ABSTRACT A fuzzy radial basis function neural network (Fuzzy RBFNN) adaptive control scheme, based on fixed-time high gain state observer (FTHGO), is proposed to address the unpredictability of real-time state and composite interference in the trajectory tracking of the fully driven Autonomous Underwater Vehicle (AUV), ensuring fixed-time system convergence regardless of initial conditions. Firstly, a fixed-time backstepping controller is designed and a first-order fixed-time filter is introduced to tackle the differential explosion issue. Secondly, an FTHGO is developed to observe the real-time states of the AUV without assuming global known state signal. Then, the composite interference in the AUV system is effectively compensated by integrating the Fuzzy RBFNN technique. Finally, the fixed-time stability of the entire closed-loop system is proven utilising the Lyapunov stability theory. The effectiveness of the proposed algorithm is proved by the simulation experiment.