In this work, commercial organophilic clay was used in adsorption studies for the liquid phase of Atrazine, Ametryn, Diuron, and 2-(2,4-dichlorophenoxy)acetic acid (2,4-D) in a batch type system. The affinity study showed that clay is a promising material to remove contamination from agricultural activities. The adsorbent material showed a great removal capacity, especially for Diuron because that reached a higher value than 98%. The adsorption rate was evaluated by pseudo-first-order, pseudo-second order, Elovich, intraparticle diffusion, and external film mass transfer (EFMT) models. In these models, the pseudo-second order and EFMT models represented properly experimental data for Atrazine, Ametryn, and Diuron, whereas the Elovich model was the most predictive for 2,4-D. The maximum adsorption capacities in the monolayer for each contaminant were obtained by the equilibrium isotherms, and the values were 2.275, 25.253, 47.149, and 6.450 mg g−1 for Atrazine, Ametryn, Diuron, and 2,4-D, respectively. In addition, the Langmuir model was the best adjustment to equilibrium data for Atrazine, Ametryn, and Diuron adsorption. For 2,4-D, the model that best represented the experimental data was Freundlich. Finally, characterization techniques indicated that herbicide adsorption contributed to textural, chemical, morphological, and thermal modifications in the clay mineral.