s / Drug and Alcohol Dependence 140 (2014) e86–e168 e157 approach with practical EBP implementation-progress evaluation tools. Our evaluation plan, based on developmental evaluation and complex systems analysis, incorporates (1) qualitative approaches (e.g., in-depth case studies); and (2) quantitative approaches focusing on performance indicators both at the provincial-level (e.g., hospital to community transitions) and local level (e.g., school completion rates for aboriginal youth). Conclusions: For youth with complex needs, there are a myriad of disconnected pathways intomental health and/or addictions treatment. There are also many models for EBP implementation. Our evaluation highlights the benefits and challenges of tracking implementation progress using theNIRNmodel. Our qualitative approaches demonstrate the importance of local context in both implementation progress and achievement of short-term outcomes. SISC is one of the largest attempts globally to systematically use community partnership to identify systems gaps and implement EBPs across diverse settings. Lessons learned have implications for other large implementation initiatives and could lead to improvement in the experiences of youth with complex needs. Financial support: CAMH. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.442 Gender differences in characteristics, service utilization and treatment outcomes of adult drug treatment court clients Diane Morse1, S. Gamble1, M. Ives3, M. Mittal1, Marc T. Swogger1, E. Wang2, K. Conner1 1 Psychiatry, University of Rochester School of Medicine, Rochester, NY, United States 2 Medicine, Yale University School of Medicine, New Haven, CT, United States 3 Lighthouse Institute, Chestnut Health Systems, Inc., Normal, IL, United States Aims: ADTC client needs in relation to health risks, utilization andoutcomes are poorly understood.Weexamined characteristics, health care utilization (chemical dependency treatment, mental health and physical health care) and related treatment outcomes, with a focus on gender patterns. Methods: Gender comparisons amongADTCclientswere examined using Global Appraisal of Individual Need data collected as part of a multi-site collaboration examining drug use, recidivism, service utilization and treatment. ADTC clientswho completed two or more follow-ups were included in the analyses (N=199 male, 424 female). Propensity score weights were used to control for size and intake characteristics.Weighted and unweighted comparisons were performed between female and male ADTC clients on measures of treatment need, services received, unmet needs and initial outcomes. Results:Womenweremore likely thanmen to be age 26+,married, to have children under age 21, to report weekly cocaine use and to have higher risk of mental health sequelae from trauma. Women were less likely to graduate high school, to report lifetime or past year substance dependence and to report committing interpersonal crimes. Relatedly, women reported shorter jail stays andmore time on probation or parole compared tomen. Regarding treatment women were more likely to report depression, moderate or high health problems and multiple prior substance abuse treatment episodes. Conclusions: Initial findings suggest several distinguishing characteristics of female ADTC clients, with implications for tailored treatment strategies. Women may benefit from augmenting ADTC with more treatment for cocaine abuse, mental health, and physical health needs compared to men to meet their complex needs. Financial support: NIDA 1K23DA031612-01A1, SAMHSA/ Center for Substance Abuse Treatment 270201200001c. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.443 Discriminative stimulus effects of a novel epibatidine analog RTI-102 in mice Fernando B. Moura1, Colin S. Cunningham1, L. McMahon1, F.I. Carroll 2, P. Ondachi2 1 Pharmacology, UTHSCSA, San Antonio, TX, United States 2 Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park,