You have accessJournal of UrologyStone Disease: Evaluation & Medical Management1 Apr 20112225 CARDIOVASCULAR RISK IS INCREASED IN PATIENTS WITH CALCIUM OXALATE UROLITHIASIS AND CORRELATED WITH URINARY OXALATE EXCRETION Hasan Aydin, Faruk Yencilek, Ismet Bilger Erihan, Binnur Okan, and Kemal Sarica Hasan AydinHasan Aydin Istanbul, Turkey More articles by this author , Faruk YencilekFaruk Yencilek Istanbul, Turkey More articles by this author , Ismet Bilger ErihanIsmet Bilger Erihan Istanbul, Turkey More articles by this author , Binnur OkanBinnur Okan Istanbul, Turkey More articles by this author , and Kemal SaricaKemal Sarica Istanbul, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2466AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is a strong correlation between the development of urolithiasis and metabolic syndrome(MS) that is characterized with an increase in cardiovascular disease risk. Endothelial dysfunction (ED) is a well-known indicator of cardiovascular risk. Increase in systemic ADMA levels- an indicator of ED was reported in urolithiasis in our previous animal study. The aim of this study was to assess the cardiovascular risk in patients with urolithiasis. METHODS One hundred patients with calcium oxalate urolithiasis and 100 healthy age-matched subjects as a control group were included into this study. Framingham risk score was used for the assessment of 10-year cardiovascular risk and SCORE risk scale for 10-year fatal cardiovascular risk assessment. Oxalate, calcium, citrate, uric acid and creatinine in 24-hour urine samples were used as stone development risk factors. RESULTS Mean Framingham risk score was 10,26±9,05 (14,55±9,30 in men and 6,32±8,7 in women). It was 4,39±5,11 in healthy controls (p<0,0001). The odds-ratio for the development of cardiovascular disease was 5,18 (95% CI, 2,57–10,31) and 10 year fatal cardiovascular risk was 1,52±2,75 in patients with urolithiasis. Framingham risk score was found to be correlated with urinary oxalate excretion (p=0,002, r=0,373). Urinary oxalate excretion was also correlated with systolic blood pressure (p=0,0001, r=0,444), total cholesterol (p=0,01, r=0,293) and fasting blood glucose (p=0,007, r=0,456). CONCLUSIONS This is the first study pointing out an increased cardivascular risk in patients with calcium oxalate urolithiasis in correlation with urinary stone risk factors. Further large population-based prospective studies are needed for the confirmation. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e893 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hasan Aydin Istanbul, Turkey More articles by this author Faruk Yencilek Istanbul, Turkey More articles by this author Ismet Bilger Erihan Istanbul, Turkey More articles by this author Binnur Okan Istanbul, Turkey More articles by this author Kemal Sarica Istanbul, Turkey More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...