Acute Suppurative Thyroiditis Research Articles

Two Cases of Bacterial Suppurative Thyroiditis Caused by Streptococcus anginosus

Acute suppurative thyroiditis (AST) is a rare clinical condition. Streptococcus anginosus has a propensity of producing empyema in the head and neck. Here, we reported two cases of AST caused by S. anginosus. A 44-year-old man presented with anterior neck tender swelling and odynophagia for 12 days. He had thyrotoxicosis. He was initially diagnosed as thyroid cancer due to the misleading computed tomography report. Fine needle aspiration (FNA) yielded pus and neutrophils. S. anginosus was isolated from pus. After aspiration of abscess and treatment with sensitive antibiotics, he recovered uneventfully with 3 weeks treatment. He was euthyroid 3 months later. The other case is a 40-year-old women complained of fever and left neck swelling for 20 days. Magnetic resonance imaging showed left neck inflammatory changes. FNA revealed pus and inflammatory cells infiltration. She had moderately decreased level of thyroid-stimulating hormone (TSH). Blood cultures were positive for S. anginosus. After penicillin treatment, TSH level returned to normal range, and the nodule gradually resolved. She recovered uneventfully after 5 weeks treatment. S. anginosus has a previously unappreciated clinical niche in AST. Once AST is clinically concerned, FNA procedure should be performed as early as possible.

A Case of Acute Suppurative Thyroiditis with Thyrotoxicosis in an Elderly Patient

Acute suppurative thyroiditis (AST) is a rare condition, as the thyroid gland is relatively resistant to infection. Thyroid function tests are usually normal in AST. A few cases of AST associated with thyrotoxicosis have been reported in adults. We report a case of AST that was associated with thyrotoxicosis in a 70-year-old woman. We diagnosed AST with thyroid ultrasonography and fine needle aspiration of pus. The patient improved after surgical intervention and had no anatomical abnormality. Fine needle aspiration is the best method for the difficult task of differentiating malignancy and subacute thyroiditis from AST with thyrotoxicosis. Earlier diagnosis and proper treatment for AST might improve the outcome.

Case of concurrent Riedel's thyroiditis, acute suppurative thyroiditis, and micropapillary carcinoma

Riedel's thyroiditis (RT) is a rare chronic inflammatory disease of the thyroid gland. It is characterized by a fibroinflammatory process that partially destroys the gland and extends into adjacent neck structures. Its clinical manifestation can mask an accompanying thyroid neoplasm and can mimic invasive thyroid carcinoma. Therefore, diagnosis can be difficult prior to surgical removal of the thyroid, and histopathologic examination of the thyroid is necessary for a definite diagnosis. The concurrent presence of RT and other thyroid diseases has been reported. However, to our knowledge, the association of RT with acute suppurative thyroiditis and micropapillary carcinoma has not been reported. We report a rare case of concurrent RT, acute suppurative thyroiditis, and micropapillary carcinoma in a 48-year-old patient.

A case of left-sided acute suppurative thyroiditis suggested the clinical possibility of preoperative ultrasonograhy

A case of left-sided acute suppurative thyroiditis suggested the clinical possibility of preoperative ultrasonograhy

Tireoidite supurativa aguda com múltiplas complicações

Acute suppurative thyroiditis is a rare disorder, most often caused by Staphylococcus aureus or Streptococcus pneumoniae, which affects particularly children with pyriform sinus fistula. In adults, the main pathogenic mechanism seems to be hematogenous dissemination from a focus of infection in the oropharynx or respiratory tract. The initial signs and symptoms of acute thyroiditis are similar to those of acute pharyngitis and subacute thyroiditis. This fact often delays diagnosis and increases the risk of complications. We report the case of a previously healthy, 28-year-old man who, after being affected by tonsillitis, developed suppurative thyroiditis complicated by thyrotoxicosis; a large abscess in the right lobe of the thyroid extending to the thorax introitus, which caused a trachea deviation and compressed large vessels; associated with internal jugular vein thrombosis, and sepsis.

Retrospective case review of pyriform sinus fistulae of third branchial arch origin commonly presenting as acute suppurative thyroiditis in children

Abnormalities of the third branchial arch are less common than those of the second arch and usually present with left thyroid lobe inflammation. This paper describes 15 cases of pyriform sinus fistulae of third branchial arch origin usually presenting as recurrent thyroid abscess on the left side. A retrospective review of 15 cases of third arch fistulae managed 2000 and 2008, diagnosed based on histopathology and radiological evidence of a fistulous tract, and treated with fistulectomy with left hemithyroidectomy. All patients (six boys and nine girls, aged three to 15 years) presented with recurrent low neck inflammation. Pre-operative ultrasound, computed tomography fistulography and barium swallow demonstrated a third arch fistulous tract, left-sided in all cases. The fistula was detected intra-operatively and pathologically in all cases. Surgery (successful in all cases) emphasised complete recurrent laryngeal nerve and ipsilateral pyriform sinus exposure, to facilitate tract excision, with left hemithyroidectomy. There was no recurrence over three to five years' follow up. Paediatric recurrent low neck inflammatory episodes, due to thyroidal abscess, especially left-sided, should raise suspicion of pyriform sinus fistulae.

Various presentations of fourth branchial pouch sinus tract during surgery

Conclusion: A recurrent neck abscess or acute suppurative thyroiditis should arouse suspicion of fourth branchial pouch sinus. Complete surgical excision is usually curative. The classification of sinus tract according to the area where it is emerging from the larynx may be helpful in identifying the tract during surgery. Objective: To describe our experience of the diagnosis and management of fourth branchial pouch sinus and elucidate three different emerging pathways of the sinus tract during surgery. Methods: Retrospective case series with eight patients who were diagnosed with fourth branchial pouch sinus between January 2007 and July 2011 at the First Affiliated Hospital of Zhengzhou University. Results: Six patients presented with recurrent neck abscess, two presented with acute suppurative thyroiditis. All patients had barium swallow and sinus tract was delineated in six cases. All eight patients underwent surgical excision of the sinus tract. Three different emerging pathways of the sinus tract were identified during surgery. The tract could penetrate the thyroid cartilage near the inferior horn, the inferior pharyngeal constrictor muscle or the cricothyroid membrane when it emerged from the larynx. The recurrent laryngeal nerve was commonly dissected to avoid inadvertent damage. Hemithyroidectomy was performed in six patients. All eight are currently asymptomatic.

Thyrotoxicosis with Post-Treatment Hypothyroidism in a Patient with Acute Suppurative Thyroiditis Due to Porphyromonas

Acute suppurative thyroiditis (AST) is a rare, life-threatening thyroid infection characterized by a tender neck mass and fever. As these features are shared with self-limited subacute thyroiditis (SAT), it is important to differentiate between the two disorders. We report a case of AST in a 21-year-old woman who presented with steadily worsening throat pain for 3 weeks, a tender left neck mass, and thyrotoxicosis. She was initially given prednisone for treatment of presumed SAT but then it acutely worsened. Fine needle aspiration yielded pus on gross examination, and she required intubation and emergent surgical drainage to maintain her airway. Culture of the abscess isolated Streptococcus F and Porphyromonas, a gram-negative intracellular anaerobe not previously reported to cause AST. She improved quickly after surgery, developed transient hypothyroidism that did not require treatment with thyroid hormone, and is currently euthyroid. An abnormal piriform sinus fistula was identified on the left using an esophagram. AST may be difficult to clinically differentiate from SAT. Fine needle aspiration revealing pus, culture yielding bacteria or fungi, abscess on ultrasonography and computed tomography, and left-sided predominance are important in the diagnosis of AST. AST should be considered in any patient with SAT who does not rapidly improve following institution of steroids. Further, the presence of thyrotoxicosis does not eliminate AST as an initial diagnosis.

Transient hyperthyroidism secondary to acute suppurative thyroiditis caused by pyriform sinus fistula

Transient hyperthyroidism secondary to acute suppurative thyroiditis caused by pyriform sinus fistula

Acute Suppurative Thyroiditis Treated Avoiding Invasive Procedures in a Child

Acute suppurative thyroiditis is uncommon in children (1). Acute suppurative thyroiditis is a potentially life-threatening endocrine emergency. The management of this condition has recently been reviewed (2–4), but the optimal treatment is still debated. Surgery is the traditional treatment of this condition, but a nonsurgical management has also been reported (5). This case illustrates a successful conservative approach monitored by ultrasound (US) in a 4-yr-old girl. She came to our observation for a lump of more than 2 cm in the left side of the neck (Fig. 1A1). Ten days before she was admitted to a different institution for a left anterior neck mass. The mass was painful, tender, with erythema and warmth. She presented with fever (39 C) and leucocytosis (white blood cells, 22.100; neutrophils 85%) and was treated for acute suppurative thyroiditis with iv ampicillin and gentamicyn for a week. At our first observation she presented with a firm, painless lump of more than 2 cm in the left side of the neck (Fig. 1A1). At US (Fig. 1B1), the left lobe of thyroid was enlarged, and the parenchyma looked subverted, with a large irregular hypoechoic area and effacement of the planes between prethyroid muscles and soft tissues surrounding the lobe. Adjacent to the lump, a hypoechoic area in the soft tissue, presumably an abscess, was found (arrow). She was treated with amoxicillin and clavulanic acid (100 mg/kg/d per os) for 55 d. The lump disappeared (Fig. 1A2). At US (Fig. 1B2), nearly normal parenchyma was visible as well as muscles and soft tissues. The hypoechoic area was substituted with hyperechoic tissue (arrow). After 6 months she is well, and thyroid function is normal. A transnasal laryngoscopy to evaluate a possible pyriform sinus fistula is planned if a recurrence occurs.

Diagnosis and management of congenital pyriform sinus fistula

To explore the clinical presentation and management principles of congenital pyriform sinus fistula. Seven sequential cases of congenital pyriform sinus fistula (CPSF) treated between January 2007 and January 2011 were reported. The clinical presentation were recurrent left lower neck abscess or acute suppurative thyroiditis. All of these patients had past histories of misdiagnosis ranged from 3 years to 11 years. All the patients had undergone incision and drainage several times. In acute infection period, these patients received incision and drainage, after inflammation subsided, were treated with definitive surgery. After barium swallow study and CT examination in the quiescent stage of infection, 5 patients could be seen fistula in the pyriform, all the patients were found scar tissue near the left thyroid lobe, 4 patients received direct laryngoscope examination and 3 of them could be found inner orifice near the apex of pyriform sinus, fistula and the involved lobe of thyroid were successfully excised without permanent recurrent laryngeal nerve injury or hypothyroidism. All the patients had an uneventful recovery and remained symptom free from 5 months to 40 months. The clinical history of recurrent low neck inflammatory episodes in patients, especially on the left side, should raise the suspicion of CPSF, investigation using barium swallow in combination with CT scanning is useful. CPSF can be treated by excising the fistula and involved lobe of thyroid.

Visual Diagnosis: Swelling of the Left Side of the Neck in an Adolescent

1. Raghu Varier, DO* 2. Laura Plencner, MD* 3. Douglas Rivard, DO† 4. Angela L. Myers, MD, MPH* 1. *Department of Pediatrics, Children's Mercy Hospitals & Clinics and The University of Missouri-Kansas City, Kansas City, MO. 2. †Department of Radiology, Children's Mercy Hospitals & Clinics and The University of Missouri-Kansas City, Kansas City, MO. A previously healthy 13-year-old girl presents to the emergency department with a 2-week history of worsening sore throat and a 4-day history of left neck swelling, pain, and fever. Results of evaluation by a prior clinician at the onset of symptoms included a negative rapid streptococcal antigen test and a positive heterophile antibody test, prompting treatment with oral corticosteroids for 5 days as an anti-inflammatory medication. The girl now reports pain with swallowing, decreased oral intake, and left-sided head tilt for the past 24 hours. On physical examination, the girl has a temperature of 38.4°C and appears to be in no acute distress. In addition, her heart rate is 91 beats/min, respiratory rate is 20 breaths/min, and blood pressure is 119/69 mm Hg. She has a warm, very tender, firm, anterior, left-sided 1.5-cm mass at the level of the thyroid gland. The mass moves when she swallows. Findings on the rest of her physical examination are normal. Laboratory investigation reveals a white blood cell count of 17.2×103/μL (17.2×109/L) with 74% neutrophils and 14% lymphocytes, hemoglobin of 13 g/dL (130 g/L), and platelet count of 423×103/μL (423×109/L). C-reactive protein (CRP) measurement is elevated at 1.6 mg/dL (normal, 0.3 to 1.0 mg/dL). Computed tomography (CT) scan of her neck with intravenous contrast enhancement suggests the diagnosis (Fig. 1). Figure 1. Axial computed tomography scan of the neck with intravenous contrast enhancement. The patient's physical and laboratory findings and CT scan of the neck are consistent with acute suppurative thyroiditis. The CT scan reveals a multilocular inflammatory phlegmon/abscess-in-evolution involving the superior pole of the …

Imaging Studies in Sixty Patients with Acute Suppurative Thyroiditis

Pyriform sinus fistulae are the major routes of infection in acute suppurative thyroiditis (AST). There have been only a few reports describing imaging studies in AST. We reviewed our imaging studies in patients with AST to elucidate its features so as to facilitate its diagnosis and treatment. We reviewed ultrasonography (US) examinations, computed tomography (CT) scans, and barium swallow studies performed on 60 patients with the AST who were seen for medical care between 1998 and 2008 and were retrospectively reviewed. All of these patients had pyriform sinus fistulae. In the acute inflammatory stage, US showed a hypoechoic lesion spreading in and around the affected thyroid lobe, destruction of the lobe, and abscess formation in the neck. CT scans demonstrated similar features with clearer anatomical involvement and edema in the ipsilateral hypopharynx. These findings allowed easy diagnosis of AST. However, in the early inflammatory stage US showed an unclear hypoechoic area in the affected lobe and CT scans showed a nonspecific low-density area. These findings often led to erroneous diagnoses of subacute thyroiditis. A careful review of the US studies demonstrated that the following findings are characteristic of acute suppurative thyroidits: a perithyroidal hypoechoic space, effacement of the plane between the thyroid and perithyroid tissues, and the hypoechoic lesions being unifocal. The former two are not seen in subacute thyroiditis, and hypoechoic lesions in subacute thyroiditis are usually multiple and often bilateral. In the late inflammatory stage, US and CT scans often showed atrophy and an unclear hypoechoic or low-density area in and around the affected lobe. To detect pyriform sinus fistulae, barium swallow studies are more sensitive than US or CT scans. During the acute inflammatory stage of AST, both US and CT scans showed inflammatory processes in and around the affected thyroid lobe, although the CT scans more clearly demonstrate the anatomical locations involved. In the early inflammatory stage, these features may lead to an erroneous diagnosis of subacute thyroiditis. Careful US studies should indicate the correct diagnosis, which can then be proven by a barium swallow study or fine-needle aspiration followed by cytological examination and bacterial culturing.

Acute suppurative thyroiditis in young children

We report two children with acute suppurative thyroiditis (AST). They presented with typical features of AST, which include fever, painful goiter and biochemical euthyroidism. An anatomical defect predisposed to thyroid infection, pyriform sinus fistula, was identified in one patient. Both patients responded well to surgical pus drainage and antibiotic treatment. Anatomical defects must be sought in all children with AST to perform specific surgical treatment and prevent recurrent infection.

Right-Sided Acute Suppurative Thyroiditis Caused by Infectious Endocarditis

Acute suppurative thyroiditis is a rare disorder that is mostly found in the left lobe of the thyroid gland of children due to congenital patency of the pyriform sinus fistula. Here, we report a 61-year-old man with acute right-sided suppurative thyroiditis without pyriform sinus fistula. He also showed infectious hip arthritis, spondylitis and Roth's spots. He presented with heart failure and was diagnosed with infectious endocarditis by sequential transesophageal echocardiography. A replacement with a prosthetic valve was performed and cured him. It is important to recognize that infectious endocarditis can be a focus of acute suppurative thyroiditis.

Acute Suppurative Thyroiditis Caused by Methicillin - ResistantStaphylococcus Aureusin Healthy Children

Acute suppurative thyroiditis is an uncommon condition because the thyroid gland is remarkably resistant to infec- tion. In children, anatomic defects, such as a left piriform sinus fistula, predispose subjects to this infection. It is very important yet difficult to differentiate acute thyroiditis with thyrotoxicosis from subacute thyroiditis; and if left untreated, acute suppurative thyroiditis can lead to thyroid abscess formation. Bacterial infections with staphylococ- cus and streptococcus species are the most common causes of acute suppurative thyroiditis. Occasionally, the thyroid gland can be infected with fungi, parasites, or mycobacterium. An 8-year-old boy presented with acute fever and tender neck swelling. The patient was admitted to the hospital and was diagnosed with acute suppurative thyroiditis. The culture result of the drained fluid revealed methicillin-resistant staphylococcus aureus (MRSA). The patient's condition improved after the use of antibiotics and drainage. There was no evidence of fistula formation between the thyroid and the pyriform sinus on a computed tomography (CT) scan. Here we describe rapidly progressive thyroid abscesses caused by MRSA in healthy children. (J Korean Soc Pediatr Endocrinol 2011;16: 128-132)

Complete Pyriform Sinus Fistulas: Case Series and Review of Literature

ABSTRACTPyriform sinus fistula belongs to the rarest group of cervical fistulae accounting for 3 to 10% of all branchial anomalies.1The first clinical and embryological studies were described in the early seventies by Sandborn and Tucker, but embryological knowledge in this field remains incomplete. Children and adults usually complaint of painful neck swelling accompanied by fever that is preceded by upper respiratory infection, otalgia and odynophagia. Neonates and infants may have respiratory distress, sometimes with stridor, due to tracheal compression by the abscess.1,5,6However, the most common mode of presentation is the recurrent episodes of acute thyroiditis. Eighty percent of patients with recurrent acute suppurative thyroiditis due to persistent pyriform sinus fistula present during the first decade of life. Making the distinction between third and fourth arch fistulas is difficult on clinical grounds alone and hence they are often collectively termed pyriform sinus fistula. Owing to the rarity of the condition and varied clinical presentation, diagnosis and ultimate management is often delayed leading to undue morbidity to the patient and professional frustration for the treating surgeon. We, hereby, present a case series of three classical cases of complete pyriform sinus fistulas with review of available literature in an attempt to clarify issues regarding presentation, diagnosis and management of this condition.

Diagnosis and treatment of congenital fourth branchial anomaly

To discuss the anatomic features, clinical presentations, diagnosis, differentiations and treatments of congenital fourth branchial anomaly(CFBA). The clinical data of 8 patients with CFBA were retrospectively analyzed. Of the 8 patients aging from 27 to 300 months (median age: 114 months), 4 male and 4 female; 3 untreated previously and 5 recurrent. All lesions, including 1 cyst, 3 sinus (with internal opening) and 4 fistula, located in the left necks. Three patients presented acute suppurative thyroiditis, 4 deep neck abscesses, and 1 neck lump. Preoperative examinations included barium esophagogram, direct laryngoscopy, ultrasonography, CT, MRI, and so on. The principles of managements were adequate drainage, infection control during acute period and radical surgery during quiescent period. Classic surgical approach consisted of complete excision of branchial lesions, dissection of recurrent laryngeal nerve and partial thyroidectomy. Selective neck dissection was applied in recurrent cases to extirpate branchial lesions, scarrings and inflammatory granuloma. Postoperatively, 1 case was with local incision infection which healed by wound care; 1 case was with temporary vocal cord paralysis which completely recovered 1 month after operation. No recurrence was found in all of 8 cases with follow-up of 13 to 42 months (median: 21 months). CFBA relates closely anatomically with recurrent laryngeal nerve and thyroid grand. The barium esophagogram and direct laryngoscopy are the most useful diagnostic tools. CT and MRI are all beneficial to the diagnosis of CFBA. The treatment key to CFBA is the complete excision of lesion during a quiescent period after inflammatory control, together with the dissection of recurrent laryngeal nerve, partial thyroidectomy and partial resection of lamina of thyroid cartilage (if necessary), which all can decrease the risk of complications and recurrence. For recurrent cases, selective neck dissection is a safe and effective surgical procedure.

Transient hyperthyroidism secondary to acute suppurative thyroiditis caused by pyriform sinus fistula

Abstract Acute suppurative thyroiditis is a rare, yet potentially life-threatening infectious disease commonly associated with pyriform sinus fistula, especially in children and patients with recurrent episodes. Rarely, infectious thyroiditis is accompanied by transient, self-limiting hyperthyroidism. We report a case of infectious thyroiditis associated with destructive, subclinical hyperthyroidism due to pyriform sinus fistula in a paediatric patient. In addition to high resolution neck ultrasound, fine-needle aspiration biopsy, endoscopic examination and barium swallow were invaluable for correct diagnosis. During acute exacerbation, treatment with antibiotics was indicated, but permanent cure could only be attained by surgical exploration, drainage, and finally, by complete fistulectomy.

Infectious thyroiditis as a complication of fine-needle biopsy: a systematic review

Thyroid fine-needle biopsy (FNB) is a simple, reliable and inexpensive procedure for the diagnosis of thyroid malignancy. Furthermore, it is a useful tool for the identification of the causative pathogen in cases of acute suppurative thyroiditis. However, it can also cause infectious thyroiditis, as bacterial seeding can occur. Post-FNB thyroid infection is a rare complication. Gram-positive bacteria predominate but other bacteria have also been isolated, especially in immunocompromised patients. Preventive measures include iodine skin preparation and alcohol cleansing of the skin before FNB and adequate aseptic conditions. The prognosis of post-FNB infectious thyroiditis depends on prompt recognition and treatment. The treatment of choice is antibiotics and pus drainage, but thyroid resection may be required in cases of persistent infection.