Toluene is one of typical volatile organic compounds. It is seriously threats the environment and human health for its large evaporation rate and toxicity at room temperature. Human beings are gradually realizing its hazard and paying high attention to the pollution control technology. Adsorption technology is one of the effective methods for toluene abatement.MCM-41(ordered mesoporous materials) molecular sieve as the typical representative of M41S mesoporous materials is widely used in various areas of production and life for the regular pore structure, selective absorption performance, uniform pore size distribution, high specific surface area and excellent stability. This article mainly prepared different MCM-41 mesoporous molecular sieves by adjusting different conditions and applied it in the adsorption properties of toluene. The results of toluene static adsorption effect of the two molecular sieves under different conditions indicated that the molecular sieve A using CTAB as template has higher absorption performance than molecular sieve B using TTAB as template under the same circumstances. The optimal conditions of molecular sieve A in toluene absorption performance are concluded as the pH is 11.7, calcination temperature is 550℃, calcination time is 8h and absorption time is 24h.Under the optimal conditions, the static adsorption capacity of toluene of the molecular sieve using CTAB as template is between 60.5% and 67.84%.