The consequences of drug residues' presence in ani mal organism and food products of animal origin represent an actual problem, due t o the high diversity of drugs used for therapy. The presence of residues in food products is accepted u nder some maximum residues limits (MRLs) that are strictly established and accepted for each type of molecule. The aim of this research was the comparative study of enrofloxacin and ciprofloxacin residues depletion in pork after the administration to pigs of two enrofloxacin pharmaceutical forms (oral solution 10% and powder 40%), for 5 days, in the manufacturer's recommended doses. The pigs were slaughtered at various time intervals after treatment's interruption; the samples were analyzed by high performance liquid chromatography method (HPLC). Considering the pharmacokinetics of enrofloxacin (ciprofloxacin is a metabolite of enrofloxacin), residues level in po rk was presented as sum of enrofloxacin and ciprofloxa cin in mg/kg. After the administration of enrofloxacin to pigs, t he depletion of enrofloxacin and ciprofloxacin residues in pork meat was generally b alanced, but the biggest amount of enrofloxacin wass eliminated especially during the first days af ter treatment's interruption. In the case of enrofloxacin, the determined withdra wal period for pork meat was 6-8 days, depending on the pharmaceutical form and the concentration of the drug.