Administration Of Juice Research Articles

The potential of lemon cui (<em>Citrus microcarpa</em>) from Ternate Island as a natural feed additive for broiler chickens reared at high density

This study aimed to determine the potential effects of lemon cui from Ternate Island on the performance of broiler chickens reared at high density. The study used 360 broiler chicks (14 days old) in a completely randomized design with the following treatments: T0 (chicks reared at a normal density of 8 birds/m² without lemon cui juice), T1 (chicks reared at a high density of 16 birds/m² without lemon cui juice), T2 (chicks reared at a high density of 16 birds/m² with 0.5 ml/L lemon cui juice), T3 (chicks reared at a high density of 16 birds/m² with 1.0 ml/L lemon cui juice), and T4 (chicks reared at a high density of 16 birds/m² with 1.5 ml/L lemon cui juice). The results showed that the administration of lemon cui juice in the drinking water of broiler chickens reared at high density significantly (p<0.05) improved performance. The thymus and bursa of Fabricius were smaller (p<0.05) in broiler chickens reared at high density without lemon cui juice. In conclusion, the administration of lemon cui juice from Ternate Island can improve performance and enhance the development of immune organs in broiler chickens reared at high density.

The Effect of Administration of Green Bean Juice (Phaseolus Radiates) on Hemoglobin Levels of Public Women with Anemia at The Pratama Cahaya Clinic Lubuk Pakam

Anemia is a condition in which the number of red blood cells or the concentration of hemoglobin in them decreases from normal levels. This study aims to determine hemoglobin levels in postpartum mothers before giving green bean juice and hemoglobin levels in postpartum mothers after giving green bean juice. In conducting this research, the research used a quantitative research design with a one-group pretest-posttest design model, that is, before it was carried out, observations were made on the sample and after treatment, observations were made again. The data collection technique was carried out using a total sampling technique. Based on the research results, the probability of the test results listed in the table shows that the resulting probability is 0.000. This means that the probability < level of significance (? = 0.05) so that Ha is accepted and H0 is rejected. Thus, it can be stated that there is a significant difference between the hemoglobin levels in postpartum mothers with anemia before giving green bean juice (Pretest) and the hemoglobin levels in postpartum mothers with anemia after giving green bean juice (Posttest). The conclusion that can be drawn is that giving green bean juice (Phaseolus Radiates) affects the hemoglobin levels of postpartum mothers with anemia at the Pratama Cahaya Lubuk Pakam Clinic in 2024.

Physiological response, Blood profile, and Liver histology of Broiler chickens to oral administration of White radish juice

Physiological response, Blood profile, and Liver histology of Broiler chickens to oral administration of White radish juice

Beetroot (Beta vulgaris L.) Extract Gives Superior Effect than Beetroot Juice on Increasing HDL and Decreasing LDL and IL-6 in Dyslipidemic Rats Model

BACKGROUND: Dyslipidemia derives from disturbances in lipid metabolism as an interaction between genetic and environmental factors, characterized by increased levels of cholesterol, triglycerides, low-density lipoprotein (LDL) and decreased levels of high-density lipoprotein (HDL). Continuous dyslipidemia will increase the risk of atherosclerosis. In dyslipidemia, macrophages release inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-12, IL-15, IL-18, and then induce T-cell infiltration formed atherosclerotic plaques. Beet (Beta vulgaris L.) which contains active compounds and antioxidant, such as flavonoids and betacyanin, has the ability to reduce dyslipidemia. This study evaluated effect of beetroot juice and beetroot extract on dyslipidemic rat models by evaluating the level of HDL, LDL and IL-6.METHODS: Fourty-two male Sprague Dawley rats were divided into seven groups. Rats were fed either with standard food or high fat diet (HFD) for 28 days, then different interventions using either single combination of simvastatin, beetroot juice, or beetroot extract were given alongside the standard food or HFD diet for another 28 days. LDL and HDL were measured pre- and post-intervention, while IL-6 was measured only post-treatment.RESULTS: Daily administration of a single beetroot juice or beetroot extract or in combination with simvastatin reduced LDL significantly compared to pre-intervention. The interventions also increased HDL significantly and lower IL-6 concentrations compared to group that received no intervention.CONCLUSION: Administration of beetroot juice and beetroot extract can lower LDL, increase HDL, and decrease IL-6 either alone or in combination treatment with simvastatin, it is indicated beetroot have a potential benefit for prevention and therapeutic in dyslipidemia.KEYWORDS: beetroot juice, beetroot extract, LDL, HDL, IL-6

Synthetic and Natural Vitamin C Modulation of Leaded Paint-Induced Nephrotoxicity of Automobile Painters in Ile-Ife, Nigeria.

Introduction: Lead (Pb) occupational exposure in painters has been documented to be contacted via additives in paints due to its many important properties and vitamin C has been the most widely studied when it comes to Pb- induced oxidative stress.  Aim: This study aimed at the use of freshly squeezed orange-juice due to its accessibility in investigating the modulating role of synthetic and natural vitamin-C on leaded paint-induced nephrotoxicity of automobile painters.  Study Design and Methods: Sixty (60) male automobile painters were consecutively selected and divided equally into 2 groups. Vitamin-C and orange juice were administered daily to painters for 4 weeks at dosage levels of 200 and 184 mg/day respectively. Thirty (30) male non-painters constituted the control group. Orange juice vitamin-C content was assessed by titrimetric method and synthetic vitamin-C served as the standard drug. Renal biomarkers and reduced glutathione (GSH) were done by Colorimetry. Urine aminolevulinic acid (ALA) and Pb were assessed by ELISA technique and atomic absorption spectrophotometry respectively. Phytochemical screenings (quantitative/qualitative) and proximate analysis were done using standard methods. Data were analyzed using Pearson’s correlation coefficient and One-way Analysis of Variance (ANOVA) followed by Tukey’s post-hoc test for pairwise comparison. Statistical significance was p< 0.05.  Results: Baseline results at 0-week of orange juice administered group showed a significantly (P<0.05) higher serum Pb, urea and creatinine compared to non- painters. Also, their urine baseline results at 0-week showed a significantly (P<0.05) higher levels of ALA and GSH compared to non-painters. Orange juice administration at 4 weeks showed significant (P<0.05) reductions in concentrations of lead, urea, and creatinine in serum, decreased concentrations of GSH and ALA in urine but increased urine Pb compared to baseline. However, compared with baseline, after 4 weeks of vitamin-C supplementation, serum Pb, urine GSH, and urine ALA were significantly (P<0.05) reduced and urine Pb significantly (P<0.05) increased. A positive correlation was observed at 2-weeks of taking orange- juice between serum lead and urine ALA (r= 0.703) and GSH (r= 0.913) but 4-week positive correlation between urea and urine GSH (r= 1.000). A negative correlation was observed at 2-week of taking vitamin-C between serum creatinine and urine lead (r= -0.857) while 4-week a negative correlation was observed between urine GSH and urine lead (r= -0.743). Presence of tannin, phenol, saponin, alkaloid, and flavonoid was detected in orange juice.  Conclusion: Orange juice administration conferred significant amelioration to renal and lead toxicity biomarkers by 4 weeks. The presence of phytochemicals suggests why orange juice may be a viable alternative in amelioration of toxic effects of leaded paint among automobile painters.

The Effect of Red Dragon Fruit Juice (Hylocereus Polyrhizus) on Liver Histopathological Images in Wistar Rats Exposed to Cigarette Smoke

Cigarette smoke contains toxic components, carbon monoxide, hydrogen cyanide, carbon dioxide, and tar, which can trigger the formation of ROS (Reactive Oxygen Species) and reduce antioxidant reserves, which impact oxidative stress and are known to cause damage to liver cell membranes. Red dragon fruit (Hylocereus polyrhizus) is a fruit that is rich in antioxidants that inhibit ROS and prevent damage to liver cells by cigarette smoke. This study aims to assess the effect of administering red dragon fruit juice on liver microscopic images in Wistar rats exposed to cigarette smoke. It was an experimental study with a post-test-only control group design. Thirty-five male Wistar rats (Rattus novergicus) were randomized into five groups. Four groups were exposed to cigarette smoke (K-, P1, P2, and P3), and the fifth group was used as a control (K). All the P-groups were given red dragon fruit juice 2 g/2.5 ml, 4 g/2.5 ml, and 8 g/2.5 ml, respectively, for twenty-eight days. On the 29th day, the livers of Wistar rats were taken for preparation and microscopic observation. The research data were analyzed using the Kruskall-Wallis and Mann-Whitney post hoc tests to determine group differences. The average liver cell damage in K, K-, P1, P2, and P3 were 1.23, 2.51, 1.57, 1.51, and 1.43, respectively. There was a significant difference in damage between the K- group and the P1 (p = 0.002), P2 (p = 0.004), and P3 (p = 0.002) groups. The administration of red dragon fruit juice can protect the liver cells of rats exposed to cigarette smoke.

Aerobik dan Jus Tomat Dapat Menurunkan Tekanan Darah Penderita Hipertensi di Klinik Kartika 0730 Gunung Kidul Yogyakarta

Introduction: Hypertension is recognized globally as a major public health problem. Antihypertensive drugs are effective in lowering blood pressure, but the achievement rate is still low worldwide. Although antihypertensive drugs can control blood pressure, low physical activity is a risk factor for hypertension mortality. Therefore, increasing physical activity through aerobic exercise is a recommendation for complementary therapy for the treatment of hypertension. Simultaneous implementation of moderate to high intensity exercise and weight loss through diet has been identified to be able to lower blood pressure more. And the content in tomatoes can lower blood pressure. Research Objective: This study aims to determine the effect of aerobics and the administration of tomato juice on reducing blood pressure in hypertensive patients at the Kartika Clinic 0730 Gunung Kidul Yogyakarta. Research Method: This research is a quantitative experimental study with a one group pretest-posttest design. The sample is 30 people with purposive sampling technique. The intervention was carried out 4 times for 2 weeks. Aerobic exercise is carried out for 30 minutes and 150 cc of tomato juice without sugar. Data analysis used paired t-test. Research Results: The results of the analysis show that there is an effect of aerobics and tomato juice on reducing blood pressure in hypertensive patients at the Kartika Clinic 0730 Gunung Kidul Yogyakarta. Conclusion: Aerobic exercise and giving tomato juice can reduce blood pressure in hypertension sufferers.

RESPONSE OF Citrus aurantifolia TO THE INHIBITION ZONE OF THE Aeromonas salmonicida BACTERIA IN TILAPIA (Oreochromis niloticus)

The impact of using synthetic antibacterials creates a number of new cultivation problems, including: Bacterial resistance, retention of toxic substances and residues in the consumer's body. You need antimicrobial ingredients that can kill bacteria, one of which is the use of lime juice. The aim is to find out how strongly Citrus aurantifolia inhibits the bacteria Aeromonas salmonicida from Oreochromis niloticus. Using a completely randomized design (CRD) with five treatments. The results showed that the diameter of the inhibition zone for each Treatment A was 10.8 mm, Treatment B 12.8 mm, Treatment C 14.7 mm, Treatment D 16.7 mm, and Treatment E 19.1 mm. The relationship between administration of lime juice and the average diameter of the inhibition zone produced in inhibiting the growth of Aeromonas salmonicida bacteria shows a response that increases with increasing dose. Based on the Anova test using F (0.000) > F table at the 5% level of significance, lime juice (Citrus aurantifolia) has an effect on inhibiting the growth of Aeromonas salmonicida in each treatment.

Behavioral Effects of Chronic Japanese Quince Fruit Juice Administration to Rats with Diet-Induced Metabolic Syndrome

Abstract Introduction Metabolic syndrome (MS) is often associated with anxiety and depression. Chaenomeles japonica (Thunb.) Lindl, also known as Chaenomeles maulei or Japanese quince, is a medicinal plant with a long history of use forits health-promoting properties. Aim The aim of this study was to investigate the effects of Japanese quince fruit juice (JQFJ) administration on locomotor activity, anxiety and depressive behavior in rats with diet-induced MS. Materials and methods Forty adult male Wistar rats were divided into 4 groups: MS, MS+JQFJ2.5, MS+JQFJ5 and MS+JQFJ10. All groups received a high-fat high-fructose diet for the induction of MS. MS animals were daily orally treated with distilled water and the other groups with JQFJ at doses of 2.5 ml/kg, 5 ml/kg and 10 ml/kg, respectively. During the 10th week of the experiment, behavioral tests were carried out. Results In the open Held test, no effect of JQFJ treatment on locomotor activity was observed. In the elevated plus maze test, a dose-dependent increase in the time spent in the open arms (OA) of the apparatus and in the ratio time spent in OA vs. total time spent in any of the arms was interpreted as an anxiolytic effect. The immobility time in the forced swim test did not differ significantly among the groups, which demonstrated a lack of anti-depressant action. Conclusions Chronic Japanese quince fruit juice administration produced a dose-dependent anxiolytic-like effect in rats with diet-induced MS, probably due to its high content of polyphenols.

Right Ventricular Function and Oxidative Stress Improve with the Administration of Thyroid Hormones and Grape Juice in a Pulmonary Hypertension Model.

Adverse remodeling of lung vessels elevates pulmonary pressure and provokes pulmonary arterial hypertension (PAH). PAH results in increased right ventricle (RV) afterload, causing ventricular hypertrophy and the onset of heart failure. There is no specific treatment for maladaptive RV remodeling secondary to PAH. This study aims to explore two therapeutic approaches, grape juice (GJ) and thyroid hormones (TH), on PAH-induced oxidative stress and cardiac functional changes. Parameters of echocardiography related to lung vessel resistance (AT/ET ratio), RV contractility (TAPSE), and RV diastolic function (E/A peaks ratio) were evaluated. Also, total ROS, lipid peroxidation, antioxidant enzymes, calcium handling proteins, pro-oxidant and antioxidant protein expression were measured. Values of p<0.05 were considered statistically significant. Both GJ and TH treatments demonstrated reductions in pulmonary resistance (~22%) and improvements in TAPSE (inotropism ~11%) and AT/ET ratio (~26%) (p<0.05). There were no changes amongst groups regarding the E/A peak ratio. Although ROS and TBARS were not statistically significant, GJ and TH treatments decreased xanthine oxidase (~49%) levels and normalized HSP70 and calcium handling protein expression (p<0.05). However, only TH treatment ameliorated diastolic function (~50%) and augmented NRF2 immunocontent (~48%) (p<0.05). To the best of our knowledge, this study stands as a pioneer in showing that TH administered together with GJ promoted functional and biochemical improvements in a PAH model. Moreover, our data suggest that GJ and TH treatments were cardioprotective, combined or not, and exhibited their beneficial effects by modulating oxidative stress and calcium-handling proteins.

The effect of red guava juice provision on hemoglobin levels in anemic pregnant women

During pregnancy, women must maintain nutritional intake to avoid anemia. Anemia occurs due to lack of iron, folic acid, and vitamin B12. To increase hemoglobin levels in the body, non-pharmacological therapy can be done by consuming red guava juice. This study aimed to determine the difference in hemoglobin levels before and after giving red guava to pregnant women with anemia. This study uses a pre-experimental method with a one group pretest posttest design. The population in this study was all pregnant women in second trimester with the incidence of anemia at Dina Maternity Home Medan. The sample in this study was 10 pregnant women with mild anemia taken by purposive sampling technique. Analysis of univariate and bivariate data was done by using paired sample T-test. The results showed that the hemoglobin level before administration of red guava juice had a mean value of 10.01 g/dl, while the hemoglobin level after administration of red guava juice had a mean value of 11.68 g/dl, with a mean difference of -1.670 and p-value 0.000. The conclusion of this study showed that there was a difference in the effect of giving red guava juice on hemoglobin levels in anemic pregnant women.

The Effect of Lemon Juice (Citrus limon L.) Treated with Melatonin on the Health Status and Treatment of K14HPV16 Mice.

Lemon is a fruit rich in antioxidant properties and has several health benefits, namely the reduction of skin edema and anticarcinogenic properties, which are due to its high content of bioactive compounds. Melatonin can improve and preserve the properties of lemon for longer and also has health benefits. The aim of this study was to evaluate the effects of oral administration of lemon juice after melatonin treatment on murinometric parameters of wild-type (WT) mice and transgenic mice carrying human papillomavirus (HPV). Two trials were performed for oral administration of the lemon extract compound: in drinking water and in diet. First of all, lemons were treated by immersion with melatonin at 10 mM. Then, lemons were squeezed, and the juice obtained was freeze-dried and stored to be subsequently added to drinking water or diet, according to the assay. Thus, mice were divided into eight groups in the drink assay (each with n = 5): group 1 (G1, WT, control), group 2 (G2, WT, 1 mL lemon), group 3 (G3, WT, 1.5 mL lemon), group 4 (G4, WT, 2 mL lemon), group 5 (G5, HPV16, control), group 6 (G6, HPV16, 1 mL lemon) group 7 (G6, HPV16, 1.5 mL lemon) and group 8 (G6, HPV16, 2 mL lemon). The diet assay was divided into four groups: group 1 (G1, WT, control), group 2 (G2, WT, 4 mL lemon), group 3 (G3, HPV16, control) and group 4 (G4, HPV16, 4 mL lemon). In the drink assay, the highest concentration of melatonin (308 ng/100 mL) was for groups 4 and 8, while in the food assay, there was only one concentration of melatonin (9.96 ng/g) for groups 2 and 4. Both trials lasted 30 days. During this time, body weight, food and water were recorded. Afterward, they were sacrificed, and samples were collected for different analyses. At the concentrations used, the lemon juice with melatonin had no adverse effects on the animals' health and showed a positive outcome in modifying weight gain and enhancing antioxidant activity in mice. Moreover, a reduction in the incidence of histological lesions was observed in treated animals. Further research is needed to better understand the effects of lemon extract on health and treatment outcomes in this animal model.

Gut Microbiome and Metabolome Modulation by High-Hydrostatic-Pressure-Processed Tomato Juice.

High hydrostatic pressure (HHP) is a non-thermal pasteurization technology for the enhancement of food products' safety and quality. The components of tomato juice can be affected by HHP processing. Little is known about the effects of HHP-processed tomato juice on the gut microbiome and metabolism. Here, we performed high-throughput sequencing and metabolomics profiling to determine the critical differences in gut microbiota structure and metabolic profiles in mice administered with HHP-processed tomato juice. Tomato juice administration significantly increased the gut bacterial alpha diversity and the relative abundance of Bacteroides. The mice administered with HHP-processed tomato juice were characterized by the enrichment of Bacteroidetes, Alistieps, and Faecalibaculum compared with those administered with HTST-processed tomato juice. Moreover, HHP-processed tomato juice promoted SCFA levels, which were positively correlated with the enriched Alistieps. Our results show that HHP-processed tomato juice may drive healthy gut microbes and metabolites.

Perbedaan Pemberian Jus Apel Hijau dan Air Rebusan Daun Seledri terhadap Tekanan Darah Wanita Menopause Hipertensi di Kabupaten Bojonegoro

Hypertension or high blood pressure is a chronic condition characterized by increased blood pressure on the walls of the arteries. Hypertension is caused by high sodium intake while vegetable and fruit intake is low. This study aims to determine the difference in blood pressure reduction in groups given green apple juice and boiled water from celery leaves in menopausal women who experience hypertension in Bojonegoro Regency. This type of research is quantitative research with a "True experimental" design, with a "Two Group Pre-test and Post-test Design". This sample consisted of 36 respondents who were divided into 18 respondents of green apple juice and 18 respondents of boiled celery leaf water using a purposive sampling technique. Data collection using a Stethoscope Tensimeter measuring instrument and observation sheets will be analyzed using the Paired T-Test and Independent Sample T-Test. The research results were analyzed using the Paired T-Test, it was found that there was a significant difference in systolic blood pressure (p-value = 0.003) and diastolic blood pressure (p-value 0.032) before and after administration of green apple juice. In the celery leaf boiled water group, significant results were also found to reduce systolic blood pressure (p-value = 0.000) and diastolic blood pressure (p-value = 0.017) before and after administering celery leaf boiled water. From the description above, it can be concluded that giving green apple juice and boiled water from celery leaves can significantly reduce systole and diastole. Keywords: green apple, celery, hypertension, menopausal women

Perbedaan Pemberian Jus Apel Hijau dan Air Rebusan Daun Seledri terhadap Tekanan Darah Wanita Menopause Hipertensi di Kabupaten Bojonegoro

Hypertension or high blood pressure is a chronic condition characterized by increased blood pressure on the walls of the arteries. Hypertension is caused by high sodium intake while vegetable and fruit intake is low. This study aims to determine the difference in blood pressure reduction in groups given green apple juice and boiled water from celery leaves in menopausal women who experience hypertension in Bojonegoro Regency. This type of research is quantitative research with a "True experimental" design, with a "Two Group Pre-test and Post-test Design". This sample consisted of 36 respondents who were divided into 18 respondents of green apple juice and 18 respondents of boiled celery leaf water using a purposive sampling technique. Data collection using a Stethoscope Tensimeter measuring instrument and observation sheets will be analyzed using the Paired T-Test and Independent Sample T-Test. The research results were analyzed using the Paired T-Test, it was found that there was a significant difference in systolic blood pressure (p-value = 0.003) and diastolic blood pressure (p-value 0.032) before and after administration of green apple juice. In the celery leaf boiled water group, significant results were also found to reduce systolic blood pressure (p-value = 0.000) and diastolic blood pressure (p-value = 0.017) before and after administering celery leaf boiled water. From the description above, it can be concluded that giving green apple juice and boiled water from celery leaves can significantly reduce systole and diastole.

Differences In The Effectiveness Of Date Juice And Beet Juice In Increasing Hemoglobin Levels In Anemia Pregnant Women In The Work Area Of The Tirtamulya Health Center In 2023

Background: beets and dates can increase hemoglobin for those who have anemia. The nutritional composition of dates is that they are rich in natural sugars, fiber, potassium, magnesium and B vitamins, iron, calcium and phosphorus in fairly high amounts, while beets also contain nitrates, compounds that can help improve blood flow and performance. brain so that it can be known to increase hemoglobin levels in the blood. Purpose of writing: to find out the difference in the effectiveness of giving date juice and beet juice in increasing hemoglobin levels in anemic pregnant women in the working area of the Tirtamulya Health Center in 2023. Research method: Pre-experimental study with type one group pre test – post test design by means of relationships cause and effect by involving a group of subjects. the subject group was observed before the intervention was carried out and then observed after the intervention was carried out. The sampling technique is non-probability sampling with a purposive method. The study was divided into 2 variables, namely the independent variable, namely the consumption of date juice and beetroot juice. Results: Assessment before and after administration of date palm juice obtained a value of Sig 0.000, sig value &lt;0.05 which can be concluded that there is effectiveness of giving date juice in increasing Hb levels in anemic pregnant women. While theassessment before and after giving beetroot juice obtained a Sig value of 0.000, a sig value &lt;0.05 which can be concluded that there is effectiveness of giving beetroot juice in increasing Hb levels in anemic pregnant women. Conclusions and Suggestions: The results of this study are expected to provide information that giving date palm juice and beetroot juice is a type of natural food that can increase Hb levels.

EFFECT OF BEETROOT JUICE ON THE INCREASE IN HEMOGLOBIN LEVELS AMONG PREGNANT WOMEN AT KEMILING INPATIENT COMMUNITY HEALTH CENTER IN 2022

Anemia in pregnancy is a hemoglobin level below 11gr% in the 1st and 3rd trimesters or &lt;10.5g% in the 2nd trimester. The pharmacological method to treat anemia is by administering Fe tablets and folic acid, while non-pharmacological treatment and prevention of anemia can be done by consuming beetroot. This study aims to determine the effect of beetroot juice on the increase in hemoglobin levels among pregnant women at Kemiling Inpatient CHC in 2022. This was a quantitative quasi-experimental study with one group pre-test and post-test approach. The samples involved 15 pregnant women in the third trimester with mild or moderate anemia at Kemiling Inpatient CHC. The study was conducted in January 2022. Data was collected using observation sheets. Data were analyzed using univariate and bivariate analysis (t-test). The results showed that the mean Hb level before and after the administration of beetroot juice was 10.46 gr/dl and 11.70 gr/dl, respectively. There was an effect of beetroot juice on the increase in hemoglobin levels among pregnant women at Kemiling Inpatient CHC in 2022 with a p-value of 0.000. Pregnant women need to find information about prevention and management of anemia in pregnancy and have regular prenatal checkups.

Pengaruh Pemberian Jus Tomat Terhadap Tekanan Darah Pada Penderita Hipertensi di Kelurahan Mahawu Lingkungan II Kota Manado

Hypertension or high blood pressure is a condition when there is an increase in blood pressure, which is above 140 mmHg for istolic blood pressure and 90 mmHg for diastolic blood pressure.One of the therapies used to lower blood pressure is the administration of tomato juice because it is rich in lycopeine, potassium and bioflavonoids. The purpose of this study was to determine the effect of tomato juice on lowering blood pressure in hypertensive patients in Mahawu Village sub distrit II Manado City. The method used in this study is a design experiment with One Group pretest-postest design. The sample taken amounted to 15 respondents using purposive sampling. Data collection using SOPs and observation sheets. The collected data is processed using SPSS 16.0. Statistical test using Wilcoxon Test with a meaning level ( α) of 0.05. The results of the study using Wilcoxon statistical tests obtained the results of Systolic Pre-Post with a value of P value = 0.001 and Diastolic Pre-Post with a value of p Value = 0.002 where the value of p Value &lt; α = 0.05). so that Ha was accepted and Ho was rejected so that there was an effect of giving tomato juice on lowering blood pressure in people with hypertension in Mahawu Village sub district II Manado City. The conclusion is based on the results of the study that there is an effect of giving tomato juice on reducing blood pressure in hypertensive patients in Kelurahan II Manado City.

Noni (Morinda citrifolia L.) fruit juice reduces paw edema and protects gastric mucosal injury in rats

Edema is a reliable parameter to evaluate the anti-inflammatory process. Noni (Morinda citrifolia L.) fruit has been shown to decrease inflammation. However, studies on the impact of noni juice on gastric mucosal injury are still limited. Thus, the current study aimed to assess the effect of noni fruit juice as an anti-inflammatory agent in rat paw edema and gastric mucosal injury. The rats were divided into five groups such as control, carrageenan only, carrageenan and diclofenac sodium, carrageenan and 90% noni, and carrageenan + 100% noni. Paw edema was measured, and histopathological examination of the gastric tissues was performed. The administration of noni juice significantly reduced paw edema in the carrageenan + 90% noni and carrageenan + 100% noni groups of rats. Compared to the carrageenan + diclofenac sodium group, the carrageenan + 90% noni and carrageenan + 100% noni groups were not significantly different in reducing paw edema. It suggests that the administration of noni juice can reduce paw edema with the same potential as diclofenac sodium. Gastric mucosal injury in the carrageenan + diclofenac sodium group (scores 2 to 3) was higher than in the carrageenan + 90% noni and carrageenan + 100% noni groups (scores 1 to 2), both of them had significant differences (p&lt;0.05). In conclusion, noni juice can reduce paw edema and protect against gastric mucosal injury.

Effect of Psidium guajava Juice on The Seminiferous Tubules Diameter and Epithelium Thickness in Rattus norvegicus Exposed by Lead Acetate

Lead is one of humans and animals' most common and hazardous heavy metals. This study aimed to investigate the effect of white guava (Psidium guajava) fruit juice on the seminiferous tubule diameter and epithelium thickness in rats (Rattus norvegicus) exposed to lead acetate. The research design was a completely randomized design (CRD). A total of 25 male rats with an average weight of 200 grams were used for the study, divided into 5 treatment groups, each consisting of 5 rats. The treatments were as follows: the control group (C) was given distilled water orally; the T0 group was induced with lead acetate (50 mg/Kg BW) orally; the T1, T2, T3 groups were induced with lead acetate (50 mg/Kg BW) and then given 25%, 50%, and 100% concentration of white guava fruit juice, respectively. All the treatments were conducted for 14 days. The histopathology slides of the testis were made with HE staining, and the seminiferous tubule diameter and epithelium thickness were measured. The data were analyzed using One Way ANOVA and Duncan test (p&lt;0.05). The results showed that the control group (C) which was given distilled water only had a seminiferous tubule diameter and epithelium thickness of 336.24±23.32 µm and 66.46±4.39 µm, respectively. The T0 group which was induced with lead acetate only showed a reduction in the diameter and epithelium thickness of seminiferous tubules (243.38±49.35 µm and 44.08±14.45 µm). The members of the T1, T2 and T3 groups showed positive effects on the diameter (323.49±22.82 µm; 314.41±13.04 µm; 325.04±16.88 µm, respectively) and epithelium thickness (56.36±3.36 µm; 60.50±3.81 µm; 66.744±9.50 µm, respectively). There was no significant difference reported between each group. The administration of guava juice to rats induced with lead acetate can positively affect the diameter and epithelium thickness of seminiferous tubules.