Background: This paper presents open-source computer simulation programs developed for simulating, tracking, and estimating the COVID-19 outbreak. Methods: The programs consisted of two separate parts: one set of programs built in Simulink with a block diagram display, and another one coded in MATLAB as scripts. The mathematical model used in this package was the SIR, SEIR, and SEIRD models represented by a set of differential-algebraic equations. It can be easily modified to develop new models for the problem. A generalized method was adopted to simulate worldwide outbreaks in an efficient, fast, and simple way. Results: To get a good tracking of the virus spread, a sum of sigmoid functions was proposed to capture any dynamic changes in the data. The parameters used for the input (infection and recovery rate functions) are computed using the parameter estimation tool in MATLAB. Several statistic methods were applied for the rate function including linear, mean, root-mean-square, and standard deviation. In addition, an adaptive neuro-fuzzy inference system (ANFIS) is employed and proposed to train the model and predict its output. Conclusion: Due to the fact that COVID-19 disease has not been detected in a large part of the passengers, because they do not have any symptoms yet. For this purpose, in setting our forecast model, two scenarios are considered for the probability of a symptomatic person to travel until 1) the first medical visit 2) hospitalization. Therefore, in the present study, an open source toolbox for modeling, simulation and estimating the prevalence of coronavirus was presented. This procedure is presented in such a way that it can be generalized and applied in other parts and applications of estimating the scenarios of an event, including the potential of several models, including SIR, which is sensitive to pollution, etc. In addition, several statistical measures were used to determine the optimal time parameters for sigmoid functions. also, an adaptive fuzzy neural inference system was used to generate model output based on some of the training tasks applied to the system. This program can be used as an educational tool or for research studies and this article promises some lasting contributions to field of COVID-19.