The objective of this study is to assess the knowledge and practice of taking the annual influenza vaccine among adult diabetic patients in BDF Hospital. The study is a descriptive cross-sectional hospital-based study. Three hundred diabetic patients who were eligible for the study were interviewed, using a structured questionnaire. Results of the survey indicated that males and females included are 48% to 52% respectively, 95.3% of the cohort were doing follow up, but only 55.3% were doing it regularly. Although 65.3% are aware and have heard about the flu vaccine only 10% have taken the flu vaccine in the last 2 years. Only 27.3% were advised to take the flu vaccine, 30% of the study population know that the vaccine helps reduce the flu illness and 47.33% know that it helps prevent seasonal influenza. From our study, it was found that the main reason for not taking the flu vaccine is that they mainly did not know about the vaccine which constituted 49.33% of the study population. So, knowledge and use are lower than optimal compared to the literature but here it is the lowest, which may mostly be due to reduced awareness of the benefits of the vaccine and vaccination. This will most probably increase if there are increased efforts on advising direct contacts with the patients in the diabetic or other PHC clinics or through the media, to have the seasonal flu vaccine. Keywords: Influenza vaccine, diabetes patients