Adult Growth Research Articles

Leadership at the Intersection of Healthcare and Constructive Developmental Theory: A scoping review

Objective: The purpose of this scoping review was to examine the nature and extent of the evidence for the use of a stage theory of adult development, Constructive Developmental Theory (CDT) within healthcare leadership. Design: A systematic methodology was employed, utilising inclusion and exclusion criteria and searching across seven databases. Main Outcome Measures: Summary of literature in response to three key questions. Results: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Scoping Reviews (PRISMA-ScR) flow diagram illustrates the study selection process with 154 records screened, 35 full-text articles assessed for eligibility and 7 studies included in the final analysis. Three themes emerged from the data: (1) healthcare as a complex system, (2) complexity of leadership in healthcare, (3) developmental leadership progression in healthcare. Conclusions: This review highlighted that CDT could provide a roadmap for individual change and adult developmental growth, thereby supporting the opportunity for more complex thinking and perspective taking within healthcare leadership. For the healthcare leader, the benefit of an awareness, understanding and application of CDT, is the potential for an increased capacity for recognising and dealing with complex challenges both personally and professionally. The study protocol is registered with Open Science Framework (OSF)

How much do you need to survive? Minimal nutritional levels to complete the development on Aedes aegypti (Diptera: Culicidae)

Aedes aegypti mosquito larvae develop in various aquatic microhabitats, including water-holding tires, cups and bottles. These environments may vary in nutritional characteristics, an important factor for the development of larvae and resulting adult mosquitoes. Compromised larval nutrition can result in developmental failure or affect the growth and reproductive capacity of adults. Understanding these nutritional necessities can help optimize the laboratory rearing of mosquitoes. We tested the effects of sixteen (0, 0.0013, 0.0033, 0.0066, 0.0133, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.1, 0.15, 0.2, 2 g/L) different food concentration treatments of Spirulina Alcon® larval diet on larval survival and life history characteristics of Ae. aegypti. The experiment was conducted under controlled conditions, with a temperature of 27 ± 2ºC, relative humidity of 70–80 % and a photoperiod of 12:12 h. A total of 623 (43.26 %) of the initial 1440 Ae. aegypti individuals died during the experiment. Survival curves differed significantly among food concentration treatments (Chi-Square Test = 1271, df = 15, p < 0.001). The concentrations of 0.025 (60/66.66 %) and 0.03 g/L (67/74.45 %) had the lowest survival rates and 0.15 g/L (76/84.45 %) the highest. The concentrations of 0.025 and 0.03 g/L had the shortest larval development times (8.80; 8.86 days) and longevity (9.95; 8.70 days), but adult sizes were smallest for 0.025 (3.00 mm) and largest for 0.03 (3.15 mm). The concentration of 0.15 g/L had the longest larval development time (9.59 days) and longevity (12.41 days), with intermediate adult size (3.09 mm). Laboratory survival rates for Ae. aegypti are generally associated with high mortality on low-quality and low-quantity of resources. Nutritional stress was found to impair larval development, as well as adult size and longevity. Analyzing responses to different feeding regimes is important for understanding the main mechanisms involved in larval development and the requirements for optimizing mosquito rearing systems.

1인 가구 청년의 독립생활을 통한 성장 경험

Recently, single-person households have surged across all age groups, including young adults, and there is a strong need from a social welfare perspective to understand the implications of this type of independent living in terms of human growth. Thus, this study would explore the growth experience of single young households through independent lives in depth. To gather data, this study interviewed 12 young individuals, meeting the study’s criteria, for a total of 26 hours, two sessions per each person. The study employed thematic analysis and constant comparative methods to reconstruct the participants’ experiences and perspectives. As a result, the meanings of growth experience through the independent living of single young households were identified along with five upper categories: ‘Leaving the original family and growing up in confusion,’ ‘Worries accumulated soon while enjoying freedom,’ ‘Taking a life path without minding others,’ ‘Worthy values learned while living alone,’ ‘Desiring a better world that embraces young independence,’ and the central theme of ‘Living as an adult firming up, weaving the world with my hands after leaving the nest.’ Based on these findings, recommendations were provided to enhance the quality of life and support the growth of young adults residing independently in single-person households through social welfare policies and practices.

Phenotyping and Identification of Molecular Markers Associated with Leaf Rust Resistance in the Wheat Germplasm from Kazakhstan, CIMMYT and ICARDA.

Leaf rust (LR) is the most widespread disease of common wheat worldwide. In order to evaluate leaf rust resistance, 70 uncharacterized wheat cultivars and promising lines with unknown leaf rust resistance genes (Lr genes) were exposed to Kazakhstani Puccinia triticina (Pt) races at the seedling stage. Field tests were performed to characterize leaf rust responses at the adult plant growth stage in the 2020-2021 and 2021-2022 cropping seasons. The wheat collection showed phenotypic diversity when tested with two virulent races of Pt. Thirteen wheat genotypes (18.6%) showed high resistance at both seedling and adult plant stages. In most cases, breeding material originating from international nurseries showed higher resistance to LR. Nine Lr genes, viz. Lr9, Lr10, Lr19, Lr26, Lr28, Lr34, Lr37, Lr46, and Lr68, either singly or in combination, were identified in 47 genotypes. Known Lr genes were not detected in the remaining 23 genotypes. The most commonly identified resistance genes were Lr37 (17 cultivars), Lr34 (16 cultivars), and Lr46 (10 cultivars), while Lr19, Lr68, Lr26, and Lr28 were the least frequent. Four Lr genes were identified in Keremet and Hisorok, followed by three Lr genes in Aliya, Rasad, Reke, Mataj, Egana and Almaly/Obri. The molecular screening revealed twenty-nine carriers of a single Lr gene, ten carriers of two genes, six carriers of three genes, and two carriers of four genes. Most of these accessions showed a high and moderate level of APR (Adult plant resistance) and may be utilized for the incorporation of Lr genes in well-adapted wheat cultivars. The most effective combination was Lr37, Lr34, and Lr68, the carriers of which were characterized by a low disease susceptibility index. The obtained results will facilitate breeding programs for wheat resistance in Kazakhstan.

Dysbiosis of gut microbiota by actual long-term exposure to textile wastewater treatment plant effluents in adult zebrafish (Danio rerio) using aquatic microcosm systems

In the future, textile industry wastewater may create greater possibilities of releasing emerging contaminants into aquatic environments. Research on textile dyeing wastewater has focused on its adverse effects on biota. However, the effects of textile wastewater on gut microbiome and host health have not yet been elucidated, especially for the toxic assessment of combined pollutants under receiving water environment conditions. During this study, adult zebrafish were exposed to realistic textile wastewater treatment plant (TWTP) effluents in aquatic microcosm systems (AMS) for six months, a histopathological examination was performed, after which 16S rRNA and metagenomic sequencing of the intestinal microbiota was conducted and fish growth performance was also examined. As a result of exposure to TWTP effluents, adult zebrafish growth was significantly inhibited, the condition factor was exacerbated, and mortality was significantly increased. Also, significant alterations were observed in zebrafish guts after chronic exposure, which are the opportunistic pathogens Flavobacterium, Aeromonas, and Escherichia. The chronic effects of increased probiotic Cetobacterium, Bacteroides, and Planctomyces deserve further attention. Metagenomic sequencing also showed that genes of core metabolism pathways were affected by TWTP effluent exposure. The study has, for the first time, demonstrated gut microbiota's susceptibility and host health of adult zebrafish to TWTP effluents using aquatic microcosm systems, which are assumed to be clean, thus warranting additional research to reveal their mode of toxicity.

A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants.

Previous computer models have successfully predicted cardiac growth and remodeling in adults with pathologies. However, applying these models to infants is complicated by the fact that they also undergo normal, somatic cardiac growth and remodeling. Therefore, we designed a computational model to predict ventricular dimensions and hemodynamics in healthy, growing infants by modifying an adult canine left ventricular growth model. The heart chambers were modeled as time-varying elastances coupled to a circuit model of the circulation. Circulation parameters were allometrically scaled and adjusted for maturation to simulate birth through 3 yrs of age. Ventricular growth was driven by perturbations in myocyte strain. The model successfully matched clinical measurements of pressures, ventricular and atrial volumes, and ventricular thicknesses within two standard deviations of multiple infant studies. To test the model, we input 10th and 90th percentile infant weights. Predicted volumes and thicknesses decreased and increased within normal ranges and pressures were unchanged. When we simulated coarctation of the aorta, systemic blood pressure, left ventricular thickness, and left ventricular volume all increased, following trends in clinical data. Our model enables a greater understanding of somatic and pathological growth in infants with congenital heart defects. Its flexibility and computational efficiency when compared to models employing more complex geometries allow for rapid analysis of pathological mechanisms affecting cardiac growth and hemodynamics.

Somatic Growth and Maturity for Four Species of River Cooter Including Pseudemys concinna suwanniensis, P. nelsoni, P. peninsularis, and P. texana.

Pseudemys is a genus of commonly occurring freshwater turtles with limited growth information across their long lifespans. We used 11,361 mark-recapture events to estimate the somatic growth rates of P. nelsoni, P. peninsularis, P. concinna suwanniensis, and P. texana from freshwater springs and developed a Bayesian growth model to estimate the species-specific, site-specific, and individual effects on growth. We corroborated evidence for fast juvenile growth and slower adult growth in Pseudemys but found uncommonly fast growth rates, with turtles doubling or tripling in size in the first year. P. texana males had the smallest average maximum size (L∞, 243 mm), while P. c. suwanniensis females had the largest (423 mm). Environmental conditions at springs had significant effects on k, the growth coefficient, but not L∞. We derived, using a ratio of length at maturity to L∞ (71.7% and 87%, males and females), that females matured 1.15-1.57 times older than males except for P. c. suwanniensis, which matured three times older. Given the local abundance declines in many Pseudemys from anthropogenic impacts, this study provides important baseline life history information for Pseudemys species for use in ongoing conservation efforts and presents a novel hierarchical modeling approach using a long-term mark-recapture dataset.

Goal pursuing styles and the emergence of post-traumatic growth: a study with Hong Kong young adults under the ‘double hit’ of social movement and COVID

ABSTRACT Between 2019 and 2020, Hong Kong faced a mental health crisis due to the Anti-Extradition Law Amendment Bill social movement and the COVID-19 pandemic. This study explored post-traumatic growth (PTG) in young adults in Hong Kong who experienced these challenges. We focused on two goal-pursuing styles, tenacious goal pursuit (TGP) and flexible goal adjustment (FGA), and their impact on cognitive processes related to PTG. Our findings revealed that high FGA, coupled with a greater perceived impact of the social movement, led to increased reflective rumination and subsequently higher levels of PTG. These results emphasize the significance of FGA and the perceived impact of the social movement in promoting constructive cognitive processes and PTG.

Hormonal changes in veterans with Gulf War Illness

AimsGulf War Illness (GWI) is a multi-system condition of complex etiology and pathophysiology without specific treatment. There is an overlap between the symptoms of GWI and endocrinopathies. This study aimed to identify hormonal alterations in 1990–91 Gulf War (GW) veterans and the relationship between GWI and hormonal dysregulation. Main methodsData from 81 GW veterans (54 with GWI and 27 controls without GWI) was analyzed in a cross-sectional, case-control observational study. Participants completed multiple questionnaires, neuropsychiatric assessments, and a comprehensive set of hormone assays including a glucagon stimulation test (GST) for adult growth hormone deficiency (AGHD) and a high-dose adrenocorticotropic hormone (ACTH) stimulation test for adrenal insufficiency. Key findingsThe GWI group had lower quality of life and greater severity of all symptoms compared to controls. Pain intensity and pain-related interference with general activity were also higher in the GWI group. AGHD was observed in 18 of 51 veterans with GWI (35.3 %) and 2 of 26 veterans without GWI (7.7 %) (p = 0.012 for interaction). Veterans with GWI also exhibited reduced insulin-like growth factor 1 (IGF-1) levels and IGF-1 Z-scores compared to controls. One participant with GWI met the criteria for adrenal insufficiency. No significant changes were observed in other hormonal axes. SignificanceThe frequency of AGHD was significantly higher in veterans with GWI compared to controls. Recombinant human growth hormone replacement therapy (GHRT) may become a breakthrough therapeutic option for this subgroup. A large clinical trial is needed to evaluate the efficacy of GHRT in patients with GWI and AGHD.

Evidence for energy reallocation, not oxygen limitation, driving the deceleration in growth of adult fish.

The lifetime growth of almost all fishes follows a biphasic relationship - juvenile growth is rapid and adult growth subsequently decelerates. For a trend that is so ubiquitous, there is no general agreement as to the underlying mechanisms causing adult growth to decelerate. Ongoing theories argue that adult growth slows because either the gills fail to supply the body with surplus oxygen needed for continued somatic gain (i.e. oxygen limited), or sexual maturation induces a switch in energy allocation towards reproduction and away from growth (i.e. energy limited). Here, we empirically tested these notions by tracking the individual growth trajectories of ∼100 female Galaxias maculatus, ranging in size, during their first 3 months of adulthood. At a summer temperature of 20°C, we provided subsets of fish with additional energy (fed once versus twice a day), supplementary oxygen (normoxia versus hyperoxia), or a combination of the two, to assess whether we could change the trajectory of adult growth. We found that growth improved marginally with additional energy, yet remained unaffected by supplementary oxygen, thereby providing evidence for a role for energy reallocation in the deceleration of adult growth. Interestingly, additional dietary energy had a disproportionately larger effect on the growth of fish that matured at a greater size, revealing size-dependent variance in energy acquisition and/or allocation budgets at summer temperatures. Overall, these findings contribute towards understanding the mechanisms driving widespread declines in the body size of fish with climate warming.

Case Study of a Literature Therapy Program for Post-Traumatic Growth of Young Adults Who Experienced Parental-Bereavement -Using “Simcheongjeon”-

Case Study of a Literature Therapy Program for Post-Traumatic Growth of Young Adults Who Experienced Parental-Bereavement -Using “Simcheongjeon”-

Divergent selection for timing of vegetative phase change

AbstractVegetative phase change is a key trait in plant development and marks the transition from juvenile to adult growth phases. In maize (Zea mays L.), juvenile plants and plants with a late phase change can be identified by the increased production of tillers, aerial roots, and distinctive epicuticular wax. Resistance to agronomically significant pathogens can also differ between juvenile and adult plants. Using last leaf with juvenile wax as the target of selection, the maize population Minnesota 11 underwent 16 cycles of divergent selection. The objectives of this research were to identify emergent trends for each trait and to determine the magnitude and direction of phenotypic changes over long‐term selection compared to the source population. Phenotypic data on plant architecture traits, ear traits, and common rust resistance were collected in 2020 and 2021 by concurrently growing plants from selection cycles representing both directions of selection. Last leaf with juvenile wax, the direct target of selection increased to leaf 17.8 in the late phase change population and decreased to leaf 5 in the early phase change population from leaf 9 in the source population. Late vegetative phase change was positively correlated with increased common rust infection and plant height, and negatively correlated with ear size traits. This study shows that the observed phenotypic changes follow patterns of genetic variation consistent with divergent selection, but with possible effects of inbreeding.

Factors affecting effectiveness of teaching activities for adult education in China’s Henan Province

With China's economic development and social progress in recent years, people must improve their work skills through adult education in order to meet market demands. This paper will take Henan Province as an example, Adult education is crucial for the improvement of the population's knowledge base and for the economic development of Henan Province.
 The PLS-SEM model and OLS regression model are used to conduct questionnaires and in-depth interviews with the target population in Henan Province. The survey results are analyzed qualitatively and quantitatively by SPSS software. allowing the research conclusion to be drawn.
 The final results of this paper show that motivation is relatively strongly associated with adult learning satisfaction and personal growth, whereas age, time, situational barriers, and environmental barriers are associated with adult learning satisfaction and personal growth.

Home care aides' perspectives of occupational tobacco smoke exposure: A Q methodology study.

The increased growth of older adults has generated demand for home care aides (HCAs). Occupational tobacco smoke exposure (OTSE) may risk their health that should be paid attention to. This study explored the HCAs' perspectives of OTSE to inform health promotion programs catering to individual needs. A two-stage Q methodology was employed for data collection and analysis. 39 Q statements were extracted in the first stage and then 51 HCAs with OTSE were recruited to complete Q sorting in the second stage. PQ Method software was used for data analysis. Principal component analysis was performed to determine the most appropriate number of factors. The five factors identified from HCAs' perspective of OTSE explained 51% of the variance. The HCAs agreed that OTSE could increase cancer risk. The HCAs with Factor I did not care about OTSE, tending to complete their work. The HCAs with Factor II agreed the health hazards of OTSE, but did not know how to help their clients stop smoking. The HCAs with Factor III cared about OTSE but were afraid of disrupting the client-provider relationship. The HCAs with Factor IV regarded OTSE as a priority for occupational interventions whereas the HCAs with Factor V did not think OTSE was an issue and believed that they could balance work and OTSE health hazards. Our findings will inform the design of home care pre-service and on-the-job training courses. Long-term care policies should be developed to promote smoke-free workplaces. There are five types of home care aides' perspective on occupational tobacco smoke exposure (OTSE). The tailor interventions can be developed to help them avoid the OTSE (e.g., opening windows for ventilation or using air purification equipment) and have an OTSE-free spaces.

Ponderal Index: An Important Anthropometric Indicator for Physical Growth

The Ponderal Index (PI) is an essential measure to study physical growth of fetus, infants, newborn babies, adolescents, and adults. Lower PI is found among the malnourish infants and newborn babies and higher in obese ones. PI is also applied in maternity treatment to detect impaired fetal growth. Neonatal PI is essential to identify the effects of gestation age, sex, and maternal parity. In this study aspects of Ponderal Index (PI) are discussed to increase the measurement area for the reduction of risk factors of the infants and children morbidity and mortality.

Susceptibility of processed and stored cassava, plantain, yam, and cocoyam to coffee bean weevil (Araecerus fasciculatus De Geer)

BackgroundCoffee bean weevil (Araecerus fasciculatus DeGeer) (Coleoptera: Anthribidae) infestation is a major challenge affecting processed, dried, and stored foods globally. However, the growth performance of this insect pest in processed and stored cassava, plantain, yam, and cocoyam is poorly understood. Resolving this will guide future biotechnological efforts on these food products. In the study, the susceptibility rate of the processed and stored product of cassava, yam, cocoyam, and plantain to the growth performance of the coffee bean weevil at laboratory conditions (20 ± 5 °C and 70 ± 5% R.H.) was investigated. The anti-nutritional (phytate, alkaloids, saponin, tannin, and oxalate) contents of this stored food were used to characterize the survival rate of A. fasciculatus. The study was carried out for 6 months between December 2012 and May 2013.ResultsResults show that the adult longevity, growth, and feeding of the adult A. fasciculatus decrease in order from Cassava, Plantain, Yam to Cocoyam. Cocoyam has the highest tannin, alkaloid, and phytate values, which are possible factors that inhibited the growth of the larvae, pupae, and adults’ A. fasciculatus. The highest weight loss occurred in cassava followed by plantain. The anti-nutritional factors determine the hatchability of the A. fasciculatus eggs and throughout its development stages. This study revealed that processed and stored products (e.g., cocoyam) with high anti-nutritional factors can survive A. fasciculatus under prolonged storage.ConclusionsFrom this study, it is observed that high anti-nutritional compounds in the stored food products inhibit the growth of Araecerus fasciculatus, especially in cocoyam. The result is important in food security and management in developing countries where food insecurity has become a major challenge.

Metabolic and quality of life effects of growth hormone replacement in patients with TBI and AGHD: A pilot study

ObjectiveTraumatic brain injury (TBI), a common cause of adult growth hormone deficiency (AGHD), affects 20% of Veterans returning from Iraq and Afghanistan (OEF/OIF/OND). Growth hormone replacement therapy (GHRT) improves quality of life (QoL) in AGHD but remains unexplored in this population. This pilot, observational study investigates the feasibility and efficacy of GHRT in AGHD following TBI. DesignIn this 6-month study of combat Veterans with AGHD and TBI starting GHRT (N = 7), feasibility (completion rate and rhGH adherence) and efficacy (improvements in self-reported QoL) of GHRT were measured (primary outcomes). Secondary outcomes included body composition, physical and cognitive function, psychological and somatic symptoms, physical activity, IGF-1 levels and safety parameters. It was hypothesized that participants would adhere to GHRT and that QoL would significantly improve after six months. ResultsFive subjects (71%) completed all study visits. All patients administered daily rhGH injections, 6 (86%) of whom consistently administered the clinically-prescribed dose. While QoL demonstrated numeric improvement, this change did not reach statistical significance (p = 0.17). Significant improvements were observed in total lean mass (p = 0.02), latissimus dorsi strength (p = 0.05), verbal learning (Trial 1, p = 0.02; Trial 5, p = 0.03), attention (p = 0.02), short-term memory (p = 0.04), and post-traumatic stress disorder (PTSD) symptoms (p = 0.03). Body weight (p = 0.02) and total fat mass (p = 0.03) increased significantly. ConclusionGHRT is a feasible and well-tolerated intervention for U.S. Veterans with TBI-related AGHD. It improved key areas impacted by AGHD and symptoms of PTSD. Larger, placebo-controlled studies testing the efficacy and safety of this intervention in this population are warranted.

Community arts engagement supports perceptions of personal growth in older adults

PurposeThe effects of arts engagement on older adults have been well-documented. However, the ways older adults overcome common situational and dispositional barriers to enhance personal growth and well-being are less known. MethodsFifty-six community dwelling older adults (71.3 ± 4.6 years) took part in dance, music, or a control workshop two times/week for ten weeks. Participants' personal growth was examined through focus groups and surveys in this mixed-methods study. ResultsFocus group and survey results revealed participants experienced personal growth through engaging in the dance and music arms of the experiment. Participants, especially those in arts workshops, described personal growth experiences aligning with four themes: increased social connections, developed new skills, utilized a growth mindset, and used creativity to overcome situational and dispositional barriers to participation. The barriers included musculoskeletal challenges, hearing impairments, and difficulty retaining new information. ConclusionsThe study yielded high adherence and retention rates, and participants reported increased engagement within their communities. Our observations provide avenues for future practitioners and facilitators to create programming that empowers older adults and utilizes participants' ongoing feedback to support access, inclusion, and sense of community.

Effects of Dietary Protein and Lipid Levels on Growth, Metabolism, Antioxidative Capacity, and Fillet Quality of Adult Triploid Rainbow Trout Farmed in Net Cage.

The research is aimed at investigating the effects of dietary protein and lipid levels on adult triploid rainbow trout growth performance, feed utilization, digestive and metabolic enzyme activities, antioxidative capacity, and fillet quality. Nine diets containing three dietary protein levels (DP) (300, 350, and 400 g kg-1) and three dietary lipid levels (DL) (200, 250, and 300 g kg-1) were prepared using a 3 × 3 factorial design. In freshwater cages, 13,500 adult female triploid rainbow trout (3.2 ± 0.1 kg) were cultured for 77 days. Triplicate cages (500 fish per cage) were used as repetitions of each experimental diet. The findings revealed that as DP increased to 400 g kg-1 and DL raised to 300 g kg-1, the weight gain ratio (WGR) elevated significantly (P < 0.05). However, when DP ≥ 350 g kg-1, WGR was similar in the DL250 and DL300 groups. As DP raised to 350 g kg-1, the feed conversion ratio (FCR) notably decreased (P < 0.05). In the DP350DL300 group, lipids had a protein-sparing impact. High DP diet (400 g kg-1) generally improved fish health status by increasing antioxidant capacity in the liver and intestine. A high DL diet (300 g kg-1) showed no harmful effect on hepatic health based on plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and antioxidant capacity in the liver. For fillet quality, a high DP diet could increase fillet yield, improve fillet hardness, springiness, and water-holding capacity values, and inhibit the production of off-flavors caused by n-6 fatty acids. A high DL diet could increase odor intensity, and EPA, DHA, and n-3 fatty acid concentrations decrease the thrombogenicity index value. The maximum fillet redness value was discovered in the DP400DL300 group. Overall, for adult triploid rainbow trout (≥3 kg), the minimum recommended DP and DL according to growth performance were 400 and 250 g kg-1, respectively; DP and DL based on feed utilization were 350 and 200 g kg-1, respectively; DP and DL based on fillet quality were 400 and 300 g kg-1, respectively.

TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila

Adult stem cells are essential for tissue maintenance and repair. Although genetic pathways for controlling adult stem cells are extensively investigated in various tissues, much less is known about how mechanosensing could regulate adult stem cells and tissue growth. Here, we demonstrate that shear stress sensing regulates intestine stem cell proliferation and epithelial cell number in adult Drosophila. Ca2+ imaging in ex vivo midguts shows that shear stress, but not other mechanical forces, specifically activates enteroendocrine cells among all epithelial cell types. This activation is mediated by transient receptor potential A1 (TrpA1), a Ca2+-permeable channel expressed in enteroendocrine cells. Furthermore, specific disruption of shear stress, but not chemical, sensitivity of TrpA1 markedly reduces proliferation of intestinal stem cells and midgut cell number. Therefore, we propose that shear stress may act as a natural mechanical stimulation to activate TrpA1 in enteroendocrine cells, which, in turn, regulates intestine stem cell behavior.