Adenoma Of Salivary Gland Research Articles

Role of Fine Needle Aspiration Cytology in the Diagnosis Of Pleomorphic Adenoma With Histological Correlation

Background: Fine Needle Aspiration Cytology (FNAC) has been widely accepted as an accurate and minimally invasive diagnostic procedure in the investigations of salivary gland masses. The aim of this study was to determine the accuracy of FNAC in the diagnosis of pleomorphic adenoma. Materials and methods: A cross sectional comparative study was carried out on a total of 28 patients with salivary gland swellings who underwent preoperative FNA examination. After surgical excision of tumours, all FNAC findings were subsequently verified with histopathological examination. All the necessary and relevant data were recorded methodically and meticulously and statistical analysis was done by computer software device (SPSS-18 version). Results: On preoperative FNA examination, among the 28 cases, 19 (67.9%) cases were pleomorphic adenomas. On histopathological examination, out of 28 cases, 20 (71.4%) cases were pleomorphic adenomas. Out of 19 cases of pleomorphic adenomas diagnosed by cytology, 17 cases were confirmed by histopathology. Remaining two cases revealed different diagnosis. In three cases of pleomorphic adenomas diagnosed by histopathology, the cytology revealed different diagnosis. In six cases of tumours other than pleomorphic adenoma there was agreement between cytological and histological diagnosis. The diagnostic sensitivity, specificity and accuracy of preoperative FNAC of pleomor phic adenoma were 85%, 75% and 82.1% respectively. The Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of FNAC were 89.5% and 66.7% respectively. Conclusion: Fine needle aspiration cytology is a useful preoperative diagnostic tool in evaluating Pleomorphic adenoma of salivary gland.
 JCMCTA 2019 ; 30 (1) : 56-60

Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival.

Identify variables that are independent predictors of survival in carcinoma ex pleomorphic adenoma (CXPA) of the major salivary glands using a population-based database and evaluate the incidence and management strategies for this rare malignancy. The Surveillance, Epidemiology, and End Results (SEER) database was queried for all cases of major salivary gland CXPA from 1973 to 2015. Of the 619 patients identified, the parotid gland was the most common site of involvement (76.9%, 476/619). The reported incidence of CXPA has risen in the past decade (2005-2015, 0.24 to 0.63 per 1,000,000). The 2-year and 5-year disease-specific survival (DSS) rates were 90.3% and 80.4%, respectively. On univariate analysis, facial nerve sacrifice was not a statistically significant predictor of survival (HR = 1.213, 95% CI [0.588-2.058], P = 0.602). Patients with a tumor size >4 cm, multiple positive lymph nodes, and distant metastatic disease had a 2 to 4-fold statistically significant increase in mortality using a multivariate analysis. Statistical significance was not demonstrated in the DSS of patients who underwent partial versus total parotidectomy procedures. CXPA is a rare salivary malignancy that has a reported increased incidence in the last decade. Tumor size >4 cm, multiple positive lymph nodes, and distant metastatic disease are predictors of disease-specific mortality. Further research should be conducted to improve early detection and survival strategies for this salivary cancer. 4.

Pleomorphic Adenoma of minor Salivary Gland arising from Thyroglossal Duct: Uncommon Presentation

Pleomorphic Adenoma of minor Salivary Gland arising from Thyroglossal Duct: Uncommon Presentation

Benign tumors in myotonic dystrophy type I target disease-related cancer sites.

ObjectivesRecent evidence showed that myotonic dystrophy type I (DM1) patients are at increased risk of certain cancers, but the risk of benign tumors is unknown. We compared the risk of benign tumors in DM1 patients with matched DM1‐free individuals and assessed the association between benign tumors and subsequent cancers.MethodsWe identified 927 DM1 patients and 13,085 DM1‐free individuals matched on gender, birth‐year, clinic, and clinic‐registration year from the UK Clinical Practice Research Datalink, a primary care records database. We used Cox regression models for statistical analyses.ResultsDM1 patients had elevated risks of thyroid nodules (Hazard Ratio [HR] = 10.4; 95% Confidence Interval [CI] = 3.91–27.52; P < 0.001), benign tumors of the brain or nervous system (HR = 8.4; 95% CI = 2.48–28.47; P < 0.001), colorectal polyps (HR = 4.3; 95% CI = 1.76–10.41; P = 0.001), and possibly uterine fibroids (HR = 2.7; 95% CI = 1.22–5.88; P = 0.01). Pilomatricomas and salivary gland adenomas occurred almost exclusively in DM1 patients (Fisher's exact P < 0.001). The HR for colorectal polyps was elevated in DM1 males but not in females (HR = 8.2 vs. 1.3, respectively; P‐heterogeneity < 0.001), whereas endocrine and brain tumors occurred exclusively in females. The data suggested an association between benign tumors and subsequent cancer in classic DM1 patients (HR = 2.7; 95% CI = 0.93–7.59; P = 0.07).InterpretationOur study showed a similar site‐specific benign tumor profile to that previously reported for DM1‐associated cancers. The possible association between benign tumors and subsequent cancer in classic DM1 patients warrants further investigation as it may guide identifying patients at elevated risk of cancer. Our findings underscore the importance of following population‐based screening recommendations in DM1 patients, for example, for colorectal cancer.

Pleomorphic Adenoma of the upper lip

The pleomorphic adenoma is a benign salivary gland tumor, presenting usually in the parotid gland. This case report describes an unusual case of 29 years old female with a single, nodular swelling evident in the upper lip which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip .The lesion measured 1.0 x 1.0 cm in size for 2 years duration cause depression of labial cortical bone apical to lateral and canine teeth. It is characterized by slow growth. Complete excision was performed and the histopathological analysis supported by immunohistochemistry showed pleomorphic adenoma .It did not recur 18 months after operation.&#x0D;

Salivary gland neoplasms in non-human primates: A case series and brief literature review.

Salivary gland neoplasms are rare in non-human primates. Thirty-five years of pathology records were reviewed at the Southwest (SNPRC) and Yerkes (YNPRC) National Primate Research Centers. An in-depth literature search for salivary gland neoplasms in non-human primates was performed. Seventeen salivary gland neoplasms (nine from SNPRC and YNPRC, eight from published literature) were identified. There were seven malignant, nine benign, and one of undetermined behavior identified in eight rhesus macaques, six baboons, a chimpanzee, a bonnet macaque, and a moustached tamarin. Parotid gland was the most frequent origin (n=7), followed by mandibular (n=4) or minor salivary glands (n=2). Two animals with salivary gland adenoma had a history of prior radiation exposure. Parotid glands are the most common origin for salivary gland neoplasms. Salivary gland neoplasms should be considered in the differential diagnoses of head and neck masses in non-human primates.

Cytological features of basal cell adenocarcinoma of the salivary glands.

The cytological features of basal cell adenocarcinoma (BAC) of the salivary gland, a rare carcinoma, have not been well described. This study included patients who were histopathologically diagnosed with BAC and who underwent preoperative fine-needle aspiration cytological examination. Cytological characteristics, including background, arrangement and shape of the neoplastic cells, nuclear and cytoplasmic features, and presence of stromal spindle cells, were reviewed. Seven patients were enrolled in the study. The cytological specimens were cellular and composed of large or small clusters with occasional discohesive neoplastic cells at the periphery. The predominant cellular morphology was spindle-shaped in four cases, and small round-shaped in three cases. These neoplastic cells were tightly packed, showed high cellularity and overlapping nuclei, and had mildly to moderately enlarged round to oval nuclei with occasional small nucleoli and scant cytoplasm. Stromal spindle cells were observed around the basaloid cells in three cases (42.9%). All histology-proven stromal spindle cell-positive cases had stromal spindle cells in the cytological specimens. The study findings clearly demonstrate the relatively high frequency of stromal spindle cells in cytological specimens of BAC. This finding is characteristic of BAC, although basal cell adenoma of salivary gland frequently has stromal spindle cells in the cytological specimens. The characteristic that differentiates BAC from basal cell adenoma is the presence of tightly packed and high cellular clusters with discohesive neoplastic cells. An understanding of these cytological features can aid the cytodiagnosis of BAC.

Clinical Presentation and Histological Variation of Pleomorphic Adenoma of Salivary Glands

Background: Pleomorphic Adenoma is the most common salivary gland tumour accounts 40-70% of all salivary gland tumour and about 60-80% of the benign tumours and 60- 70% of all parotid tumours. There is no study conducted in Bangladesh to observe the clinical and histological variation of the tumour. This study presents 36 cases of Pleomorphic adenoma collected over 11 months at the different territory hospital of Dhaka city. Design: Observational study (November’ 2011 to September’ 2012) Setting: Department of Oral and Maxillofacial Surgery (Dhaka Dental College and Hospital, Bangabandhu Sheikh Mujib Medical Universityl), Department of ENT and Head- Neck Surgery (Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University).&#x0D; Method: The entire patient clinically and cytologically diagnosed as Pleomorphic adenoma were selected. Data were collected in a summarized data sheet. Then histopathological types of them were analyzed from excisional biopsized tissue.&#x0D; Result: There were 36 patients of Pleomorphic adenoma of which 24(66.67%) in Parotid glands, 4(11.11%) in Submandibular glands and 8(22.22%) in minor salivary glands. Among the respondents, female was predominant 20(55.56%) with ages were between 29 years to 65 years old (mean age 44.83 ± 8.32 years) with most patients (44.44%) in 41 to 50 years of life. In histophathological study showed Stromal rich 38.89%, cell rich 36.11% and classic 25%. Cuboidal cells were the most commonly found cellular type followed by plasmacytoid and spindle.Trabeculae and duct like structures were the most frequent pattern by the epithelial cells.Myxoid and Hyalinization were the most frequently found mesenchymal like tissue.Cases presented with symptoms such as swelling (100%), limitation of mouth opening, paesthesia and pain.&#x0D; Conclusion: The knowledge about clinical presentation and the immense variety of cells, architectures and morphological characteristics present in Pleomorphic adenoma of the salivary gland is essential for correct diagnosis and prognosis. The need for improved diagnostic facilities and upgrading of infrastructure was stressed.&#x0D; J Bangladesh Coll Phys Surg 2019; 37(2): 72-77

Pleomorphic adenoma of the parotid gland

Abstract Pleomorphic adenomas of salivary glands in children's ages is one of the rare finds. These tumors are 1–3% of the head and neck tumors. The most common pleomorphic adenoma of the salivary gland is found in the parotid (60–65%). This slowly growing tumor is most commonly seen in women in the 5th-6th decades. Histologically, these tumors include epithelial, mesenchymal, mioepitelial components covered by pseudocapsules. Pleomorphic adenoma is found to be very late as 1–1.5% for children aged 16 and under [4].

Histomorphological comparison of pleomorphic adenoma in major and minor salivary glands of oral cavity: A comparative study.

Background and Objectives:Pleomorphic adenoma, being the most common benign tumors of salivary gland, is morphologically characterized by a biphasic pattern containing the epithelial and mesenchymal components. The modified myoepithelial cells present are thought to play an important role in its histologic diversity by the formation of extracellular matrix. The aim of the present study was to observe, compare and correlate the histomorphological diversity of epithelial and stromal components along with different morphological cell types of modified myoepithelial cells.Materials and Method:Histomorphological features were compared in twenty cases of pleomorphic adenoma of major salivary glands and twenty cases of minor salivary glands using hematoxylin and eosin stains. The features were analyzed by observing under the light microscope.Results:Statistical analysis showed significance of plasmacytoid cells, and squamous metaplasia was extensive with formation of keratin cyst-like structure resembling cystic pleomorphic adenoma, in minor salivary gland tumors.Conclusion:Plasmacytoid cells, squamous cells and areas of hyalinization were observed predominantly in major salivary gland tumors compared to minor salivary glands. Keratin pearls were predominant in minor salivary gland tumors.

A Comparative Study of Histopathological and Immunohistochemical Expression of MCM3 and MMP-2 in Pleomorphic Adenoma of Major and Minor Salivary Glands

A Comparative Study of Histopathological and Immunohistochemical Expression of MCM3 and MMP-2 in Pleomorphic Adenoma of Major and Minor Salivary Glands

Pleomorphic adenoma of minor salivary gland in the floor of mouth

Pleomorphic adenoma of minor salivary gland in the floor of mouth

Pleomorphic Adenoma of Upper Lip: A Rare Case Presentation.

Pleomorphic adenoma is the most common neoplasm of the salivary glands and is most commonly located in the parotid followed by the submandibular glands. The most common intraoral site includes hard and soft palate. This case report describes a rare and unusual lesion found in a 21years old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed and firm mass, about 3cm in diameter, almost protruding below the nose. Complete excision was performed by intraoral route and the histo-pathologic analysis showed pleomorphic adenoma. The tumor did not recur.

Immunohistoc hemical localization of Inducible Nitric Oxide Synthase in Pleomorphic Adenoma of Salivary Gland: Correlation with Cyclooxygenase-2 and Tumor Proliferative Activity

Objectives: to investigate immunohistochemically localization pattern and distribution ofinducible Nitric Oxide Synthase (iNOS) in pleomorphic adenoma (PA ) of salivary glands and tofind a correlation of its expression with Cyclooxygenase-2 (COX -2) and tumor proliferative activity.Material and Methods: 18 cases of PA were subjected to immunohistochemical stainingfor iNOS, COX-2 and proliferative cell nuclear antigen (PCNA) using streptavidin-peroxidasetechnique. 10 samples of normal salivary glands tissues (NSG) were used as a control. COX-2,iNOS and PCNA expression were statistically compared.Results: in PA , expression of iNOS was increased as that of COX-2 when compared withthe control. The expression intensity and pattern of distribution of studied proteins were differentwithin the tumor tissue. The strong expression was localized mainly at the tumor periphery whilethe center of tumor showed weak or even negative expression. The PCNA-LI mean percentage washigher in the periphery of the tumors. The low expression scores of iNOS were detected in 4 cases,moderate in 5 cases and high in 7 cases, whereas the expression scores of COX-2 were observed in5 cases (low), in 9 cases (moderate) and 5 cases (high). The expression scores of iNOs and COX-2were significantly correlated (P≤0.05). Significant correlation of expression scores of COX -2 andiNOS with PCNA-LI (P≤0.01) were found.Conclusion: this study revealed that COX -2 and iNOS expression was increased significantlyin PA . Their pattern of expression was more in the periphery of the lesion than the center. Thelabelling index of PCNA was higher in the periphery of the lesion indicating that the tumorousand proliferative activity of PA is more at tumor tissues near the margins suggesting that theaggressiveness of PA is at the tumor peripheries.

Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

Solitary Fibrous Tumor: a Rare Lesion with Oral Manifestations

Solitary fibrous tumor is a rare soft tissue tumor, initially described as a pleural neoplasm and subsequently found in other places, including the head and neck region. A 53-year-old Caucasian woman came to a stomatology outpatient unit with an increase in the face volume for about 1 year. An extraoral examination revealed a submerged tumor covered by an intact and normochromic skin; intraorally, this lesion could be palpated. The mucosa was intact and normochromic. The increase was mobile, of fibrous consistency, with about 2 cm in its largest diameter, located in the left buccal mucosa. The diagnostic hypotheses were accessory salivary gland adenoma, fibrolipoma, or neurilemmoma. Due to the clinical characteristics and size of the lesion, an excisional biopsy was conducted at the same time as the final treatment. The histopathological report was of solitary fibrous tumor. The patient is in outpatient control and does not present any intercurrence.

Pleomorphic Adenoma of the Sublingual Salivary Gland - A Rare Occurrence

Pleomorphic Adenoma of the Sublingual Salivary Gland - A Rare Occurrence

Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features.

Pleomorphic adenoma (PA) is the most common salivary gland tumor and is characterized by cytomorphological and architectural diversity. On CT and MR images, PAs are shown as well-defined lesions occasionally accompanied by characteristic lobulated contours. On T2-weighted images, typical PAs show marked hyperintensity, which reflects the abundant myxochondroid stroma, with a hypointense rim indicating the fibrous capsule. However, intratumoral signal intensity varies according to the cellular density, proportion of epithelial and stromal components, and type of stromal components. In addition, a variety of secondary histological changes, including fibrosis, lipometaplasia, ossification, cystic degeneration, and infarction, occur rarely in PAs; therefore, they are associated with difficulty in differential diagnosis from other salivary gland tumors. This review article describes the common and uncommon CT and MR imaging features of PA of the salivary glands.

Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland.

Cripto-1 is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family. Besides being critical for early embryonic development, Cripto-1 is also associated with the development and behavior of several cancers. We analyzed the immunoexpression of Cripto-1 in normal salivary glands (NSGs), pleomorphic adenomas (PAs), and carcinoma ex pleomorphic adenomas (CaExPAs) of salivary glands. A total of 12 NSGs, 16 PAs and 12 CaExPAs underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were evaluated semiquantitatively (scores 0-3). For statistical analysis, Mann-Whitney and Kruskal-Wallis tests were performed and a significance level of p ≤ 0.05 was established. Most CaExPAs (n = 10) were strong positive (score 3) for Cripto-1, and only three cases of PAs and two specimens of NSGs exhibited some expression (score 1), being statistically significant these findings (p < 0.001). No difference between the expression of this protein in tumors of major and minor salivary glands was observed. Overexpression was found mainly in cases of CaExPAs with invasive growth (n = 8) when compared to those without capsular invasion (intracapsular pattern) (p = 0.036). Patients with or without lymph node metastasis showed no difference (p = 0.294). The results revealed a significantly higher expression of Cripto-1 in CaExPA compared to PA and NSG, suggesting this protein is possibly deregulated in PA malignant transformation. Furthermore, the increased expression of this protein is associated with a more aggressive behavior (invasive growth) in salivary gland tumors.

Pleomorphic Adenoma of Buccal Minor Salivary Gland: A Case Report

Salivary gland tumors are relatively uncommon tumors, accounting approximately 3-10% of head and neck neoplasm. Most of them are benign and pleomorphic adenoma is the commonest among them that involves both major (90%) and minor (10%) salivary glands. The most predominant site of pleomorphic adenoma is palate; however, it may occur in any part of oral cavity like lip, floor of mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. Mucosa of cheek (4%) is an extremely rare site. A case of 25 years young male is reported here possessing pleomorphic adenoma of buccal minor salivary gland that was presented to us with a mobile swelling over right cheek that found to be pleomorphic adenoma of buccal minor salivary gland after histopathological examination. Surgical excision was done by intra oral approach with adequate margins. Patient had an uneventful postoperative course and discharged same day on oral antibiotics.