Adenoma Research Articles

Sellar Pathologies Mimicking Pituitary Tumors.

The most common sellar pathology that merits neurosurgical attention is the pituitary adenoma. However, some developmental, inflammatory, and neoplastic lesions may primarily or secondarily involve the sella, mimicking pituitary tumors. Advances in imaging and endocrinological assessment have helped in the recognition of these less common sellar, supra sellar pathologies, which may occasionally create confusion in management. The most common developmental anomaly is the Rathke's cleft cyst and an increasingly recognized inflammatory pathology is the spectrum of hypophysitis. Neoplasms, viz. Craniopharyngioma, Germinoma, Langerhans's cell histiocytosis or metastasis, have more distinctive features in various age groups and are more likely to be correctly diagnosed on current imaging and managed accordingly. This review looks at mainly intraparenchymal pathologies, namely Rathke's Cleft Cyst and various hypophysitides, and will discuss their management strategies.

Hepatic tumors: pitfall in diagnostic imaging.

On computed tomography (CT) and magnetic resonance imaging (MRI), hepatocellular tumors are characterized based on typical imaging findings. However, hepatocellular adenoma, focal nodular hyperplasia, and hepatocellular carcinoma can show uncommon appearances at CT and MRI, which may lead to diagnostic challenges. When assessing focal hepatic lesions, radiologists need to be aware of these atypical imaging findings to avoid misdiagnoses that can alter the management plan. The purpose of this review is to illustrate a variety of pitfalls and atypical features of hepatocellular tumors that can lead to misinterpretations providing specific clues to the correct diagnoses. (www.actabiomedica.it)

Surgery for Acromegaly.

Growth hormone (GH) hypersecretion from a pituitary adenoma results in acromegaly, an endocrinological disorder with multiple systemic manifestations that presents several unique challenges in terms of perioperative management and long term outcomes. Current guidelines provide stringent criteria for determining biochemical remission, necessitating an aggressive approach to management. Despite the development of several non-surgical therapies, transsphenoidal surgery, the endoscopic approach in particular, remains the primary line of treatment for rapid normalization of GH and Insulin-like growth factor with a low incidence of perioperative morbidity. Tumor size and invasiveness are important factors predicting surgical outcomes with better rates of postoperative remission seen in smaller and non-invasive tumors. Postoperative remission rates reported in literature with the 2020 consensus criteria vary from 30 to 85% probably reflecting varying prevalence rates of invasive tumors. Thus, a significant proportion of patients fail to achieve remission after surgery for whom treatment options for residual disease must be carefully considered. This review article discusses the surgical management of acromegaly and provides a summary of contemporary outcomes and current treatment controversies.

Reduced serum exosomal miR-874 expression predicts poor prognosis in colorectal cancer.

Emerging evidence has indicated that serum exosomal microRNAs (miRNAs) have promising diagnostic and prognostic value for colorectal cancer (CRC). This study aimed to detect serum exosomal miR-874 expression in CRC patients and assess its potential clinical significance. Blood samples were collected from 125 CRC patients, 45 cases with benign adenomas (AD) and 70 healthy individuals. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to examine serum exosomal miR-874 levels. The results showed that serum exosomal miR-874 levels were significantly downregulated in CRC patients compared to AD cases and healthy controls. Receiver operating characteristic (ROC) curve analysis revealed that serum exosomal miR-874 expression could discriminate CRC patients from healthy controls, as well as patients with AD. In addition, low serum exosomal miR-874 expression was associated with positive distant metastasis, positive lymph node metastasis, poor differentiation, and advanced TNM stage. Moreover, serum exosomal miR-874 expression was identified as a statistically significant independent prognostic factor for overall survival of CRC patients. Collectively, serum exosomal miR-874 expression might serve as a reliable marker for CRC diagnosis and prognosis prediction.

Nipple Ultrasound: A Pictorial Essay

Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma in situ (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify and characterize nipple lesions. Additionally, we have presented the mammography and MRI outcomes correlated with histopathologic features for the relevant cases.

Çocukluk Çağı Meme Kitlelerinde Güncel Cerrahi Yaklaşım

Objectives: To evaluate the surgical approach to pediatric breast masses.Patients and Methods: Patients who underwent a surgical intervention due to breast mass between the years of 2005-2017 were evaluated retrospectively. They were evaluated in terms of age, primary diagnosis, radiological characteristics, surgical treatment method, complications, length of hospital stay and follow-up.Results: The mean age of the 29 cases that were operated on for a breast mass was 14.86 years 6-17 years . The most common complaint at admission was a palpable breast mass. Two cases had bloody discharge from the nipple. The mean duration of the symptoms was 32.3 weeks 2 weeks-1 year . Six cases 20.6% had a family history associated with breast disease. The mean BMI was 18.8 . In 15 patients, the mass was in the left breast, whereas in 13 patients, the mass was in the right breast. However, in one case, two masses were localized bilaterally.Regarding radiological examination, ultrasonography USG was performed on all patients while magnetic resonance imaging MRI was obtained as a supplement in five cases. The mean size of the masses measured radiologically was 2.9 cm 0.9-7 cm . There were multiple lesions in five cases. Needle biopsy was performed in six cases with the suspicion of malignancy in the preoperative period, and they were all found to be consistent with fibroadenoma.Histopathological examination was performed after the surgical excision and revealed fibroadenoma n:26 , borderline phylloides n: 1 , nipple adenoma n: 1 and galactocele n: 1 .The mean follow-up period was 36.6 months 3 months-10 years . New lesions were developed ipsilaterally in three cases and contralaterally in one case during follow-up. Conclusion: Most of pediatric breast masses are benign. Although malignancy is rarely encountered, MRI and needle biopsy are required for accurate surgical planning in case of suspicious ultrasonography findings

Follow-up Colonoscopy in Patients with Small Nonadvanced Adenomas

Many average-risk patients who undergo screening colonoscopy have a few small tubular adenomas without high-grade dysplasia. Although the 2012

Value of dynamic contrast-enhanced CT combined with MRI in differential diagnosis of adrenal adenoma and metastatic tumor

Objective To investigate the clinical significance of dynamic contrast-enhanced computed tomography (CT) combined with magnetic resonance imaging (MRI) in differential diagnosis of adrenal adenoma and metastasis. Methods 120 patients with adrenal adenoma who were examined by enhanced MRI and enhanced CT before operation were collected. According to the pathological examination after operation, they were divided into adrenal adenoma group (86 cases) and adrenal metastasis group (34 cases). The difference of time-density curve between the two groups was compared, and the diagnostic criteria were evaluated by using receiver operating characteristic (ROC) curve. Results Dynamic CT and dynamic MRI were mainly type A, followed by type C, B, D and E. Dynamic CT and dynamic MRI were mainly type B, followed by type D/E, type A and type C. There were significant differences in type A, B, C, E dynamic CT and dynamic MRI between the two groups (P 0.05). The AZ value of adrenal adenomas ranged from 0.714 to 0.825 and that of adrenal metastasis ranged from 0.872 to 0.965 at 3-30 minutes delay. Conclusions Dynamic contrast-enhanced CT combined with MRI in patients with adrenal adenoma and metastasis has a time-density difference, 5min has high discriminant value in time lapse. Key words: Image enhancement; Tomography, X-ray computed; Magnetic resonance imaging; Adrenal gland neoplasms

Nipple adenoma: a review of the literature

Nipple adenomas (NA) are benign proliferations that can behave in a locally infiltrative manner and can thus mimic and present with features of breast malignancy. This article presents an up-to-date review of the literature on the presentation, diagnosis pathological assessment and surgical treatment of these rare lesions. A Medline, PubMed and OVID search was performed for all articles on nipple adenomata using keywords “nipple” and “adenoma, papillomatosis, adenosis, syringomatous, erosive, pathology and nodule”. The literature on nipple adenomata consists mainly of case series or case reports, with a variety of management techniques described. Nipple adenomata remain rare benign proliferations with most standard breast units expecting to see one to two cases per year. Mammography and ultrasound remain the most common imaging modalities for diagnosis. They can be locally infiltrative and definitive treatment remains surgical excision with clear margins. Assessment by histological analysis is essential to accurately confirm diagnosis, exclude malignancy and confirm clear margins.

Application of microprobe vascular Doppler in the operation of skull base lesions

Objective To investigate the effect of microprobe vascular Doppler (MVD) on the operation of skull base lesions. Methods From September 2017 to September 2018, 13 patients with skull base lesions at Neurosurgery Department of the first Affiliated Hospital of Soochow University were retrospectively analyzed. The 13 cases included 6 cases of meningioma in Sellar region, 2 cases of meningioma in petroclival region, 3 cases of pituitary adenoma of Knosp Ⅲ-Ⅳ grade, 1 case of chordoma in Sellar clival region, and 1 case of invasive growth of granulation tissue in intraorbital, skull base, sphenoid and ethmoid sinus after Aspergillus infection. The surgical methods included neuroendoscopic transnasal approach and microsurgical resection under craniotomy microscope. MVD was applied in all operations of this series. Medical imaging examination and follow-up were performed after operation. Results Among the 13 patients, total resection of meningioma in Sellar region was performed in 6 cases and subtotal resection in 2, total resection of Knosp grade Ⅲ-Ⅳ pituitary adenoma was conducted in 2 and subtotal resection in 1. Total resection was performed in 1 case of invasive growth of granulation tissue in intraorbital, skull base, sphenoid and ethmoid sinus after Aspergillus infection and 1 case of chordoma in Sellar base clival region. Uncorrected left eye vision was reported in the patient with Aspergillus infection post surgery. Postoperative symptoms of the other patients were improved. The prolactin level of 1 patient with prolactin adenoma was more than 204 ng/ml before operation. At 2 months post operation, the prolactin level was 105.66 ng/ml after oral bromocriptine combined with radiotherapy. The last reexamination was 11.3 ng/ml without hypophysis dysfunction. Six patients had varying degrees of electrolyte disorder after operation. Four patients had fever after operation and all returned to normal before discharge from hospital after treatment. All patients were followed up for (16.1±3.3) months(10-22 months), and there was no recurrence in imaging examination. Conclusion With the aid of MVD during the surgical resection of invasive growth lesions and large space occupying lesions in the skull base, the important blood vessels invaded, wrapped, pushed and displaced by the lesions can be monitored in real time, which might help avoid the disastrous consequences during and after operation and reduce the risk of surgery. Key words: Skull base neoplasms; Microsurgery; Natural orifice endoscopic surgery; Microprobe vascular Doppler

Repeated epistaxis caused by primary hyperparathyroidism with multiple brown tumors: One case report

To report the clinical, imaging and pathological feature of a case of primary hyperparathyroidism(PHPT) with multiple brown tumors whose complain was repeated epistaxis, and to conduct a retrospective analysis with relevant literatures. A postmenopausal middle-aged woman, with a history of joint pain, fracture, and kidney stone which were neglected due to the lack of specificity of symptoms for years, went to hospital due to repeated epistaxis. Laboratory results showed high blood calcium, hypophosphatemia, alkaline phosphatase(ALP), and parathyroid hormone(PTH) levels, as well as increased urinary calcium. Imaging examination showed systemically multiple brown tumors and extensive osteoporosis. Meanwhile an abnormal mass was found behind the right thyroid. Taking all findings into account, the diagnosis was made with PHPT, and the histopathology further confirmed that the lesion was a parathyroid adenoma. This case seems to be a rare case of multiple brown tumor caused by parathyroid adenoma, which compressed and destructed nasal blood vessels, thus induced a repeated nasal discharge. After resection of parathyroid adenoma, the patient experienced a transient hypocalcemia and PTH level elevation. After 5-month follow up, part of the brown tumors spontaneously regressed, bone density increased, and her clinical symptoms were mostly relieved. Key words: Primary hyperparathyroidism; Parathyroid adenoma; Brown tumor; Epistaxis

Application of CYP11B2 immunohistochemistry in the histopathological diagnosis of primary aldosteronism

Objective To evaluate the value of CYP11B2 immunohistochemistry in the histopathological diagnosis of primary aldosteronism(PA) among Chinese population. Methods Ninety-six cases of unilateral PA patients were retrospectively enrolled, and with 15 cases of non-hyperfunctioning adenoma, and 15 cases of cortisol producing adenoma as control. CYP11B2 immunohistochemistry was performed in the tumor sections of these patients and was analysed by semi-quantified method. The positive rate of CYP11B2 in tumor specimen of all cases enrolled was calculated and PA patients were subtypely classified based on their histopathological features and CYP11B2 expressions. Results The immune-positive rate of CYP11B2 in the PA group was 91.7% (88/96), with the control group being 6.7% (2/30, P<0.001). Subgroup analysis revealed that the immune-positive rate of CYP11B2 in the aldosterone producing adenoma group and unilateral hyperplasia group were 91.8% (78/85) and 90.9% (10/11), respectively. Based upon histopathological feature and CYP11B2 immunohistochemistry, PA patients were further subtypely classified as aldosterone producing adenoma (85/96), unilateral diffuse adrenocortical hyperplasia (7/96), unilateral mono-adrenocortical micronodules (1/96), unilateral multiple adrenocortical micronodules (1/96), and unilateral multiple aldosterone-producing cell clusters (multiple APCCs, 2/96). Conclusion CYP11B2 immunohistochemistry may serve as an useful tool for the histopathological diagnosis of PA. Key words: Primary aldosteronism; Immunohistochemistry; Pathological diagnosis

Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells.

Reactive oxygen species (ROS) promote the development and progression of cancer by their effects on several signaling pathways. Lycopene, a major carotenoid natural product, is known to display antioxidant activity and to induce apoptosis of cancer cells. The aim of the present study was to investigate the mechanism by which lycopene induces apoptosis of the human gastric cancer AGS cells. In the present study, we showed that lycopene reduces the viability of AGS cells by inducing DNA fragmentation and increasing the Bax/Bcl-2 ratio. To determine the mechanistic basis for these effects, studies were conducted to assess the effects of this carotenoid on activation and nuclear translocation of β-catenin, and the expression of β-catenin target genes in AGS cells. The results showed that lycopene reduces the levels of ROS. It also inhibits activation of β-catenin signaling by changing the Wnt/β-catenin multi-protein complex such as a reduction in phosphorylation of glycogen synthase kinase 3β [GSK3β] and an increase in adenomatous polyposis coli [APC] and β-transducin repeats-containing proteins [β-TrCP]). It suppresses nuclear translocation of β-catenin and the expression of the β-catenin target survival genes c-myc and cyclin D1. Lycopene induces apoptosis by reducing ROS levels and suppressing β-catenin-c-myc/cyclin D1 axis. Thus, lycopene induces apoptosis of gastric cancer cells by disrupting nuclear translocation of β-catenin and expression of key cell survival genes.

Analysis of pathological diagnosis by fine needle aspiration cytologyand paraffin in thyroid disease

Objective To explore an economical and effective method for the diagnosis of thyroid diseases by fine needle aspiration cytology (FNAC). Methods The clinicopathological diagnosis of 1200 cases of thyroid diseases in our department was analyzed. Results There were 827 cases (68.9%) of thyroid carcinoma, 267 cases (22.2%) of thyroid adenoma, 66 cases (5.5%) of thyroid cyst, 31 cases (2.6%) of hyperthyroidism, and 9 cases (0.8%) of thyroiditis. FNAC cell diagnosis and postoperative paraffin standard comparison, benign lesions diagnosed percentage were 28.4% and 31.1% respectively, Diagnosis of malignant change percentage were 65.5% and 68.9% respectively, FNAC diagnosis of benign and malignant diagnosis efficiency cells percentage were 91.3% and 95.1% respectively, The specificity of the diagnosis of benign and malignant lesions compared percentage, there was no statistically significant difference (χ2=7.145, P>0.05). Conclusion FNAC method is reliable, convenient and economical in diagnosing thyroid diseases. It can also be used for preoperative diagnosis of thyroid surgery. Key words: Fine needle aspiration cytology; Thyroid disease; Pathological experiments

Relationship between colorectal polyps and Helicobacter pylori typing and serum gastrin 17

Objective To investigate the relationship between Helicobacter pylori infection and serum gastrin 17 levels and colorectal polyps. Methods The clinical data of 214 patients with colorectal polyps who underwent gastrointestinal endoscopy at the Affiliated Hospital of Xuzhou Medical University from June 2017 to April 2019 were collected.The specimens were divided into two groups after pathological diagnosis.The group included 126 cases with adenomatous polyps (adenomatous polyps group) and 88 cases with hyperplastic polyps(hyperplastic polyps group). Another 89 patients without obvious abnormality were selected as the control group.Serum Hp antibody was detected by western blot, and serum gastrin 17 levels were quantitatively detected by ELISA.Hp infection rate and serum gastrin 17 levels were compared between the groups. Results The infection rate of 74.2% (66 / 89) type I HP in adenomatous polyp group was significantly higher than that of 55.6% (30 / 54) in proliferative polyp group and 48.7% (19 / 39) in control group, the difference was statistically significant( χ2=5.271, P=0.022; χ2=7.867, P=0.005). The infection rate of type I HP in proliferative polyp group was not statistically significant (P>0.05). The HP infection rate in colorectal polyp group was 66.8% (143 / 214) and 67.1% (96 / 143) respectively, which was significantly higher than that in control group (43.8% (39 / 89) and 48.7% (19 / 39), the difference was statistically significant (χ2=13.87, 4.467, all P<0.05). The infection rate of Hp in colorectal proliferative polyp group was 61.4% (54/88) and adenomatous polyp group was 70.6% (89/126) higher than that in control group (43.8% (39/89), the difference was statistically significant( χ2=5.46, 15.57, all P<0.05). The serum gastrin 17 level in adenomatous polyp group (11.35 (6.67, 20.87) pmol/L)was significantly higher than that in proliferative polyp group (7.88(3.11, 13.07) pmol/L) and control group (5.69 (2.94, 11.37) pmol/L), the difference was statistically significant (Z=4.91, all P<0.05). The serum gastrin 17 level in adenomatous polyps group with type I Hp infection (14.35 (8.12, 23.68) pmol/L) was significantly higher than that of Hp-negative patients (8.42 (2.42, 20.84) pmol/L), and the difference was statistically significant (Z=2.87, P<0.05). Conclusion HP infection is closely related to colorectal polyps, especially adenomatous polyps.The increased level of serum gastrin 17 is a risk factor for colorectal adenomatous polyps.Type I HP infection can increase the level of serum gastrin 17, and it is more closely related to adenomatous polyps. Key words: Colorectal polyps; Adenomatous polyps; Hyperplastic polyps; Helicobacter pylori; Gastrin

83P - Helicobacter bilis may play a role in the carcinogenesis of colitis associated colon cancer correlating to increased number of CD4+CD45RB+ T cells

BackgroundThe role of Helicobacter bilis (H.bilis) in the development of inflammatory bowel disease (IBD) and colitis-associated carcinogenesis (CAC) has seldom been investigated. MethodsUsing 16S rRNA fluorescence in situ hybridization (FISH), we examined the abundance of H.bilis in 58 colorectal cancers (CRCs), 20 IBDs, 40 normal colorectal mucosae (NCs) and 20 adenomas (ADs). Number of CD4+CD45RB+T cell and expression of IFN-γ and TNF-α in these tissues was determined by immunofluorescence. ResultsThe abundance of H.bilis was significantly higher in CRCs (33.7±27.7) than that in IBDs (15.0±16.3; P = 0.006), ADs (4.01±7.3; P < 0.001) and NCs (1.1±3.0; P < 0.0001). The abundance of H.bilis in IBDs was significantly higher than that in ADs (P = 0.013). Moreover, the average number of CD4+CD45RB+T cell was significantly higher in CRCs (5.7±3.2) than that in IBDs (1.9±1.8, P = 0.013) and NCs (1.0±1.0, P = 0.008). In addition, there was a positive correlation between the H.bilis abundance and density of CD4+CD45RB+T cells in 30 colorectal tissues (including 19 CRCs, 6 IBDs and 5 NCs) (Spearman correlation coefficients 0.6625, 95%CI 0.3875-0.8292, P < 0.0001). The frequency of co-staining for CD4+CD45RB+T cells and IFN-γ was significantly higher in H.bilis positive group (including 5 CRCs and 4 IBDs)than that in H.bilis negative group (including 5 CRCs and 4 IBDs) (P = 0.002). ConclusionsH.bilis may play a role in the initiation of IBD and CAC, possibly through promoting the transformation of T cells into CD4+CD45RB+T cells and increasing the expression of proinflammatory cytokines IFN-γ. Legal entity responsible for the studyXiangsheng Fu. FundingHas not received any funding. DisclosureAll authors have declared no conflicts of interest.

Clinical effect of low frequency ultrasound combined with high frequency ultrasound in the diagnosis of gallbladder polypoid lesions

Objective To explore the clinical effect of low frequency ultrasound combined with high frequency ultrasound in the diagnosis of polypoid lesions of gallbladder, and to provide reference for clinical diagnosis. Methods From January 2013 to January 2017, 87 patients with gallbladder polypoid lesions in Hankou Hospital were selected as the subjects, all the patients were checked by low frequency ultrasound and high frequency ultrasound, the results were compared with postoperative pathological findings.The diagnostic effect were compared between the low frequency ultrasound and low frequency ultrasound combined with high frequency ultrasound, and the consistency between the two inspection methods and postoperative pathological results was analyzed. Results The postoperative pathological report showed that among the 87 patients, 59 cases (67.82%) had gallbladder polyp, 6 cases (6.90%) had adenomyosis, 10 cases (11.49%)had gallbladder adenoma, 12 (13.79%) had small nodular gallbladder cancer, 65 (86.67%) had benign polypoid lesions, 73 (97.33%) had low frequency ultrasound combined with high frequency ultrasound.The accuracy of combined high-frequency ultrasound in the diagnosis of benign gallbladder polypoid lesions was significantly higher than that of low frequency ultrasound (χ2=5.797, P<0.05); the specificity and positive predictive value of combined low frequency ultrasound and high frequency ultrasound in the diagnosis of benign gallbladder polypoid lesions were significantly higher than those of low frequency ultrasound(90.00% and 41.18%, 97.33% and 86.67%). The difference was statistically significant (χ2=6.217, 5.797, P=0.013, 0.016). Conclusion Compared with low frequency ultrasound, low frequency ultrasound combined with high frequency ultrasound improves the differential diagnosis effect of gallbladder polypoid lesions, which is worthy of clinical attention. Key words: Polypoid lesions of gallbladder; Low frequency ultrasound; High frequency ultrasound

Pleomorphic Adenoma of a Supernumerary Male Nipple

Pleomorphic Adenoma of a Supernumerary Male Nipple

The progress of hepatocellular adenoma malignant transforming in molecule mechanism researches

Hepatocellular adenoma is a rare type of benign tumor in the liver. It has high risk of rupture and low risk of malignant transform. Recently the incidence of hepatocellular adenoma malignant transforming has been increasing. The malignant progress of hepatocellular adenoma develop to hepatocellular carcinoma has the transition state. This course not only relyes on the CTNNB1 gene exon 3 mutations, but also depends on TERT gene promoter mutation. This article will elaborate the hepatocellular adenoma malignant transforming in molecule mechanism, pathological diagnosis and therapies. Key words: Adenoma, liver cell; Mechanism; Genes, TERT; β-catenin

Effects of intelligent nursing and transfusion system on transfusion management in patients with growth hormone adenoma complicated with cardiomyopathy

Objective To evaluate the effects of the intelligent nursing and transfusion system on transfusion management in patients with growth hormone adenoma complicated with cardiomyopathy. Methods The patients with growth hormone adenoma complicated with cardiomyopathy treated in the Department of Neurosurgery in a ClassⅢ Grade A hospital from January 2018 to May 2019 were selected. Totally 78 patients receiving conventional transfusion management from January to October 2018 were included into the control group, while 70 patients admitted from November 2018 to May 2019 after the intelligent nursing and transfusion system was applied were included into the experimental group. The incidence rate of adverse effects in transfusion, correct rate of transfusion speed, incidence rate of arrhythmia and patients' compliant rate in terms of transfusion were evaluated between the two groups. Results The incidence rate of adverse effects in transfusion in the experimental group was 5.7%, lower than 16.7% in the control group. The correct rate of transfusion speed was 97.0% in the experimental group, higher than 89.3% in the control group, and there was statistically significant difference between the two groups (P 0.05) . The compliant rate about transfusion was 5.7% in the experimental group, lower than 16.7% in the control group, and there was statistically significant difference between the two groups (P<0.05) . Conclusions The intelligent nursing and transfusion system can improve transfusion management in clinical practice, which not only reduce the incidence rate of adverse effects in transfusion and improve the transfusion safety in patients with growth hormone adenoma complicated with cardiomyopathy, and also reduce the compliant rate about transfusion and improve patients' satisfaction. Key words: Growth hormone adenoma; Cardiomyopathy; Venous transfusion; Intelligent nursing and transfusion system; Transfusion management; Informatization