According to motion characteristic of an asymmetric rolling missile with damage fin, a three-channel controlled model is established. The controller which is used to realize non-linear tracking and decoupling control of the roll and angle motion is introduced based on an improved trajectory linearization control method. The improved method is composed of the classic trajectory linearization control method and a compensation control law. The classic trajectory linearization control method is implemented in the time-scale separation principle. The Lipschitz non-linear state observer systematically obtained by solving the linear matrix inequality approach is provided to estimate state variables and unknown parameters, and then the compensation control law utilizing the estimated unknown parameters improves the TLC method. Simulation experiments show that the adaptive decoupling control ensure tracking performance, and the robustness and accuracy of missile attitude control are ensured under the condition of the system parameters uncertainty, random observation noise and external disturbance caused by damage fin.