 2019 the change in the state of the people’s perceived quality of life led to the transformation in the structure of their values. At the same time, a decrease or increase in their importance was influenced by the change of the socio-economic state of people and the international position of Russia, which in turn affected the state of their quality of life. Taken together, these parameters make up the social mechanism for the formation of the value structure of the population of Russia.

Распространение ожирения в различных социально-демографических группах населения России

Распространение ожирения в различных социально-демографических группах населения России

The transit of Russian nation nutrition at the turn of the 20th and 21st centuries

The assessment of the individual dietary intake of the population acquired critical importance in the Russian Federation when implementing socio-economic reforms in the 1990s. This was due to the difficulties of the transition period from a planned economy to market relations, which was reflected in a decrease in the level of the socio-economic condition of the population. The purpose of this study was to analyze objective and reliable information about the nature of consumption of nutrients and energy, as well as food products by the adult population of Russia in the period 1994-2018. Material and methods. The paper analyzes and summarizes the results of sample surveys of household budgets conducted by the Federal State Statistics Service (Rosstat) in 1991-2018 and of large-scale epidemiological studies of the actual dietary intake of the population of the Russian Federation, which are presented by the data of the "Russian Longitudnal Monitoring Surveys" (RLMS) in 1994-2012 and large-scale nutrition surveys conducted by Rosstat in all constituent entities of the Russian Federation in 2013 and 2018. All nutrition surveys were carried out according to a unified methodology for collecting, processing and reporting actual data developed at the Federal Research Center of Nutrition, Biotechnology and Food Safety. Using a unified methodological basis allows us to build an analysis of the dietary intake of the population for the period from 1994 to 2018. Results. The objective data on the consumption of energy, nutrients, individual and aggregated groups of food products were analyzed depending on a number of socio-demographic and socio-economic variables that determine the nutrition pattern of the population of the Russian Federation during the period of economic reforms in the 1990s and 2000s. According to budget surveys, over the past years, the structure of the diet in households has changed significantly: the consumption of potatoes decreased by 45% and bakery products by 6%, the consumption of fish and fruits almost doubled, the consumption of meat products increased by 60%, of vegetables by 20%. According to epidemiological studies, the fat content increased from 31 to 36.8% of calorie content, the protein content didn't changed significantly, although in recent years there has been a tendency to increase to 12.1% of calorie content. The average per capita consumption of protein and fat by adults, including saturated fat acids were significantly higher in 2005-2018, compared with the 1990s, both in absolute quantities and in per cents of the caloric intake. At the same time, the consumption of total carbohydrates in per cents of the calorie intake and the amount of dietary fiber in the diet decreased. Parallel to fat intake changes, an increase in the prevalence of overweight and obesity in the adult population has been shown. A consistent decrease in adult consumption of added sugar in per cents of the total calorie intake was revealed from 14.0% in 1994 to 12.3-12.8% in 2012-2018. Changes in the structure of energy consumption and macronutrients are due to changes in the structure of the food ration set that have occurred over the years of observation. The total consumption of dairy products in terms of milk increased: the consumption of the amount of dairy products (drinks and "spoons"), curd products and cheeses increased, only the consumption of drinking milk did not change. In 2012 and 2013 consumption of meat products and sausages was significantly higher than in previous years. There was an increase in the consumption of fish, vegetables, fruits, fats and oils, juices in the 2000s compared with the 1990s. On the contrary, over the years of observation, a consistent decrease in the consumption of the total grain products was observed. These changes in the consumption of macronutrients and foods are a characteristic feature of the transition period from "poor" to "rich" dietary intake and the increase in 2000s in the diet energy density due to an increase in the proportion of fat and a decrease in the proportion of carbohydrates, which contribute to weight gain and an increase in the prevalence of overweight and obesity. The dependence of the structure of the diet on the economic situation of the family has been established, which implies the problem of malnutrition, both general malnutrition and insufficient intake of micronutrients (vitamins and minerals), in poor families. Conclusion. An assessment of the current nutritional status of the Russian population implies a double burden of disruption, determined both by the simultaneous presence of malnutrition problems and the increase in the prevalence of overweight and obesity.

The social economic indices of regions and population morbidity of myocardium infarction

In Russia, in recent decades, there were regional gapping in terms of social inequality and high level of morbidity and mortality in comparison with European countries. The high morbidity and mortality of population in the Russian Federation from diseases of circulatory system on one hand, and regional differences in terms of social economic status on the other hand, determined the purpose of the study. In order to evaluate relationship between social economic status of regions of the Russian Federation and incidence rate of myocardial infarction, the analysis was applied to standardized data of adult morbidity in classes of acute myocardial infarction and repeated myocardial infarction. Also was evaluated a number of social economic indices that reflect state and conditions of life of population. The statistical analysis was applied using MS Excel and Statistica 6 software. The critical significance level of null statistical hypothesis was established as p=0.05. When analyzing morbidity of adult population of Russia with acute and repeated myocardial infarction, significant regional differences were established. The seven factors were identified that statistically significantly affect morbidity rate of the adult population with myocardial infarction, which made it possible to divide the regions into four clusters, between which differences in morbidity rate of acute myocardial infarction were revealed. The analysis of morbidity of acute and repeated myocardial infarction established significant regional differences such as in 2017 7.7 times for acute myocardium infarction and 61 times for repeated myocardium infarction. The allocation of regional clusters depending on their social economic status allows to supplement regional and federal projects with risk-oriented technologies with purpose of decreasing morbidity of diseases of circulatory system.

P0082CHARACTERISTICS OF ADULT PATIENTS WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME IN RUSSIA

Abstract Background and Aims Atypical hemolytic uremic syndrome (aHUS) is complement mediated thrombotic microangiopathy (TMA), caused by genetic abnormalities in the complement gene cluster. Information about the course of aHUS in the adult population in Russia is not enough accumulated. This study presents the characteristics of Russian adult patients (pts) with aHUS. Aim To assess the characteristics of adult pts with aHUS in Russia. Method statistical analysis of retrospective and prospective data The study included 243 pts with acute TMA (microangiopathic hemolytic anemia, thrombocytopenia, decreased haptoglobin and / or blood schizocytosis, kidney damage) from different regions of Russia. All patients were tested for ADAMTS-13 activity, and there were no accidents of TTP in our study. Cases of acute TMA associated with pregnancy and childbirth (n=134), systemic diseases (n=10), anticancer drugs treatment (n=1) and sepsis (n=13) were excluded. 85 pts with diagnosis of aHUS were selected for further analysis. Results Characteristics of pts are presented in table 1. The average age at the time of acute episode was 32.4 years, the disease was equally common among men and women. Relapsing course was rare (n=11, 13%), the maximum number of relapses – 5. In the debut, 67.8% of pts had signs of kidney damage, in 21% - gastrointestinal tract, 4.8% - CNS, 4.8% - pulmonary thromboembolism, 1.6% - visual impairment. During the acute episode, extrarenal manifestations were detected in 70% of pts, while in 38 cases (44.7%), multiple organ failure (MOF) developed with simultaneous damage from 3 to 7 organs. The most commonly observed symptoms of gastrointestinal lesions (n = 39, 45%), CNS (n = 32, 37%), heart (n = 18, 21%), less often - the organ of vision (n = 10, 12%). Kidney damage was characterized by the development of AKI in 70%, in the rest - urinary syndrome, arterial hypertension, the initial signs of renal dysfunction in various combinations. A morphological examination of kidney was performed in 40 pts (kidney biopsy - 35, autopsy - 5): acute TMA was detected in 28 pts (70%), chronic TMA - in 7 (17.5%), a combination of acute and chronic TMA - in 2 (5%), a combination of IgA-nephropathy and TMA - in 1 case (2.5%) and in 2 patients a membrane-proliferative glomerulonephritis pattern with TMA. Genetic analysis was performed in 19 pts (22%), in 7 of which (37%) identified gene variants associated with the development of aHUS (C3 in 3 pts, CFHR5 in 2 pts, CFH in 2, in 1 case - MCP and in 1-DGKE). In addition, variants of genes of the complement system with an unclear clinical value were found in all pts (n = 19). 72% of pts (n = 61) needed renal replacement therapy, almost all pts received plasma therapy (83%) and anticoagulants (85%). Only 13 pts (15%) received complement-blocking therapy with eculizumab. In the outcome of the acute episode in 12 cases (14%) renal function fully recovered, in 20 pts (23%) signs of renal dysfunction persisted (CKD 2–4 stages), 53 pts (62.3%) reached ESRD, 10 pts died (12%). Conclusion The features of aHUS in our cohort were: 1. Severe course with the development of MOF in 45% of cases 2. High frequency of ESRD in the outcome of aHUS (62.3%) 3. The incidence of genetic mutations (37%) is comparable to foreign cohorts