Addiction Group Research Articles

Individual Placement and Support for persons with alcohol and drug addiction in a Swedish context (IPS-ADAS): study protocol for a randomised controlled trial

BackgroundEmployment is a vital source for experiencing well-being and lowering the risk of long-term social marginalisation and poverty. For persons with alcohol and drug addiction, it may also improve sobriety. However, the unemployment situation for this group reflects the knowledge gap in effective interventions to support employment. While Individual Placement and Support (IPS) is recognised as evidence-based supported employment for those with serious mental health problems, no scientific evidence for the target group of addiction exists to date. The aim of the present IPS for Alcohol and Drug Addiction in Sweden (IPS-ADAS) trial is to study whether IPS has an effect on gaining employment for this group.MethodsThe IPS-ADAS trial is a multisite, pragmatic, parallel, and single-blinded, superiority randomised controlled trial (RCT). Participants (N = 330) will be randomly assigned (1:1) and participate in IPS plus treatment as usual within Addiction Services (IPS + TAU) or Traditional Vocational Rehabilitation (TVR) available plus TAU (TVR + TAU) for 12 months. The principle of intention-to-treat (ITT) will be applied. The hypothesis is that a significantly larger proportion of IPS + TAU participants will be employed for > 1 day (primary outcome), reach employment sooner, work more hours and longer periods of time, and have a higher income as compared to TVR + TAU participants at 18-month follow-up. We further anticipate that those who benefit from IPS + TAU will use less alcohol and drugs, experience better health, and use less care and support, including support from the justice system, in comparison to TVR + TAU participants, at 6, 12, and 18 months. A supplementary process evaluation, using the IPS Fidelity Scale (25 items) and adhered interviews will address delivery and receipt of the IPS as well as contextual hinders and barriers for coproduction and implementation. Working age (18–65), willingness to work, unemployment, participation in an information meeting about the RCT, treatment for addiction diagnosis, and being financially supported by welfare, constitute eligible criteria.DiscussionA primary study on the effectiveness of IPS on employment for the new target group of addictions will add to the international IPS knowledge base and inform national policy to include the underrepresented group in working life.Trial registrationWHO International Clinical Trials Registry Platform ISRCTN10492363. Registered on 14 August 2023.

Childhood trauma and sex addiction among adult men

AbstractThis study explored the relationship between childhood trauma and sex addiction among a sample of adult men (N = 149). Thirty‐eight (25.5%) men screened positive for sex addiction, whereas 111 (74.5%) did not. Using descriptive discriminant analysis, we found that four subscales of early trauma predicted risk of sex addiction group membership to varying degrees, accounting for 22.3% of the variance explained. Sexual and emotional abuse accounted for the most variance explained in the group differences, whereas physical abuse and, to a lesser extent, general trauma also contributed to the group differences. Implications of the study findings are discussed.

Holistic Rehabilitation in Action: A Data-Driven Analysis of the Impact on Quality of Life among Individuals with Psychoactive Substance Abuse.

Background: Psychoactive substance abuse can affect biological, psychological, social, and spiritual aspects, as well as the users' quality of life, and obliged to carry out medical and social rehabilitation. Purpose: The purpose of the study was to identify the effect of holistic rehabilitation programs on quality of life among drug abusers. Methods: Quasi-experimental with time series design. The sample of this study amounted to 54 people, taken by G-power, all participants who will take part in the rehabilitation program at the National Narcotics Board rehabilitation clinic. Rehabilitation interventions include health assessment, psychological assessments, health counseling, human immunodeficiency virus-related voluntary counseling and testing, addiction counseling, group therapy, family therapy, client and family monitoring, relapse prevention therapy, and postrehabilitation services. Interventions are provided for 10 weeks, and delivered by health professionals. Measurement of quality of life using World Health Organization Quality of Life-Brief Version (WHOQOL-BREF) MEAT 26 statements consisting of physical, psychological, environmental, and social relationship dimensions, with an alpha value of 0.8756. The data was analyzed with the Friedman test. Results: Holistic rehabilitation influences all dimensions quality of life of drug abusers with a P-value of <0.001. Conclusions: A holistic rehabilitation program improves the quality of life of drug abusers.

Evaluation of the Effects of Opium on the Expression of SOX2 and OCT4 in Wistar Rat Bladder.

Bladder cancer is a malignancy greatly affected by behavioral habits. The aim of this study was to examine the effect of opium on changes in the expression of OCT4 and SOX2 in the bladder tissue of rats. Thirty six rats were divided into six groups: 24 rats in the addicted group received morphine and opium for 4 months with 12 rats in the control group. Blood testing was done for the evaluation of CBC, MDA, and TAC. The bladder tissue was removed and checked by histopathological examination. All total RNA was extracted, then cDNAs were synthesized and the OCT4 and SOX2 gene expressions were evaluated by Real-time PCR. The OCT4 mRNA expression level in the opium group of rats was significantly increased compared to the control group (13.5 and 6.8 fold in males and females respectively). Also, in the morphine group, similar augmentation was detected (3.8 and 6.7 fold in males and females respectively). The SOX2 mRNA over-expression level was seen in the morphine group of both genders as compared to the control group (3.7 and 4.2 fold in male and female respectively) but in the opium group, enhancement of mRNA level was seen only in males (6.6 fold). Opium increases both OCT4 and SOX2 expression more than morphine in male rats, but in female rats, SOX2 is increased more by morphine. Over expression of OCT4 and SOX2 was observed in rats treated with opium and morphine. Increased OCT4 and SOX2 expression was seen in opium-treated male rats, but in female rats, SOX2 was increased more by morphine.

Assessment on interoceptive awareness on alcohol use and gambling disorders reveals dissociable interoceptive abilities linked to external and internal dependencies: Practical use of Body Perception Questionnaire Very Short Form (BPQ-VSF) in clinical settings.

Interoception is one of the pivotal cognitive functions for mechanisms of our body awareness, and malfunction of the interoceptive network is thought to be associated with mental illness, including addiction. Within addictive disorders, substance-based and non-substance-based addictions are known to hold dissociable reward systems. However, little is known about how interoceptive awareness between these addiction sub-types would differ. Subjective interoceptive awareness was assessed among patients with alcohol use disorder (n = 50) who were subsequently hospitalized or remained out-patient and gambling addiction (n = 41) by the Body Awareness component of the Japanese version of the Body Perception Questionnaire (BPQ-VSFBA-J) and compared them against healthy control (n = 809). Both addiction groups showed significantly lower BPQ than the control, with no substantial differences between inpatients and outpatients for alcohol samples. Notably, BPQ scores for gambling patients were significantly lower than those for the alcohol group. This evidence may suggest a putative role of interoceptive ability on the severity of behavioral addiction over substance-based addiction.

Smartphone use and social media addiction in undergraduate students

Background Children’s use of social media has increased significantly over the past decade. As a result, they are susceptible to smartphone addiction. In particular, parents' and children's well-being and behaviors are negatively affected by smartphone addiction. Such addiction likely affects both physical performance and lifestyle. Adolescents utilize their smartphones while performing other tasks. The secondary task might divert attention away from the primary task. Reaction time is the combination of brain processing and muscular movement. Texting or communicating on a smartphone while performing another task may affect reaction time. Thus, the purpose of this study was to explore the influence of smartphone use on reaction time in undergraduate students who were addicted to smartphones. Methods The Smartphone Addiction Scale-Short Version (SAS-SV) was used to assign 64 undergraduate students to the smartphone addiction group (n = 32) and the control group (n = 32). The reaction time (RT) of an organism is used to determine how rapidly it responds to stimuli. All participants were examined on the RT test under three conditions: no smartphone use (control), texting, and chatting on a smartphone. Participants were questioned by smartphone through text message or chat with the support of a researcher during the texting and conversation conditions. While responding to the questions, the participant was administered an RT test. Results The results showed that smartphone addiction tends to have a reduced influence on reaction time when compared to the control group. Also, texting or conversing on a smartphone while doing other work had a substantial impact on reaction time in the undergraduates. Conclusions Combining smartphone use with other activities tends to reduce undergraduate students' reaction time.

Mitigating Attentional Bias: The Impact of Perceived Social Self-Efficacy in Individuals with MMO Games Addiction Tendency

Low self-efficacy in interpersonal relationships, linked to MMO game addiction, worsens the inclination towards addiction as individuals seek social interaction within the game, leading to attentional bias towards game stimuli. This study aimed to investigate if manipulating perceived social self-efficacy levels could reduce attentional bias in MMO game addiction compared to non-addictive gamers. 503 undergraduates participated, including the MMO addiction group (n=60) and the control group (n=60), identified through the Korean version of the Internet Game Disorder Scale. Participants were divided into high and low perceived social self-efficacy conditions through false feedback. Dot probe tasks assessed attentional bias changes before and after manipulated feedback using a “social intelligence test.” The attentional bias score, initially higher in the addiction group, decreased after intervention with increased social self-efficacy. No significant changes were observed in control groups and the addiction group with decreased social self-efficacy. These findings confirm that boosting perceived social self-efficacy in MMO addiction can reduce attentional bias towards game stimuli, suggesting crucial interventions for alleviating addictive behaviors.

자기통제고갈이 스마트폰 중독자의 스마트폰 사용욕구 증가에 미치는 영향

This study investigated smartphone craving in individuals prone to addiction under depleted self-control conditions. Participants (N=352) were categorized into a high-risk addiction group (30 individuals) and a general usage group (30 individuals) using the Adult Smartphone Addiction Scale. They were subjected to self-control depletion (deleting the letter 'e' for 5 minutes) or a control condition. Wireless devices were then provided, and smartphone craving was assessed using a go/no-go task measuring reaction time and accuracy. Results revealed higher accuracy and faster reaction times for smartphone-related pictures in the high-risk group under self-control depletion compared to the control condition. In essence, when high-risk individuals depleted self-control, they exhibited heightened craving, indicating increased smartphone usage desire. The study underscores the importance of enhancing self-regulation in smartphone addicts, especially when self-control resources are depleted or executive functions are compromised in stressful conditions.

Assessment of Blood Lead Levels in Mothers Addicted to Opium and Their Neonates in Kerman: A Cross-sectional Study.

High blood lead levels (BLLs) in pregnant women are associated with poor outcome in neonates. One of the newest non-occupational sources of lead contamination is opium consumption. Accordingly, this study aimed to assess BLLs in mothers addicted to opium and their neonates in Kerman. This cross-sectional was conducted in Afzalipour hospital in Kerman, from February 2019 to February 2020. The BLLs were measured in 100 opium-addicted and non-addicted mothers and their newborns, and the lead levels higher than 5 μg/dL were considered contamination. Then, the demographic and anthropometric data were compared. Based on the results of the present study, the BLLs of opium-addicted mothers (33.40±9.22 μg/dL vs 3.2±1.5 μg/dL) and their neonates (13.46±4.86 vs 1.1±0.9) were significantly higher (P=0.001) than those of non-addicts. Moreover, the average birth weight of the newborns in the addicted group was significantly lower than in the non-addicted group (2572.8±77.49 vs 2946±46.87) (P=0.001). Besides, there was a significant relationship between the average birth weight and the BLL of the mother and baby, and the average weight of the babies was significantly lower at higher levels of lead. However, no correlation was observed regarding the average height and head circumference of the neonates (P>0.05). It seems that the serum level of lead in neonates of opium-addicted mothers contaminated with lead is significantly higher than that of non-addicts, but their anthropometric characteristics at birth were not different from those of the nonaddicted group.

Physician-brief advice for promoting smoking cessation among cancer patients on treatment in low and middle-income countries: a scoping review

IntroductionPhysician-brief advice has been utilized in high-income countries to promote smoking cessation among cancer patients. Empirical evidence on its effectiveness among cancer patients in low and middle-income countries (LMICs) is lacking. The gap could be due to inadequate training, and competing healthcare priorities, leading to insufficient implementation of targeted smoking cessation interventions in oncology settings. We undertook this scoping review to determine if physician-brief advice is effective in promoting smoking cessation among cancer patients in LMICs.MethodsWe conducted a literature search of all relevant articles across five databases: Cochrane Central Register of Controlled Trials, Cochrane Library (Tobacco Addiction Group trials), World Conference on Lung Cancer proceedings, PubMed, and Google Scholar up to November 2023, using pre-defined inclusion criteria and keywords. The study population was cancer survivors in LMICs, the intervention was smoking cessation advice by a physician in a clinic or oncology center during a consultation, and the outcome was the effect of smoking cessation programs in discontinuing smoking among cancer survivors in LMICs.ResultsOverall, out of every 10 cancer patients in LMICs, about seven were smokers, and one-half had received physician-brief advice for smoking cessation. Physician-brief advice was more likely to be delivered to patients with smoking-related cancer (Cohen’s d = 0.396). This means that there is a noticeable difference between patients with smoking-related cancer compared to those with cancer unrelated to smoking. Smoking cessation failure was due to the inability to cope with the symptoms of withdrawal, missed smoking cessation clinic visits, mental health disorders, limited time and resources, and minimal patient-physician contact.ConclusionThere is very little literature on the frequency of use or the efficacy of physician-brief advice on smoking cessation in LMICs. The literature suggests that cancer patients in LMICs have low self-efficacy to quit smoking, and smoking cessation is rarely part of cancer care in LMICs. Physicians in LMICs should be trained to use motivational messages and good counseling techniques to improve smoking cessation among cancer patients. Policymakers should allocate the resources to implement physician-brief advice and design training programs for physicians focusing on physician-brief advice tailored to cancer patients.

Electronic cigarettes for smoking cessation.

Electronic cigarettes for smoking cessation.

Internet addiction and depression: a study among adolescents.

The goal of our study is to determine the level of Internet addiction (IA) in adolescents by utilizing the IA scale. We employed two tools: the IA test (IAT) and the beck depression inventory (BDI), complemented by a sociodemographic information form, to assess IA and depression levels. A total of 201 participants were included. A positive correlation was found between daily Internet usage time and IAT scores (r = 0.388, p < 0.001) and between BDI scores and IAT scores (r = 0.161, p = 0.013). Females had a lower mean IAT score (63.56 ± 28.08) (p < 0.001). The BDI scores varied significantly across the groups (p = 0.004). The mean BDI scores were higher in the severe addiction group (13.53 ± 7.15) compared to the moderate (11.04 ± 6.62), mild (10.11 ± 5.38), and normal usage groups (9.28 ± 5.54). A significant difference was found in gender distribution across the groups (p = 0.001). The presence of suicidal ideation differed significantly across the groups (p = 0.002). The presence of depression showed a significant difference (p = 0.038). Our study reveals a significant correlation between increased Internet usage and heightened levels of IA and depression among adolescents, with notable gender differences in IA severity.

The Relationship of Substance Abuse with Attachment and Emotion Regulation

Objective: The purpose of this study to examine the characteristics of substance use (SU) and its relationship with psychiatric symptoms, emotion regulation and attachment in youth and young adults with substance abuse in the southeast region of Turkey who have been exposed to repetitive trauma.&#x0D; Method: Forty-four patients with substance use complaints completed Sociodemographic Form, Addiction Profile Index (BAPI), BAPI-Clinical Form. Association of SU disorder diagnosis with both emotion regulation as measured by the Emotion Regulation Questionnaire (ERQ) and the attachment style as measured by Parent Attachment Tool is evaluated.&#x0D; Results: Our sample consists of 44 male patients a mean age of 23.77 years. All of them can read and write, but none of them are university graduates. The rate of being single in marital status is 66%. 60% of them have a low income level. 45% of them do not work. 25% of the sample meets the addiction criteria. Compared to the addicted and non-addicted groups, the addicted groups had significantly higher scores on inadequate anger control, lack of safe behavior, pleasure-seeking behavior, impulsivity, depression, and anxiety. The non-addicted group had a higher mean for cognitive reappraisal. The non-addicted group had a higher mean for cognitive reappraisal. Inadequate anger control, pleasure seeking behavior and duration of anxiety about substance use were found to be risk factors for addiction.&#x0D; Conclusions: The addicted group is different from the non-addicted group for BAPI subscales and ERQ subscale- a cognitive reappraisal. The current findings expand our understanding of the psychological and behavioral aspects of addiction, especially in provinces such as Şırnak, where traumatic life events are repeated, as there are many risk factors for SUD.

Study on the correlation between prefrontal cortex thickness and alcohol addiction using magnetic resonance imaging in alcohol-dependent patients

Objective: To investigate the correlation between alcohol addiction and prefrontal cortex thickness using magnetic resonance imaging (MRI). Subject and method: Conducted at the Thai Nguyen National Hospital from 2020 to 2022, the cross-sectional study involved 70 alcohol-dependent individuals and 70 healthy counterparts. Participants, right-handed males, were categorized based on DSM-5 criteria diagnosed with alcoholism or no by a psychiatrist. MRI imaging, employing a Siemens 1.5 Tesla scanner, captured brain structural data. Statistical analysis included Student's t-test and multivariate linear regression models. Result: While age and intracranial volume showed no significant differences between healthy and addicted groups, BMI differed significantly. Dorsolateral prefrontal cortex thickness reductions were observed in various regions for the alcoholic group, with significant correlations (p&lt;0.001). Age and intracranial volume emerged as predictors for specific regions. Conclusion: Alcohol addiction is associated with decreased gray matter thickness in the prefrontal cortex, emphasizing the role of age and intracranial volume in predicting these structural changes. The study underscores the need for further research to comprehensively understand the complexities of alcohol-induced brain damage.

Similarity and difference in large-scale functional network alternations between behavioral addictions and substance use disorder: a comparative meta-analysis.

Behavioral addiction (BA) and substance use disorder (SUD) share similarities and differences in clinical symptoms, cognitive functions, and behavioral attributes. However, little is known about whether and how functional networks in the human brain manifest commonalities and differences between BA and SUD. Voxel-wise meta-analyses of resting-state functional connectivity (rs-FC) were conducted in BA and SUD separately, followed by quantitative conjunction analyses to identify the common and distinct alterations across both the BA and SUD groups. A total of 92 datasets with 2444 addicted patients and 2712 healthy controls (HCs) were eligible for the meta-analysis. Our findings demonstrated that BA and SUD exhibited common alterations in rs-FC between frontoparietal network (FPN) and other high-level neurocognitive networks (i.e. default mode network (DMN), affective network (AN), and salience network (SN)) as well as hyperconnectivity between SN seeds and the Rolandic operculum in SSN. In addition, compared with BA, SUD exhibited several distinct within- and between-network rs-FC alterations mainly involved in the DMN and FPN. Further, altered within- and between-network rs-FC showed significant association with clinical characteristics such as the severity of addiction in BA and duration of substance usage in SUD. The common rs-FC alterations in BA and SUD exhibited the relationship with consistent aberrant behaviors in both addiction groups, such as impaired inhibition control and salience attribution. By contrast, the distinct rs-FC alterations might suggest specific substance effects on the brain neural transmitter systems in SUD.

The relationship between addiction and hikikomori tendencies: a case-control study

AimThe present study examined the relationship between addiction and hikikomori (extreme social withdrawal) symptoms.MethodA group of clinically referred addiction patients (n = 31) and a group of age- and gender-matched non-clinical controls (n = 34) completed a self-report scale for measuring hikikomori symptoms (the Hikikomori Questionnaire-25) along with some other questionnaires assessing substance use (frequency and severity) and quality of life.ResultsThe results showed that addiction patients displayed significantly higher levels of hikikomori symptoms than the non-clinical control (Cohen's d = 3.41); 87.1% even showed such a high score that they were identified as being at risk for the hikikomori syndrome (vs. only 2.9% in the non-clinical control group). Correlational analyses revealed that within the addiction group, the severity of the substance use problem (as quantified by an index of craving) correlated positively with the level of hikikomori symptoms and negatively with quality of life. In other words, the more severe the addiction, the more extreme the social withdrawal tendencies and the lower the quality of life.ConclusionAltogether, the findings provide further support for the marked social impairments of people with substance use problems and underline that this should be an important target of intervention.

Effect of online game policy on smartphone game play time, addiction, and emotion in rural adolescents of China

BackgroundSmartphone game addiction has emerged as a major public health problem in China and worldwide. In November 2019 and August 2021, the National Press and Publication Administration of China implemented two increasingly strict policies, as a means of preventing smartphone game addiction in adolescents aged 18 or below. This study aimed to analyze the effect of the policies on smartphone game play time, addiction, and emotion among rural adolescents in China.MethodsWe sent the questionnaire to rural adolescents through the online survey tool Questionnaire Star, a professional online survey evaluation platform. The questionnaire included demographic data, smartphone use survey, smartphone game addiction and emotion evaluation scales. The Smartphone Addiction Scale-Short Version (SAS-SV) measured adolescents’ smartphone game addiction. The Short Version of UPPS-P Impulsive Behavior Scale (SUPPS-P) and Social Anxiety Scale for Children (SASC) measured emotion. According to SAS-SV score, the enrolled rural adolescents were divided into addiction group and non-addiction group. The t-test, Chi-square test, and repeated measure ANOVA assessed the effect of the policies on adolescents’ smartphone game addiction and emotion.ResultsAmong enrolled 459 rural adolescents with a mean age of 14.36 ± 1.37years, 151 (32.90%) were in the addiction group and 308 (67.10%) were in the non-addiction group. Adolescents in the addiction group were older, more male, and higher grade. There were time and group effects between the two groups in playtime. After a year of policies implementation, the weekly game time dropped from 3.52 ± 1.89 h to 2.63 ± 1.93 h in the addiction group and from 2.71 ± 1.75 h to 2.36 ± 1.73 h in the non-addiction group. There were also time and group effects in SAS-SV and SASC scores, but not for SUPPS-P score. In the addiction group, the SAS-SV score dropped from 41.44 ± 7.45 to 29.58 ± 12.43, which was below the cut-off value for addiction, and the level of social anxiety was consistently higher than non-addiction group.ConclusionsThe playtime of rural adolescents spent on smartphone games has decreased significantly due to the restriction of the policies rather than the lack of addiction or social anxiety. The policies had practically significant effects in reducing smartphone game play time for rural adolescents in China.

Analisis Faktor Bekas Pengguna Dadah Terlibat Dalam Dakwah Kepada Penagih Aktif: Perbincangan Menurut Hadis

Usually, duty as a preacher is pioneered by a group of individuals with Islamic studies backgrounds. This is because as a preacher, they have to guide the individual spiritually when needed. Therefore, it is a must for a group of preachers to have a wide knowledge of Islamic studies. However, there is also a group of preachers who have standard knowledge or only know the basics of religion but are active in preaching. This intended group is made up of former drug users who have contributed devotion, time, and energy to making drug addicts awake to the nature of God and faith. Because this contribution of devotion is a challenging task and not so popular, this research is intended to study the main factors contributing to their hard work in delivering preaching for this group of active drug addicts. After that, every factor that has been found will be debated according to the hadith perspective. Thematic methods are used in this research to analyse the data that has been obtained through data collection methodology and an interview with the preacher. The obtained data will be analysed using thematic methods and NVIVO software. The results show that there are 7 reasons that contribute to and motivate preaching: get busy to control addiction; advise others as well as yourself; reduce longing for drugs; get close to religion; help others in need; experience makes them understand active drug users; and also make up for old mistakes that surround people in drug addiction.

Smartphone Addiction and its Impacts on Loneliness, Happiness, and Satisfaction with Life in Medical Students with Different Personalities During COVID-19 Pandemic.

In this digital era, around the globe, smartphones have become ubiquitous and an indispensable part of everyday life. Despite being a highly productive tool, smartphone is often overused or misused leading to addiction. Studies have been carried out to assess factors influencing smartphone addiction, but very little focus has been placed on psychosocial changes in adults with different personalities, especially among medical students. Hence, this study aimed to investigate the influence of smartphone addiction on personality among medical students in South India. A validated extrovert and Introvert Personality Inventory (IPEI) was administered to assess the personality after obtaining the necessary permissions. Using a validated questionnaire, the satisfaction with life, subjective happiness, and loneliness scales were administered via Google Forms. The results showed there was a statistically significant increase in life satisfaction and loneliness scores among the extroverts in the mobile phone addiction group compared with the non-addiction group (P<0.0001). Considering the impact of cell phones on various factors in adults in different areas can complement the nationwide statistics so as to formulate a health policy to address the vulnerable population and thus prevent the deterioration of the psychosocial behavior of the young generation.

Relationship between lead concentration in maternal and umbilical cord blood and some neonatal outcomes in primiparous opium-dependent mothers in Zahedan, Southeast of Iran in 2022

BackgroundThere are limited studies on maternal and umbilical cord blood lead levels and their relationship with each other and with pregnancy outcomes in women addicted to opium. The present study was conducted with the aim of investigating the relationship between lead concentrations in maternal blood and umbilical cord blood with some neonatal outcomes in primiparous opium-dependent mothers.MethodThe present study is a cross-sectional and analytical research. A total of 35 mothers addicted to opium and 35 women without addiction from Zahedan city of Iran participated in this study in 2022. Convenience sampling was done, lead levels were measured and pregnancy outcomes checked by a checklist to collect information. Data analysis was done by independent t-tests, Pearson’s correlation coefficient, Point-Biserial Correlation Coefficient, multivariate linear regression and multivariate logistic regression using SPSS version 26 software.ResultsThere was a significant difference in maternal blood lead levels (24.97 ± 8.45 in addicted mothers and 7.5 ± 4.25 in healthy mothers) and in umbilical cord blood lead concentrations (18.68 ± 6.95 in the addicted group and 5.7 ± 2.84 in the healthy group) between the two groups (P < 0.0001 and P < 0.0001, respectively).The lead concentration of all the samples in the addicted group was higher than the high-risk levels. Birth weight, Apgar score, admission to NICU and need for resuscitation were significantly different between the two groups (P < 0.0001, P < 0.0001, p = 0.03 and p = 0.04, respectively). Based on the results of multivariate linear regression test, only addiction can reversely predict the birth weight (Beta= -0.74, P < 0.0001), 1-minute Apgar score (Beta = -0.47, P = 0.004) and 5th minute (Beta= -0.62, P = 0.001). According to multivariate logistic regression test, OR of none of the predictor variables was significant with the outcomes. Maternal and umbilical cord blood lead concentrations were not predictors of pregnancy outcomes.ConclusionThe use of opium during pregnancy leads to an increase in the level of lead in maternal blood and umbilical cord blood. Addiction increased adverse pregnancy outcomes but lead concentration did not predict pregnancy complications. It is recommended that the addiction treatment program be included in pre-pregnancy and pregnancy care plans.