The understanding of the intraplate tectonics of Central Europe requires a detailed picture of how stress is transferred from the interaction of the Eurasian, Nubian and Anatolian plates to the Alpine, Carpathian, Pannonian and Dinaric regions. Recent strain distribution is controlled by the Adria horizontal push, by the Vrancea vertical slab pull and associated horizontal displacements, and by the Aegean/Anatolia extension and slab-roll back. We present a horizontal velocity field for the Alpine-Carpathian-Pannonic-Dinaric and Balkan regions resulting from a new combination of seven different GPS networks formed from permanent and campaign stations. Dedicated velocity profiles in two specific regions are studied in detail. One is the Alpine Pannonian region, with a detailed picture of the NS indentation of the Adria microplate into the Southern Alps, in NE Italy, the deformation in the Tauern Window and the eastwards kinematics of a Pannonian plate fragment. The second study region includes Transylvania, the Southern Carpathians up to the Aegean sea and Albania, where a major right lateral shear deformation exists as a consequence of the NE convergence of the Apulia platform towards the Dinarids, and the SSW motion of Macedonia, Western Bulgaria and Rumania, related to the Hellenic arc dynamics in the Eastern Mediterranean. The profiles in the Alpine–Pannonian area indicate that a velocity drop of 2.5 +/− 0.4 mm/yr associated with the Adria indentation concentrates on a segment of some 50 km south of the Periadriatic fault. The deformation becomes extensional by a similar amount just north of the Periadriatic fault, in the Tauern Window, where the updoming of the Tauern Window implies vertical motion which could well be associated with surface extension. In the EW profile, we observe a sudden velocity change of 1.5 +/− 0.2 mm/yr in 20 km, corresponding to the right lateral Lavant fault, which seems to mark the border between dominant indentation kinematics to the West and dominant extrusion kinematics to the East. Three profiles are considered in Southern and Eastern Europe: one across the lower Adriatic sea from Apulia in Italy to the southern Dinarides, which enables it to constrain the velocity drop associated with the subduction of the Adria microplate into the Dinarides to 3.2 +/− 0.5 mm/yr in 140 km. The second profile is longitudinal and constrains the velocity inversion of 7.4 +/− 1.0 mm/yr in 350 km associated with right lateral shear faults in Albania. The third profile crosses the Transylvania region with a shortening of 2.3 +/− 1.0 mm/yr in 220 km, and the Wallachian–Moesian region up to the Chalcidic peninsula in N Greece. This lower part of the profile implies an extensional stretch of the upper crust of 3.2 +/− 0.9 mm/yr in 440 km, culminating in the Hellenic arc. Strain rate maps are presented in this regional scale, showing the excellent agreement between fault plane solutions of crustal earthquakes and the eigenvectors of the GPS derived two dimensional strain rate tensor. Three profiles are considered in the Balkan and SE Carpathians: one across the lower Adriatic sea from Apulia in Italy to the southern Dinarides, which enables to constrain the velocity drop associated to the subduction of the Adria microplate into the Dinarides to 3.2 +/− 0.5 mm/yr in 140 km. The second profile is longitudinal and constrains the velocity inversion of 7.4 +/− 1.0 mm/yr in 350 km associated to right lateral shear faults in Macedonia, a highly seismic region. The third profile crosses the Transylvania with a shortening2.3 +/− 1.0 mm/yr in 220 km, and the Wallachian–Moesian region up to the Chalcidic peninsula in N Greece. This lower part of the profile implies an extensional stretch of the upper crust of 3.2 +/− 0.9 mm/yr in 440 km, culminating in the Hellenic arc.