The digital transformation of Small and Medium-sized Enterprises (SMEs) is a critical phenomenon shaping the global business landscape. This paper presents a comparative review between the United States and Africa, exploring the diverse trajectories of digitalization within these regions. While the USA is often at the forefront of technological advancements, Africa's SMEs exhibit unique challenges and opportunities in their digital transformation journey. In the United States, SMEs have embraced digital technologies to enhance operational efficiency, improve customer experiences, and gain a competitive edge. The adoption of cloud computing, data analytics, and e-commerce platforms has become ubiquitous, fostering innovation and scalability. This comparative study delves into the specific strategies employed by American SMEs to navigate the complexities of the digital era. On the contrary, African SMEs face distinct hurdles in their digital transformation efforts. Infrastructure limitations, limited access to capital, and a diverse economic landscape present unique challenges. However, this review sheds light on the innovative approaches taken by African SMEs to overcome these barriers. Leveraging mobile technology, localized digital solutions, and collaborative networks, African SMEs are carving out their digital paths. Moreover, this comparative review emphasizes the role of government policies and support mechanisms in shaping the digital transformation landscape for SMEs in both regions. By examining regulatory frameworks, funding initiatives, and skill development programs, this paper provides a comprehensive analysis of the ecosystem supporting SMEs in their digital evolution. The digital transformation of SMEs is a dynamic process with distinct nuances in the USA and Africa. While American SMEs benefit from advanced technological infrastructures, African SMEs showcase resilience and adaptability in leveraging digital tools to overcome challenges. Understanding these diverse trajectories is essential for policymakers, businesses, and researchers seeking to foster inclusive and sustainable digital growth globally.
 Keywords: Digital Transformation, SMEs, USA, Africa, Review.