Adoption Of Practices Research Articles

Factors Affecting the Adoption of E-HRM Practices in Public Service Organizations in Tanzania: A Case Study of the Tanzania Judicial Service Commission Headquarters

The scanty understanding on the factors affecting the adoption of e-HRM practices among public service organizations in Tanzania posed a rationale of undertaking this study. The study took place at the Judicial Service Commission of Tanzania. This study sought to address three specific objectives; to assess HRM practices which are under e-HRM, factors influencing the adoption of e-HRM practices and challenges facing the adoption of e-HRM practices in the study area. This study was guided by innovation adoption theory. The study used descriptive case-study research design with a mix of qualitative and quantitative research approaches. Simple random sampling was used to sample 77 respondents out of 96 employees who constitute the target population from the study area. Data collection was done through interview and questionnaire methods where contents analysis and descriptive statistics analysis were used in data analysis. The study findings revealed seven HRM practices in the study area are under e-HRM namely planning, recruitment and selection, training and development, performance appraisal, compensation, health related, safety and labour relations practices. The study findings further revealed social, economic and institutional factors as the major factors influencing the adoption of e-HRM practices in the study area. This study concluded inadequate ICT skills among employees, competent ICT experts, financial resources, e-HRM practices awareness, capacity building programs, supportive laws and policies as the major challenges facing the adoption of e-HRM practices. The study further concludes the e-HRM having strong contribution to the entire organizational performance. In the view of the revealed study findings, the study hereby recommends to the public service organizations to conduct routine capacity building programs for creating awareness and strengthening the adoption of e-HRM practices in the organizational undertakings.

Influences affecting adoption of management to mitigate impacts of intensive winter grazing of forage crops

ABSTRACT Intensive winter grazing on forage crops helps overcome winter feed shortages but is associated with soil pugging and high rates of sediment and nutrient losses. A recently recommended approach to intensive winter grazing management–grazing from the top of the slope downwards (‘top-down’)–can substantially reduce sediment and nutrient losses as part of a suite of practices called ‘strategic grazing’. We hypothesised that this new management has had significant uptake and that a farmer’s risk preferences, values, and demographics influence adoption of these practices. Using a national-scale survey of farmers from 2023, we found that 52.5% of respondents who grazed winter forage crops on slopes, grazed top-down. Location had a modest impact on this decision, with Otago respondents being 17–24% more likely to graze top-down than those from other regions. Māori farmers were 30% more likely to graze top-down than non-Māori farmers. Profitability was positively correlated with this decision. We conclude that the adoption of top-down grazing practices on slopes for winter forage crops is widespread, with just over half of the farmers surveyed grazing winter forage crops top-down.

Distributed Ledger Technology and Financial Reporting Integrity in Nigerian Quoted Banks: A Study on Error Reduction and Enhanced Transparency

This study investigated the effect of distributed ledger technology (DLT) factors on eliminating financial reporting errors (FREs) in quoted Nigerian banks. Using an exploratory survey design, data was collected from 300 employees of 14 quoted banks involved in financial reporting. DLT factors of public, private, hybrid, and blockchain were examined as independent variables affecting the dependent variable of FRE elimination. Descriptive analysis showed that all DLT types were perceived as highly effective for error reduction. Correlation analysis revealed strong positive relationships between DLT factors and FRE mitigation. Regression modeling found that hybrid DLT had the largest impact on error elimination, followed by private, public, and blockchain DLT. Together, the DLT factors explained 98.1% of the variance in FRE reduction. The results statistically established the significant positive effects of DLT factors on eliminating prevalent FREs like principle, omission, entry, disclosure, and reversal errors. Key contributions include providing robust empirical evidence that leveraging DLT, especially hybrid DLT, can eliminate common financial reporting errors in Nigerian banks. The pioneering study expands conceptualizations, theories, and literature regarding DLT's potential to comprehensively transform financial reporting accuracy. It offers important implications for policy, practice, and research on regulating, adopting, and studying DLT solutions to address persistent financial statement errors undermining stakeholder trust in Nigeria's banking sector. The study concludes by strongly recommending for policy and, in practice, the regulation and full adoption of DLT for the elimination of FREs in Nigeria.

Background of Environmental Awareness and Pro-Environmental Behavior Among Amazonian Farmers - Emphasis on the State of Rondônia

Objective: The study aims to identify levels of environmental knowledge, environmental beliefs, environmental awareness, and sustainable practices among Amazonian farmers, associating these factors with socioeconomic and demographic characteristics. Theoretical Framework: Environmental awareness is the understanding of the importance of protecting the environment and promoting sustainability, influenced by backgrounds such as environmental knowledge and beliefs, and social and income factors, resulting in pro-environmental behaviors. Method: Interviews with 308 farmers from the central region of Rondônia assessed socioeconomic and demographic characteristics, environmental knowledge, environmental beliefs, environmental awareness, and sustainable agricultural practices. Quantitative analysis used t-tests and analysis of variance to identify significant differences between categories such as age, gender, property size, and education. Results and Discussion: Although it was expected that environmental components would be crucial for sustainable rural development, the variation between groups was small. Environmental awareness was positively associated with education and property size. Higher education expanded environmental understanding and the adoption of sustainable practices. Surprisingly, larger properties, despite focusing on profit maximization, showed greater environmental awareness. Female-led properties had lower adoption of sustainable practices, possibly due to reduced access to resources and support networks. Research Implications: Despite assumptions that environmental dimensions would be strongly associated with socioeconomic and demographic characteristics, little variation was observed, indicating increasing uniformity in environmental awareness among farmers. Originality/Value: Understanding the environmental awareness of farmers in the Amazon is crucial for developing effective conservation strategies. Direct research with these often-overlooked farmers can provide valuable insights for public policies and environmental education, promoting sustainable agricultural practices and forest preservation.

Adoption of Life Cycle Thinking: Impact-driven comparative assessment of Japanese construction corporations’ trends in practices

Although life cycle thinking offers a well-founded set of concepts, methods, and tools for organizational contexts, only little is known about its relevance in the construction sector. In this sector, construction corporations are key players. In this work, a novel impact-driven method to assess the adoption of life cycle thinking by construction corporations is introduced. Japan, as a high-income country with a relatively long history of environmental policies informed by material flow analysis, is chosen as the context. Five Japanese construction corporations and respective reporting are used as case studies. Trends in environmental impacts over time of the case study corporations are assessed using two indicators: resource and carbon productivity. In comparison, an automated text corpus analysis workflow is presented to explore the corporate report’s life cycle thinking-related content in a meaningful way. Comparing the period of 2014–2018 and 2019–2023, an overall relative increase in framework adoptions (77%) and their integration in corporate categories (85%) in corporate reports indicates its increased procedural relevance among Japanese construction contractors. Findings show how the carbon indicator is embedded in various frameworks and, for instance, reveal an increased relevance of Scope 3 emissions as a framework on a low level. However, Scope 3 is also utilized as a performance indicator. To this end, considerable temporal differences in adoption practices are observed. Finally, a potentially effective corporate adoption model is identified through the comparative research design. The proposed method can be applied to other construction corporations and regional contexts.

Interventions to reduce racial/ethnic disparities across the breast cancer care continuum.

160 Background: In the United States, racial/ethnic disparities in adoption of breast cancer evidence-based practices (EBPs) persist along the cancer care continuum. This scoping review applied an implementation science lens to describe the current evidence base for interventions to reduce disparities, synthesizing evidence on effective interventions while highlighting gaps in the literature. Methods: A formalized search strategy identified USA-based interventional studies aiming to improve adoption of an EBP along the breast cancer care continuum among racially/ethnically minoritized patients. Relevant articles from 1/2010 - 8/2022 (Medline, Embase, Cochrane, and Scopus) were included. For each article, two reviewers screened and extracted data, with a third resolving discrepancies. The PRISMA-ScR checklist and JBO Manual for Evidence Synthesis framework were followed. Results: Our search strategy yielded 45,215 articles. After applying inclusion/exclusion criteria, 59 articles were retained, targeting screening (85%, 50 of 59), treatment (12%, 7 of 59), and survivorship (5%, 3 of 59) (2 targeted multiple areas). No articles targeted end-of-life care. Of these, 49% (29 of 59) were randomized controlled trials (RCTs). Among 24 screening RCTs, the most common interventions—and fraction with statistically significant improved screening uptake—were patient navigation (100%, 11 of 11) and patient education (80%, 4 of 5). Among 4 treatment RCTs, 3 targeted adjuvant chemotherapy uptake. Of these, 1 had significant improvements and used patient navigation. The 2 studies without significant improvements used a patient tracking tool/alert system or patient education. Among 2 survivorship RCTs, one used email interventions, resulting in significantly improved physical activity and dietary health. A second used a nurse-facilitated internet support group, resulting in significantly improved physical/psychological symptoms. Early to mid-stage implementation outcomes (acceptability, adoption, appropriateness, feasibility, or fidelity) were commonly measured (81%, 48 of 59). No study measured later stage implementation outcomes (sustainability or costs). Conclusions: In multiple studies, patient navigation and education improved breast cancer screening among racially/ethnically minoritized populations. In one study, patient navigation improved completion of adjuvant treatment. Despite these studies, patient navigation is not reimbursed for cancer screening, and adoption has not been widespread. Future studies should focus on evaluating and improving later stage implementation outcomes (sustainability and costs). Based on these results, insurance reimbursement mechanisms for screening-related navigation may be warranted. Future breast cancer care delivery disparities research should also be expanded to include treatment, survivorship, and end-of-life care.

Factors associated with Ontario dairy producers' management and care of down dairy cattle.

The objective of this study was to better understand current management practices for down cows in Ontario, Canada, and to identify factors associated with the adoption of acceptable practices. An online survey was distributed to all dairy producers in Ontario, Canada (n = 3,367) and was available from November 2020 to March 2021, inclusive. Dairy producers were identified through their provincial dairy organization and contacted via email, and the survey was also promoted via social media. The survey was comprised of 134 questions, 31 of which were related to down cow management. Descriptive statistics were evaluated, and 2 logistic regression models were generated using Stata 17, exploring factors associated with 1) relocating down cows with hip lifters and 2) assisting cows to stand within an hour after discovering a down cow. A total of 226 producers responded (7.4%). Participants were predominantly male (68%), farm owners (78%), and 30-39 years old (29%). Producers reported relocating down cows with a boat or sled (32.6%), front-end loader bucket (31.4%), hip lifters (28.0%), or 'other' (with a text box to further describe) (8.0%). The median time to relocating a down cow after identifying her was 1 h (range 0 - 17h). Farms that relocated a down cow sooner after identifying her as down, were more likely to use appropriate methods to move the cow. However, we also found that farms that provided feed and water sooner to down cows, were more likely to use an inappropriate method (hip lifters) to move her. Farms that used hip lifters to move cows had higher odds of assisting a cow to stand within an hour following the discovery of recumbency. Additionally, producers who waited longer to relocate a down cow were less likely to assist the cow to stand within one hour of finding them down. Research has identified effective management practices for down cows, yet there remains a gap in understanding the implementation and the decision-making process of producers. Data from this study will be helpful in designing future research that further explores the barriers and motivations of producers when implementing evidence-based management plans to care for down dairy cows and may help inform current industry extension efforts.

The evolving landscape of neuromodulation for pain care

Here, we present five different insights on the use of neuromodulation strategies for effective pain management in clinical practice. Experts briefly illustrate the various techniques available and the complexities involved in evaluating their effectiveness. Additionally, they highlight the challenges for widespread adoption in clinical practice and explore some future directions. These viewpoints underscore the evolving landscape of neuromodulation in pain management and the ongoing efforts to optimize these treatments for diverse patient needs.

Do CEOs’ and board directors’ environmental governance experience, corporations’ age and financial performance influence adoption of green management practices? A study of energy-intensive industries in Malaysia

Do CEOs’ and board directors’ environmental governance experience, corporations’ age and financial performance influence adoption of green management practices? A study of energy-intensive industries in Malaysia

The Adoption and Impact of Climate-Smart Water Management Technologies in Smallholder Farming Systems of Sub-Saharan Africa: A Systematic Literature Review

Agriculture plays a significant role in global water consumption, accounting for approximately 70% of the world’s freshwater usage. This makes this sector a critical factor in the depletion of water resources. Accordingly, this paper explores potential mitigatory impacts of climate-smart water management (CSWM) technologies in sub-Saharan Africa. About 70% of the population in sub-Saharan Africa is dependent on agriculture for sustaining their livelihoods. This is despite the low agricultural output in smallholder farming systems (SFS) due to water scarcity. This has spurred several attempts to promote the adoption of climate-smart agriculture (CSA) to raise agricultural outputs and improve smallholder farmers’ livelihoods. However, there has not been a comprehensive analysis of data categorised by various aspects of climate-smart water management technologies. In this systematic literature review, climate-smart water management technologies in sub-Saharan Africa’s agricultural sector were identified and analysed to determine strategies that could enhance their adoption and impact. To this end, academic articles reporting on the adoption of climate-smart water management technologies in databases were reviewed. Four significant literature databases were used. These were limited to Springer Link, ScienceDirect, MDPI, Wiley Online, and Google Scholar. The findings demonstrate that rainwater harvesting and micro-irrigation are the primary climate-smart water management technologies used by smallholder farmers. The literature review shows that adoption of CSWM practices is constrained by inadequate technological infrastructure, financial implications, unsuitable policies, and low user skills, particularly. It is therefore recommended that government agricultural departments and relevant advocates of CSA should incentivise and subsidise smallholder farmers to encourage CSWM technology adoption. This can be achieved through the implementation of suitable policies directed at technological infrastructure development, financial support for adoption, and technical skills training.

Leveraging HIV self-testing to achieve the UNAIDS 2025 targets in the South and Southeast Asia region.

The South and Southeast Asia region has the second-highest number of people living with HIV globally. Despite progress in reducing HIV incidence and AIDS-related deaths, the region still has a long way to go in achieving the Joint United Nations Programme on HIV and AIDS (UNAIDS) 95-95-95 HIV testing, treatment and viral suppression targets. HIV self-testing (HIVST) is recommended by the World Health Organization as an additional approach to HIV testing. This paper provides a commentary on the implementation status, benefits, barriers and recommendations for HIVST implementation in South and Southeast Asia. Additionally, it presents perspectives from HIV testing service experts from 11 countries in the region to put forth recommendations to accelerate the implementation of HIVST in South and Southeast Asia. There is uneven progress in national HIVST policy development and implementation across the region. HIVST, as an additional testing approach, can help to enhance testing coverage, frequency and demand for follow-up HIV services among key populations. Key factors influencing the implementation and scale-up of HIVST include the degree of awareness of HIVST among general and key populations, the development and implementation of supportive national HIVST policies and the availability of public funding for HIVST. To address barriers and leverage enablers to HIVST implementation, generating evidence on cost-effectiveness and budget impact, developing multisectoral partnerships for market shaping, promoting differentiated and decentralized delivery models, and optimizing linkage to further testing and care are recommended. It is crucial to accelerate the implementation and scale-up of HIVST to differentiate and decentralize the delivery of HIV testing services in South and Southeast Asian countries. Sharing experiences among country experts is vital to foster the adoption of best practices and facilitate the trial-and-error process of HIVST implementation. Such collaborative approaches can help South and Southeast Asian countries attain the UNAIDS 95-95-95 targets, especially the first 95 on HIV diagnosis, and play a significant role in ending the global AIDS epidemic.

Advancing quality of care using a knowledge transfer approach to foster the use of single-fraction radiation therapy.

288 Background: There are significant barriers between the publication of scientific evidence and its adoption in clinical practice. Research in bone metastasis has demonstrated the effectiveness of single-fraction radiation therapy for uncomplicated cases. A persistent reluctance to adopt this approach in favor of multi-treatment courses remain. The aim of this project was to advocate for a better treatment method by employing a knowledge transfer approach to disseminate information, gather clinician feedback, and change practices. Methods: Initially, experts were invited to share best practices and raise awareness about the issue. Quality measures were developed with help from a consortium-wide working group and were introduced in 2020. The performance metric was steadily increased from 20% to a consortium-wide rate of ≥45% in 2023. The knowledge transfer project involved using video presentations to educate clinicians on the benefits of single-fraction treatment, a post-session survey to assess the impact of the information provided, and a 30-minute virtual discussion that followed days after the presentation. The 30-minute recorded video presentation by a radiation oncologist with expertise in palliative care presented evidence in support of the treatment and dispelled myths surrounding single-fraction treatment. This was first piloted at four sites before being rolled out consortium wide. Results: The project was effective. Physicians at 22 radiation oncology centers reported an increased awareness of single-fraction treatment and a willingness to try it. The table shows: 100% reported the topic was relevant, 94% were prompted to reflect on their current practice, 63% reported their thoughts about fractionation changed and 84% acknowledged an increase in their knowledge of the evidence supporting single-fraction treatment. Annual rates of single-fraction use increased over time. The consortium wide target promoting the use of single fraction for uncomplicated patients was met in 2023– single fraction was used 46% of the time for the treatment of uncomplicated bone metastases patients as compared to about 37% in 2021. Conclusions: Patient care can be enhanced by supporting providers who make health care decisions daily. Quality care can be encouraged by conveying evidence-based knowledge to providers, who are responsible for making healthcare treatment decisions. This project illustrates that sustained efforts in knowledge transfer can effectively change clinical practice patterns to align with evidence-based recommendations. Knowledge transfer project. Physician participation vs. those invited to participate 22/24 (91.67%) Survey Responses: a. Relevant to Practice 100% b. Usefulness to practice and reflection on current practice 94% c. Thoughts changed about fractionation treatment 63% d. Knowledge of evidence supporting treatment increased 84%

Climate-smart agriculture and food security in climate-vulnerable coastal areas of Bangladesh

The issue of global climate change is increasingly worrisome, particularly for countries heavily reliant on agriculture. To reduce the negative impact of climate change on agriculture, farmers of Bangladesh started adopting different climate smart agriculture (CSA) practices. The CSA sustainably increases productivity, resilience, and food security, which can contribute to the achievement of a number of sustainable development goals (SDGs). However, the adoption of CSA is low especially in the climate-vulnerable coastal areas of Bangladesh. Therefore, this study was conducted to identify the factors affecting the adoption of CSA and its influence on coastal household’s food security. A total of 327 sample farmers from three coastal districts of Bangladesh were interviewed. The collected data were then analyzed by using the binary probit and ordered probit model. The findings indicated that highest 65% of farmers adopted early planting of rice as one of CSA practices. The adoption of CSA practices positively affected by the household annual income, extension services and awareness regarding CSA practices. Moreover, the adopters of CSA were more food secure than non-adopters. For instance, adoption of one additional CSA practice leads to an increase in the likelihood of being food secure by 4.3%. In terms of policy perspective, the adoption of CSA in the coastal areas can be increased through creation of employment opportunities, increasing access to extension services, and broadcasting of CSA-related programs on mass media.

Maize crop residue cover mapping using Sentinel-2 MSI data and random forest algorithms

The return of crop residues to cultivated fields has numerous agronomic and soil quality benefits and, therefore, the areal extent of crop residue cover (CRC) could provide a rapid measure of the sustainability of agricultural production systems in a region. Recognizing the limitations of traditional CRC methods, a new method is proposed for estimating the spatial and temporal distribution of maize residue cover (MRC) in the Jilin Province, NE China. The method used random forest (RF) algorithms, 13 tillage indices and 9 textural feature indicators derived from Sentinel-2 data. The tillage indices with the best predictive performance were STI and NDTI (R2 of 0.85 and 0.84, respectively). Among the texture features, the best-fitting was Band8AMean-5*5 (R2 of 0.56 and 0.54 for the line-transect and photographic methods, respectively). Based on MSE and InNodePurity, the optimal combination of RF algorithm for the line-transect method was STI, NDTI, NDI7, NDRI5, SRNDI, NDRI6, NDRI7 and Band3Mean-3*3. Likewise, the optimal combination of RF algorithm for the photographic method was STI, NDTI, NDI7, SRNDI, NDRI6, NDRI5, NDRI9 and Band3Mean-3*3. Regional distribution of MRC in the Jilin Province, estimated using the RF prediction model, was higher in the central and southeast sections than in the northwest. That distribution was in line with the spatial heterogeneity of maize yield in the region. These findings showed that the RF algorithm can be used to map regional MRC and, therefore, represents a useful tool for monitoring regional-scale adoption of conservation agricultural practices.

Advancing the common good through business excellence awards: A legitimacy‐seeking perspective

AbstractCompeting for and winning business excellence awards (BEAs) is essential for firms' long‐term performance. However, the role of these BEAs in inspiring good and generating sustainable business practices has often been overlooked. In this article, we draw on the legitimacy‐seeking theory to explore the “socially good” transformations firms go through by competing for BEAs. Data for the inquiry come from semi‐structured interviews with managers whose firms competed in two BEAs in the United Kingdom. Providing insight into BEAs as a competitive legitimating frame in organizing, our findings shed light on how BEAs may serve as competitive crucibles that provide opportunities for feedback and learning, potentiality for brand positioning, and a possibility for stimulating excellence in the adoption of good business practices. The implications of these findings for the theory and practice of advancing the “common good” are outlined.

Clinical Approach to STRIDE-II in Real-Life Settings: Analysis and Practical Recommendations.

We aimed to (1) analyze the applicability of the updated Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) recommendations in real-world clinical practice, (2) identify barriers to their implementation, and (3) propose practical measures to overcome these obstacles. This qualitative study was based on a survey, a literature review, and expert opinions. Nine inflammatory bowel disease (IBD) experts identified 7 areas likely to be controversial or potential implementation barriers in daily clinical practice: endoscopy, histology, ultrasound, quality of life, biomarkers, symptom control, and patient-reported outcomes (PROs). Based on this, a survey was carried out among educational course participants. The experts discussed the literature review and survey results and proposed several statements and practical actions. A total of 55 gastroenterologists answered the survey. The reported difficulty level in reaching STRIDE-II treatment goals in clinical practice was high. Only 22% of participants performed clinical remission assessments using clinical indexes and PROs. Seventy percent of responders did not use fecal calprotectin cutoffs and considered changes from the previous levels instead. Mucosal healing as a long-term therapeutic goal was considered necessary to be individualized in specific patient subgroups (eg, elderly/fragile patients, multiple treatment failures, and last-line therapies). Other barriers, like the lack of access to imaging techniques or insufficient knowledge and skills among healthcare professionals, were detected. The experts suggested adding less stringent treatment goals and measurements, patient stratification, local adaptations, educational activities, and research. STRIDE-II recommendations face various implementation barriers needing careful evaluation in order to enhance their adoption in clinical practice, and ultimately improve outcomes in IBD patients.

Multimodality Imaging in the Management of Tricuspid Valve Regurgitation.

Approximately 5% of elderly patients suffer from moderate or severe tricuspid valve regurgitation, which is an independent predictor of high morbidity and mortality. Surgical treatment of isolated tricuspid valve regurgitation has been associated with elevated fatality rate, leading to a growing interest in minimal invasive, transcatheter-based therapies such as transcatheter edge-to-edge repair and transcatheter valve replacement. Nevertheless, despite high procedural efficacy and safety of transcatheter-based therapies, a number of challenges limit their rapid adoption in routine clinical practice. In particular, the wide range of transcatheter approaches to address the significant variability in tricuspid valve pathology challenges the reproducibility of clinical outcomes. Multimodality imaging is pivotal for grading the regurgitation severity, determining the underlying pathology, assessing RV function and pulmonary pressures, identifying concomitant cardiac disease, and selecting the most beneficial treatment modality and access. This article reviews the role of different imaging modalities in guiding the management of patients with significant tricuspid valve regurgitation.

Performance analysis of a blockchain-based messaging system implementation for air cargo supply chains

ABSTRACT The air cargo supply chain’s goal is to achieve fast shipment movement through multistage coordination among multiple air cargo stakeholders. The lack of transparency in the end-to-end supply chain and complex digital connectivity is what limits the traditional peer-to-peer communication flow in the fragmented air cargo industry. Blockchain technology can enhance communication transparency by streamlining multistage message flows via smart contracts and by acting as an intermediary to simplify digital connections among air cargo stakeholders. Despite the benefits of applying blockchain for air cargo messaging, as blockchain is an emerging technology, technical concerns in the areas of performance, privacy, and interoperability can hinder the practical adoption of the blockchain system. To address practical implementation concerns, a blockchain-based messaging system using the Algorand public blockchain is developed in our work to demonstrate the practicality of blockchain. Transaction data privacy can be protected by the encryption key exchange algorithm, which supports forward secrecy. Our experimental results provide practical performance insights into the Algorand blockchain for streamlined messaging from various aspects related to transaction submission, confirmation, and retrieval. Our results show that by leveraging the Algorand blockchain, our proposed system can offer scalable, efficient, reliable, and cost-effective communication channels for air cargo messaging.

Bilayer Interphase for Air-Stable and Dendrite-Free Lithium Metal Anode Cycling in Carbonate Electrolytes.

The intrinsic reactivity of lithium (Li) toward ambient air, combined with insufficient cycling stability in conventional electrolytes, hinders the practical adoption of Li metal anodes in rechargeable batteries. Here, a bilayer interphase for Li metal is introduced to address both its susceptibility to corrosion in ambient air and its deterioration during cycling in carbonate electrolytes. Initially, the Li metal anode is coated with a conformal bottom layer of polysiloxane bearing methacrylate, followed by further grafting with poly(vinyl ethylene carbonate) (PVEC) to enhance anti-corrosion capability and electrochemical stability. In contrast to single-layer applications of polysiloxane or PVEC, the bilayer design offers a highly uniform coating that effectively resists humid air and prevents dendritic Li growth. Consequently, it demonstrates stable plating/stripping behavior with only a marginal increase in overpotential over 200 cycles in carbonate electrolytes, even after exposure to ambient air with 46% relative humidity. The design concept paves the way for scalable production of high-voltage, long-cycling Li metal batteries.

Single-center retrospective review of standard versus minimal monitoring for hepatitis C direct-acting antiviral therapy

BackgroundHighly effective direct-acting antiviral (DAA) therapies have transformed the landscape of hepatitis C virus (HCV) treatment. However, there continues to be limited data regarding the efficacy and safety of required in-person clinic visits (standard monitoring) versus completely telehealth clinic visits (minimal monitoring) during HCV therapy, which could delay practice adoption. ObjectivesThis study aimed to assess the rates of undetectable HCV ribonucleic acid (RNA) in sustained viral load 12 weeks after therapy (SVR12) in standard versus minimal monitoring approaches during DAA. MethodsA 12-month, single-center retrospective cohort study was conducted in treatment-naïve HCV-infected adults who received DAA therapy between May 1, 2020, and April 30, 2021. The standard monitoring group had ≥1 in-person clinic visit with HCV RNA laboratory monitoring during DAA treatment. The minimal monitoring group had entirely telehealth visits without HCV RNA laboratory monitoring during treatment. Both groups received telephonic touchpoints throughout DAA treatment from a clinical pharmacist practitioner and a nurse care coordinator. The primary outcome was SVR12. ResultsFrom May 2020 to April 2021, 133 patients with HCV met inclusion criteria and were treated with DAA (standard, n = 56; minimal, n = 77), with no differences in baseline demographics. Overall, total encounters during DAA treatment remained significantly higher in the standard than minimal monitoring group (standard, 2.1 ± 0.8, vs. minimal, 1.7 ± 0.9; P < .01). Although minimal monitoring had higher loss to follow-up rates (standard, 7.1%, vs. minimal, 18.2%; P = 0.06), the modified intention-to-treat analysis showed no differences in sustained virologic response (SVR) between standard and minimal monitoring approaches (standard, 98.1%, n = 51, vs. minimal, 95.3%, n = 60; P = 0.41). ConclusionsThis single-center retrospective cohort study demonstrated that minimal monitoring during HCV treatment was as effective in achieving SVR cure rates as standard monitoring. Eliminating required in-person clinic visits during DAA therapy alongside a collaborative approach may play a major role in overcoming barriers to HCV care in select patients.