Biochemical Alterations Following Repeated Intramuscular Administration of Cefquinome in Cow Calves during its Safety Assessment

Abstract

The present study was carried out to investigate biochemical alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg -1 body weight in five healthy cow calves during its safety assessment study. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1 st , 2 nd , 3 rd , 4 th , 5 th and 6 th from jugular vein into vacutainers without K 3 EDTA for serum biochemical parameters (serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), serum alkaline phosphatase (AKP), serum acid phosphatase (ACP) and serum bilirubin) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic dose produced non-significant (p<0.05) difference in values of serum biochemical parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in serum biochemical parameters following intramuscular administration of cefquinome, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.