Background: Previous research has demonstrated that oppositional defiant is a strong predictor of mental illness that cause significant distress for adolescents who manifest the disorder and pose remarkable costs for society. Objectives: The aim of this study was to investigate the role of callous-unemotional traits and emotion regulation diculties in pre- dicting oppositional defiant disorder. Materials and Methods: This is a descriptive-correlative study performed on a sample of 320 male high school students, chosen via multi-stage random sampling. Instruments used to collect data are inclusive of oppositional defiant behavior inventory (ODBI), di- culties in emotion regulation strategies scale (DERS) and inventory of callous-unemotional traits (ICU). Results: The results suggest a significant relationship between oppositional defiant behavior, impulse control diculties and callous- ness. Regression analysis revealed that 16% variance of oppositional defiant behavior can be explained by impulse control diculties and callousness. Conclusions: Our findings highlight the importance of callousness and impulse control diculties in development of oppositional defiant disorder. Moving forward, clinicians should consider the importance of these variables in their future research to identify mech- anism through which callousness and impulse control diculties enhances risk of oppositional defiant disorder.