This study was conducted to examine the effects of nurses' difficulties in quitting smoking and their socio-demographic characteristics on Nicotine addictions. A cross-sectional study was conducted between August and November 2022. The study reached 410 nurses. The Fagerström Test for Nicotine Dependence and the challenges to stopping smoking were used in the study. In the analysis of data; percentage, number, and linear regression techniques were used. It was determined that 30.3% of the nurses had high Nicotine Addiction. It was determined that the mean score of the Internal factors sub-dimension of the Nurses' challenges to stopping smoking was 28.89±8.06, the mean score of the Extrinsic Factors sub-dimension was 23.07±8.36, and the mean Nicotine Addiction scale score was 4.20±2.51. It was determined that the smoking nurse's age, perceived income level, smoking duration, and internal factors sub-dimension of the difficulties in quitting smoking had a 34% effect on the Nicotine addiction test. It was determined that the smoking addiction levels of the nurses who had difficulties in quitting smoking were higher. The Extrinsic Factors sub-dimension of the challenges to stopping smoking of nurses who smoked did not affect Nicotine Addiction status.