Administration Of Cefquinome Research Articles

Biochemical Alterations Following Repeated Intramuscular Administration of Cefquinome in Cow Calves during its Safety Assessment

The present study was carried out to investigate biochemical alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg -1 body weight in five healthy cow calves during its safety assessment study. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1 st , 2 nd , 3 rd , 4 th , 5 th and 6 th from jugular vein into vacutainers without K 3 EDTA for serum biochemical parameters (serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), serum alkaline phosphatase (AKP), serum acid phosphatase (ACP) and serum bilirubin) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic dose produced non-significant (p<0.05) difference in values of serum biochemical parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in serum biochemical parameters following intramuscular administration of cefquinome, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.

Safety Assessment of Cefquinome Following Multiple Intramuscular Administration Regarding Haematology of Cow Calves

The present study was carried out to investigate haematological alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg -1 body weight in five healthy male cow calves. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1 st , 2 nd , 3 rd , 4 th , 5 th and 6 th from jugular vein into Ethylene Diaminetetraacetic Acid Tripotassium Salt (K3EDTA) coated vacutainers for haematological parameters (Hemoglobin, Packed cell volume, total leukocyte count and differential leukocyte count) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic doses produced non-significant difference (p<0.05) in values of haematological parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in haematological parameters following intramuscular administration, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.

Blood parameters on concurrent administration of cefquinome and tolfenamic acid in sheep

A study was designed to determine haemato-biochemical profile following daily intramuscular administration of cefquinome (@2.0 mg/kg b.wt.) along with tolfenamic acid (@2.0 mg/kg b.wt.) for 5 days in sheep. The mean values of any of hematological and serum biochemical parameters did not alter significantly following daily intramuscular administrations of both drugs in comparison to the corresponding control values (day 0). Thus, daily intramuscular administrations of cefquinome with tolfenamic acid were well tolerated in sheep and cefquinome may be useful in combination with tolfenamic acid to treat bacterial diseases accompanied by inflammatory condition in sheep.

Population pharmacokinetics of cefquinome in pigs

This study was performed in 145 pigs to develop a population pharmacokinetics (PPK) model by i.m. administration of cefquinome (CEQ) at the dose of 2 mg/kg in the neck muscle. Serum physiological and biochemical parameters for each pig were determined before administration. After administration, 2-4 samples were collected at random, with the sampling point evenly distributed in the three periods (<1 h, 1-4 h and >4 h). The plasma concentration of CEQ was determined by high performance liquid chromatography with UV detector. The pharmacostatistical analyses of concentration-time data, weight, age, gender, serum physiological and biochemical parameters were performed with nonlinear mixed effect modeling (NONMEM). A one-compartmental model with first-order absorption and elimination adequately described the data from the study group. The optimal random effect model of pharmacokinetics parameters was of log-normal distribution and the residual errors assumed a mixed-type model (proportional and additive) to best explain intra-individual variability. Covariate analysis showed that body weight is positively correlated with apparent volume of distribution (V/F) and body clearance (CL/F). The typical PPK parameters of Ka , CL, and V were 0.564/h, 5.15 L/h, and 1.36 L, respectively.