Adenosquamous Carcinoma Of Gallbladder Research Articles

Comparison of clinicopathological characteristics and long-term survival between patients with gallbladder adenosquamous carcinoma and pure gallbladder adenocarcinoma after curative-intent surgery: a single-center experience in China and a meta-analysis.

The aim of the study was to evaluate the similarities and differences between gallbladder adenosquamous carcinoma (GBASC) and pure gallbladder adenocarcinoma (GBAC). Patients with GBASC and GBAC from 2010 to 2020 were analyzed in terms of clinicopathological features and long-term survival. Moreover, a meta-analysis was also performed for further validation. Our experience: A total of 304 patients with resected GBC were identified, including 34 patients with GBASC and 270 patients with GBAC. Patients with GBASC had a significantly higher preoperative CA199 level (P <0.0001), a significantly higher incidence of liver invasion (P <0.0001), a relatively larger tumor size (P = 0.060), and a significantly higher proportion of patients with T3-4 (P <0.0001) or III-IV disease (P = 0.003). A comparable R0 rate was obtained between two groups (P = 0.328). A significantly worse overall survival (OS) (P = 0.0002) or disease-free survival (DFS) (P = 0.0002) was observed in the GBASC. After propensity score matching, comparable OS (P = 0.9093) and DFS (P = 0.1494) were obtained. Clear margin (P = 0.001), node metastasis (P <0.0001), T stage (P <0.0001), and postoperative adjuvant chemoradiotherapy (P <0.0001) were independent prognostic factors for OS for the entire cohort. Adjuvant chemoradiotherapy had a survival benefit for patients with GBAC, while the survival benefit was still being validated in patients with GBASC. Meta-analysis: With our cohort incorporated, a total of seven studies involving 1,434 patients with GBASC/squamous carcinoma (SC) were identified. GBASC/SC shared a worse prognosis (P <0.00001) and more aggressive tumor biological features than GBAC. GBASC/SC shared more aggressive tumor biological features and a much worse prognosis than those with pure GBAC.

Adenosquamous Carcinoma of Gallbladder with Unusual Prognosis: A Case Report.

carcinoma; case reports; cholecystectomy; prognosis.

Epidemiology and survival outcomes in adenosquamous carcinoma: a population-based study.

The relationship between the location of the primary tumor and survival of adenosquamous carcinoma (ASC) remains poorly understood. This study aimed to evaluate the impact of primary tumor location on the survival outcome of patients with ASC. Patients with ASC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database with ≥ 150 cases per tumor location. The Kaplan-Meier method was used to generate survival curves and differences among them were compared using the log-rank test. On the other hand, Cox proportional hazards models were used to evaluate factors that had independent predictive effects on cancer-specific survival (CSS). A total of 14,829 eligible patients with ASC were included in this study. Lung and bronchus ASC accounted for 51.1%, followed by the cervix uteri (17.0%), corpus uteri (13.9%), pancreas (4.9%), esophagus (3.1%), gallbladder (2.5%), stomach (2.2%), colon and rectum (2.0%), head and neck (1.8%), and breast ASC (1.3%). The 5-year CSS of breast, cervix uteri, colon and rectum, corpus uteri, esophagus, gallbladder, head and neck, lung and bronchus, pancreas, and stomach ASC was 76.9%, 66.0%, 34.8%, 72.9%, 12.0%, 10.8%, 45.0%, 24.7%, 4.3%, and 17.3%, respectively. COX analysis demonstrated that the primary tumor location was an independent prognostic factor for CSS. Besides, the breast, uterine corpus, and cervix as well as head and neck ASC were significantly associated with better prognosis, while pancreas and gallbladder ASC were significantly associated with poor CSS; stomach and colorectal were roughly the same as ASC prognosis. Our study showed that the CSS of patients with ASC depends on the location of the primary tumor. Besides, tumor location is an important factor that should guide the use of chemotherapy and radiation.

A case of gallbladder adenosquamous carcinoma with measured tumor doubling in 111 days

A case of gallbladder adenosquamous carcinoma with measured tumor doubling in 111 days

En bloc total biliary resection hepatectomy for the treatment of gallbladder adenosquamous carcinoma: a case report

INTRODUCTION: Gallbladder cancer is a rare type of biliary tract malignancy with poorly defined pathogenesis, difficult treatment and often inoperable. CASE REPORT: A 84-year-old male presented with pain in the right hypochondrium with three months of progressive worsening. Ultrasound routine examination showed the presence of a large mass in the gallbladder adjacent topography that also showed signs of invasion in the liver tissue. He was submitted to preoperative staging with chest and abdomen MRI with intravenous contrast. A resection of the IVB, V and VI hepatic segments was performed associated to complete resection of the extra hepatic bile duct en bloc. Main bile duct reconstruction with Y-Roux jejunostomy was also performed. DISCUSSION: Gallbladder carcinoma with squamous component is a rare type of cancer with poor prognosis whose treatment with a curative potential is only possible with surgery, in case the lesion is resectable.

Adenosquamous Carcinoma of Gallbladder – A Case Report

Gallbladder cancer is an uncommon malignancy and majority of these carcinomas are adenocarcinomas. Adenosquamous carcinoma of gallbladder is a rare histopathological subtype of gallbladder carcinoma. It usually presents with symptoms of cholelithiasis like epigastric pain, nausea and bloating. On clinical examination, tenderness is usually present. Radiologically in most of the cases, gallstones are found leading to the diagnosis of cholelithiasis for which cholecystectomy is done. Gallbladder carcinomas are found mostly as an incidental finding on microscopic examination of cholecystectomy specimen. This disease is curable if diagnosed earlier but in most of the cases they present at advanced stages when resection is not possible and prognosis is poor. As this disease is extremely rare so published information is largely based on the case reports and case series. This is a case of 60 years old female patient who underwent cholecystectomy for cholelithiasis with incidental finding of Adenosquamous carcinoma on histopathology report.

Gallbladder Adenosquamous Cancer with Situs Inversus Totalis: A Case Report and Literature Review

BackgroundSitus inversus totalis (SIT) is a rare genetic congenital disease, characterized with complete right-to-left inversion of all the internal organs. We herein describe a meaningful case which was diagnosed as gallbladder adenosquamous carcinoma, a rare histology type of gallbladder cancer, with SIT.Case PresentationA 59-year-old Chinese woman was admitted for persistent epigastric distention and intermittent abdominal pain. The abdominal CT scan revealed a huge mass at the gallbladder bottom, involving the adjacent transverse colon and liver. En-bloc radical resection of the gallbladder cancer, including partial colectomy and hepatectomy with regional node dissection, followed by colocolostomy and Roux-en-Y choledochojejunostomy, was successfully performed. Pathology analysis indicated an adenosquamous carcinoma with positive adenocarcinoma markers (CK7, CK19) and squamous carcinoma markers (CK5/6, P63).ConclusionThe SIT anomaly might increase the risk of malignancies by sharing genome mutations, suggesting the importance of surveillance in the SIT settings.

A Case of Gallbladder Adenosquamous Carcinoma Diagnosed Accidentally After Surgery for Gallbladder Torsion

A Case of Gallbladder Adenosquamous Carcinoma Diagnosed Accidentally After Surgery for Gallbladder Torsion

Clinical efficacy of radical resection for stage T3 gallbladder cancer and prognostic analysis

Clinical efficacy of radical resection for stage T3 gallbladder cancer and prognostic analysis

Gallbladder Adenosquamous Carcinoma Associated with Biliopancreatic Maljunction: aggressive resection and survival

Background: Pancreaticobiliary maljunction (PBM) is a congenital malformation in which the pancreatic and bile ducts join outside the duodenal wall. It has been reported to be associated with an increased risk of gallbladder carcinoma. Gallbladder adenosquamous carcinoma is rare, with a worse prognosis compared to patients with adenocarcinoma. We report a case of adenosquamous carcinoma of gallbladder associated with PBM. Methods: A 56-year-old woman was admitted to the hospital complaining of pain in right hypochondrium. Ultrasonography and computed tomography revealed an elevated lesion inside the gallbladder and dilated extrahepatic bile duct. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography showed PBM with biliary dilatation of 15mm in the largest diameter. Results: Cholecystectomy, bile duct resection with a Roux-en-Y hepaticojejunostomy and hepatic resection (S4b-S5) with regional lymphadenectomy was performed. Histology demonstrated an adenosquamous cell carcinoma of the gallbladder with invasion to the muscle layer and two metastases of the resected lymph nodes (T2N1M0). Fourteen months after the operation, the patient is doing well with no signs of recurrence. Conclusion: PBM is a high risk factor for the development of gallbladder carcinoma because of a continuous reflux of pancreatic juice into the biliary tract. Aggressive surgical resection without residual tumor (R0) provides a chance for long-term survival in patients with gallbladder adenosquamous carcinoma.

Gallbladder adenosquamous carcinoma associated with biliopancreatic maljunction: aggressive resection and survival

Gallbladder adenosquamous carcinoma associated with biliopancreatic maljunction: aggressive resection and survival

Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers.

Adenosquamous/squamous cell carcinoma (AS/SCC) of the gall bladder is a rare histopathologic subtype that accounts for 1 to 12% of all the gall bladder carcinomas (GBC). Literature on these malignancies is limited. A retrospective analysis of 8 cases (study group) of pathologically proven AS/SCC of the gallbladder among 94 patients who underwent surgery for GBC from January 2001 to December 2014 was done. Twenty-four conventional gall bladder adenocarcinoma cases were selected as control group after matching for age and gender. Mean patient age was 57.8years and six were females. Clinical presentation did not seem to be too different among the study and control group. Average tumor thickness was significantly higher in AS/SCC cases as compared to the control group (mean 3.1 versus 1.44cm; p=0.001). Immunohistochemistry for Ki-67 in adenosquamous carcinoma of the gall bladder showed much higher proliferative index in squamoid area than the adenocarcinoma areas (mean 31.3 versus 16.8%; p=0.0004). Study group showed 87.5% patients were in higher stage whereas only 37.5% of the patients in control group presented at a higher stage. AS/SCC of the gall bladder presented at an advanced stage. Higher proliferation index in squamous component of adenosquamous carcinomas may account for higher T stage in these malignancies.

腺扁平上皮癌と肉腫の混在した長期生存中の進行胆嚢癌肉腫の1例

症例は85歳，女性．数十年前より続く右下腹部痛を主訴に来院．腹部CT・MRCPで胆嚢内に腫瘍性病変を認め，進行胆嚢癌と診断した．術中所見で胆嚢は腫大し横行結腸への浸潤を認めたが，総胆管への浸潤はなく，胆嚢摘出術，結腸部分切除術および肝床切除術を施行した．病理組織学検査では，低分化腺癌および扁平上皮癌が混在した腺扁平上皮癌部分（免疫組織化学染色でepithelial membrane antigen （EMA）・keratin陽性）と異型の強い紡錘形細胞に一部骨化形成のある肉腫の混在した部分（vimentin陽性）が認められ，腺扁平上皮癌と肉腫が混在した胆嚢癌肉腫と診断された．7年経過した現在も再発の徴候は認めていない．腺扁平上皮癌と肉腫からなる胆嚢癌肉腫の報告は少ない．また腺扁平上皮癌は，大半が高度進行癌で予後不良かつ肉腫併存例での長期生存も少なく，極めて稀であり文献的考察を加えて報告する．

Gallbladder Adenosquamous Carcinoma Associated with Biliopancreatic Maljunction and Cystic Metastases of the Liver Miming Abscess.

Gallbladder adenosquamous carcinoma is a rare tumor with glandular and squamous malignant components. We report a special case of this rare tumor with cystic metastasis of the liver miming hepatic abscess and associated with biliopancreatic maljunction.

Clinicopathological features of gallbladder adenosquamous carcinoma

Objective To analyze the clinicopathological features of gallbladder adenosquamous carcinoma.Methods The clinical data of 8 patients with gallbladder adenosquamous carcinoma who were admitted to the Peking Union Medical College Hospital from January 2000 to December 2010 were retrospectively analyzed.The clinicopathological features,diagnosis and treatment strategies were summarized.The survival curve was drawn by Kaplan-Meier method,and the survival of the patients was analyzed by Log-rank test. Results The clinical manifestation of the 8 patients was non-specific,and all the patients were misdiagnosed as with primary gallbladder cancer complicated with cholecystolithiasis or chronic cholecystitis.The levels of carcinoembryonic antigen and γ-glutamyl transferase of 3 patients were higher than the normal,the level of alkaline phosphatase of 2 patients was higher than the normal,the level of aspartate transaminase of 1 patient was higher than the normal,the level of CA242 of 3 patients was higher than the normal and the level of CA19-9 of 4 patients was higher than the normal.The levels of aspartate transaminase,total bilirubin and direct bilirubin were in the normal range. Different surgical approaches were selected according to different tumor positions.The mean diameter of the tumor was (5 ±3)cm. Lymph node metastasis was detected at the hepatic hilar,hepatoduodenal ligament and area behind pancreatic head. Postoperative pathological examination confirmed that all the patients were with gallbladder adenosquamous carcinoma. All patients were followed up till April 2011. Two patients survived with no discomfort,and the survival time was 2-3 months.Six patients died of tumor recurrence or metastasis,and their median survival time was 8 months (range,4-13 months). Conclusions The clinical manifestation of gallbladder adenosquamous carcinoma is non-specific, and definite diagnosis depends on the results of postoperative pathological examination.Surgical treatment is the only effective method in improving the prognosis of patients with gallbladder adenosquamous carcinoma,and the prognosis of patients is poor. Key words: Gallbladder neoplasms; Clinicopathological features; Diagnosis; Prognosis

すい胆管合流異常を伴った胆嚢腺へん平上皮癌の１例

すい胆管合流異常を伴った胆嚢腺へん平上皮癌の１例

A case of synchronous early gastric cancer and gallbladder adenosquamous carcinoma

A case of synchronous early gastric cancer and gallbladder adenosquamous carcinoma