The main objective of the current endeavor is to monitor hypothetical processes utilizing a Sisko tri-hybrid fluid over a rotating disk with entropy generation suspended in Darcy-Forchheimer porous medium. Electro Magneto Hydro Dynamics (EMHD), non-linear thermal radiation and exponential and thermal- space dependent heat source/sink coefficients are considered with the intent of conceiving an Runge-Kutta-Fehlberg method with shooting procedures integrated with a combination of an Adaptive Neuro-Fuzzy Inference System (ANFIS) and Reptile Search Algorithm (RSA). Then, ANFIS-RSA, is used to predict the Nusselt number, skin friction co-efficient in radial and tangential velocities. Reliable self-similarity variables have reduced a non-linear partial differential set of equations into an ordinary differential equation. According to the empirical evidence, Sisko fluid parameter rises the radial velocity whereas for magnetic field and Darcy-Forchheimer the azimuthal and axial velocities visualizations decreasing trend, respectively. The entropy generation and Bejan number rises for electric and radiation effects. Also, ANFIS-RSA indicates that the model attained a high level of precision in terms of radial velocity (98.13%), tangential velocity (98.18%) and Nusselt number (98.91%). Thus, the longer rendering of the nanoparticles used here might, makes them potentially helpful for regulating the therapeutic impact in the management and treatment of cancer.
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