A novel condition monitoring method based on the adaptive multivariate control charts and the supervisory control and data acquisition (SCADA) system is developed. Two types of control charts are adopted: one is the adaptive exponential weighted moving average (AEWMA) control chart for abnormal state detection, and the other is the multivariate exponential weighted moving average (MEWMA) control chart for anomaly location determination. Optimization procedures for these control charts are implemented to achieve minimum out-of-control average running length. Multivariate regression analysis is utilized to obtain the normal condition prediction model of wind turbine with fault-free SCADA data. After comparing the regression accuracy of several popular algorithms in the MRA, the random forest is adopted for feature selection and regression prediction. Various tests on the wind turbine with normal and abnormal states are conducted. The performance and robustness of various control charts are compared comprehensively. Compared with conventional control charts, the AEWMA control chart is more sensitive to the abnormal state and thus has a more effective anomaly identification ability and better robustness. It is shown that the MEWMA control chart combined with the out-of-limit number index can effectively locate and identify the abnormal component.