Surface physicochemical phenomena have a crucial role in phase interaction and in various processes in real heterogeneous systems with an advanced interfacial surface. Research into application opportunities for highly-effective surfactants in the processes of the oil-and-gas industry and the usage of petroleum products is essential. The purpose of the work is to increase the understanding of the impact of introducing surfactants in micro-concentrations on certain physical properties of multicomponent hydrocarbon systems, individual hydrocarbons and their derivatives. Patterns of the surfactants’ micro concentrations effect on the surface tension, vapor pressure, boiling rate under given conditions and the rate of the phase transition “vapor-liquid” were substantiated. Recommendations on the use of surfactants in the processes of the oil-and-gas industry (rectification by various technologies, glycol dehydration of gases, adsorptive fractionation of the associated petroleum gas, storage of petroleum and light petroleum products in tanks) and the improvement of the properties of gasoline were proposed.