The ability to consistently fabricate dimensionally accurate, custom-made, removable orthodontic appliances in large quantities is a manufacturing challenge that has only recently been met through advances in scanning and automation technology. The production of the Invisalign orthodontic appliance 1 Wong B. Invisalign A to Z. Am J Orthod Dentofacial Orthop. 2002; 121: 540-541 Abstract Full Text Full Text PDF PubMed Scopus (91) Google Scholar , 2 Miller R.J. Derakhshan M. The Invisalign system case report of a patient with deep bite, upper incisor flaring, and severe curve of Spee. Semin Orthod. 2002; 8: 43-50 Abstract Full Text PDF Scopus (19) Google Scholar , 3 Miller R.J. Duong T. Derakhshan M. Lower incisor extraction treatment with the Invisalign system. J Clin Orthod. 2002; 36: 95-102 PubMed Google Scholar , 4 Boyd R.L. Miller R.J. Vlaskalic V. Three-dimensional diagnosis and orthodontic treatment of complex malocclusions with the Invisalign appliance. Semin Orthod. 2001; 7: 274-293 Abstract Full Text PDF Scopus (74) Google Scholar , 5 Miethke RR (editor), Boyd R, Brachwitz J, John HD, Kuo E, Kuch A, et al. Sonderheft Invisalign. Kieferorthopadie 2001;15:3-58 Google Scholar , 6 Owen III, A.H. Accelerated Invisalign treatment. J Clin Orthod. 2001; 35: 381-384 PubMed Google Scholar , 7 Vlaskalic V. Boyd R.L. Orthodontic treatment of a mildly crowded malocclusion using the Invisalign system. Aust Orthod J. 2001; 17: 41-46 PubMed Google Scholar , 8 Boyd R.L. Miller R.J. Vlaskalic V. The Invisalign system in adult orthodontics mild crowding and space closure cases. J Clin Orthod. 2000; 34: 203-212 Google Scholar (Align Technology, Inc, Santa Clara, Calif) is a complex process that uses innovative solutions to accurately and efficiently fabricate orthodontic appliances.